Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma

Faruk Erdem Kombak; Süheyla Uyar Bozkurt; Toluy Özgümüş; İşık Kaygusuz Atagündüz

doi:10.5472/marumj.518989

Case Report

Kitle oluşturarak Hodgkin lenfomayı taklit eden ekstramedüller hematopoez olgusu

Year 2019, Volume: 32 Issue: 1, 55 - 57, 29.01.2019

Faruk Erdem Kombak Süheyla Uyar Bozkurt Toluy Özgümüş İşık Kaygusuz Atagündüz

https://doi.org/10.5472/marumj.518989

Abstract

Ekstramedüller hematopoez (EMH), hematopoetik öncül

hücrelerin kemik iliği dışında çoğalması olarak tanımlanmaktadır.

EMH, vücudun farklı bölgelerinde kitlesel lezyon olarak karşımıza

çıkabilmektedir. Bu olgu sunumunda; ayırıcı tanı, bir tanı hatası ve

olası tuzaklar üzerinden irdelenmektedir.

Keywords

Ekstramedüller hematopoez, Arka mediasten kitlesi, Hemolitik anemi

References

1. Yamamoto K, Miwa Y, Abe-Suzuki S, et al. Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review). Mol Med Rep 2016;13:587-91. doi: 10.3892/mmr.2015.4621.
2. Solazzo A, D’Auria V, Moccia LG, Vatrella A, Bocchino M, Rea G. Posterior mediastinal extramedullary hematopoiesis secondary to hypoxia. Transl Med UniSa 2016;14:1-4.
3. Koch M, Kurian EM. Pleural fluid extramedullary hematopoiesis case report with review of the literature. Diagn Cytopathol 2016;44:41-4. doi: 10.1002/dc.23390.
4. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol 2016;25:371-4. doi: 10.1016/j.carpath.2016.05.007.
5. Sekar S, Burad D, Abraham A, Paul MJ. Adrenal incidentaloma caused by extramedullary haematopoiesis: conservative management is optimal. BMJ Case Rep 2015;2015. doi: 10.1136/bcr-2015-211014.
6. Humphrey PA, Vollmer RT. Extramedullary hematopoiesis in the prostate. Am J Surg Pathol 1991;15:486-90.
7. Khuraijam B, Sobti P, Shangpliang D, Khurana N. Extramedullary haematopoiesis in a case of pilomatricoma. JClin Diagn Res 2016;10:ED17-ED18. doi: 10.7860/ JCDR/2016/18947.8068
8. Ohta Y, Shichinohe H, Nagashima K. Spinal cord compression due to extramedullary hematopoiesis associated with polycythemia vera—case report. Neurol Med Chir 2002;42:40-3.
9. Pornsuriyasak P, Suwatanapongched T, Wangsuppasawad N, Ngodngamthaweesuk M, Angchaisuksiri P. Massive hemothorax in a beta-thalassemic patient due to spontaneous rupture of extramedullary hematopoietic masses: diagnosis and successful treatment. Respir Care 2006;51:272-6.
10. Tsitouridis J, Stamos S, Hassapopoulou E, Tsitouridis K, Nikolopoulos P. Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol 1999;30:33-8.
11. Bowling MR, Cauthen CG, Perry CD, et al. Pulmonary extramedullary hematopoiesis. J Thorac Imaging 2008;23:138-41. doi: 10.1097/RTI.0b013e31815b89aa.
12. Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS. Extramedullary hemopoiesis. Semin Ultrasound, CT, MR 2014;35:255-62.
13. Nakayama F, Nishihara S, Iwasaki H, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem 2001;276:16100-6.
14. Sheibani K, Battifora H, Burke JS, Rappaport H. Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases. Am J Surg Pathol 1986;10:227-36.
15. Swerdlow SH, Wright SA. The spectrum of Leu-M1 staining in lymphoid and hematopoietic proliferations. Am J Clin Pathol 1986 ;85:283-8.
16. Pinkus GS, Said JW. Leu-M1 immunoreactivity in nonhematopoietic neoplasms and myeloproliferative disorders. An immunoperoxidase study of paraffin sections. Am J Clin Pathol 1986;85:278-82.
17. Hall PA, D’Ardenne AJ. Value of CD15 immunostaining in diagnosing Hodgkin’s disease: a review of published literature. JClin Pathol 1987 ;40:1298-304.

Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma

Year 2019, Volume: 32 Issue: 1, 55 - 57, 29.01.2019

Faruk Erdem Kombak Süheyla Uyar Bozkurt Toluy Özgümüş İşık Kaygusuz Atagündüz

https://doi.org/10.5472/marumj.518989

Abstract

Extramedullary hematopoiesis (EMH) refers to the proliferation

of hematopoietic precursors outside the bone marrow. EMH often

presents as a mass lesion in several areas of the body. In this

report, we present a case misdiagnosed and explain the cause of

the diagnostic error.

