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Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration

Year 2023, Volume: 27 Issue: 3, 1143 - 1156, 28.06.2025

Suresh Velayutham Arunprasanth Sundararaju Thamotharan Govindhaswamy Muthukumaran Gurupackiyam Anbukarasi Balakrishnan Mohamed Yasar Abdul Chetan Ashok J Srikanth

Abstract

This study was designed to investigate the effect of ethanolic extract of Pedalium murex linnleaf (EEPML) in 3-Nitropropionic acid (3-NPA) induced neurodegeneration in a Sprague Dawley rat model. EEPML at a dose of 200 and 400mg/kg was given orally to desired group of animals for a period of 14 days. Neurodegeneration was induced by administering 3-Nitropropionic acid (10 mg/kg/i.p) on 14th day. Two hours after drug administration on 14th day of drug treatment, parameters such as in vitro anticholinesterase activity, DPPH Radical Scavenging Activity, behavioural test for memory and learning (Rotarod test, Open field test), Acetylcholine (ACh) content, Acetylcholinesterase (AChE) activity, Superoxide dismutase (SOD) level in brain homogenate were analysed. EEPML at both doses, i.e., 200 and 400 mg/kg, decreased the acetylcholinesterase in neurodegenerated rats. The EEPML 400 mg/kg/i.p had more pronounced effect on memory, learning test and motor coordination. The EEPML also decreased the body weight of neurodegenerated animals. Acetylcholine was found to be decreased in untreated neurodegenerated rats due to neuronal inflammation. The EEPML at both doses increased the acetylcholine level in neurodegenerated rats. Modulation of Acetylcholine level by the EEPML is related with its potential anti-oxidant and cholinesterase inhibitory activity.

Keywords

Acetylcholinesterase Pedalium murex Linn Superoxide dismutase Huntington’s disease

References

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There are 28 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Suresh Velayutham

Arunprasanth Sundararaju

Thamotharan Govindhaswamy

Muthukumaran Gurupackiyam

Anbukarasi Balakrishnan

Mohamed Yasar Abdul

Chetan Ashok

J Srikanth

Publication Date June 28, 2025
Published in Issue Year 2023 Volume: 27 Issue: 3

Cite

APA Velayutham, S., Sundararaju, A., Govindhaswamy, T., Gurupackiyam, M., et al. (2025). Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. Journal of Research in Pharmacy, 27(3), 1143-1156.
AMA Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. June 2025;27(3):1143-1156.
Chicago Velayutham, Suresh, Arunprasanth Sundararaju, Thamotharan Govindhaswamy, Muthukumaran Gurupackiyam, Anbukarasi Balakrishnan, Mohamed Yasar Abdul, Chetan Ashok, and J Srikanth. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy 27, no. 3 (June 2025): 1143-56.
EndNote Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J (June 1, 2025) Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. Journal of Research in Pharmacy 27 3 1143–1156.
IEEE S. Velayutham, A. Sundararaju, T. Govindhaswamy, M. Gurupackiyam, A. Balakrishnan, M. Y. Abdul, C. Ashok, and J. Srikanth, “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”, J. Res. Pharm., vol. 27, no. 3, pp. 1143–1156, 2025.
ISNAD Velayutham, Suresh et al. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy 27/3 (June 2025), 1143-1156.
JAMA Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. 2025;27:1143–1156.
MLA Velayutham, Suresh et al. “Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration”. Journal of Research in Pharmacy, vol. 27, no. 3, 2025, pp. 1143-56.
Vancouver Velayutham S, Sundararaju A, Govindhaswamy T, Gurupackiyam M, Balakrishnan A, Abdul MY, Ashok C, Srikanth J. Neuroprotective Effect of Ethanolic Extract of Pedalium Murex Linn Leaf in 3-Nitropropionic Acid Induced Neurodegeneration. J. Res. Pharm. 2025;27(3):1143-56.