Research Article
Year 2025,
Volume: 15 Issue: 1, 112 - 118, 30.04.2025
Abstract
References
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- 8. Dirican N, Dirican A, Anar C, Atalay S, Ozturk O, Bircan A, et al. A new inflammatory prognostic index, based on C-reactive protein, the neutrophil to lymphocyte ratio and serum albumin is useful for predicting prognosis in non-small cell lung cancer cases. Asian Pac J Cancer Prev. 2016;17:5101–6.
- 9. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al.;ESC Scientific Document Group. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2024;13:55–161.
- 10. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with STsegment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39:119–77.
- 11. Pizzetti F, Turazza FM, Franzosi MG, Barlera S, Ledda A, Maggioni AP, et al. GISSI-3 Investigators. Incidence and prognostic significance of atrial fibrillation in acute myocardial infarction: the GISSI-3data. Heart. 2001;86:527–32.
- 12. Ulus T, Isgandarov K, Yilmaz AS, Vasi I, Moghanchızadeh SH, Mutlu F. Predictors of new-onset atrial fibrillation in elderly patients with acute coronary syndrome under going percutaneous coronary intervention. Aging Clin Exp Res. 2018;30:1475–82.
- 13. Elliott AD, Middeldorp ME, Van Gelder IC, Albert CM, Sanders P. Epidemiology and modifiable risk factors for atrial fibrillation. Nat Rev Cardiol. 2023;20:404–17.
- 14. Wagdy S, Sobhy M, Loutfi M. Neutrophil/Lymphocyte ratio as a predictor of In-hospital major adverse cardiac events, newonset atrial fibrillation, and No-reflow phenomenon in patients with ST elevation myocardial infarction. Clin Med Insights Cardiol. 2016;10:19–22.
- 15. Bağcı A, Aksoy F. Systemic immune-inflammation index predicts new-onset atrial fibrillation after ST elevation myocardial infarction. Biomark Med. 2021;15:731–39.
- 16. Hu X, Sang K, Chen C, Lian L, Wang K, Zhang Y, et al. Prognostic nutritional index and major cardiovascular events in patients undergoing invasive coronary angiography: a clinical retrospective study. J Pers Med. 2022;12:1679.
- 17. Aksoy F, Uysal D, Ibrişim E. Relationship between c-reactive protein/albumin ratio and new-onset atrial fibrillation after coronary artery bypass grafting. Rev Assoc Med Bras (1992). 2020;66:1070–76.
- 18. Erdoğan AP, Ekinci F, Karabaş A, Balçık OY, Barutça S, Dirican A. Could the inflammatory prognostic index predict the efficacy of regorafenib in patients with metastatic colorectal cancer? JGastrointest Cancer. 2022;53:45–51.
- 19. He J, Yang Y, Zhang G, Lu XH. Clinical risk factors for newonset atrial fibrillation in acute myocardial infarction: a systematic review and meta-analysis. Medicine (Baltimore) . 2019;98:e15960.
- 20. Wu N, Li J, Xu X, Yuan Z, Yang L, Chen Y, et al. Prediction Model of New Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome. Int J Clin Pract. 2023;2023:3473603.
- 21. Asanin M, Perunicic J, Mrdovic I, Matic M, Vujisic-Tesic B, Arandjelovic A, et al. Prognostic significance of new atrial fibrillation and its relation to heart failure following acute myocardial infarction. Eur J Heart Fail. 2005;7:671–76.
The inflammatory prognostic index predicts new-onset atrial fibrillation in patients after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
Abstract
Introduction&Objective: New-onset atrial fibrillation (NOAF) is an independent predictor of mortality and a strong indicator of poor prognosis following ST-segment elevation myocardial infarction (STEMI). The Inflammatory Prognostic Index (IPI) is clinically significant in predicting patient outcomes and serves as a novel inflammatory prognostic marker based on C-reactive protein (CRP), the neutrophil-to-lymphocyte ratio (NLR), and serum albumin levels. This study aimed to investigate the relationship between the IPI and NOAF in patients with STEMI who underwent primary percutaneous coronary intervention (pPCI).
Material&Methods: The population for this retrospective study consisted of 1,132 consecutive patients diagnosed with STEMI who underwent pPCI. Out of these, 946 patients were included in the study sample and were divided into two groups based on whether they developed NOAF or not.
Results: The study’s primary outcome, that is, IPI was significantly higher in patients with NOAF than in those with No-AF (42.15 (17.6-81.7) vs. 12.77 (5.72-27.01), p<0.001) Univariate logistic regression analysis revealed significant correlations between NOAF; IPI, LVEF and age. Further analysis of these variables using the multivariate logistic regression analysis indicated that IPI (Odds Ratio [OR]: 2.026, 95% confidence interval [CI]: 1.081-3.799; p=0.028), LVEF and age were independent predictors for the development NOAF. IPI optimal cut-off value of >17.5 predicted NOAF with 76% sensitivity and 62.7% specificity (AUC: 0.740 [95% CI: 0.711–0.768, p<0.0001] (P<0.0001).
Conclusion: This study finds that the IPI independently predicts NOAF in STEMI patients treated with pPCI.
Keywords
Inflammatory prognostic index ST-segment elevation myocardial infarction Atrial fibrillation.
