Research Article
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Rutin patoloji pratiğinde sık karşılaşılan intrakardiyak kitleler: Literatür eşliğinde değerlendirme

Year 2025, Volume: 17 Issue: 1, 13 - 21, 29.04.2025

Elif Kuzucular , Aslı Çakır , Özben Yalçın , Sergulen Dervisoglu

https://doi.org/10.35514/mtd.2025.122

Abstract

Amaç: Kardiyak kitleler nadirdir, neoplastik ve non-neoplastik olarak ayrılmaktadır. Bu makalenin amacı kardiyak kitlelere genel bir bakış sağlamak ve klinikopatolojik özelliklerini gözden geçirmektir.
Materyal ve Metodlar: Merkezimizde 2014-2022 yılları arasında kardiyak kitle nedeniyle opere edilen 35 vakayı retrospektif olarak inceledik.
Bulgular: Vakaların yaşları 7 ay ile 79 yıl arasında değişmektedir (ortalama yaş 46,2 yıl) ve 25’i kadındır. Serimizin büyük bir kısmını primer benign kalp tümörleri oluşturmaktadır ve en sık görülen tümöral lezyon miksoma olup, bunu sırasıyla fibroelastom, fibroma, rabdomyom ve glomus tümör izlemektedir. İki vaka metastatik karsinom tanılıdır. Non-neoplastik kitle lezyonları da çoğunlukta olup insidansına göre trombüs, kalsifiye kardiyak psödotümör ve infektif endokardit olarak sıralanmaktadır.
Sonuç: Bu çalışmada, çeşitli kardiak kitlelerin klinikopatolojik bulgularının bir arada değerlendirildiği geniş bir vaka serisi sunulmaktadır.

