Effects of olive oil-based propolis, caffeic acid phenethyl ester, and methylprednisolone on differentiation of human acute myeloid leukemia cells
Abstract
Leukemia, originating from the hematopoietic system, is a malignant disease for the treatment of which
various glucocorticoids are used. The use of natural products alongside conventional therapy has focused on increasing
drug-drug interactions and reducing potential side effects. Based on the idea that propolis and caffeic acid phenethyl
ester (CAPE) can stimulate cancer cells to differentiation and enhance the effect of chemotherapeutic drugs, we
conducted this study. In this study, we investigated whether the synergistic effect of olive oil-based propolis and CAPE
is effective with metylprednisolone (MP), which is used for supportive therapy in AML. In the study, OEP (Olive Oil-
Based Propolis), CAPE, MP and their combinations were applied to HL -60 cells for 1-3 days. Then, CD11b, CD14 and
CD68 antigens were detected on HL -60 cells using flow cytometry techniques to determine the cellular differentiations.
As a result, HL -60 cells were found to be significantly directed to CD11b differentiation. OEP and CAPE will enhance
the effect of chemotherapy by differentiating cells and ensure treatment completion by minimizing damage to normal
tissues and cells.
Keywords
Acute myeloid leukemia differentiation Caffeic acid phenethyl ester Metylprednisolon Olive Oil-Based Propolis
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Details
| Primary Language | English |
|---|---|
| Subjects | Pharmacology and Pharmaceutical Sciences (Other) |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 27, 2025 |
| Published in Issue | Year 2023 Volume: 27 Issue: 2 |