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Effect of Cognitive Impairments in Multiple Sclerosis on Caregivers’ Quality of Life: A Review

Year 2025, Volume: 17 Issue: 4, 707 - 715, 30.12.2025

Sena Kıcıklar

https://doi.org/10.18863/pgy.1502949

Abstract

Multiple sclerosis (MS), which has symptoms like balance problems, fatigue, numbness, loss of vision and tremors, also leads to impairment in cognitive functions. Most patients with MS have difficulties with numbers of cognitive domains including memory, attention, information processing and executive functions. These difficulties also negatively affect the daily life of individuals. As cognitive impairments in MS have been investigated, the impact of these difficulties on both the patients themselves and their caregivers has begun to be recognized. The aim of this study is to overview cognitive impairment in MS patients within the context of caregiver quality of life (QoL). As studies have shown, impairment in cognitive abilities negatively affects the QoL of both patients and caregivers. In conclusion cognitive abilities have an important role in the integration of MS patients and their caregivers into daily life.

Keywords

multiple sclerosis cognitive impairment caregiver quality of life

References

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Multipl Sklerozda Bilişsel Bozuklukların Bakım Verenlerin Yaşam Kalitesi Üzerindeki Etkisi: Bir Gözden Geçirme

Year 2025, Volume: 17 Issue: 4, 707 - 715, 30.12.2025

Sena Kıcıklar

https://doi.org/10.18863/pgy.1502949

Abstract

Denge problemleri, yorgunluk, uyuşukluk, görme kaybı ve tremor gibi semptomları olan multipl skleroz (MS), bilişsel işlevlerde de bozulmaya yol açmaktadır. MS hastalarının önemli bir kısmı bellek, dikkat, bilgi işleme ve yürütücü işlevler de dahil olmak üzere çok sayıda bilişsel alanda zorluk yaşamaktadır. Yaşanan bu zorluklar kişilerin günlük yaşamını da olumsuz yönde etkilemektedir. MS’deki bilişsel bozulmanın araştırılmasıyla birlikte, bu becerilerdeki eksikliklerin hem hastaların kendileri hem de bakım verenlerin üzerindeki etkisi fark edilmeye başlanmıştır. Bu çalışma, MS hastalarında bilişsel bozukluklara bakım verenlerinin yaşam kalitesi bağlamında genel bir bakış sunmayı amaçlamaktadır. Çalışmaların ortaya koyduğu üzere, bilişsel becerilerdeki bozulma hem hastaların hem de bakım verenlerin yaşam kalitesini olumsuz yönde etkilemektedir. Bu bulgular ışığında, MS hastaları ve bakım verenleri için bilişsel becerilerin günlük yaşama entegrasyonda önemli bir role sahip olduğu sonucuna varılmaktadır.

