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Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles

Year 2019, Volume: 23 Issue: 6, 1115 - 1122, 27.06.2025

Erkan Özbay , Ülkü Çömelekoglu , Yusuf Vayısoğlu , Önder Albayrak Rabia Bozdoğan Arpaci Burcu Demirbağ Döndü Anış Deniz Derya Ümit Talaş

Abstract

Toxic effects of silica nanoparticle of rats exposed intratympanically for 7 days were investigated using brainstem auditory evoked potential and distortion product otoacoustic emission techniques. The histopathological changes were evaluated with light microscopy and field emission-scanning electron microscopy were demonstrated in cochleas using based energy-dispersive X-ray spectroscopy. The reduction in the amplitude and prolongation at the peak latency and interpeak latencies of brainstem auditory evoked potential were observed. Silica nanoparticles significantly reduced distortion product otoacoustic emission amplitude in the 2, 3 and 4 kHz frequencies. In the light microscopic evaluation, the samples obtained from the experimental group showed a significant loss of hair cells. Field emission scanning electron microscope analysis of experimental group showed considerable hair cell damage compared to control group. The findings of this study show that intratympanic administration of silica nanoparticles may lead to hearing impairment by causing structural changes in cochlear hair cells.

Keywords

Silica nanoparticle cochlea brainstem auditory potential otoacoustic emission hair cell histopathology

References

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There are 24 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Biochemistry
Journal Section Articles
Authors

Erkan Özbay

Ülkü Çömelekoglu

Yusuf Vayısoğlu

Önder Albayrak

Rabia Bozdoğan Arpaci

Burcu Demirbağ

Döndü Anış Deniz

Derya Ümit Talaş

Publication Date June 27, 2025
Published in Issue Year 2019 Volume: 23 Issue: 6

Cite

APA Özbay, E., Çömelekoglu, Ü., Vayısoğlu, Y., Albayrak, Ö., et al. (2025). Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. Journal of Research in Pharmacy, 23(6), 1115-1122.
AMA Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. July 2025;23(6):1115-1122.
Chicago Özbay, Erkan, Ülkü Çömelekoglu, Yusuf Vayısoğlu, Önder Albayrak, Rabia Bozdoğan Arpaci, Burcu Demirbağ, Döndü Anış Deniz, and Derya Ümit Talaş. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy 23, no. 6 (July 2025): 1115-22.
EndNote Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ (July 1, 2025) Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. Journal of Research in Pharmacy 23 6 1115–1122.
IEEE E. Özbay, Ü. Çömelekoglu, Y. Vayısoğlu, Ö. Albayrak, R. Bozdoğan Arpaci, B. Demirbağ, D. A. Deniz, and D. Ü. Talaş, “Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles”, J. Res. Pharm., vol. 23, no. 6, pp. 1115–1122, 2025.
ISNAD Özbay, Erkan et al. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy 23/6 (July 2025), 1115-1122.
JAMA Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. 2025;23:1115–1122.
MLA Özbay, Erkan et al. “Cochlear Electrophysiology and Histopathology of Rats Exposed to Intratympanic Silica Nanoparticles”. Journal of Research in Pharmacy, vol. 23, no. 6, 2025, pp. 1115-22.
Vancouver Özbay E, Çömelekoglu Ü, Vayısoğlu Y, Albayrak Ö, Bozdoğan Arpaci R, Demirbağ B, Deniz DA, Talaş DÜ. Cochlear electrophysiology and histopathology of rats exposed to intratympanic silica nanoparticles. J. Res. Pharm. 2025;23(6):1115-22.