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Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease

Year 2024, Volume: 28 Issue: 5, 1691 - 1703, 28.06.2025

Reema Mitra Payal Mittal Pradeep Goyal

Abstract

The objective of the present study was to determine the renoprotective activity of Embelia tserjiam-cottam fruit extract in a streptozotocin-induced model of diabetic nephropathy in rats. The renoprotective effect of the ethanolic extract of Embelia tserjiam-cottam (EET) fruit (200mg/kg BW and 400 mg/kg BW) was studied by measuring blood glucose levels, body weight, kidney hypertrophy, serum and urine creatinine, urine microalbumin, blood urea nitrogen (BUN) and glycosylated hemoglobin (HbA1C) levels. Levels of enzymes like malondialdehyde (MDA), superoxide dismutase (SOD), glutathione reductase (GSH), and catalase was also measured. Renal histopathology studies were carried out. Treatment with the high dose of EET 400mg/kg BW caused a significant decrease (p

Keywords

Diabetic nephropathy urine albumin embeliatserjiam-cottam renal hypertrophy oxidative stress

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There are 42 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Reema Mitra 0000-0001-8436-786X

Payal Mittal 0000-0001-5336-3479

Pradeep Goyal 0000-0003-1800-8759

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 5

Cite

APA Mitra, R., Mittal, P., & Goyal, P. (2025). Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease. Journal of Research in Pharmacy, 28(5), 1691-1703.
AMA Mitra R, Mittal P, Goyal P. Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease. J. Res. Pharm. July 2025;28(5):1691-1703.
Chicago Mitra, Reema, Payal Mittal, and Pradeep Goyal. “Evaluation of the Renoprotective Effect of Embelia Tserjiam-Cottam Fruits in a Rat Model of Diabetic Kidney Disease”. Journal of Research in Pharmacy 28, no. 5 (July 2025): 1691-1703.
EndNote Mitra R, Mittal P, Goyal P (July 1, 2025) Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease. Journal of Research in Pharmacy 28 5 1691–1703.
IEEE R. Mitra, P. Mittal, and P. Goyal, “Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease”, J. Res. Pharm., vol. 28, no. 5, pp. 1691–1703, 2025.
ISNAD Mitra, Reema et al. “Evaluation of the Renoprotective Effect of Embelia Tserjiam-Cottam Fruits in a Rat Model of Diabetic Kidney Disease”. Journal of Research in Pharmacy 28/5 (July 2025), 1691-1703.
JAMA Mitra R, Mittal P, Goyal P. Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease. J. Res. Pharm. 2025;28:1691–1703.
MLA Mitra, Reema et al. “Evaluation of the Renoprotective Effect of Embelia Tserjiam-Cottam Fruits in a Rat Model of Diabetic Kidney Disease”. Journal of Research in Pharmacy, vol. 28, no. 5, 2025, pp. 1691-03.
Vancouver Mitra R, Mittal P, Goyal P. Evaluation of the renoprotective effect of Embelia tserjiam-cottam fruits in a rat model of diabetic kidney disease. J. Res. Pharm. 2025;28(5):1691-703.