Case Report
Year 2024,
Volume: 2 Issue: 3, 363 - 367, 28.08.2024
Abstract
Amaç:Gebelikte nikotine maruz kalmanın fetus üzerine zararlı etkileri bilinmektedir ancak fetusların ortak plasentaya sahip olması anomalisine etkisi nadir görülmektedir. Bu çalışmanın amacı gebelik süresince nikotine maruz kalan bir ratta meydana gelen monokoryonic monoamniyotik gebelik ve ölü doğum anomalisini sunmaktır.
Yöntem: Wistar Albino cinsi rata gebeliğin başladığı günden yirmi birinci güne kadar subkutan yol ile 6 mg/kg nikotin verildi. 21. günde sezaryen ile yavrular izole edildi. Amniyon keselerinden çıkarılan fetus ve plasentalar tartıldı ve fotoğrafları çekildi. Morfometrik özellikleri incelendi.
Bulgular: Bir gebe rata ait on bir adet amniyon kesesi bulunmaktaydı. On adet amniyon kesesinde on adet fetus ve on adet plasenta olduğu görülürken; bir adet amniyon kesesinde iki adet fetusa bağlı bir adet plasenta olduğu (monokoryonic monoamniyotik gebelik) görüldü. On adet fetus canlı iken ortak plasentası olan iki fetus ölü doğdu.
Sonuç: Bir rat örneğinde gebelik döneminde kullanılan nikotin plasenta malformasyonları yapabileceği gibi monokoryonik monoamniyotik gebeliklerde fetus ölümlerine de neden olabili
Keywords
References
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- Khairudin, D., & Khalil, A. (2022). Monochorionic monoamniotic twin pregnancies.Best Pract Res Clin Obstet Gynaecol,84, 96–103. https://doi.org/10.1016/j.bpobgyn.2022.08.004
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- Morales-Suárez-Varela, M., Puig, BM., Kaerlev, L., Peraita-Costa, I., & Perales-Marín, A. (2022). Safety of Nicotine Replacement Therapy during Pregnancy: A Narrative Review. Int J Environ Res Public Health, 20(1), 250. https://doi.org/10.3390/ijerph20010250
- Pintican, D., Poienar, A. A., Strilciuc, S., & Mihu, D. (2019). Effects of maternal smoking on human placental vascularization: A systematic review. Taiwan J Obstet Gynecol,58(4), 454-459. https://doi.org/10.1016/j.tjog.2019.05.004
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- Suter, M. A., & Aagaard, K. M. (2020). The impact of tobacco chemicals and nicotine on placental development. Prenatal diagnosis, 40(9), 1193–1200. https://doi.org/10.1002/pd.5660
- Van Mieghem, T., Abbasi, N., Shinar, S., Keunen, J., Seaward, G., Windrim, R., & Ryan, G. (2022). Monochorionic monoamniotic twin pregnancies. Am J Obstet Gynecol MFM, 4(2), 100520. https://doi.org/10.1016/j.ajogmf.2021.100520
- Wickström, R. (2007). Effects of nicotine during pregnancy: human and experimental evidence.Curr Neuropharmacol,5(3),213-222. https://doi.org/10.2174/157015907781695955
Year 2024,
Volume: 2 Issue: 3, 363 - 367, 28.08.2024
Abstract
References
- Beltrán-Castillo, S., Bravo, K., & Eugenín, J. (2023). Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development. Adv Exp Med Biol, 1428, 233-244. https://doi.org/10.1007/978-3-031-32554-0_10
- Gude, N. M., Roberts, C. T., Kalionis, B., & King, R. G. (2004). Growth and function of the normal human placenta. Thromb Res,114(5-6), 397-407. https://doi.org/10.1016/j.thromres.2004.06.038
- Khairudin, D., & Khalil, A. (2022). Monochorionic monoamniotic twin pregnancies.Best Pract Res Clin Obstet Gynaecol,84, 96–103. https://doi.org/10.1016/j.bpobgyn.2022.08.004
- Larsen, L. G., Clausen, H. V., & Jønsson, L. (2002). Stereologic examination of placentas from mothers who smoke during pregnancy. Am J Obstet Gynecol,186(3), 531-537. https://doi.org/10.1067/mob.2002.120481
- Morales-Suárez-Varela, M., Puig, BM., Kaerlev, L., Peraita-Costa, I., & Perales-Marín, A. (2022). Safety of Nicotine Replacement Therapy during Pregnancy: A Narrative Review. Int J Environ Res Public Health, 20(1), 250. https://doi.org/10.3390/ijerph20010250
- Pintican, D., Poienar, A. A., Strilciuc, S., & Mihu, D. (2019). Effects of maternal smoking on human placental vascularization: A systematic review. Taiwan J Obstet Gynecol,58(4), 454-459. https://doi.org/10.1016/j.tjog.2019.05.004
- Sun, Q. R., Wu, D. Y., Zhang, J. J., Wu, L. H., Zhang, X., Zhou, J., & Miao, Y. L. (2023). Nicotine exposure disrupts placental development via the Notch signaling pathway. Reproduction (Cambridge, England), 166(3), 187–197. https://doi.org/10.1530/REP-22-0458
- Suter, M. A., & Aagaard, K. M. (2020). The impact of tobacco chemicals and nicotine on placental development. Prenatal diagnosis, 40(9), 1193–1200. https://doi.org/10.1002/pd.5660
- Van Mieghem, T., Abbasi, N., Shinar, S., Keunen, J., Seaward, G., Windrim, R., & Ryan, G. (2022). Monochorionic monoamniotic twin pregnancies. Am J Obstet Gynecol MFM, 4(2), 100520. https://doi.org/10.1016/j.ajogmf.2021.100520
- Wickström, R. (2007). Effects of nicotine during pregnancy: human and experimental evidence.Curr Neuropharmacol,5(3),213-222. https://doi.org/10.2174/157015907781695955
There are 10 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Clinical Sciences (Other) |
| Journal Section | Olgu Sunumu |
| Authors | |
| Publication Date | August 28, 2024 |
| Submission Date | May 9, 2024 |
| Acceptance Date | August 26, 2024 |
| Published in Issue | Year 2024 Volume: 2 Issue: 3 |
