Research Article
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SREBP Araştırmalarında Küresel İşbirlikleri: Bilimsel Üretkenlik ve Etki

Year 2025, Volume: 15 Issue: 2, 739 - 748, 30.05.2025

Ş. Efsun Antmen , Cem Yalaza

https://doi.org/10.31020/mutftd.1641269

Abstract

Amaç: Bu çalışma, SREBP araştırmalarının bilimsel etkisini ve zaman içindeki gelişimini değerlendiren kapsamlı bir bibliyometrik analiz sunmaktadır. Sterol düzenleyici element bağlayıcı proteinler (SREBP'ler) lipit sentezini ve alımını düzenleyen transkripsiyon faktörleridir. Lipogenez, endoplazmik retikulum stresi, inflamasyon, otofaji ve apoptozda hayati rol oynarlar.
Yöntem: Web of Science Core Collection veri tabanını kullanarak 1997'den 2023'e kadar yayınlanmış orijinal araştırma makalelerini analiz ettik. Veri analizi VOSviewer, Bibliometrix, Biblioshiny ve Microsoft Excel kullanılarak gerçekleştirilmiş ve yayın çıktıları, ülkeler, kurumlar, dergiler, yazarlar, anahtar kelimeler ve atıflar incelenmiştir.
Bulgular: 13.910 araştırmacı tarafından yazılmış toplam 3.863 makale tespit edilmiştir. En üretken ülkeler Çin, ABD ve Güney Kore olurken, toplam atıflarda ABD başı çekmiştir. Seul Ulusal Üniversitesi ve Nanjing Tarım Üniversitesi kilit kurumlar olarak belirlenmiştir. Analiz, önemli küresel işbirliklerini ortaya çıkarmış ve SREBP'nin metabolik hastalıklar ve kanser biyolojisi üzerindeki etkisini vurgulamıştır.
Sonuç: Bu bibliyometrik analiz, SREBP araştırmalarına ilişkin değerli bilgiler sunmakta, önde gelen katkıda bulunanları, eğilimleri ve gelecekteki araştırma yönlerini belirlemektedir. Araştırmacılar için uygun dergileri, işbirlikçileri ve odak alanlarını seçmede bir rehber görevi görmektedir.

Keywords

SREBP bibliometric analysis lipid metabolism transcription factors VOSviewer Bibliometrix

Project Number

-

References

  • 1. Kou Y, Geng F, Guo D. Lipid metabolism in glioblastoma: from de novo synthesis to storage. Biomedicines. 2022; 10(8):1943.
  • 2. Zhao Q, Lin X, Wang G. Targeting SREBP-1-Mediated lipogenesis as potential strategies for cancer. Front Oncol. 2022; 12: 952371.
  • 3. Dorotea D, Koya D, Ha H. Recent insights into SREBP as a direct mediator of kidney fibrosis via lipid-independent pathways. Front Pharmacol. 2020; 11:265.
  • 4. Chandrasekaran P, Weiskirchen R. The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis. Int J Mol Sci. 2024; 25(2):1109.
  • 5. Shao W, Espenshade PJ. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP). JBC. 2014; 289(11):7547-7557.
  • 6. Ye J, DeBose-Boyd RA. Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb Perspect Biol. 2011; 3(7): a004754.
  • 7. Liu H, et al. Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021. Int J Environ Res Public Health. 2023; 20(3):2382.
  • 8. Donthu N, et al. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021; 133:285-296.
  • 9. Karger E, Kureljusic M. Using artificial intelligence for drug discovery: A bibliometric study and future research agenda. Pharmaceuticals. 2022; 15(12):1492.
  • 10. Moral-Muñoz JA, et al. Software tools for conducting bibliometric analysis in science: An up-to-date review. Prof Inform. 2020; 29(1).
  • 11. Aria M, Cuccurullo C. Bibliometrix: An R-tool for comprehensive science mapping analysis. J Inform. 2017; 11(4):959-975.
  • 12. Zhang J, Yu Q, Zheng F. Comparing keywords plus of WOS and author keywords: A case study of patient adherence research. JASIST. 2016; 67(4):967-972.
  • 13. Manjareeka M. Evaluation of researchers: H-Index or G-Index which is better? J Integr Med. 2023; 1(1):34-36.
  • 14. AlBashtawi J, Al-Jaber H, Ahmed S. Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets. Biomedicines. 2024; 12(4):793.
  • 15. Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology. Nat Rev Endocrinol. 2017; 13(12):710-730.
  • 16. Wang X, Chen Y, Meng H. SREBPs as the potential target for solving the polypharmacy dilemma. Front Physiol. 2024; 14:1272540.
  • 17. He Y, et al. The roles and mechanisms of SREBP1 in cancer development and drug response. Genes & Diseases. 2024; 11(4): 100987.

Global Collaborations in SREBP Research: Scientific Productivity and Impact

Year 2025, Volume: 15 Issue: 2, 739 - 748, 30.05.2025

Ş. Efsun Antmen , Cem Yalaza

https://doi.org/10.31020/mutftd.1641269

Abstract

Aim: This study provides a comprehensive bibliometric analysis of SREBP research, assessing its scientific impact and evolution over time.
Background: Sterol regulatory element-binding proteins (SREBPs) are transcription factors regulating lipid synthesis and uptake. They play vital roles in lipogenesis, endoplasmic reticulum stress, inflammation, autophagy, and apoptosis.
Methods: We analyzed original research articles published from 1997 to 2023 using the Web of Science Core Collection database. Data analysis was performed using VOSviewer, Bibliometrix, Biblioshiny, and Microsoft Excel, examining publication outputs, countries, institutions, journals, authors, keywords, and citations.
Results: A total of 3,863 articles were identified, authored by 13,910 researchers. The most productive countries were China, the USA, and South Korea, with the USA leading in total citations. Seoul National University and Nanjing Agricultural University were identified as key institutions. The analysis revealed significant global collaborations and emphasized SREBP’s impact on metabolic diseases and cancer biology.
Conclusion: This bibliometric analysis offers valuable insights into SREBP research, identifying leading contributors, trends, and future research directions. It serves as a guide for researchers in selecting appropriate journals, collaborators, and focus areas.

