Research Article
Year 2025,
Volume: 15 Issue: 1, 16 - 23, 26.06.2025
Abstract
Project Number
1919B012325412.
References
- Abdelnour, S. A., El-Hack, M. E. A., Swelum, A. A., Perillo, A., & Losacco, C. (2018). The vital roles of boron in animal health and production: A comprehensive review. Journal of Trace Elements in Medicine and Biology, 50, 296–304. https://doi.org/10.1016/j.jtemb.2018.07.018
- Bolaños, L., Lukaszewski, K., Bonilla, I., & Blevins, D. (2004). Why boron? Plant Physiology and Biochemistry, 42(11), 907–912. https://doi.org/10.1016/j.plaphy.2004.11.002
- Bolt, H. M., Başaran, N., & Duydu, Y. (2020). Effects of boron compounds on human reproduction. Archives of Toxicology, 94(3), 717–724. https://doi.org/10.1007/s00204-020-02700-x
- Cengiz, M. (2018). Boric acid protects against cyclophosphamide- induced oxidative stress and renal damage in rats. Cellular and Molecular Biology, 64(12), 11–14. https://doi.org/10.14715/cmb/2018.64.12.3
- Devirian, T. A., & Volpe, S. L. (2003). The Physiological Effects of Dietary Boron. Critical Reviews in Food Science and Nutrition, 43(2), 219–231. https://doi.org/10.1080/10408690390826491
- Durmuş, İ., İnce, S., Salim, M. N., Eryavuz, A., & Küçükkurt, İ. (2018). Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri. Kocatepe Veterinary Journal, 11(2), 11–12. https://doi.org/10.30607/kvj.394370
- Etim, N. N., Enyenihi, G. E., Akpabio, U., Offiong, E. E. (2014). Effects of nutrition on haematology of rabbits: a review. European Scientific Journal, 10(3), 413-24.
- Hjelm, C., Harari, F., & Vahter, M. (2019). Pre- and postnatal environmental boron exposure and infant growth: Results from a mother-child cohort in northern Argentina. Environmental Research, 171, 60–68. https://doi.org/10.1016/j.envres.2019.01.012
- Ince, S., Filazi, A., & Yurdakök-Dikmen, B. (2016). Boron, Gupta RC (Ed): Reproductive and Developmental Toxicology, 978-0-12-804239-7, 257-94, Academic Press. United States.
- Ince, S., Kucukkurt, I., Acaroz, U., Arslan‐Acaroz, D., & Varol, N. (2018). Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats. Journal of Biochemical and Molecular Toxicology, 33(2). https://doi.org/10.1002/jbt.22252
- Kabu, M., Civelek, T., & Birdane, F. M. (2014). Effects of boron, propylene glycol and methionine administration on some hematological parameters in dairy cattle during periparturient period. Vet Arh, 84(1), 19-29.
- Kan, F., & Kucukkurt, I. (2023). The effects of boron on some biochemical parameters: A review. Journal of Trace Elements in Medicine and Biology, 79, 127249. https://doi.org/10.1016/j.jtemb.2023.127249
- Kucukkurt, I., Ince, S., Eryavuz, A., Demirel, H. H., Arslan‐Acaroz, D., Zemheri‐Navruz, F., & Durmus, I. (2022). The effects of boron‐ supplemented diets on adipogenesis‐related gene expressions, anti‐ inflammatory, and antioxidative response in high‐fat fed rats. Journal of Biochemical and Molecular Toxicology, 37(2). https://doi.org/10.1002/jbt.23257
- Kuru, R., & Yarat, A. (2017). Boron and a Current Overview of its Effects On Health. Clinical and Experimental Health Sciences, 7(3), 107–114. https://doi.org/10.5152/clinexphealthsci.2017.314
- Kuru, R., Yilmaz, S., Balan, G., Tuzuner, B. A., Tasli, P. N., Akyuz, S., Ozturk, F. Y., Altuntas, Y., Yarat, A., & Sahin, F. (2019). Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial. Journal of Trace Elements in Medicine and Biology, 54, 191– 198. https://doi.org/10.1016/j.jtemb.2019.04.021
- Kusaka, S., Morizane, Y., Tokumaru, Y., Tamaki, S., Maemunah, I. R., Akiyama, Y., Sato, F., & Murata, I. (2022). Cerebrospinal fluid-based boron delivery system may help increase the uptake boron for boron neutron capture therapy in veterinary medicine: A preliminary study with normal rat brain cells. Research in Veterinary Science, 148, 1–6. https://doi.org/10.1016/j.rvsc.2022.04.008
- Nielsen, F. H., & Eckhert, C. D. (2019). Boron. Advances in Nutrition, 11(2), 461–462. https://doi.org/10.1093/advances/nmz110
- İlhan, A. O., Can, B., Kar, F., Gündoğdu, A. Ç., Söğüt, İ., & Kanbak, G. (2023). An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption. Biological Trace Element Research, 201(11), 5346–5357. https://doi.org/10.1007/s12011-023-03699-9
- Onder, G. O., Goktepe, O., Karaman, E., Karakas, E., Mat, O. C., Bolat, D., Okur, E., Tan, F. C., Balcioglu, E., Baran, M., Ermis, M., & Yay, A. (2023). Nonylphenol Exposure-Induced Oocyte Quality Deterioration Could be Reversed by Boric Acid Supplementation in Rats. Biological Trace Element Research, 201(9), 4518–4529. https://doi.org/10.1007/s12011- 023-03657-5
- Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician’s Journal, 14(4), 35.
