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Serum oreksin seviyelerinin obezite ile ilişkisi: kesitsel ilişkilendirme çalışması

Year 2018, Volume: 9 Issue: 4, 37 - 43, 25.12.2018

Ayşe Bülbül Eda Evgen Tülüceoğlu , Önder Öztürk , Nilüfer Şahin Calapoğlu , Taner Gonca Mustafa Calapoğlu

https://doi.org/10.22312/sdusbed.417347

Abstract

Amaç: Bu
çalışmanın amacı, çalışma bölgesinde obez erişkin kohortunda, oreksin-A
hormonunun obezite ile ilişkisini değerlendirmektir.



Materyal Metot: Çalışmaya,
bir şehrimizin Tıp
Fakültesi ve Devlet Hastanesi Göğüs Hastalıkları Uyku Laboratuvarlarına başvuran 20-59
yaş arasındaki 261 birey dahil edildi. Vücut kitle indekslerine (VKİ) göre,
bireyler beş kategoriye (normal kilolu, fazla kilolu, orta obez, ağır obez ve
morbid obez) ayrıldı. Bireylerden alınan plazma örnekleri, ticari olarak temin
edilebilen analitik sistemler kullanılarak her bir plazma parametresi analiz
edildi.



Bulgular: Plazma
oreksin-A seviyelerinin VKİ ve C-reaktif protein (CRP) ile negatif korelasyon
gösterdiği belirlendi. Orta, ağır ve morbid obez gruplarda, normal ve fazla
kilolu gruplara göre oreksin-A düzeyleri anlamlı olarak daha düşük bulundu.
VKİ, düşük dansiteli lipoprotein kolesterol (LDL-C) ve CRP ile pozitif
korelasyon gösterdi. Orta obez grubun diğer VKİ gruplarına göre
karşılaştırıldığında anlamlı olarak yüksek plazma VLDL-C (çok düşük yoğunluklu
lipoprotein kolesterol), trigliserid ve total kolesterol seviyelerine sahip
olduğu belirlendi.



Sonuç: Elde ettiğimiz
sonuçlar, oreksin-A'nın periferal olarak etki gösterdiğini doğruladı. Obez
bireylerde daha düşük plazma oreksin-A düzeylerinin bulunması, insan enerji
metabolizmasının düzenlenmesinde rol oynadığını ve obezitede oreksin-A'nın
aktivitesinin bozulduğunu göstermektedir. Obezitenin artmış CRP seviyeleri ile
pozitif ilişkili olması, obezite tedavisinin veya sağlıklı kilo kaybının
obeziteye bağlı oluşan sistemik inflamasyonun azaltılmasında önemli olduğunu
göstermektedir.

