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Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies

Year 2022, Volume: 26 Issue: 5, 1432 - 1442, 28.06.2025

Sudarshana Shetty Rangaswamy Javarappa Nagaraja Naik

Abstract

Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives 8(a-e) and 9(a-e) have been
synthesized by a three step reaction. The structures of the synthesized compounds were established based on the
analytical and spectral data. The in-vitro anticancer and antimicrobial activity of compounds against MCF-7 and HeLa
cancer cell lines and microbes were studied. The compounds 8c and 9c showed significant levels of anticancer activity
compared to the standard. Molecular docking studies were performed on the active site of transferase (PDB ID: 4ANM)
with the synthesized ligands 8(a-e) and 9(a-e) for the optimization of the investigated compounds as potential cancer
cell inhibitors. The antimicrobial activity was performed by using well diffusion method, compounds 8d and 9d showed
maximum inhibition effect against the tested microbial pathogens, respectively.

Keywords

Benzofuran fused pyrimidine pyrazole anticancer antimicrobial molecular docking

References

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There are 30 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Chemistry
Journal Section Articles
Authors

Sudarshana Shetty 0000-0002-7684-5806

Rangaswamy Javarappa 0000-0001-8131-2118

Nagaraja Naik 0000-0002-9303-1193

Publication Date June 28, 2025
Published in Issue Year 2022 Volume: 26 Issue: 5

Cite

APA Shetty, S., Javarappa, R., & Naik, N. (2025). Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies. Journal of Research in Pharmacy, 26(5), 1432-1442.
AMA Shetty S, Javarappa R, Naik N. Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies. J. Res. Pharm. June 2025;26(5):1432-1442.
Chicago Shetty, Sudarshana, Rangaswamy Javarappa, and Nagaraja Naik. “Benzofuran Fused Phenyl pyrimidine/pyrazole Schiff Base Derivatives As Bioactive Agents: Anticancer, Antimicrobial and Molecular Docking Studies”. Journal of Research in Pharmacy 26, no. 5 (June 2025): 1432-42.
EndNote Shetty S, Javarappa R, Naik N (June 1, 2025) Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies. Journal of Research in Pharmacy 26 5 1432–1442.
IEEE S. Shetty, R. Javarappa, and N. Naik, “Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies”, J. Res. Pharm., vol. 26, no. 5, pp. 1432–1442, 2025.
ISNAD Shetty, Sudarshana et al. “Benzofuran Fused Phenyl pyrimidine/pyrazole Schiff Base Derivatives As Bioactive Agents: Anticancer, Antimicrobial and Molecular Docking Studies”. Journal of Research in Pharmacy 26/5 (June 2025), 1432-1442.
JAMA Shetty S, Javarappa R, Naik N. Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies. J. Res. Pharm. 2025;26:1432–1442.
MLA Shetty, Sudarshana et al. “Benzofuran Fused Phenyl pyrimidine/pyrazole Schiff Base Derivatives As Bioactive Agents: Anticancer, Antimicrobial and Molecular Docking Studies”. Journal of Research in Pharmacy, vol. 26, no. 5, 2025, pp. 1432-4.
Vancouver Shetty S, Javarappa R, Naik N. Benzofuran fused phenyl pyrimidine/pyrazole schiff base derivatives as bioactive agents: anticancer, antimicrobial and molecular docking studies. J. Res. Pharm. 2025;26(5):1432-4.