Keywords

SREBP bibliometric analysis lipid metabolism transcription factors VOSviewer

Ethical Statement

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Supporting Institution

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Project Number

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Thanks

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References

  • 1. Kou Y, Geng F, Guo D. Lipid metabolism in glioblastoma: from de novo synthesis to storage. Biomedicines. 2022; 10(8):1943.
  • 2. Zhao Q, Lin X, Wang G. Targeting SREBP-1-Mediated lipogenesis as potential strategies for cancer. Front Oncol. 2022; 12: 952371.
  • 3. Dorotea D, Koya D, Ha H. Recent insights into SREBP as a direct mediator of kidney fibrosis via lipid-independent pathways. Front Pharmacol. 2020; 11:265.
  • 4. Chandrasekaran P, Weiskirchen R. The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis. Int J Mol Sci. 2024; 25(2):1109.
  • 5. Shao W, Espenshade PJ. Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP). JBC. 2014; 289(11):7547-7557.
  • 6. Ye J, DeBose-Boyd RA. Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb Perspect Biol. 2011; 3(7): a004754.
  • 7. Liu H, et al. Global Trends of Lipid Metabolism Research in Epigenetics Field: A Bibliometric Analysis from 2012–2021. Int J Environ Res Public Health. 2023; 20(3):2382.
  • 8. Donthu N, et al. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res. 2021; 133:285-296.
  • 9. Karger E, Kureljusic M. Using artificial intelligence for drug discovery: A bibliometric study and future research agenda. Pharmaceuticals. 2022; 15(12):1492.
  • 10. Moral-Muñoz JA, et al. Software tools for conducting bibliometric analysis in science: An up-to-date review. Prof Inform. 2020; 29(1).
  • 11. Aria M, Cuccurullo C. Bibliometrix: An R-tool for comprehensive science mapping analysis. J Inform. 2017; 11(4):959-975.
  • 12. Zhang J, Yu Q, Zheng F. Comparing keywords plus of WOS and author keywords: A case study of patient adherence research. JASIST. 2016; 67(4):967-972.
  • 13. Manjareeka M. Evaluation of researchers: H-Index or G-Index which is better? J Integr Med. 2023; 1(1):34-36.
  • 14. AlBashtawi J, Al-Jaber H, Ahmed S. Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets. Biomedicines. 2024; 12(4):793.
  • 15. Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology. Nat Rev Endocrinol. 2017; 13(12):710-730.
  • 16. Wang X, Chen Y, Meng H. SREBPs as the potential target for solving the polypharmacy dilemma. Front Physiol. 2024; 14:1272540.
  • 17. He Y, et al. The roles and mechanisms of SREBP1 in cancer development and drug response. Genes & Diseases. 2024; 11(4): 100987.
There are 17 citations in total.

Details

Primary Language English
Subjects Implementation Science and Evaluation
Journal Section Research Article
Authors

Ş. Efsun Antmen 0000-0003-1270-2408

Cem Yalaza 0000-0002-9073-5611

Project Number -
Early Pub Date May 28, 2025
Publication Date May 30, 2025
Submission Date February 17, 2025
Acceptance Date May 4, 2025
Published in Issue Year 2025 Volume: 15 Issue: 2

Cite

APA Antmen, Ş. E., & Yalaza, C. (2025). Global Collaborations in SREBP Research: Scientific Productivity and Impact. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, 15(2), 739-748. https://doi.org/10.31020/mutftd.1641269
AMA Antmen ŞE, Yalaza C. Global Collaborations in SREBP Research: Scientific Productivity and Impact. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. May 2025;15(2):739-748. doi:10.31020/mutftd.1641269
Chicago Antmen, Ş. Efsun, and Cem Yalaza. “Global Collaborations in SREBP Research: Scientific Productivity and Impact”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi 15, no. 2 (May 2025): 739-48. https://doi.org/10.31020/mutftd.1641269.
EndNote Antmen ŞE, Yalaza C (May 1, 2025) Global Collaborations in SREBP Research: Scientific Productivity and Impact. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 15 2 739–748.
IEEE Ş. E. Antmen and C. Yalaza, “Global Collaborations in SREBP Research: Scientific Productivity and Impact”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, vol. 15, no. 2, pp. 739–748, 2025, doi: 10.31020/mutftd.1641269.
ISNAD Antmen, Ş. Efsun - Yalaza, Cem. “Global Collaborations in SREBP Research: Scientific Productivity and Impact”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 15/2 (May 2025), 739-748. https://doi.org/10.31020/mutftd.1641269.
JAMA Antmen ŞE, Yalaza C. Global Collaborations in SREBP Research: Scientific Productivity and Impact. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2025;15:739–748.
MLA Antmen, Ş. Efsun and Cem Yalaza. “Global Collaborations in SREBP Research: Scientific Productivity and Impact”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, vol. 15, no. 2, 2025, pp. 739-48, doi:10.31020/mutftd.1641269.
Vancouver Antmen ŞE, Yalaza C. Global Collaborations in SREBP Research: Scientific Productivity and Impact. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2025;15(2):739-48.
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