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Verapamil versus tamoxifen in treatment of experimentally induced infertility

Year 2024, Volume: 28 Issue: 5, 1485 - 1491, 28.06.2025

Mohammed J Manna Luma S Baqir Haidar A Abdulamir

Abstract

Clinical and epidemiological studies indicated that there is an increased incidence of male infertility, with many cases that do not respond well to treatments. This study is aimed at evaluating the therapeutic effects of verapamil and tamoxifen against infertility, which may provide an essential strategy for the treatment of this disorder. A case-control study was conducted on 64 male albino rats, divided into four groups (16 for each); group A (control group); group B (infertile group that is induced by the ornidazole); and groups C and D, which are pretreated with verapamil and tamoxifen, respectively, in combination with ornidazole every day for four weeks. Serum levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) were assessed, and sperm parameters, including sperm count, sperm motility percentage, sperm morphology percentage, and sperm viability, were investigated. Furthermore, Motic Image Plus 2.0 ML was used to measure the mean diameter of the seminiferous tubules (SNT), and a morphometric analysis of 20 tubules per rat was also performed. The results revealed that both verapamil and tamoxifen provide a significant improvement in sperm count, motility, morphology, and dead sperm, with a significant improvement in testosterone, FSH, LH, GSH, NO, MDA, and SOD levels compared with the infertile group. Histophotometric results showed that verapamil and tamoxifen improved the number and size of SNT, Leydig cells, and Sertoli cell counts, which may indicate the promise of using these agents in the treatment of male infertility.

Keywords

Infertility Ornidazole Verapamil Tamoxifen

References

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There are 44 citations in total.

Details

Primary Language English
Subjects Medical Pharmacology
Journal Section Articles
Authors

Mohammed J Manna 0000-0001-5307-1361

Luma S Baqir 0000-0003-0807-6774

Haidar A Abdulamir

Publication Date June 28, 2025
Submission Date July 5, 2024
Acceptance Date July 15, 2024
Published in Issue Year 2024 Volume: 28 Issue: 5

Cite

APA Manna, M. J., Baqir, L. S., & Abdulamir, H. A. (2025). Verapamil versus tamoxifen in treatment of experimentally induced infertility. Journal of Research in Pharmacy, 28(5), 1485-1491.
AMA Manna MJ, Baqir LS, Abdulamir HA. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. July 2025;28(5):1485-1491.
Chicago Manna, Mohammed J, Luma S Baqir, and Haidar A Abdulamir. “Verapamil Versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy 28, no. 5 (July 2025): 1485-91.
EndNote Manna MJ, Baqir LS, Abdulamir HA (July 1, 2025) Verapamil versus tamoxifen in treatment of experimentally induced infertility. Journal of Research in Pharmacy 28 5 1485–1491.
IEEE M. J. Manna, L. S. Baqir, and H. A. Abdulamir, “Verapamil versus tamoxifen in treatment of experimentally induced infertility”, J. Res. Pharm., vol. 28, no. 5, pp. 1485–1491, 2025.
ISNAD Manna, Mohammed J et al. “Verapamil Versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy 28/5 (July 2025), 1485-1491.
JAMA Manna MJ, Baqir LS, Abdulamir HA. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. 2025;28:1485–1491.
MLA Manna, Mohammed J et al. “Verapamil Versus Tamoxifen in Treatment of Experimentally Induced Infertility”. Journal of Research in Pharmacy, vol. 28, no. 5, 2025, pp. 1485-91.
Vancouver Manna MJ, Baqir LS, Abdulamir HA. Verapamil versus tamoxifen in treatment of experimentally induced infertility. J. Res. Pharm. 2025;28(5):1485-91.