Abstract
Abstract
Background:
Diabetic neuropathy, particularly distal symmetric polyneuropathy, which is common complication of uncontrolled diyabetes mellitus (DM). Recent studies have linked impaired fasting glucose, OGTT results, HbA1c levels, and electromyography findings with neuropathy,but there is inconsistency in which parameters are most significant. The study aims to clarify the associations between metabolic parameters and neuropathy.
Method:
In this retrospective study, 1,000 neuropathic pain patients were reviewed, and 310 meeting the criteria were included. They were grouped as newly diagnosed or previously diagnosed with diabetes. The study aims to evaluate the relationship between insulin, insulin resistance, OGTT, fasting glucose, HbA1c, vitamin B12, and nerve conduction studies. Statistical analyses will be performed using SPSS 18.0, with a significance level of p ≤ 0.05.
Results:
The study included 310 patients (165 women, 145 men), with 255 diagnosed with polyneuropathy. Neuropathy was more common in diabetic patients (p=0.0001) and significantly associated with age (p=0.0001). No correlations were found with glucose metabolism parameters. Sensory and sensorimotor polyneuropathy were most common in non-diabetic patients.
Conclusion:
This study suggests aging accelerates nerve degeneration and vascular changes in polyneuropathy. No strong link was found between glucose metabolism and neuropathy, but insulin resistance remains relevant. Larger studies are needed to explore metabolic risk factors, especially prediabetes. Early diagnosis and management are crucial to prevent progressive neuropathy.
References
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Details
| Primary Language | English |
|---|---|
| Subjects | Pain |
| Journal Section | Original Article |
| Authors | |
| Early Pub Date | April 28, 2025 |
| Publication Date | May 1, 2025 |
| Submission Date | March 12, 2025 |
| Acceptance Date | March 26, 2025 |
| Published in Issue | Year 2025 Volume: 1 Issue: 1 |
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