Abstract
References
- [1] Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery system. J Pharm Sci. 2003;6(1):33–66.
- [2] Kumar KV, Sivakumar T, Mani TT. Colon targeting drug delivery system: A review on recent approaches. Int J Pharm Biomed Sci. 2011;2(1):11–19.
- [3] Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Varghese Publ. House: Hind Rajasthan Building, 1991, p. 293.
- [4] Patel A, Bhatt N, Patel KR, Patel NM, Patel MR. Colon Targeted Drug Delivery System: A Review System. JPSBR. 2011;1(1):37–49.
- [5] Jagdale SC, Hude RU. Guar Gum and HPMC Coated Colon Targeted Delivery of 6-Mercapto-Purine. The Natural Products Journal. 2017;7(1):18–19.
- [6] Cheetham NWH, Mashimba ENM. Conformational aspects of xanthan-galactomannan gelation. Further evidence from optical-rotation studies. Carbohydr Polym. 1991;14:17–27. [CrossRef]
- [7] Brosio E, Dubado A, Verzegnassi B. Pulsed field gradient spin-echo NMR measurement of water diffusion coefficient in thickening and gelling agents: Guar galactomannan solution and pectin gels. Cell Mol Biol. 1994;40:569–573.
- [8] Elsabbagh H, Sakr A, Abd-Elhadi SE. Effect of guar gum on the dissolution rate of ephidrine hydrochloride and sulphadimidine tablets. Pharmazie. 1978;33:730–731. [CrossRef]
- [9] Bhalla HL, Shah AA. Controlled release matrices for ketoprofen. Ind Drugs. 1991;28(9):420–422.
- [10] Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm. 2001;224(1–2):19–38. [CrossRef]
- [11] Randhawa R, Bassi P, Kaur G. In vitro, in vivo evaluation of inter polymer complexes between carboxymethyl fenugreek gum and chitosan or carboxymethyl guar gum and chitosan for colon delivery of tamoxifen. Asian Pac J Trop Med. 2012;5(3):202–207. [CrossRef]
- [12] Prasad YVR, Krishnaiah YSR, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J Control Release. 1998;51(2–3):281–287. [CrossRef]
- [13] Fahima MH, Shaker SD, Nasr M, Saad IE, Ragaey R. Guar gum and hydroxy propyl methylcellulose compressed coated tablets for colonic drug delivery: in vitro and in vivo evaluation in healthy human volunteers. Drug Discov Ther. 2011;5(2):90–95. [CrossRef]
- [14] Frohooff HMA, Lippold BC, McGinity JW. Aqueous ethyl cellulose dispersion containing plasticizers at different water solubility and HPMC as coating material for diffusion pellets II: Properties of sprayed films. Eur J Pharm Biopharm. 1999;48(1):67–75. [CrossRef]
- [15] Lindstedt B, Sjöberg M, Hjärtstam J. Osmotic pumping release from KCL tablets coated with porous and nonporous ethyl cellulose. Int J Pharm. 1991;67:21–27. [CrossRef]
- [16] Llabolt JM, Manzo RH, Allemandi DA. Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system. Int J Pharm. 2004;276(1–2):59–66. [CrossRef]
- [17] Kumar VM, Rajat K, Saraogi GK, Singhai AK, Sharma D. Formulation and Evaluation of Sustained Release Floating Tablets of Ciprofloxacin. IRJP. 2011;3(9):120–122.
- [18] Krishnaiah YS, Satyanarayana S, Prasad YVR, Rao SN. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm. 1998;171:137–146. [CrossRef]
- [19] Macfarlane GT, Hay S, Macfarlane S, Gibson GR. Effect of different carbohydrates on growth, polysaccharidase and glycosidase production by Bacteroides ovatus, in batch and continuous culture. J Appl Bacteriol. 1990;68(2):179–187. [CrossRef]
- [20] Rujivipat S. Novel Formulation and Processing aspects for Compression-Coated Tablets and for the Compression of Polymer-Coated Multiparticulates. Mater Sci. 2010. [CrossRef]
- [21] Hariharan M, Gupta VK. A Novel Compression Coated Tablet Dosage Form. Pharm Technol Year Book. 2001.
- [22] Bodhke AA, Rase S, Zurao P, Chandewar AV. pH Dependent Colon Specific Delivery Of Ornidazole and Ciprofloxacin Hydrochloride in Stomach. Der Pharm Lett. 2010;2(3):101–115.
Formulation and Evaluation of Ciprofloxacin Colon Targeted Tablets By Compression Coating Technique Using Guar Gum and Hydroxypropyl Methylcellulose
Abstract
The aim of the present study is to develop colon targeted drug delivery system for ciprofloxacin drug which is used to treat the Crohn’s disease using various proportions of guar gum and HPMC K4M polymer using as coating materials for extending drug release. The compression coated tablets of ciprofloxacin were prepared and were evaluated for hardness, thickness, friability, diameter, drug content, weight variation and in vitro drug release studies. The IR spectrum of ciprofloxacin drug was compared with the IR spectrum of ciprofloxacin physical mixtures and crushed studies confirm that the drug and other excipients in the formulation were compatible with each other. At different pH, % drug release was calculated. The compression coated tablets with 175 mg of guar gum coat released 24.96±2.68 % for formulation F1, whereas combination of Guar gum and HPMC K 4M as coat in the ratio of 5% (F2), 10% (F3) and 20% (F4) release 51.79±1.65%, 36.53±0.79% and 31.61 ±1.87% respectively observed at different time periods in 0.1N HCl for 2hrs, 7.4 pH phosphate buffers for 3hrs and followed by 6.8 pH phosphate buffer for the remaining 19hrs indicating the susceptibility of the guar gum formulations in simulated colonic fluids. But the Formulation F5 (containing mixture of Guar gum in combination with 30% of HPMC K 4M as coat for compressed tablet) gave very soft coats and so more drug release occurs before it reaches to colon pH. The mechanism of drug release with the formulations F1 and F3 was dominantly case-II transport diffusion and followed zero order kinetics, whereas the formulation F4 followed Korsemeyer peppas equation. The ciprofloxacin compression coated tablets showed no change either in physical appearance, drug content or in dissolution pattern during stability study. Based on the R² value obtained, F3 is considered as the best formulation.
