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Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets

Year 2024, Volume: 28 Issue: 5, 1704 - 1719, 28.06.2025

Ilyasu Salim Garba Mohammed Khalid Abubakar Sadiq Wada Suleiman Danladi Fatima Shuaibu Kurfı Mahmud Sani Gwarzo

Abstract

This research implements a computer-aided formulation development algorithm based on a novel SeDeM-ODT expert system in establishing the design space for paediatric pyridoxine hydrochloride orodispersible tablets (ODTs) using Prosolv® ODTG2, Prosolv® EasyTab SP, and Ludiflash® systems. For each formulation ingredient, expert system-defined preformulation parameter values were experimentally determined according to standardized methods and then normalized to the theoretical radius range [0,10]. Expert diagrams were constructed and the quantitative performance of each ingredient was evaluated using parametric profile index (IPP), flowability (ff’), and compressibility (ffc) functions. The net direct compression capability was quantitatively expressed as the product of expert system reliability and IPP. Direct compression was conducted in an eccentric tablet press and properties were evaluated using weight, dimension, disintegration test, contact angle, tensile strength, x-ray diffraction, and Fourier-transform infrared spectroscopy. The ODTs dissolution profiles were fitted and compared using zero-order, first-order, Hixson-Crowell, and Hopfenberg models. Results of the expert diagram of pyridoxine hydrochloride indicated suboptimal normalized radii values in 8 out of 12 parameters, implying a compromised mechanical zone (ff’=3.61, ffc=2.11). By setting a target ffc for the optimized formulation mix at 5.0, the predicted proportions of the fillers to remedy the direct compression deficits of the drug were computed as 89.00%, 83.23%, and 76.62% for Prosolv® ODTG2 (ffc=5.36), Prosolv® EasyTab SP (ffc=5.58), and Ludiflash® (ffc=5.88), respectively. The produced ODTs were of acceptable target quality, hence the SeDeM-ODT system was considered a reliable formulation tool for establishing the design space of this particular drug-filler systems.

Keywords

paediatric-centric formulations orodispersible systems computer-aided drug design expert systems pyridoxine hydrochloride direct compaction technology

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There are 58 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Ilyasu Salim 0000-0002-6961-5703

Garba Mohammed Khalid 0000-0003-4045-7702

Abubakar Sadiq Wada 0000-0001-8221-1159

Suleiman Danladi 0000-0002-2017-3887

Fatima Shuaibu Kurfı 0000-0003-1652-6931

Mahmud Sani Gwarzo 0000-0001-8030-7974

Publication Date June 28, 2025
Submission Date November 18, 2023
Acceptance Date January 3, 2024
Published in Issue Year 2024 Volume: 28 Issue: 5

Cite

APA Salim, I., Khalid, G. M., Wada, A. S., Danladi, S., et al. (2025). Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets. Journal of Research in Pharmacy, 28(5), 1704-1719.
AMA Salim I, Khalid GM, Wada AS, Danladi S, Kurfı FS, Gwarzo MS. Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets. J. Res. Pharm. July 2025;28(5):1704-1719.
Chicago Salim, Ilyasu, Garba Mohammed Khalid, Abubakar Sadiq Wada, Suleiman Danladi, Fatima Shuaibu Kurfı, and Mahmud Sani Gwarzo. “Implementing Novel Expert Systems in the Design of Personalized Paediatric Pyridoxine Hydrochloride Orodispersible Tablets”. Journal of Research in Pharmacy 28, no. 5 (July 2025): 1704-19.
EndNote Salim I, Khalid GM, Wada AS, Danladi S, Kurfı FS, Gwarzo MS (July 1, 2025) Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets. Journal of Research in Pharmacy 28 5 1704–1719.
IEEE I. Salim, G. M. Khalid, A. S. Wada, S. Danladi, F. S. Kurfı, and M. S. Gwarzo, “Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets”, J. Res. Pharm., vol. 28, no. 5, pp. 1704–1719, 2025.
ISNAD Salim, Ilyasu et al. “Implementing Novel Expert Systems in the Design of Personalized Paediatric Pyridoxine Hydrochloride Orodispersible Tablets”. Journal of Research in Pharmacy 28/5 (July 2025), 1704-1719.
JAMA Salim I, Khalid GM, Wada AS, Danladi S, Kurfı FS, Gwarzo MS. Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets. J. Res. Pharm. 2025;28:1704–1719.
MLA Salim, Ilyasu et al. “Implementing Novel Expert Systems in the Design of Personalized Paediatric Pyridoxine Hydrochloride Orodispersible Tablets”. Journal of Research in Pharmacy, vol. 28, no. 5, 2025, pp. 1704-19.
Vancouver Salim I, Khalid GM, Wada AS, Danladi S, Kurfı FS, Gwarzo MS. Implementing novel expert systems in the design of personalized paediatric pyridoxine hydrochloride orodispersible tablets. J. Res. Pharm. 2025;28(5):1704-19.