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Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi

Year 2015, Volume: 13 Issue: 2, 151 - 154, 01.09.2015
https://doi.org/10.4274/jcp.21033

Abstract

Lidokain ve atrikain yüksek etkinlikleri ve etkilerinin hızlı başlaması nedeni ile infiltrasyon anestezisinde, ekstremite bloklarında, topikal anestezide ve intravenöz rejyonel anestezide yaygın olarak kullanılmaktadır. Yaygın kullanımlarına rağmen lokal anesteziklerle ilaç allerjisi nadir olarak bildirilmektedir. Ancak sistemik toksisitelerine bağlı reaksiyonlar görülebilmektedir. Burada lidokain ve atrikaine uygulamaları sonrası konvülziyon geçiren ve ilaç allerjisi tanısı alan 2 olgu sunulmuştur

References

  • 1. Snoeck M. Atricaine: a review of its use for local and regional anesthesia. Local Reg Anesth 2012;5:23-33.
  • 2. Bigger JT, Hoffman DF. Antiarrhythmic drugs. In: Gillman AG, Rall TW, Nies AS (eds). Goodman&Gillman: The pharmacological basis of therapeutics 8th edititon. Newyork: Pergamon Pres; 1990. p.857-61.
  • 3. Berkun Y, Ben-Zvi A, Levy Y, Galili D, Shalit M. Evaluation of adverse reactions to local anesthetics: experience with 236 patients. Ann Allergy Asthma Immunol 2003;91:342-5.
  • 4. Morgan GE, Mikhail MS, Murray MJ. LANGE Clinical Anesthesiology, 4th edition By; 2004;264-74.
  • 5. Benjamin G, Wildsmith CAW, Wildsmith JAW. Clinical pharmacology of local anestheticagents. In: Cousins MJ, Bridenbaugh PO (eds). Neural blockage in clinical anesthesia and management of pain. 3th edition. Philadelphia: Lippincott Raven Press; 1998. p.97-128.
  • 6. Miller RD. Local anesthetics. Anesthesia. 4th edition. Churchill: Livingstone; 1994. p.510-6.
  • 7. World Health Organization. International drug monitoring: the role of the hospital. Geneva: The Organization, 1966.
  • 8. Gruchalla RS. Drug metabolism, danger signals, and druginduced hypersensitivity. J Allergy Clin Immunol 2001;108:475- 88.
  • 9. Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005;5:309-16.
  • 10. Simons FER, Ardusso LRF, Bilo MB, El-Gamal YM, Ledford DK, Ring J, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. J Allergy Clin Immunol 2011;127:587-93.
  • 11. Çelik M, Uysal Soyer Ö, Şekerel BE. Lidokaine bağlı allerji veya toksisite? Astım Allerji İmmünoloji 2008;6:22-4.
  • 12. Özer AB, Erhan ÖL. Systemic toxicity to local anesthesia in an infant undergoing circumcision. Agrı 2014;26:43-6.
  • 13. Ayas M, Işık B. Düşük doz lidokain konvülzyon yapar mı? Turk J Anaesth Reanim 2014;42:106-8.
  • 14. Berde CB, Strichartz GR. Local anesthetics. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JO (eds). Young WL Miller’s anesthesia. 7th edition. Philadelphia: Churchill Livingstone; 2010. p.913-40.
  • 15. Nelsen J, Holland M, Dougherty M, Bernad J, Stork C, Marraffa J. Severe central nervous system and cardiovascular toxicity in a pediatric patient after ingestion of an over-the-counter local anesthetic. Pediatr Emerg Care 2009;25:670-3.
  • 16. Erhan ÖL, Demir S. Bebekte prilocaine (70 mg/kg) uygulanması sonucu solunum arresti (olgu sunumu). Fırat Üniversitesi Dergisi (Sağlık Bilimleri) 1991;5:77-9.

Local Anaesthetic Neurotoxicity Mimicking Anaphylaxis

Year 2015, Volume: 13 Issue: 2, 151 - 154, 01.09.2015
https://doi.org/10.4274/jcp.21033

Abstract

Lidocaine and articaine are commonly used in infiltration anesthesia, extremity blockage, topical anesthesia and intravenous regional anesthesia due to high activity and rapid onset effect. Although commonly administered, the allergic drug reactions of local anesthetics are rarely reported. However, reactions related to systemic toxicity can be seen Hereby, we reported two cases related to drug allergy and convulsion after administering of lidocaine and articaine