Keywords

kardiak kitleler tümörler tümör dışı lezyonlar

References

  • 1. Basso C, Rizzo S, Valente M, Thiene G. Cardiac masses and tumours. Heart. 2016;102(15):1230-1245.
  • 2. Tyebally S, Chen D, Bhattacharyya S, Mughrabi A, Hussain Z, Manisty C, et al. Cardiac Tumors: JACC CardioOncology State-of-the-Art Review. JACC CardioOncol. 2020;2(2):293-311.
  • 3. Poterucha TJ, Kochav J, O'connor DS, Rosner GF. Cardiac Tumors: Clinical Presentation, Diagnosis, and Management. Curr Treat Options Oncol. 2019;20(8):66.
  • 4. Maleszewski JJ, Anavekar NS, Moynihan TJ, Klarich KW. Pathology, imaging, and treatment of cardiac tumours. Nat Rev Cardiol. 2017;14(9):536-549.
  • 5. Board WCOTE. Thoracic Tumours: WHO Classification of Tumours. 5th edition ed. Lyon, France: IARC Publications, 2021.
  • 6. Yu K, Liu Y, Wang H, Hu S, Long C. Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases. Interact Cardiovasc Thorac Surg. 2007;6(5):636-639.
  • 7. Wang H, Li Q, Xue M, Zhao P, Cui J. Cardiac Myxoma: A Rare Case Series of 3 Patients and a Literature Review. J Ultrasound Med. 2017;36(11):2361-2366.
  • 8. Roberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol. 1997;80(5):671-682.
  • 9. Wang JG, Li YJ, Liu H, Li NN, Zhao J, Xing XM. Clinicopathologic analysis of cardiac myxomas: Seven years' experience with 61 patients. J Thorac Dis. 2012;4(3):272-283.
  • 10. Strecker T, Agaimy A, Zelzer P, Weyand M, Wachter DL. Incidental finding of a giant asymptomatic right atrial tumor. Int J Clin Exp Pathol. 2014;7(7):4528-4530.
  • 11. Hill M, Cherry C, Maloney M, Midyette P. Surgical resection of atrial myxomas. AORN J. 2010;92(4):393-406, quiz 407-399.
  • 12. Velez Torres JM, Martinez Duarte E, Diaz-Perez JA, Rosenberg AE. Cardiac Myxoma: Review and Update of Contemporary Immunohistochemical Markers and Molecular Pathology. Adv Anat Pathol. 2020;27(6):380-384.
  • 13. Wittersheim M, Heydt C, Hoffmann F, Büttner R. KRAS mutation in papillary fibroelastoma: a true cardiac neoplasm? J Pathol Clin Res. 2017;3(2):100-104.
  • 14. Tamin SS, Maleszewski JJ, Scott CG, Khan SK, Edwards WD, Bruce CJ, et al. Prognostic and Bioepidemiologic Implications of Papillary Fibroelastomas. J Am Coll Cardiol. 2015;65(22):2420-2429.
  • 15. Sun JP, Asher CR, Yang XS, Cheng GG, Scalia GM, Massed AG, et al. Clinical and echocardiographic characteristics of papillary fibroelastomas: a retrospective and prospective study in 162 patients. Circulation. 2001;103(22):2687-2693.
  • 16. Darvishian F, Farmer P. Papillary fibroelastoma of the heart: report of two cases and review of the literature. Ann Clin Lab Sci. 2001;31(3):291-296.
  • 17. Tzani A, Doulamis IP, Mylonas KS, Avgerinos DV, Nasioudis D. Cardiac Tumors in Pediatric Patients: A Systematic Review. World J Pediatr Congenit Heart Surg. 2017;8(5):624-632.
  • 18. Nir A, Tajik AJ, Freeman WK, Seward JB, Offord KP, Edwards WD, et al. Tuberous sclerosis and cardiac rhabdomyoma. Am J Cardiol. 1995;76(5):419-421.
  • 19. Gorlin RJ. Nevoid basal cell carcinoma (Gorlin) syndrome. Genet Med. 2004;6(6):530-539.
  • 20. Grunau GL, Leipsic JA, Sellers SL, Seidman MA. Cardiac Fibroma in an Adult AIRP Best Cases in Radiologic-Pathologic Correlation. Radiographics. 2018;38(4):1022-2026.
  • 21. Castiglione V, Aimo A, Murzi B, Pucci A, Aquaro GD, Barison A, et al. What Is Hidden Behind Inferior Negative T Waves: Multiple Cardiac Glomangiomas. JACC Case Rep. 2019;1(4):657-662.
  • 22. Balisan OP, Radin Ii CPT, Arias R, Templo Jr F. Malignant Glomus Tumor of the Heart in a 64-year-old Male Presenting with Stroke. Philipp J Pathol. 2018;3(1):20-23.
  • 23. Masson P. Le glomusneuromyo-drterialeds resions tactiles et ses tumeurs. Lyon Chil. 1924;21:257-280.
  • 24. Ejaz K, Raza MA, Aleem A, Maroof S, Tahir H. Glomangiosarcoma Involving the Heart with an Unknown Primary Lesion. Cureus. 2018;10(7):e2907.
  • 25. Kate Y, Syed MP, Doshi A, Patil S, Kumar D. Atrial Mass Versus Thrombus. Balkan Med J. 2020;37(3):166-167.
  • 26. Lee WC, Huang MP, Fu M. Multiple intracardiac masses: myxoma, thrombus or metastasis: a case report. J Med Case Rep. 2015;9:179.
  • 27. Testa M, Lombardo E, Avogadri E, Agostini M, Forte G, Piccolo S, et al. Infective endocarditis or myxoma? Description of a patient with new diagnosis of congestive heart failure. Monaldi Arch Chest Dis. 2012;78(2):107-108.
  • 28. Rajani R, Klein JL. Infective endocarditis: A contemporary update. Clin Med (Lond). 2020;20(1):31-35.
  • 29. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60(1):27-34.
  • 30. Vlachostergios PJ, Daliani DD, Papandreou CN. Basic Concepts in Metastatic Cardiac Disease. Cardiol Res. 2012;3(2):47-48.
  • 31. Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004;15(3):375-381.
  • 32. Taşdemir A, Tuncay A, Karaman H, Canoz O, Aşık R, Özmen R, et al. Cardiac Masses: Pathological and Surgical Features - A Multicenter Study. Braz J Cardiovasc Surg. 2021;36(5):656-662.