- Tokay, F., & Bağdat, S. (2022). A novel and simple approach to element fractionation analysis: Single step fractionation of milk. Food Chemistry, 379, 132162. https://doi.org/10.1016/j.foodchem.2022.132162
- Tokay, F., & Bağdat, S. (2022a). Schiff base functionalized silica gel for simultaneous separation and preconcentration of Cu(II), Ni(II), and Cd(II) in pharmaceuticals and water samples. TURKISH JOURNAL OF CHEMISTRY, 46(2), 459–474. https://doi.org/10.55730/1300-0527.3320
- Uluisik, I., Karakaya, H. C., & Koc, A. (2017). The importance of boron in biological systems. Journal of Trace Elements in Medicine and Biology, 45, 156–162. https://doi.org/10.1016/j.jtemb.2017.10.008
- Wang, S., Zhou, Y., & Gao, C. (2018). Novel high boron removal polyamide reverse osmosis membranes. Journal of Membrane Science, 554, 244–252. https://doi.org/10.1016/j.memsci.2018.03.014
- Watson, A. T. D., Sutherland, V. L., Cunny, H., Miller-Pinsler, L., Furr, J., Hebert, C., Collins, B., Waidyanatha, S., Smith, L., Vinke, T., Aillon, K., Xie, G., Shockley, K. R., & McIntyre, B. S. (2020). Postnatal effects of gestational and lactational gavage exposure to boric acid in the developing Sprague Dawley rat. Toxicological Sciences, 176(1), 65–73. https://doi.org/10.1093/toxsci/kfaa061
- Yiğit, P., Eren, M., Sarıca, Z. S., & Şentürk, M. (2013). Tavşanlarda borik asidin kan kimyasına etkisi. Erciyes. Üniversitesi Veteriner Fakültesi Dergisi, 10(2), 77-85.
- Yildirim, S., Celikezen, F. C., Oto, G., Sengul, E., Bulduk, M., Tasdemir, M., & Cinar, D. A. (2017). An investigation of protective effects of litium borate on blood and histopathological parameters in acute Cadmium- Induced rats. Biological Trace Element Research, 182(2), 287–294. https://doi.org/10.1007/s12011-017-1089-9
The Effect of Distance to Boron on Serum Boron Concentration and Some Biochemical and Hematological Parameters in Sheep
Abstract
Boron is an essential element in relation to underground resources, with Turkey possessing 73.5 per cent of the global boron reserves. Its prevalence in the field of industry has made it the subject of research in the field of health in recent years. There is a very thin boundary between deficiency and toxicity. Its mechanisms in living organisms are not fully understood, therefore, sufficient and complete and consistent data on human and ecosystem health and its place and dose in these areas have not been reached, and data are needed to maintain and increase its importance and necessity in these areas. The amount and duration of boron exposure may increase in boron fields. This is because boron can be found in air, soil and water. This study investigates the changes in boron levels in living organisms as a function of the distance of boron exposure. Statistically significant differences in serum boron, urea, creatinine and BUN levels were observed between different locations. In parallel, statistically significant differences were also observed between some haemogram parameters. The data obtained are valuable with regard to the possible interaction between boron exposure distance and serum boron levels.