References

  • 1. Snoeck M. Atricaine: a review of its use for local and regional anesthesia. Local Reg Anesth 2012;5:23-33.
  • 2. Bigger JT, Hoffman DF. Antiarrhythmic drugs. In: Gillman AG, Rall TW, Nies AS (eds). Goodman&Gillman: The pharmacological basis of therapeutics 8th edititon. Newyork: Pergamon Pres; 1990. p.857-61.
  • 3. Berkun Y, Ben-Zvi A, Levy Y, Galili D, Shalit M. Evaluation of adverse reactions to local anesthetics: experience with 236 patients. Ann Allergy Asthma Immunol 2003;91:342-5.
  • 4. Morgan GE, Mikhail MS, Murray MJ. LANGE Clinical Anesthesiology, 4th edition By; 2004;264-74.
  • 5. Benjamin G, Wildsmith CAW, Wildsmith JAW. Clinical pharmacology of local anestheticagents. In: Cousins MJ, Bridenbaugh PO (eds). Neural blockage in clinical anesthesia and management of pain. 3th edition. Philadelphia: Lippincott Raven Press; 1998. p.97-128.
  • 6. Miller RD. Local anesthetics. Anesthesia. 4th edition. Churchill: Livingstone; 1994. p.510-6.
  • 7. World Health Organization. International drug monitoring: the role of the hospital. Geneva: The Organization, 1966.
  • 8. Gruchalla RS. Drug metabolism, danger signals, and druginduced hypersensitivity. J Allergy Clin Immunol 2001;108:475- 88.
  • 9. Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005;5:309-16.
  • 10. Simons FER, Ardusso LRF, Bilo MB, El-Gamal YM, Ledford DK, Ring J, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. J Allergy Clin Immunol 2011;127:587-93.
  • 11. Çelik M, Uysal Soyer Ö, Şekerel BE. Lidokaine bağlı allerji veya toksisite? Astım Allerji İmmünoloji 2008;6:22-4.
  • 12. Özer AB, Erhan ÖL. Systemic toxicity to local anesthesia in an infant undergoing circumcision. Agrı 2014;26:43-6.
  • 13. Ayas M, Işık B. Düşük doz lidokain konvülzyon yapar mı? Turk J Anaesth Reanim 2014;42:106-8.
  • 14. Berde CB, Strichartz GR. Local anesthetics. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JO (eds). Young WL Miller’s anesthesia. 7th edition. Philadelphia: Churchill Livingstone; 2010. p.913-40.
  • 15. Nelsen J, Holland M, Dougherty M, Bernad J, Stork C, Marraffa J. Severe central nervous system and cardiovascular toxicity in a pediatric patient after ingestion of an over-the-counter local anesthetic. Pediatr Emerg Care 2009;25:670-3.
  • 16. Erhan ÖL, Demir S. Bebekte prilocaine (70 mg/kg) uygulanması sonucu solunum arresti (olgu sunumu). Fırat Üniversitesi Dergisi (Sağlık Bilimleri) 1991;5:77-9.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Deniz Özçeker

Zeynep Tamay

Nermin Güler

Publication Date September 1, 2015
Published in Issue Year 2015 Volume: 13 Issue: 2

Cite

APA Özçeker, D., Tamay, Z., & Güler, N. (2015). Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi. Güncel Pediatri, 13(2), 151-154. https://doi.org/10.4274/jcp.21033
AMA Özçeker D, Tamay Z, Güler N. Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi. Güncel Pediatri. September 2015;13(2):151-154. doi:10.4274/jcp.21033
Chicago Özçeker, Deniz, Zeynep Tamay, and Nermin Güler. “Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi”. Güncel Pediatri 13, no. 2 (September 2015): 151-54. https://doi.org/10.4274/jcp.21033.
EndNote Özçeker D, Tamay Z, Güler N (September 1, 2015) Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi. Güncel Pediatri 13 2 151–154.
IEEE D. Özçeker, Z. Tamay, and N. Güler, “Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi”, Güncel Pediatri, vol. 13, no. 2, pp. 151–154, 2015, doi: 10.4274/jcp.21033.
ISNAD Özçeker, Deniz et al. “Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi”. Güncel Pediatri 13/2 (September 2015), 151-154. https://doi.org/10.4274/jcp.21033.
JAMA Özçeker D, Tamay Z, Güler N. Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi. Güncel Pediatri. 2015;13:151–154.
MLA Özçeker, Deniz et al. “Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi”. Güncel Pediatri, vol. 13, no. 2, 2015, pp. 151-4, doi:10.4274/jcp.21033.
Vancouver Özçeker D, Tamay Z, Güler N. Anafilaksiyi Taklit Eden İlaç Reaksiyonu: Lokal Anestezik Nörotoksisitesi. Güncel Pediatri. 2015;13(2):151-4.