Keywords

Extramedullary hematopoiesis, Posterior mediastinal mass, Hemolytic anemia

References

1. Yamamoto K, Miwa Y, Abe-Suzuki S, et al. Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review). Mol Med Rep 2016;13:587-91. doi: 10.3892/mmr.2015.4621.
2. Solazzo A, D’Auria V, Moccia LG, Vatrella A, Bocchino M, Rea G. Posterior mediastinal extramedullary hematopoiesis secondary to hypoxia. Transl Med UniSa 2016;14:1-4.
3. Koch M, Kurian EM. Pleural fluid extramedullary hematopoiesis case report with review of the literature. Diagn Cytopathol 2016;44:41-4. doi: 10.1002/dc.23390.
4. Mahadevan NR, Morgan EA, Mitchell RN. Case report and literature review: cardiac tamponade as a complication of pericardial extramedullary hematopoiesis. Cardiovasc Pathol 2016;25:371-4. doi: 10.1016/j.carpath.2016.05.007.
5. Sekar S, Burad D, Abraham A, Paul MJ. Adrenal incidentaloma caused by extramedullary haematopoiesis: conservative management is optimal. BMJ Case Rep 2015;2015. doi: 10.1136/bcr-2015-211014.
6. Humphrey PA, Vollmer RT. Extramedullary hematopoiesis in the prostate. Am J Surg Pathol 1991;15:486-90.
7. Khuraijam B, Sobti P, Shangpliang D, Khurana N. Extramedullary haematopoiesis in a case of pilomatricoma. JClin Diagn Res 2016;10:ED17-ED18. doi: 10.7860/ JCDR/2016/18947.8068
8. Ohta Y, Shichinohe H, Nagashima K. Spinal cord compression due to extramedullary hematopoiesis associated with polycythemia vera—case report. Neurol Med Chir 2002;42:40-3.
9. Pornsuriyasak P, Suwatanapongched T, Wangsuppasawad N, Ngodngamthaweesuk M, Angchaisuksiri P. Massive hemothorax in a beta-thalassemic patient due to spontaneous rupture of extramedullary hematopoietic masses: diagnosis and successful treatment. Respir Care 2006;51:272-6.
10. Tsitouridis J, Stamos S, Hassapopoulou E, Tsitouridis K, Nikolopoulos P. Extramedullary paraspinal hematopoiesis in thalassemia: CT and MRI evaluation. Eur J Radiol 1999;30:33-8.
11. Bowling MR, Cauthen CG, Perry CD, et al. Pulmonary extramedullary hematopoiesis. J Thorac Imaging 2008;23:138-41. doi: 10.1097/RTI.0b013e31815b89aa.
12. Orphanidou-Vlachou E, Tziakouri-Shiakalli C, Georgiades CS. Extramedullary hemopoiesis. Semin Ultrasound, CT, MR 2014;35:255-62.
13. Nakayama F, Nishihara S, Iwasaki H, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem 2001;276:16100-6.
14. Sheibani K, Battifora H, Burke JS, Rappaport H. Leu-M1 antigen in human neoplasms. An immunohistologic study of 400 cases. Am J Surg Pathol 1986;10:227-36.
15. Swerdlow SH, Wright SA. The spectrum of Leu-M1 staining in lymphoid and hematopoietic proliferations. Am J Clin Pathol 1986 ;85:283-8.
16. Pinkus GS, Said JW. Leu-M1 immunoreactivity in nonhematopoietic neoplasms and myeloproliferative disorders. An immunoperoxidase study of paraffin sections. Am J Clin Pathol 1986;85:278-82.
17. Hall PA, D’Ardenne AJ. Value of CD15 immunostaining in diagnosing Hodgkin’s disease: a review of published literature. JClin Pathol 1987 ;40:1298-304.

There are 17 citations in total.

Details

Primary Language	English
Subjects	Clinical Sciences
Journal Section	Case Reports
Authors	Faruk Erdem Kombak Süheyla Uyar Bozkurt Toluy Özgümüş İşık Kaygusuz Atagündüz
Publication Date	January 29, 2019
Published in Issue	Year 2019 Volume: 32 Issue: 1

Cite

APA	Kombak, F. E., Uyar Bozkurt, S., Özgümüş, T., Kaygusuz Atagündüz, İ. (2019). Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma. Marmara Medical Journal, 32(1), 55-57. https://doi.org/10.5472/marumj.518989
AMA	Kombak FE, Uyar Bozkurt S, Özgümüş T, Kaygusuz Atagündüz İ. Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma. Marmara Med J. January 2019;32(1):55-57. doi:10.5472/marumj.518989
Chicago	Kombak, Faruk Erdem, Süheyla Uyar Bozkurt, Toluy Özgümüş, and İşık Kaygusuz Atagündüz. “Mass-Forming Extramedullary Hematopoiesis Mimicking Hodgkin’s Lymphoma”. Marmara Medical Journal 32, no. 1 (January 2019): 55-57. https://doi.org/10.5472/marumj.518989.
EndNote	Kombak FE, Uyar Bozkurt S, Özgümüş T, Kaygusuz Atagündüz İ (January 1, 2019) Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma. Marmara Medical Journal 32 1 55–57.
IEEE	F. E. Kombak, S. Uyar Bozkurt, T. Özgümüş, and İ. Kaygusuz Atagündüz, “Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma”, Marmara Med J, vol. 32, no. 1, pp. 55–57, 2019, doi: 10.5472/marumj.518989.
ISNAD	Kombak, Faruk Erdem et al. “Mass-Forming Extramedullary Hematopoiesis Mimicking Hodgkin’s Lymphoma”. Marmara Medical Journal 32/1 (January 2019), 55-57. https://doi.org/10.5472/marumj.518989.
JAMA	Kombak FE, Uyar Bozkurt S, Özgümüş T, Kaygusuz Atagündüz İ. Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma. Marmara Med J. 2019;32:55–57.
MLA	Kombak, Faruk Erdem et al. “Mass-Forming Extramedullary Hematopoiesis Mimicking Hodgkin’s Lymphoma”. Marmara Medical Journal, vol. 32, no. 1, 2019, pp. 55-57, doi:10.5472/marumj.518989.
Vancouver	Kombak FE, Uyar Bozkurt S, Özgümüş T, Kaygusuz Atagündüz İ. Mass-forming extramedullary hematopoiesis mimicking Hodgkin’s lymphoma. Marmara Med J. 2019;32(1):55-7.