Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Fatih Tok; Muhammed Oğuzhan Doğan; Burçak Gürbüz; Bedia Kaymakçıoğlu

Research Article

Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity

Year 2022, Volume: 26 Issue: 5, 1453 - 1460, 28.06.2025

Fatih Tok , Muhammed Oğuzhan Doğan Burçak Gürbüz , Bedia Kaymakçıoğlu

Abstract

In this study, new nine pyrazoline derivatives were synthesized from chalcone derivatives. The
antimicrobial activity of nine pyrazoline derivatives to four standard bacterial strains (Staphylococcus aureus, Escherichia
coli, Pseudomonas aeruginosa, Enterococcus faecalis) and four standard yeast strains (Candida albicans, Candida glabrata,
Candida parapsilosis, Candida tropicalis) was investigated by the microdilution method for in accordance with the Clinical
and Laboratory Standards Institute (CLSI) standard, and the Minimal Inhibitory Concentration (MIC) values of these
derivatives were determined. Among these derivatives; compounds 7 and 8 against bacterial strains and compounds 2
and 3 against yeast strains exhibited good antimicrobial activity.

Keywords

Pyrazoline, bacteria, yeast, MIC

References

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There are 17 citations in total.

Details

Primary Language	English
Subjects	Pharmaceutical Chemistry, Pharmaceutical Microbiology
Journal Section	Articles
Authors	Fatih Tok 0000-0002-4569-008X Muhammed Oğuzhan Doğan 0000-0002-3911-6858 Burçak Gürbüz 0000-0002-1002-8264 Bedia Kaymakçıoğlu 0000-0003-0817-8236
Publication Date	June 28, 2025
Published in Issue	Year 2022 Volume: 26 Issue: 5

Cite

APA	Tok, F., Doğan, M. O., Gürbüz, B., Kaymakçıoğlu, B. (2025). Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of Research in Pharmacy, 26(5), 1453-1460.
AMA	Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. June 2025;26(5):1453-1460.
Chicago	Tok, Fatih, Muhammed Oğuzhan Doğan, Burçak Gürbüz, and Bedia Kaymakçıoğlu. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy 26, no. 5 (June 2025): 1453-60.
EndNote	Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B (June 1, 2025) Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. Journal of Research in Pharmacy 26 5 1453–1460.
IEEE	F. Tok, M. O. Doğan, B. Gürbüz, and B. Kaymakçıoğlu, “Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity”, J. Res. Pharm., vol. 26, no. 5, pp. 1453–1460, 2025.
ISNAD	Tok, Fatih et al. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy 26/5 (June 2025), 1453-1460.
JAMA	Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. 2025;26:1453–1460.
MLA	Tok, Fatih et al. “Synthesis of Novel Pyrazoline Derivatives and Evaluation of Their Antimicrobial Activity”. Journal of Research in Pharmacy, vol. 26, no. 5, 2025, pp. 1453-60.
Vancouver	Tok F, Doğan MO, Gürbüz B, Kaymakçıoğlu B. Synthesis of novel pyrazoline derivatives and evaluation of their antimicrobial activity. J. Res. Pharm. 2025;26(5):1453-60.