Keywords
Ciprofloxacin; Guar gum HPMC K 4M Crospovidone Colon targeted drug delivery Compression coating technique
References
- [1] Chourasia MK, Jain SK. Pharmaceutical approaches to colon targeted drug delivery system. J Pharm Sci. 2003;6(1):33–66.
- [2] Kumar KV, Sivakumar T, Mani TT. Colon targeting drug delivery system: A review on recent approaches. Int J Pharm Biomed Sci. 2011;2(1):11–19.
- [3] Lachman L, Lieberman HA, Kanig JL. The theory and practice of industrial pharmacy. Varghese Publ. House: Hind Rajasthan Building, 1991, p. 293.
- [4] Patel A, Bhatt N, Patel KR, Patel NM, Patel MR. Colon Targeted Drug Delivery System: A Review System. JPSBR. 2011;1(1):37–49.
- [5] Jagdale SC, Hude RU. Guar Gum and HPMC Coated Colon Targeted Delivery of 6-Mercapto-Purine. The Natural Products Journal. 2017;7(1):18–19.
- [6] Cheetham NWH, Mashimba ENM. Conformational aspects of xanthan-galactomannan gelation. Further evidence from optical-rotation studies. Carbohydr Polym. 1991;14:17–27. [CrossRef]
- [7] Brosio E, Dubado A, Verzegnassi B. Pulsed field gradient spin-echo NMR measurement of water diffusion coefficient in thickening and gelling agents: Guar galactomannan solution and pectin gels. Cell Mol Biol. 1994;40:569–573.
- [8] Elsabbagh H, Sakr A, Abd-Elhadi SE. Effect of guar gum on the dissolution rate of ephidrine hydrochloride and sulphadimidine tablets. Pharmazie. 1978;33:730–731. [CrossRef]
- [9] Bhalla HL, Shah AA. Controlled release matrices for ketoprofen. Ind Drugs. 1991;28(9):420–422.
- [10] Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm. 2001;224(1–2):19–38. [CrossRef]
- [11] Randhawa R, Bassi P, Kaur G. In vitro, in vivo evaluation of inter polymer complexes between carboxymethyl fenugreek gum and chitosan or carboxymethyl guar gum and chitosan for colon delivery of tamoxifen. Asian Pac J Trop Med. 2012;5(3):202–207. [CrossRef]
- [12] Prasad YVR, Krishnaiah YSR, Satyanarayana S. In vitro evaluation of guar gum as a carrier for colon-specific drug delivery. J Control Release. 1998;51(2–3):281–287. [CrossRef]
- [13] Fahima MH, Shaker SD, Nasr M, Saad IE, Ragaey R. Guar gum and hydroxy propyl methylcellulose compressed coated tablets for colonic drug delivery: in vitro and in vivo evaluation in healthy human volunteers. Drug Discov Ther. 2011;5(2):90–95. [CrossRef]
- [14] Frohooff HMA, Lippold BC, McGinity JW. Aqueous ethyl cellulose dispersion containing plasticizers at different water solubility and HPMC as coating material for diffusion pellets II: Properties of sprayed films. Eur J Pharm Biopharm. 1999;48(1):67–75. [CrossRef]
- [15] Lindstedt B, Sjöberg M, Hjärtstam J. Osmotic pumping release from KCL tablets coated with porous and nonporous ethyl cellulose. Int J Pharm. 1991;67:21–27. [CrossRef]
- [16] Llabolt JM, Manzo RH, Allemandi DA. Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system. Int J Pharm. 2004;276(1–2):59–66. [CrossRef]
- [17] Kumar VM, Rajat K, Saraogi GK, Singhai AK, Sharma D. Formulation and Evaluation of Sustained Release Floating Tablets of Ciprofloxacin. IRJP. 2011;3(9):120–122.
- [18] Krishnaiah YS, Satyanarayana S, Prasad YVR, Rao SN. Evaluation of guar gum as a compression coat for drug targeting to colon. Int J Pharm. 1998;171:137–146. [CrossRef]
- [19] Macfarlane GT, Hay S, Macfarlane S, Gibson GR. Effect of different carbohydrates on growth, polysaccharidase and glycosidase production by Bacteroides ovatus, in batch and continuous culture. J Appl Bacteriol. 1990;68(2):179–187. [CrossRef]
- [20] Rujivipat S. Novel Formulation and Processing aspects for Compression-Coated Tablets and for the Compression of Polymer-Coated Multiparticulates. Mater Sci. 2010. [CrossRef]
- [21] Hariharan M, Gupta VK. A Novel Compression Coated Tablet Dosage Form. Pharm Technol Year Book. 2001.
- [22] Bodhke AA, Rase S, Zurao P, Chandewar AV. pH Dependent Colon Specific Delivery Of Ornidazole and Ciprofloxacin Hydrochloride in Stomach. Der Pharm Lett. 2010;2(3):101–115.
Details
| Primary Language | English |
|---|---|
| Subjects | Pharmaceutical Delivery Technologies |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 28, 2025 |
| Published in Issue | Year 2022 Volume: 26 Issue: 6 |