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Year 2023, Volume: 27 Issue: Current Research Topics In Pharmacy: Microbiology Debates, 12 - 13, 27.06.2025

Vildan Çeliksoy Rachael L. Moses Alastair J. Sloan Ryan Moseley Charles M. Heard

https://doi.org/10.29228/jrp.389

Abstract

References

  • [1] Celiksoy V, Heard CM. Antimicrobial potential of pomegranate extracts. In: Pomegranate. IntechOpen. 2021, pp1-22. [CrossRef].
  • [2] Celiksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. Synergistic in vitro antimicrobial activity of pomegranate rind extract and zinc (II) against Micrococcus luteus under planktonic and biofilm conditions. Pharmaceutics. 2021; 13(6): 851. [CrossRef].
  • [3] Celiksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. Synergistic activity of pomegranate rind extract and Zn (II) against Candida albicans under planktonic and biofilm conditions, and a mechanistic insight based upon intracellular ROS induction. Sci Reports. 2022; 12(1): 19560. [CrossRef].

POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS

Year 2023, Volume: 27 Issue: Current Research Topics In Pharmacy: Microbiology Debates, 12 - 13, 27.06.2025

Vildan Çeliksoy Rachael L. Moses Alastair J. Sloan Ryan Moseley Charles M. Heard

https://doi.org/10.29228/jrp.389

Abstract

Periodontal diseases, such as gingivitis and periodontitis, are amongst the most common diseases affecting most of the population and have been highly associated with dental plaque. The main strategy to prevent periodontal diseases is through control of dental plaque via physical and chemical methods. However, currently used anti-plaque agents have adverse effects such as tooth staining and taste alteration. Whilst increased antimicrobial resistance is another issue in the management of periodontal diseases. Therefore, the discovery of new alternative treatment agents is necessary. Pomegranate rind extract (PRE) is a wellestablished folkloric medicine and abundant with hydrolysable tannins, especially punicalagin, with beneficial health properties. More recently, addition of Zn (II) to PRE exerted a synergistic antimicrobial activity against microbes, including some bacteria and viruses [1-2]. Thus, the aim of this study was to investigate potential use of PRE, Zn (II) and PRE/Zn (II) in relation to treating oral diseases. PRE (1-8 mg/mL), Zn (II) (0.39-6.25 mM) and PRE/Zn (II) demonstrated a broad-spectrum antimicrobial activity in planktonic and biofilm conditions against oral microbes. These agents also exhibited anti- adhesive properties by reducing attachment of S. gordonii, S. mutans and C. albicans to glass surfaces. Synergistic antimicrobial activity for PRE/Zn (II) was found against S. gordonii and C. albicans, it was associated with an increased reactive oxygen species (ROS) level which can be active against C. albicans [3]. This work has provided a basis for using PRE and PRE/Zn (II) as a novel therapeutic system for periodontal diseases, such as gingivitis and periodontitis. Moreover, PRE and PRE/Zn (II) could be developed as cost-effective products with potential for improving oral health globally.

Keywords

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References

  • [1] Celiksoy V, Heard CM. Antimicrobial potential of pomegranate extracts. In: Pomegranate. IntechOpen. 2021, pp1-22. [CrossRef].
  • [2] Celiksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. Synergistic in vitro antimicrobial activity of pomegranate rind extract and zinc (II) against Micrococcus luteus under planktonic and biofilm conditions. Pharmaceutics. 2021; 13(6): 851. [CrossRef].
  • [3] Celiksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. Synergistic activity of pomegranate rind extract and Zn (II) against Candida albicans under planktonic and biofilm conditions, and a mechanistic insight based upon intracellular ROS induction. Sci Reports. 2022; 12(1): 19560. [CrossRef].
There are 3 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Microbiology
Journal Section Commentary
Authors

Vildan Çeliksoy 0000-0002-9261-7053

Rachael L. Moses 0000-0004-5994-4786

Alastair J. Sloan 0000-0002-1791-0903

Ryan Moseley 0000-0002-2812-6735

Charles M. Heard 0000-0001-9703-9777

Publication Date June 27, 2025
Published in Issue Year 2023 Volume: 27 Issue: Current Research Topics In Pharmacy: Microbiology Debates

Cite

APA Çeliksoy, V., Moses, R. L., Sloan, A. J., Moseley, R., et al. (2025). POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS. Journal of Research in Pharmacy, 27(Current Research Topics In Pharmacy: Microbiology Debates), 12-13. https://doi.org/10.29228/jrp.389
AMA Çeliksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS. J. Res. Pharm. July 2025;27(Current Research Topics In Pharmacy: Microbiology Debates):12-13. doi:10.29228/jrp.389
Chicago Çeliksoy, Vildan, Rachael L. Moses, Alastair J. Sloan, Ryan Moseley, and Charles M. Heard. “POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS”. Journal of Research in Pharmacy 27, no. Current Research Topics In Pharmacy: Microbiology Debates (July 2025): 12-13. https://doi.org/10.29228/jrp.389.
EndNote Çeliksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM (July 1, 2025) POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS. Journal of Research in Pharmacy 27 Current Research Topics In Pharmacy: Microbiology Debates 12–13.
IEEE V. Çeliksoy, R. L. Moses, A. J. Sloan, R. Moseley, and C. M. Heard, “POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS”, J. Res. Pharm., vol. 27, no. Current Research Topics In Pharmacy: Microbiology Debates, pp. 12–13, 2025, doi: 10.29228/jrp.389.
ISNAD Çeliksoy, Vildan et al. “POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS”. Journal of Research in Pharmacy 27/Current Research Topics In Pharmacy: Microbiology Debates (July 2025), 12-13. https://doi.org/10.29228/jrp.389.
JAMA Çeliksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS. J. Res. Pharm. 2025;27:12–13.
MLA Çeliksoy, Vildan et al. “POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS”. Journal of Research in Pharmacy, vol. 27, no. Current Research Topics In Pharmacy: Microbiology Debates, 2025, pp. 12-13, doi:10.29228/jrp.389.
Vancouver Çeliksoy V, Moses RL, Sloan AJ, Moseley R, Heard CM. POMEGRANATE RIND EXTRACT WITH ZN (II) COMBINATION AS A NEW THERAPEUTIC AGENT FOR ORAL CARE PRODUCTS. J. Res. Pharm. 2025;27(Current Research Topics In Pharmacy: Microbiology Debates):12-3.