References
- 1. Băghină RM, Crișan S, Luca S, Pătru O, Lazăr MA, Văcărescu C, et al. Association between inflammation and new-onset atrial fibrillation in acute coronary syndromes. J Clin Med. 2024;13:5088.
- 2. Tanık VO, Tunca Ç, Kalkan K, Kivrak A, Özlek B. The monocyte-to-HDL-cholesterol ratio predicts new-onset atrial fibrillation in patients with acute STEMI. Biomark Med. 2025;29:1–8.
- 3. Schmitt J, Duray G, Gersh BJ, Hohnloser SH. Atrial fibrillation in acute myocardial infarction: A systematic review of the incidence, clinical features and prognostic implications. Eur Heart J 30:1038–45.
- 4. Wong CK, White HD, Wilcox RG, Criger DA, Califf RM, Topol EJ, et al. Significance of atrial fibrillation during acute myocardial infarction, and its current management: insights from the GUSTO-3 trial. Card Electrophysiol Rev. 2003;7:201–7.
- 5. Kinjo K, Sato H, Sato H, Ohnishi Y, Hishida E, Nakatani D, et al. Prognostic significance of atrial fibrillation/atrial flutter in patients with acute myocardial infarction treated with percutaneous coronary intervention. Am J Cardiol. 2003;92:1150–54.
- 6. Aviles RJ, Martin DO, Apperson-Hansen C, Houghtaling PL, Rautaharju P, Kronmal RA, et al. Inflammation as a risk factor for atrial fibrillation. Circulation. 2003;108:3006–10. 7. Ucar HI, Tok M, Atalar E, Dogan OF, Oc M, Farsak B, et al. Predictive significance of plasma levels of interleukin-6 and highsensitivity C-reactive protein in atrial fibrillation after coronary artery bypass surgery. Heart Surg Forum. 2007;10:E131–5.
- 8. Dirican N, Dirican A, Anar C, Atalay S, Ozturk O, Bircan A, et al. A new inflammatory prognostic index, based on C-reactive protein, the neutrophil to lymphocyte ratio and serum albumin is useful for predicting prognosis in non-small cell lung cancer cases. Asian Pac J Cancer Prev. 2016;17:5101–6.
- 9. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al.;ESC Scientific Document Group. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J Acute Cardiovasc Care. 2024;13:55–161.
- 10. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with STsegment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39:119–77.
- 11. Pizzetti F, Turazza FM, Franzosi MG, Barlera S, Ledda A, Maggioni AP, et al. GISSI-3 Investigators. Incidence and prognostic significance of atrial fibrillation in acute myocardial infarction: the GISSI-3data. Heart. 2001;86:527–32.
- 12. Ulus T, Isgandarov K, Yilmaz AS, Vasi I, Moghanchızadeh SH, Mutlu F. Predictors of new-onset atrial fibrillation in elderly patients with acute coronary syndrome under going percutaneous coronary intervention. Aging Clin Exp Res. 2018;30:1475–82.
- 13. Elliott AD, Middeldorp ME, Van Gelder IC, Albert CM, Sanders P. Epidemiology and modifiable risk factors for atrial fibrillation. Nat Rev Cardiol. 2023;20:404–17.
- 14. Wagdy S, Sobhy M, Loutfi M. Neutrophil/Lymphocyte ratio as a predictor of In-hospital major adverse cardiac events, newonset atrial fibrillation, and No-reflow phenomenon in patients with ST elevation myocardial infarction. Clin Med Insights Cardiol. 2016;10:19–22.
- 15. Bağcı A, Aksoy F. Systemic immune-inflammation index predicts new-onset atrial fibrillation after ST elevation myocardial infarction. Biomark Med. 2021;15:731–39.
- 16. Hu X, Sang K, Chen C, Lian L, Wang K, Zhang Y, et al. Prognostic nutritional index and major cardiovascular events in patients undergoing invasive coronary angiography: a clinical retrospective study. J Pers Med. 2022;12:1679.
- 17. Aksoy F, Uysal D, Ibrişim E. Relationship between c-reactive protein/albumin ratio and new-onset atrial fibrillation after coronary artery bypass grafting. Rev Assoc Med Bras (1992). 2020;66:1070–76.
- 18. Erdoğan AP, Ekinci F, Karabaş A, Balçık OY, Barutça S, Dirican A. Could the inflammatory prognostic index predict the efficacy of regorafenib in patients with metastatic colorectal cancer? JGastrointest Cancer. 2022;53:45–51.
- 19. He J, Yang Y, Zhang G, Lu XH. Clinical risk factors for newonset atrial fibrillation in acute myocardial infarction: a systematic review and meta-analysis. Medicine (Baltimore) . 2019;98:e15960.
- 20. Wu N, Li J, Xu X, Yuan Z, Yang L, Chen Y, et al. Prediction Model of New Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome. Int J Clin Pract. 2023;2023:3473603.
- 21. Asanin M, Perunicic J, Mrdovic I, Matic M, Vujisic-Tesic B, Arandjelovic A, et al. Prognostic significance of new atrial fibrillation and its relation to heart failure following acute myocardial infarction. Eur J Heart Fail. 2005;7:671–76.
There are 20 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences (Other) |
| Journal Section | Research Article |
| Authors | |
| Publication Date | April 30, 2025 |
| Submission Date | February 17, 2025 |
| Acceptance Date | February 27, 2025 |
| Published in Issue | Year 2025 Volume: 15 Issue: 1 |
