Case Report
BibTex RIS Cite

Süt Çocuğunda Nadir Bir Durum: Eksantem Subitum Kaynaklı Ensefalit

Year 2025, Issue: 3, 150 - 154, 14.03.2025

Umut Yorulmaz , Osman Yiğitoğlu , Derviş Barın , Saliha Yavuz Eravcı , Hüseyin Çaksen , Abdullah Akkuş

https://doi.org/10.70846/nigdetip.1564248

Abstract

Viral ensefalit virüslerin neden olduğu beyin parankimi inflamasyonudur. Human Herpesvirüs -6 (HHV-6)da bu viral enfeksiyon sebeplerinden biri olup bebeklerde ve çocuklarda ateş, döküntü, farenjit ve genellikle hafif sistemik belirtilerle karakterizeyken nadiren ensefalit sebebi olabilmektedir. Sunulan vakada da dirençli nöbetlerle karakterize olan hastadan gerekli tetkikler yapılmış olup HHV-6 ensefaliti tanısı konulmuştur. Dirençli nöbet ile gelen vakalarda eksantem subitum enfeksiyonuna bağlı olabileceği akılda tutulmalıdır.

Keywords

ÇOCUK KONVULSİYON ENSEFALİT EKSANTEM SUBİTUM

References

  • Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
  • Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
  • Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
  • CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
  • Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
  • Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
  • Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
  • Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
  • Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
  • Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
  • Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
  • Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
  • Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
  • Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
  • Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
  • Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.

A Rare Condition in Infants: Exanthem Subitum-Induced Encephalitis

Year 2025, Issue: 3, 150 - 154, 14.03.2025

Umut Yorulmaz , Osman Yiğitoğlu , Derviş Barın , Saliha Yavuz Eravcı , Hüseyin Çaksen , Abdullah Akkuş

https://doi.org/10.70846/nigdetip.1564248

Abstract

Viral encephalitis is inflammation of the brain parenchyma caused by viruses. HHV-6 is one of the causes of this viral infection and is characterized by fever, rash, pharyngitis and generally mild systemic symptoms in infants and children, but it can rarely cause encephalitis. In the present case, a patient with refractory seizures underwent necessary investigations and was diagnosed with HHV-6 encephalitis. In patients presenting with refractory seizures, it should be kept in mind that the seizure may be due to exanthem subitum infection.

Keywords

CHILD ENCEPHALITIS CONVULSION EXANTHEMA SUBITUM

References

  • Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
  • Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
  • Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
  • CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
  • Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
  • Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
  • Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
  • Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
  • Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
  • Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
  • Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
  • Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
  • Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
  • Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
  • Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
  • Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Pediatric Neurology
Journal Section Case Reports
Authors

Umut Yorulmaz 0009-0004-7354-2828

Osman Yiğitoğlu 0009-0007-3508-5234

Derviş Barın 0009-0005-3145-8596

Saliha Yavuz Eravcı 0000-0002-5277-5583

Hüseyin Çaksen 0000-0002-8992-4386

Abdullah Akkuş 0000-0002-0642-8759

Publication Date March 14, 2025
Submission Date October 14, 2024
Acceptance Date March 5, 2025
Published in Issue Year 2025 Issue: 3

Cite

Vancouver Yorulmaz U, Yiğitoğlu O, Barın D, Yavuz Eravcı S, Çaksen H, Akkuş A. Süt Çocuğunda Nadir Bir Durum: Eksantem Subitum Kaynaklı Ensefalit. Niğde Tıp Dergisi. 2025(3):150-4.
 Download Cover Image