Keywords

multipl skleroz bilişsel bozulma bakım veren yaşam kalitesi

References

  • Achiron A, Barak, Y (2003) Cognitive impairment in probable multiple sclerosis. J Neurol Neurosurg Psychiatry, 74:443-446.
  • Amato MP, Ponziani G, Pracucci G, Bracco L, Siracusa G, Amaducci L (1995) Cognitive impairment in early-onset multiple sclerosis: pattern, predictors, and impact on everyday life in a 4-year follow-up. Arch Neurol, 52:168-172.
  • Amato M P, Ponziani G, Siracusa G, Sorbi S. (2001) Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol, 58:1602-1606.
  • Amato MP, Goretti B, Ghezzi A, Lori S, Zipoli V, Moiola L et al. (2010) Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up. Neurology, 75:1134-1140.
  • Andaloro A, Russo M, Pastura C, Sessa E, Calatozzo P, Maggio MG, Bramanti P (2021) Is there a correlation between dyslipidemia and cognitive impairment in patients with multiple sclerosis?. Int J Neurosci, 132:201-206.
  • Arnett PA, Higginson CI, Voss WD, Wright B, Bender WI, Wurst JM, Tippin JM (1999) Depressed mood in multiple sclerosis: relationship to capacity-demanding memory and attentional functioning. Neuropsychology, 13:434.
  • Arnett PA, Strober, LB (2011) Cognitive and neurobehavioral features in multiple sclerosis. Expert Rev Neurother, 11:411-424.
  • Aronson K J (1997) Quality of life among persons with multiple sclerosis and their caregivers. Neurology, 48:74-80.
  • Ayromlou H, Hosseini S, Khalili M, Ayromlou S, Khamudchiyan S, Farajdokht F et al. (2023) Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross‐sectional study. J Neuroendocrinol, 35:e13288.
  • Barker-Collo SL (2006) Quality of life in multiple sclerosis: does information-processing speed have an independent effect?. Arch Clin Neuropsychol, 21:167-174.
  • Bayen E, Papeix C, Pradat-Diehl P, Lubetzki C, Joël, ME (2015) Patterns of objective and subjective burden of informal caregivers in multiple sclerosis. Behav Neurol, 2015:648415.
  • Beatty WW, Monson N (1996) Problem solving by patients with multiple sclerosis comparison of performance on the Wisconsin and California Card Sorting Tests. J Int Neuropsychol Soc, 2:134-140.
  • Beatty WW, Wilbanks SL, Blanco CR, Hames K A, Tivis R, Paul R H (1996) Memory disturbance in multiple sclerosis: reconsideration of patterns of performance on the selective reminding test. J Clin Exp Neuropsychol 18:56-62.
  • Beer S, Khan F, Kesselring J (2012) Rehabilitation interventions in multiple sclerosis: an overview. J Neurol, 259:1994–2008.
  • Benedict RH, Zivadinov R (2011) Risk factors for and management of cognitive dysfunction in multiple sclerosis. Nat Rev Neurol, 7:332-342.
  • Benedict RH, Amato MP, DeLuca J, Geurts JJ (2020) Cognitive impairment in multiple sclerosis: clinical management, MRI, and therapeutic avenues. Lancet Neurol, 19:860-871.
  • Ben‐Zacharia AB (2011) Therapeutics for multiple sclerosis symptoms. Mt Sinai J Med, 78:176-191.
  • Bogosian A, Moss-Morris R, Yardley L, Dennison L (2009) Experiences of partners of people in the early stages of multiple sclerosis. Mult Scler, 15:876-884.
  • Brandstadter R, Fabian M, Leavitt VM, Krieger S, Yeshokumar A, Katz Sand I et al. (2020) Word-finding difficulty is a prevalent disease-related deficit in early multiple sclerosis. Mult Scler, 26:1752-1764.
  • Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, Thompson A J (2014) Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology, 83:1022-1024.
  • Buchanan RJ, Radin D, Huang C (2011) Caregiver burden among informal caregivers assisting people with multiple sclerosis. Int J MS Care, 13:76–83.
  • Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol, 7:1139-1151.
  • Chipchase SY, Nadina BL, (2001) Factors associated with carer strain in carers of people with multiple sclerosis. Disabil Rehabil, 23:768-776.
  • Corry M, While A (2009) The needs of carers of people with multiple sclerosis: a literature review. Scand J Caring Sci, 23:569-588.
  • Dayapoğlu N, Tan M (2017) The care burden and social support levels of caregivers of patients with multiple sclerosis. Kontakt, 19:e17-e23.
  • DeSousa EA, Albert RH, Kalman B (2002) Cognitive impairments in multiple sclerosis: a review. Am J Alzheimers Dis Other Demen, 17:23-29.
  • Dewis MME, Niskala H (1992) Nurturing a valuable resource: family caregivers in multiple sclerosis. Axon, 13:87–94
  • Diamond BJ, DeLuca J, Kim H, Kelley SM (1997) The question of disproportionate impairments in visual and auditory information processing in multiple sclerosis. J Clin Exp Neuropsychol, 19:34-42.
  • Diamond BJ, Johnson SK, Kaufman M, Graves L (2008) Relationships between information processing, depression, fatigue and cognition in multiple sclerosis. Arch Clin Neuropsychol, 23:189-199.
  • Drew M, Tippett LJ, Starkey NJ, Isler RB (2008) Executive dysfunction and cognitive impairment in a large community-based sample with Multiple Sclerosis from New Zealand: a descriptive study. Arch Clin Neuropsychol, 23:1-19.
  • Drulovic J, Pekmezovic T, Matejic B, Mesaros S, Manigoda M, Dujmovic I et al. (2007) Quality of life in patients with multiple sclerosis in Serbia. Acta Neurol Scand, 115:147-152.
  • Figved N, Myhr KM, Larsen JP, Aarsland D (2007) Caregiver burden in multiple sclerosis: the impact of neuropsychiatric symptoms. J Neurol Neurosurg Psychiatry, 78:1097-1102.
  • Fenu G, Fronza M, Lorefice L, Arru M, Coghe G, Frau, J et al. (2018) Performance in daily activities, cognitive impairment and perception in multiple sclerosis patients and their caregivers. BMC Neurol, 18:212.
  • Finlayson M, Cho C (2008) A descriptive profile of caregivers of older adults with MS and the assistance they provide. Disabil Rehabil, 30:1848-1857.
  • Foong J, Rozewicz L, Quaghebeur G, Davie CA, Kartsounis LD, Thompson AJ et al. (1997) Executive function in multiple sclerosis. The role of frontal lobe pathology. Brain, 120:15-26.
  • Gil-González I, Martín-Rodríguez A, Conrad R, Pérez-San-Gregorio MÁ (2020) Quality of life in adults with multiple sclerosis: a systematic review. BMJ Open, 10:e041249.
  • Glad SB, Aarseth JH, Nyland H, Riise T, Myhr KM (2010) Benign multiple sclerosis: a need for a consensus. Acta Neurol Scand, 122:44-50.
  • Glanz BI, Healy BC, Rintell DJ, Jaffin SK, Bakshi R, Weiner HL (2010) The association between cognitive impairment and quality of life in patients with early multiple sclerosis. J Neurol Sci, 290:75-79.
  • Goverover Y, Genova HM, DeLuca J, Chiaravalloti ND (2017) Impact of multiple sclerosis on daily life. In Changes in the Brain (Eds N Chiaravalloti, Y Goverover):145-165. New York, NY, Springer.
  • Graves JS, Krysko KM, Hua LH, Absinta M, Franklin RJ, Segal BM (2023) Ageing and multiple sclerosis. Lancet Neurol, 22:66-77.
  • Gregory RJ, Disler P, Firth S (1996) Caregivers of people with multiple sclerosis: a survey in New Zealand. Rehabil Nurs, 21:31-37.
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Details

Primary Language English
Subjects Clinical Neuropsychology
Journal Section Review
Authors

Sena Kıcıklar 0009-0003-3780-1514

Publication Date December 30, 2025
Submission Date September 9, 2024
Acceptance Date February 26, 2025
Published in Issue Year 2025 Volume: 17 Issue: 4

Cite

AMA Kıcıklar S. Effect of Cognitive Impairments in Multiple Sclerosis on Caregivers’ Quality of Life: A Review. Psikiyatride Güncel Yaklaşımlar - Current Approaches in Psychiatry. December 2025;17(4):707-715. doi:10.18863/pgy.1502949

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