Intracardiac masses in our routine practice: Evaluation with the literature

Year 2025, Volume: 17 Issue: 1, 13 - 21, 29.04.2025

Elif Kuzucular , Aslı Çakır , Özben Yalçın , Sergulen Dervisoglu

https://doi.org/10.35514/mtd.2025.122

Abstract

Aim: Cardiac masses are uncommon, they can be non-neoplastic or neoplastic. The purpose of this article is to provide an overview of cardiac masses and to review their clinicopathological features.
Material and Methods: We retrospectively reviewed 35 cases of cardiac surgery performed in our institution from 2014 to 2022 due to cardiac mass.
Results: The age of patients ranged from 7 months to 79 years, with a mean age of 46,2 years and a female to male ratio of 25/10. Primary benign cardiac tumors constituted the majority of our series. The most common tumoral lesion is myxoma, followed by papillary fibroelastoma, fibroma, rhabdomyoma and glomus tumour respectively. There were two metastatic carcinoma cases. Non-neoplastic mass lesions were also in the majority and can be listed as thrombus, calcified cardiac pseudotumor and infective endocarditis according to their incidence.
Conclusion: This study, using a relatively large sample, reveals the clinical incidences and pathological characteristics of various cardiac masses in our institution.

Keywords

cardiac masses neoplastic non-neoplastic lesions

References

  • 1. Basso C, Rizzo S, Valente M, Thiene G. Cardiac masses and tumours. Heart. 2016;102(15):1230-1245.
  • 2. Tyebally S, Chen D, Bhattacharyya S, Mughrabi A, Hussain Z, Manisty C, et al. Cardiac Tumors: JACC CardioOncology State-of-the-Art Review. JACC CardioOncol. 2020;2(2):293-311.
  • 3. Poterucha TJ, Kochav J, O'connor DS, Rosner GF. Cardiac Tumors: Clinical Presentation, Diagnosis, and Management. Curr Treat Options Oncol. 2019;20(8):66.
  • 4. Maleszewski JJ, Anavekar NS, Moynihan TJ, Klarich KW. Pathology, imaging, and treatment of cardiac tumours. Nat Rev Cardiol. 2017;14(9):536-549.
  • 5. Board WCOTE. Thoracic Tumours: WHO Classification of Tumours. 5th edition ed. Lyon, France: IARC Publications, 2021.
  • 6. Yu K, Liu Y, Wang H, Hu S, Long C. Epidemiological and pathological characteristics of cardiac tumors: a clinical study of 242 cases. Interact Cardiovasc Thorac Surg. 2007;6(5):636-639.
  • 7. Wang H, Li Q, Xue M, Zhao P, Cui J. Cardiac Myxoma: A Rare Case Series of 3 Patients and a Literature Review. J Ultrasound Med. 2017;36(11):2361-2366.
  • 8. Roberts WC. Primary and secondary neoplasms of the heart. Am J Cardiol. 1997;80(5):671-682.
  • 9. Wang JG, Li YJ, Liu H, Li NN, Zhao J, Xing XM. Clinicopathologic analysis of cardiac myxomas: Seven years' experience with 61 patients. J Thorac Dis. 2012;4(3):272-283.
  • 10. Strecker T, Agaimy A, Zelzer P, Weyand M, Wachter DL. Incidental finding of a giant asymptomatic right atrial tumor. Int J Clin Exp Pathol. 2014;7(7):4528-4530.
  • 11. Hill M, Cherry C, Maloney M, Midyette P. Surgical resection of atrial myxomas. AORN J. 2010;92(4):393-406, quiz 407-399.
  • 12. Velez Torres JM, Martinez Duarte E, Diaz-Perez JA, Rosenberg AE. Cardiac Myxoma: Review and Update of Contemporary Immunohistochemical Markers and Molecular Pathology. Adv Anat Pathol. 2020;27(6):380-384.
  • 13. Wittersheim M, Heydt C, Hoffmann F, Büttner R. KRAS mutation in papillary fibroelastoma: a true cardiac neoplasm? J Pathol Clin Res. 2017;3(2):100-104.