Ethical Statement
During the writing process of the study titled ‘The Effect of Distance to Boron on Serum Boron Concentration and Some Biochemical and Haematological Parameters in Sheep’, scientific, ethical and citation rules were followed; no falsification was made on the collected data and this study was not sent to another academic medium for evaluation. Approval for this study was granted by the Balıkesir University Animal Experiments Local Ethics Committee (Approval no. 2024/4-8). Significant efforts were made to minimise animal suffering, with strict adherence to the '3Rs' rule in accordance with established ethical principles.
Supporting Institution
TÜBİTAK-2209 University Students Research Projects Support Programme
Project Number
1919B012325412.
References
- Abdelnour, S. A., El-Hack, M. E. A., Swelum, A. A., Perillo, A., & Losacco, C. (2018). The vital roles of boron in animal health and production: A comprehensive review. Journal of Trace Elements in Medicine and Biology, 50, 296–304. https://doi.org/10.1016/j.jtemb.2018.07.018
- Bolaños, L., Lukaszewski, K., Bonilla, I., & Blevins, D. (2004). Why boron? Plant Physiology and Biochemistry, 42(11), 907–912. https://doi.org/10.1016/j.plaphy.2004.11.002
- Bolt, H. M., Başaran, N., & Duydu, Y. (2020). Effects of boron compounds on human reproduction. Archives of Toxicology, 94(3), 717–724. https://doi.org/10.1007/s00204-020-02700-x
- Cengiz, M. (2018). Boric acid protects against cyclophosphamide- induced oxidative stress and renal damage in rats. Cellular and Molecular Biology, 64(12), 11–14. https://doi.org/10.14715/cmb/2018.64.12.3
- Devirian, T. A., & Volpe, S. L. (2003). The Physiological Effects of Dietary Boron. Critical Reviews in Food Science and Nutrition, 43(2), 219–231. https://doi.org/10.1080/10408690390826491
- Durmuş, İ., İnce, S., Salim, M. N., Eryavuz, A., & Küçükkurt, İ. (2018). Gentamisin verilen sıçanlara bor uygulamasının hematolojik parametre düzeylerine etkileri. Kocatepe Veterinary Journal, 11(2), 11–12. https://doi.org/10.30607/kvj.394370
- Etim, N. N., Enyenihi, G. E., Akpabio, U., Offiong, E. E. (2014). Effects of nutrition on haematology of rabbits: a review. European Scientific Journal, 10(3), 413-24.
- Hjelm, C., Harari, F., & Vahter, M. (2019). Pre- and postnatal environmental boron exposure and infant growth: Results from a mother-child cohort in northern Argentina. Environmental Research, 171, 60–68. https://doi.org/10.1016/j.envres.2019.01.012
- Ince, S., Filazi, A., & Yurdakök-Dikmen, B. (2016). Boron, Gupta RC (Ed): Reproductive and Developmental Toxicology, 978-0-12-804239-7, 257-94, Academic Press. United States.
- Ince, S., Kucukkurt, I., Acaroz, U., Arslan‐Acaroz, D., & Varol, N. (2018). Boron ameliorates arsenic‐induced DNA damage, proinflammatory cytokine gene expressions, oxidant/antioxidant status, and biochemical parameters in rats. Journal of Biochemical and Molecular Toxicology, 33(2). https://doi.org/10.1002/jbt.22252
- Kabu, M., Civelek, T., & Birdane, F. M. (2014). Effects of boron, propylene glycol and methionine administration on some hematological parameters in dairy cattle during periparturient period. Vet Arh, 84(1), 19-29.
