Research Article
BibTex RIS Cite

Year 2020, Volume: 24 Issue: 6, 874 - 881, 27.06.2025

Farah Al-mamoori

https://doi.org/10.35333/jrp.2020.246

Abstract

References

  • [1] Al-Mamoori F, Al-Samydai A, Aburjai T. Medicinal Plants For The Prevention And Management Of Nephrolithiasis: A Review. IJSTR. 2019; 8(11): 2700-2705.
  • [2] Abhirama BR, ShanmugaSundaram R. Antiurolithic and antioxidant activity of ethanol extract of whole-plant Biophytum sensitivum (Linn.) DC in Ethylene-Glycol-induced urolithiasis in rats. Pharmacogn Mag. 2018; 10(2): 181.
  • [3] Ferraro PM, Bargagli M, Trinchieri A, Gambaro G. Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan Diets. Nutrients. 2020; 12(3): 779. [CrossRef]
  • [4] Saha S, Verma RJ. Antinephrolithiatic and antioxidative efficacy of Dolichos biflorus seeds in a lithiasic rat model. Pharm Biol. 2015; 53(1): 16-30. [CrossRef]
  • [5] Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis: alternative or complementary? Planta Med. 2009; 75(10): 1095. [CrossRef]
  • [6] Khazaei M, Nematollahi-Mahani SN, Mokhtari T, Sheikhbahaei F. Review on Teucrium polium biological activities and medical characteristics against different pathologic situations. J Contemp Med Sci. 2018; 4: 1-6.
  • [7] Alzweiri M, Al Sarhan A, Mansi K, Hudaib M, Aburjai T. Ethnopharmacological survey of medicinal herbs in Jordan, the Northern Badia region. J Ethnopharmacol. 2011; 137(1): 27-35. [CrossRef]
  • [8] Meguellati H, Ouafi S, Saad S, Djemouai N. Evaluation of acute, subacute oral toxicity and wound healing activity of mother plant and callus of Teucrium polium L. subsp. geyrii Maire from Algeria. S Afr J Bot. 2019; 127: 25-34. [CrossRef]
  • [9] Knoll T, Schubert AB, Fahlenkamp D, Leusmann DB, Wendt-Nordahl G, Schubert G. Urolithiasis through the ages: data on more than 200,000 urinary stone analyses. World J Urol. 2011; 185: 1304-1311. [CrossRef]
  • [10] Ingale KG, Thakurdesai PA, Vyawahare NS. Effect of Hygrophila spinosa in ethylene glycol induced nephrolithiasis in rats. Indian J Pharmacol. 2012; 44(5): 639-642. [CrossRef]
  • [11] Kumar BN, Wadud A, Jahan N, Sofi G, Bano H, Makbul SA, Husain S. Antilithiatic effect of Peucedanum grande CB Clarke in chemically induced urolithiasis in rats. J Ethnopharmacol. 2016; 194: 1122-1129. [CrossRef]
  • [12] Erickson SB, Vrtiska TJ, Lieske JC. Effect of Cystone® on urinary composition and stone formation over a one year period. Phytomedicine. 2011; 18(10): 863–867. [CrossRef]
  • [13] Yadav M, Gulkari VD, Wanjari MM. Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats. Anc Sci Life. 2016; 36(2): 90. [CrossRef]
  • [14] Malki S, Yahia AL. Evaluation of diuretic activity from Teucrium polium L. capitatum extracts (Lamiaceae) in rats. Int. J Pharm. Sci. 2014; 5(4): 1259-1262.
  • [15] Kohlstadt I, Frassetto L. Treatment and Prevention of Kidney Stones: An Update. Am Fam Physician. 2011; 84(11): 1234-1242.
  • [16] Soundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J Exp Biol. 2006; 44(12): 981-986.
  • [17] Saghafi E, Mianabadi M, Hadadchi G. Inhibition effects of Teucrium polium extract on gout. Zahedan. J Res Med. Sci. 2013; 15(11): 24-28.
  • [18] Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Compr Physiol. 2011; 2(2): 1303-1353. [CrossRef]
  • [19] Basavaraj DR, Biyani CS, Browning AJ, Cartledge JJ. The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium containing renal stones. EAU-EBU update series. 2007; 5(3): 126-136. [CrossRef]
  • [20] Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, Bishayee A. Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci. 2018; 19(3): 765. [CrossRef]
  • [21] Acute oral toxicity- acute toxic class method. OECD guideline for testing of chemicals 423. 2001. http://www.oecd.org (accessed on 08 Feb 2002)
  • [22] Ghaeni FA, Amin B, Hariri AT, Meybodi NT, Hosseinzadeh H. Antilithiatic effects of crocin on ethylene glycolinduced lithiasis in rats. Urolithiasis. 2014; 42(6): 549-558. [CrossRef]
  • [23] Hasani P, Yasa N, Vosough-Ghanbari S, Mohammadirad A, Dehghan G, Abdollahi M. In vivo antioxidant potential of Teucrium polium, as compared to α-tocopherol. Acta Pharmaceutica. 2007; 57(1): 123-129. [CrossRef]
  • [24] Laker MF, Hofmann AF, Meeuse BJ. Spectrophotometric determination of urinary oxalate with oxalate oxidase prepared from moss. Clin Chem. 1980; 26(7): 827-830.

Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model

Year 2020, Volume: 24 Issue: 6, 874 - 881, 27.06.2025

Farah Al-mamoori

https://doi.org/10.35333/jrp.2020.246

Abstract

The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I (normal control) received distilled water for 40 days. Group II(nephrolithiatic control) to IV(treatment groups)animals received 1% v/v ethylene glycol (EG) in distilled water for 20 days. Group III (standard group) received Cystone® (750 mg/kg) from 20th day - 40th day. Group IV received (200mg/kg) from 20th to 40th day. Urinary volume, pH, and biochemical parameters such as calcium, uric acid, urea, phosphorus and oxalate; and serum calcium, blood urea nitrogen(BUN), uric acid, phosphorus, creatinine and magnesium were assessed. In addition, histopathological changes in kidney were carried out. Supplementation with aqueous extract of T. polium significantly increased urine volume (P˂0.01) and urine pH (P˂0.05). Aqueous extract of T. polium significantly reduced the elevated urinary and serum levels of uric acid (P˂0.001). Moreover, it significantly lowered the urinary, serum levels of phosphorus(P˂0.05) and significantly improved serum magnesium level(P˂0.05). It is noteworthy to mention that T. polium revealed no effect on the other biochemical parameters. We can conclude that T. polium aqueous extract could decrease the risk of formation of CaOx stones by affecting many biochemical parameters other than oxalate.

Keywords

Nephrolithiasis kidney stone calcium oxalate (CaOx) Teucrium polium thylene glycol