  • 14. Tamin SS, Maleszewski JJ, Scott CG, Khan SK, Edwards WD, Bruce CJ, et al. Prognostic and Bioepidemiologic Implications of Papillary Fibroelastomas. J Am Coll Cardiol. 2015;65(22):2420-2429.
  • 15. Sun JP, Asher CR, Yang XS, Cheng GG, Scalia GM, Massed AG, et al. Clinical and echocardiographic characteristics of papillary fibroelastomas: a retrospective and prospective study in 162 patients. Circulation. 2001;103(22):2687-2693.
  • 16. Darvishian F, Farmer P. Papillary fibroelastoma of the heart: report of two cases and review of the literature. Ann Clin Lab Sci. 2001;31(3):291-296.
  • 17. Tzani A, Doulamis IP, Mylonas KS, Avgerinos DV, Nasioudis D. Cardiac Tumors in Pediatric Patients: A Systematic Review. World J Pediatr Congenit Heart Surg. 2017;8(5):624-632.
  • 18. Nir A, Tajik AJ, Freeman WK, Seward JB, Offord KP, Edwards WD, et al. Tuberous sclerosis and cardiac rhabdomyoma. Am J Cardiol. 1995;76(5):419-421.
  • 19. Gorlin RJ. Nevoid basal cell carcinoma (Gorlin) syndrome. Genet Med. 2004;6(6):530-539.
  • 20. Grunau GL, Leipsic JA, Sellers SL, Seidman MA. Cardiac Fibroma in an Adult AIRP Best Cases in Radiologic-Pathologic Correlation. Radiographics. 2018;38(4):1022-2026.
  • 21. Castiglione V, Aimo A, Murzi B, Pucci A, Aquaro GD, Barison A, et al. What Is Hidden Behind Inferior Negative T Waves: Multiple Cardiac Glomangiomas. JACC Case Rep. 2019;1(4):657-662.
  • 22. Balisan OP, Radin Ii CPT, Arias R, Templo Jr F. Malignant Glomus Tumor of the Heart in a 64-year-old Male Presenting with Stroke. Philipp J Pathol. 2018;3(1):20-23.
  • 23. Masson P. Le glomusneuromyo-drterialeds resions tactiles et ses tumeurs. Lyon Chil. 1924;21:257-280.
  • 24. Ejaz K, Raza MA, Aleem A, Maroof S, Tahir H. Glomangiosarcoma Involving the Heart with an Unknown Primary Lesion. Cureus. 2018;10(7):e2907.
  • 25. Kate Y, Syed MP, Doshi A, Patil S, Kumar D. Atrial Mass Versus Thrombus. Balkan Med J. 2020;37(3):166-167.
  • 26. Lee WC, Huang MP, Fu M. Multiple intracardiac masses: myxoma, thrombus or metastasis: a case report. J Med Case Rep. 2015;9:179.
  • 27. Testa M, Lombardo E, Avogadri E, Agostini M, Forte G, Piccolo S, et al. Infective endocarditis or myxoma? Description of a patient with new diagnosis of congestive heart failure. Monaldi Arch Chest Dis. 2012;78(2):107-108.
  • 28. Rajani R, Klein JL. Infective endocarditis: A contemporary update. Clin Med (Lond). 2020;20(1):31-35.
  • 29. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007;60(1):27-34.
  • 30. Vlachostergios PJ, Daliani DD, Papandreou CN. Basic Concepts in Metastatic Cardiac Disease. Cardiol Res. 2012;3(2):47-48.
  • 31. Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004;15(3):375-381.
  • 32. Taşdemir A, Tuncay A, Karaman H, Canoz O, Aşık R, Özmen R, et al. Cardiac Masses: Pathological and Surgical Features - A Multicenter Study. Braz J Cardiovasc Surg. 2021;36(5):656-662.
There are 32 citations in total.

Details

Primary Language English
Subjects Clinical Oncology, Clinical Sciences (Other)
Journal Section Research Article
Authors

Elif Kuzucular 0000-0002-0600-5801

Aslı Çakır 0000-0003-0128-6947

Özben Yalçın 0000-0002-0019-1922

Sergulen Dervisoglu 0000-0002-9516-5793

Publication Date April 29, 2025
Submission Date March 19, 2025
Acceptance Date April 23, 2025
Published in Issue Year 2025 Volume: 17 Issue: 1

Cite

Vancouver Kuzucular E, Çakır A, Yalçın Ö, Dervisoglu S. Intracardiac masses in our routine practice: Evaluation with the literature. Maltepe tıp derg. 2025;17(1):13-21.
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