- Kan, F., & Kucukkurt, I. (2023). The effects of boron on some biochemical parameters: A review. Journal of Trace Elements in Medicine and Biology, 79, 127249. https://doi.org/10.1016/j.jtemb.2023.127249
- Kucukkurt, I., Ince, S., Eryavuz, A., Demirel, H. H., Arslan‐Acaroz, D., Zemheri‐Navruz, F., & Durmus, I. (2022). The effects of boron‐ supplemented diets on adipogenesis‐related gene expressions, anti‐ inflammatory, and antioxidative response in high‐fat fed rats. Journal of Biochemical and Molecular Toxicology, 37(2). https://doi.org/10.1002/jbt.23257
- Kuru, R., & Yarat, A. (2017). Boron and a Current Overview of its Effects On Health. Clinical and Experimental Health Sciences, 7(3), 107–114. https://doi.org/10.5152/clinexphealthsci.2017.314
- Kuru, R., Yilmaz, S., Balan, G., Tuzuner, B. A., Tasli, P. N., Akyuz, S., Ozturk, F. Y., Altuntas, Y., Yarat, A., & Sahin, F. (2019). Boron-rich diet may regulate blood lipid profile and prevent obesity: A non-drug and self-controlled clinical trial. Journal of Trace Elements in Medicine and Biology, 54, 191– 198. https://doi.org/10.1016/j.jtemb.2019.04.021
- Kusaka, S., Morizane, Y., Tokumaru, Y., Tamaki, S., Maemunah, I. R., Akiyama, Y., Sato, F., & Murata, I. (2022). Cerebrospinal fluid-based boron delivery system may help increase the uptake boron for boron neutron capture therapy in veterinary medicine: A preliminary study with normal rat brain cells. Research in Veterinary Science, 148, 1–6. https://doi.org/10.1016/j.rvsc.2022.04.008
- Nielsen, F. H., & Eckhert, C. D. (2019). Boron. Advances in Nutrition, 11(2), 461–462. https://doi.org/10.1093/advances/nmz110
- İlhan, A. O., Can, B., Kar, F., Gündoğdu, A. Ç., Söğüt, İ., & Kanbak, G. (2023). An Investigation into the Protective Effects of Various Doses of Boric Acid on Liver, Kidney, and Brain Tissue Damage Caused by High Levels of Acute Alcohol Consumption. Biological Trace Element Research, 201(11), 5346–5357. https://doi.org/10.1007/s12011-023-03699-9
- Onder, G. O., Goktepe, O., Karaman, E., Karakas, E., Mat, O. C., Bolat, D., Okur, E., Tan, F. C., Balcioglu, E., Baran, M., Ermis, M., & Yay, A. (2023). Nonylphenol Exposure-Induced Oocyte Quality Deterioration Could be Reversed by Boric Acid Supplementation in Rats. Biological Trace Element Research, 201(9), 4518–4529. https://doi.org/10.1007/s12011- 023-03657-5
- Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician’s Journal, 14(4), 35.
- Tokay, F., & Bağdat, S. (2022). A novel and simple approach to element fractionation analysis: Single step fractionation of milk. Food Chemistry, 379, 132162. https://doi.org/10.1016/j.foodchem.2022.132162
- Tokay, F., & Bağdat, S. (2022a). Schiff base functionalized silica gel for simultaneous separation and preconcentration of Cu(II), Ni(II), and Cd(II) in pharmaceuticals and water samples. TURKISH JOURNAL OF CHEMISTRY, 46(2), 459–474. https://doi.org/10.55730/1300-0527.3320
- Uluisik, I., Karakaya, H. C., & Koc, A. (2017). The importance of boron in biological systems. Journal of Trace Elements in Medicine and Biology, 45, 156–162. https://doi.org/10.1016/j.jtemb.2017.10.008
- Wang, S., Zhou, Y., & Gao, C. (2018). Novel high boron removal polyamide reverse osmosis membranes. Journal of Membrane Science, 554, 244–252. https://doi.org/10.1016/j.memsci.2018.03.014
- Watson, A. T. D., Sutherland, V. L., Cunny, H., Miller-Pinsler, L., Furr, J., Hebert, C., Collins, B., Waidyanatha, S., Smith, L., Vinke, T., Aillon, K., Xie, G., Shockley, K. R., & McIntyre, B. S. (2020). Postnatal effects of gestational and lactational gavage exposure to boric acid in the developing Sprague Dawley rat. Toxicological Sciences, 176(1), 65–73. https://doi.org/10.1093/toxsci/kfaa061
- Yiğit, P., Eren, M., Sarıca, Z. S., & Şentürk, M. (2013). Tavşanlarda borik asidin kan kimyasına etkisi. Erciyes. Üniversitesi Veteriner Fakültesi Dergisi, 10(2), 77-85.
- Yildirim, S., Celikezen, F. C., Oto, G., Sengul, E., Bulduk, M., Tasdemir, M., & Cinar, D. A. (2017). An investigation of protective effects of litium borate on blood and histopathological parameters in acute Cadmium- Induced rats. Biological Trace Element Research, 182(2), 287–294. https://doi.org/10.1007/s12011-017-1089-9
There are 27 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Pharmacology |
| Journal Section | Research Article |
| Authors | |
| Project Number | 1919B012325412. |
| Publication Date | June 26, 2025 |
| Submission Date | February 19, 2025 |
| Acceptance Date | April 23, 2025 |
| Published in Issue | Year 2025 Volume: 15 Issue: 1 |