References

  • [1] Al-Mamoori F, Al-Samydai A, Aburjai T. Medicinal Plants For The Prevention And Management Of Nephrolithiasis: A Review. IJSTR. 2019; 8(11): 2700-2705.
  • [2] Abhirama BR, ShanmugaSundaram R. Antiurolithic and antioxidant activity of ethanol extract of whole-plant Biophytum sensitivum (Linn.) DC in Ethylene-Glycol-induced urolithiasis in rats. Pharmacogn Mag. 2018; 10(2): 181.
  • [3] Ferraro PM, Bargagli M, Trinchieri A, Gambaro G. Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan Diets. Nutrients. 2020; 12(3): 779. [CrossRef]
  • [4] Saha S, Verma RJ. Antinephrolithiatic and antioxidative efficacy of Dolichos biflorus seeds in a lithiasic rat model. Pharm Biol. 2015; 53(1): 16-30. [CrossRef]
  • [5] Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis: alternative or complementary? Planta Med. 2009; 75(10): 1095. [CrossRef]
  • [6] Khazaei M, Nematollahi-Mahani SN, Mokhtari T, Sheikhbahaei F. Review on Teucrium polium biological activities and medical characteristics against different pathologic situations. J Contemp Med Sci. 2018; 4: 1-6.
  • [7] Alzweiri M, Al Sarhan A, Mansi K, Hudaib M, Aburjai T. Ethnopharmacological survey of medicinal herbs in Jordan, the Northern Badia region. J Ethnopharmacol. 2011; 137(1): 27-35. [CrossRef]
  • [8] Meguellati H, Ouafi S, Saad S, Djemouai N. Evaluation of acute, subacute oral toxicity and wound healing activity of mother plant and callus of Teucrium polium L. subsp. geyrii Maire from Algeria. S Afr J Bot. 2019; 127: 25-34. [CrossRef]
  • [9] Knoll T, Schubert AB, Fahlenkamp D, Leusmann DB, Wendt-Nordahl G, Schubert G. Urolithiasis through the ages: data on more than 200,000 urinary stone analyses. World J Urol. 2011; 185: 1304-1311. [CrossRef]
  • [10] Ingale KG, Thakurdesai PA, Vyawahare NS. Effect of Hygrophila spinosa in ethylene glycol induced nephrolithiasis in rats. Indian J Pharmacol. 2012; 44(5): 639-642. [CrossRef]
  • [11] Kumar BN, Wadud A, Jahan N, Sofi G, Bano H, Makbul SA, Husain S. Antilithiatic effect of Peucedanum grande CB Clarke in chemically induced urolithiasis in rats. J Ethnopharmacol. 2016; 194: 1122-1129. [CrossRef]
  • [12] Erickson SB, Vrtiska TJ, Lieske JC. Effect of Cystone® on urinary composition and stone formation over a one year period. Phytomedicine. 2011; 18(10): 863–867. [CrossRef]
  • [13] Yadav M, Gulkari VD, Wanjari MM. Bryophyllum pinnatum leaf extracts prevent formation of renal calculi in lithiatic rats. Anc Sci Life. 2016; 36(2): 90. [CrossRef]
  • [14] Malki S, Yahia AL. Evaluation of diuretic activity from Teucrium polium L. capitatum extracts (Lamiaceae) in rats. Int. J Pharm. Sci. 2014; 5(4): 1259-1262.
  • [15] Kohlstadt I, Frassetto L. Treatment and Prevention of Kidney Stones: An Update. Am Fam Physician. 2011; 84(11): 1234-1242.
  • [16] Soundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J Exp Biol. 2006; 44(12): 981-986.
  • [17] Saghafi E, Mianabadi M, Hadadchi G. Inhibition effects of Teucrium polium extract on gout. Zahedan. J Res Med. Sci. 2013; 15(11): 24-28.
  • [18] Basile DP, Anderson MD, Sutton TA. Pathophysiology of acute kidney injury. Compr Physiol. 2011; 2(2): 1303-1353. [CrossRef]
  • [19] Basavaraj DR, Biyani CS, Browning AJ, Cartledge JJ. The role of urinary kidney stone inhibitors and promoters in the pathogenesis of calcium containing renal stones. EAU-EBU update series. 2007; 5(3): 126-136. [CrossRef]
  • [20] Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, Bishayee A. Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci. 2018; 19(3): 765. [CrossRef]
  • [21] Acute oral toxicity- acute toxic class method. OECD guideline for testing of chemicals 423. 2001. http://www.oecd.org (accessed on 08 Feb 2002)
  • [22] Ghaeni FA, Amin B, Hariri AT, Meybodi NT, Hosseinzadeh H. Antilithiatic effects of crocin on ethylene glycolinduced lithiasis in rats. Urolithiasis. 2014; 42(6): 549-558. [CrossRef]
  • [23] Hasani P, Yasa N, Vosough-Ghanbari S, Mohammadirad A, Dehghan G, Abdollahi M. In vivo antioxidant potential of Teucrium polium, as compared to α-tocopherol. Acta Pharmaceutica. 2007; 57(1): 123-129. [CrossRef]
  • [24] Laker MF, Hofmann AF, Meeuse BJ. Spectrophotometric determination of urinary oxalate with oxalate oxidase prepared from moss. Clin Chem. 1980; 26(7): 827-830.
There are 24 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Farah Al-mamoori

Publication Date June 27, 2025
Published in Issue Year 2020 Volume: 24 Issue: 6

Cite

APA Al-mamoori, F. (2025). Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model. Journal of Research in Pharmacy, 24(6), 874-881. https://doi.org/10.35333/jrp.2020.246
AMA Al-mamoori F. Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model. J. Res. Pharm. June 2025;24(6):874-881. doi:10.35333/jrp.2020.246
Chicago Al-mamoori, Farah. “Anti-Nephrolithiatic Efficacy of Teucrium Polium Aerial Parts Extract in a Lithiasic Rat Model”. Journal of Research in Pharmacy 24, no. 6 (June 2025): 874-81. https://doi.org/10.35333/jrp.2020.246.
EndNote Al-mamoori F (June 1, 2025) Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model. Journal of Research in Pharmacy 24 6 874–881.
IEEE F. Al-mamoori, “Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model”, J. Res. Pharm., vol. 24, no. 6, pp. 874–881, 2025, doi: 10.35333/jrp.2020.246.
ISNAD Al-mamoori, Farah. “Anti-Nephrolithiatic Efficacy of Teucrium Polium Aerial Parts Extract in a Lithiasic Rat Model”. Journal of Research in Pharmacy 24/6 (June 2025), 874-881. https://doi.org/10.35333/jrp.2020.246.
JAMA Al-mamoori F. Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model. J. Res. Pharm. 2025;24:874–881.
MLA Al-mamoori, Farah. “Anti-Nephrolithiatic Efficacy of Teucrium Polium Aerial Parts Extract in a Lithiasic Rat Model”. Journal of Research in Pharmacy, vol. 24, no. 6, 2025, pp. 874-81, doi:10.35333/jrp.2020.246.
Vancouver Al-mamoori F. Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model. J. Res. Pharm. 2025;24(6):874-81.