Research Article
Year 2023,
Volume: 27 Issue: 2, 883 - 892, 27.06.2025
Abstract
A biocompatible nano-drug delivery vehicle can efficiently deliver the toxic drug to the targeted site in
nano-quantity to treat cancer patients. Considering this, the current study aims to fabricate stable egg albumin
nanoparticles by using chloroacetic acid to modify their surfaces. The carboxyl functionalized egg albumin (FEA)
nanoparticles were prepared through the desolvation process using ethanol as the desolvating agent; the generated
nanoparticles were stabilized by glutaraldehyde. To obtain stable nanoparticles of suitable size, various reaction
parameters viz concentration of FEA, pH, agitation speed, glutaraldehyde concentration, and rate of ethanol addition
were examined. In neutral and alkaline mediums, we can get nanoparticles of 120-160 nm with -32 mV zeta potential.
The pH of the medium played a decisive role, which strongly influences the FEA particle diameter and surface charge,
while other parameters show little influence. SEM monochrome image of functionalized EA nanoparticles also
supported the particle size of around 130 nm. Gallic acid (GA) has been encapsulated under optimal desolvation
conditions using the FEA/GA acid ratios of 1:1, 2:1, 4:1, and 8:1. The obtained GA entrapped FEA spherical
nanoparticles (GA-FEA) had a -30.9mV zeta potential and were negatively charged. At a 2:1 polymer/drug ratio, an
entrapment efficiency (EE) of 90.4 % (w/w) and drug loading capacity of about 28.7 % (w/w) were achieved. This work
is beneficial to the scientists involved in the field of cancer research.
Keywords
Egg albumin surface modification gallic acid nanoparticles desolvation process drug delivery
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There are 49 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Pharmaceutical Chemistry |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 27, 2025 |
| Published in Issue | Year 2023 Volume: 27 Issue: 2 |