Keywords

Oreksin Obezite C-reaktif protein İştah kontrolü Dolaşımdaki lipidler

References

  • [1] Arora, S. Role of Neuropeptides in Appetite Regulation and Obesity–a Review. Neuropeptides, 2006, 40, 375-401.
  • [2] Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Arch, J. R. Orexins and Orexin Receptors: a Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors That Regulate Feeding Behavior. Cell, 1998, 92, 573-585.
  • [3] Rodgers, R. J., Ishii, Y., Halford, J. C. G., Blundell, J. E. Orexins and Appetite Regulation. Neuropeptides, 2002, 36, 303-325.
  • [4] Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sakurai, T. Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity. Neuron, 2001, 30, 345-354.
  • [5] Kastin, A. J., Akerstrom, V. Orexin A but not Orexin B Rapidly Enters Brain from Blood by Simple Diffusion. Journal of Pharmacology and Experimental Therapeutics, 1999, 289, 219-223.
  • [6] American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care, 2014, 37 Supplement 1, S14-S80.
  • [7] Slyper, A. H. Childhood Obesity, Adipose Tissue Distribution, and the Pediatric Practitioner. Pediatrics, 1998, 102, e4-e4.
  • [8] Stone, P. H., Lloyd-Jones, D. M., Kinlay, S., Frei, B., Carlson, W., Rubenstein, J.,Orav, J. Effect of İntensive Lipid Lowering, with or without Antioxidant Vitamins, Compared with Moderate Lipid Lowering on Myocardial is Chemia in Patients with Stable Coronary Artery Disease: the Vascular Basis for the Treatment of Myocardial Ischemia Study. Circulation, 2005, 111(14), 1747-1755.
  • [9] Randall, O. S., Feseha, H. B., Illoh, K., Xu, S., Ketete, M., Kwagyan, J., Wrenn, M. Response of Lipoprotein (a) Levels to Therapeutic Life-style Change in Obese African–Americans. Atherosclerosis, 2004, 172(1), 155-160.
  • [10] Onat, A., Yıldırım, B., Erer, B., Başar, Ö., Çetinkaya, A., Ceyhan, K., Sansoy, V. Total Kolesterol/HDL-Kolesterol Oranı Koroner Hastalığın En İyi Lipid Öngördürücüsü: Trigliserid Ortalama Düzeyimiz Yılda 1 Mg Yükselme Gösteriyor. Türk Kardiyoloji Derneği Arşivi, 2001, 29, 334-343.
  • [11] Li, Z., McNamara, J. R., Fruchart, J. C., Luc, G., Bard, J. M., Ordovas, J. M., Schaefer, E. J. Effects of Gender and Menopausal Status on Plasma Lipoprotein Subspecies and Particle Sizes. Journal of Lipid Research, 1996, 37, 1886-1896.
  • [12] Tremollieres, F. A., Pouilles, J. M., Cauneille, C., Ribot, C. Coronary Heart Disease Risk Factors and Menopause, a Study in 1684 French Women. Atherosclerosis, 1999, 142(2), 415-423.
  • [13] Haverkate, E., Thompson, S. G., Pyke, S. D., Gallimore, J. R. Production of C-reactive protein and risk of coronary events in stable and unstable angina. The Lancet, 1997, 349(9050), 462-466.
  • [14] Bahceci, M., Gokalp, D., Bahceci, S., Tuzcu, A., Atmaca, S., Arikan, S. The Correlation Between Adiposity and Adiponectin, Tumor Necrosis Factor α, Interleukin-6 and High Sensitivity C-reactive Protein Levels. Is Adipocyte Size Associated with Inflammation in Adults?. Journal of Endocrinological Investigation, 2007, 30(3), 210-214.
  • [15] Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Rifai, N. Markers of Inflammation and Cardiovascular Disease, Application to Clinical and Public Health Practice, A Statement for Healthcare Professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 2003, 107(3), 499-511.
  • [16] Haddy, N., Sass, C., Droesch, S., Zaiou, M., Siest, G., Ponthieux, A., Visvikis, S. IL-6, TNF-α and AtherosclerosisRisk İndicators in a Healthy Family Population: the STANISLAS Cohort. Atherosclerosis, 2003,170(2), 277-283.
  • [17] Wilding, J. P. H. Neuropeptides and Appetite Control. Diabetic Medicine, 2002, 19(8), 619-627.
  • [18] Yamanaka, A., Sakurai, T., Katsumoto, T., Yanagisawa, M., Goto, K. Chronic Intracerebroventricular Administration of Orexin-A to Rats Increases Food Intake in Daytime, but has no Effect on Body Weight. Brain Research, 1999, 849(1-2), 248-252.
  • [19] Haynes, A. C., Jackson, B., Overend, P., Buckingham, R. E., Wilson, S., Tadayyon, M., Arch, J. R. Effects of Single and Chronic Intracerebroventricular Administration of the Orexins on Feeding in the Rat. Peptides, 1999, 20(9), 1099-1105.
  • [20] Rodgers, R. J., Ishii, Y., Halford, J. C. G., Blundell, J. E. Orexins and Appetite Regulation. Neuropeptides, 2002, 36(5), 303-325.
  • [21] Iqbal, J., Henry, B. A., Pompolo, S., Rao, A., Clarke, I. J. Long-term Alteration in Bodyweight and Food Restriction does not affect the Gene Expression of Either Preproorexin or Prodynorphin in the Sheep. Neuroscience, 2003, 118(1), 217-226.
  • [22] Baranowska, B., Wolinska-Witort, E., Martynska, M., Chmielowska, M., Baranowska-Bik, A. Plasma Orexin A, Orexin B, Leptin, Neuropeptide Y (NPY) and Insulin in Obese Women. Neuroendocrinology Letters, 2005, 26(4), 293-296.
  • [23] Adam, J. A., Menheere, P. P. C. A., Van Dielen, F. M. H., Soeters, P. B., Buurman, W. A., Greve, J. W. M. Decreased Plasma Orexin-A Levels in Obese Individuals. International Journal of Obesity, 2002, 26(2), 274.
  • [24] Beck, B., Richy, S. Hypothalamic Hypocretin/Orexin and Neuropeptide Y: Divergent Interaction with Energy Depletion and Leptin. Biochemical and Biophysical Research Communications, 1999, 258(1), 119-122.
  • [25] Horvath, T. L., Diano, S., Van Den Pol, A. N. Synaptic Interaction Between Hypocretin, Orexin and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus, a Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal of Neuroscience, 1999, 19(3), 1072-1087.

Year 2018, Volume: 9 Issue: 4, 37 - 43, 25.12.2018

Ayşe Bülbül Eda Evgen Tülüceoğlu , Önder Öztürk , Nilüfer Şahin Calapoğlu , Taner Gonca Mustafa Calapoğlu

https://doi.org/10.22312/sdusbed.417347

Abstract

References

  • [1] Arora, S. Role of Neuropeptides in Appetite Regulation and Obesity–a Review. Neuropeptides, 2006, 40, 375-401.
  • [2] Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Arch, J. R. Orexins and Orexin Receptors: a Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors That Regulate Feeding Behavior. Cell, 1998, 92, 573-585.
  • [3] Rodgers, R. J., Ishii, Y., Halford, J. C. G., Blundell, J. E. Orexins and Appetite Regulation. Neuropeptides, 2002, 36, 303-325.
  • [4] Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sakurai, T. Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity. Neuron, 2001, 30, 345-354.
  • [5] Kastin, A. J., Akerstrom, V. Orexin A but not Orexin B Rapidly Enters Brain from Blood by Simple Diffusion. Journal of Pharmacology and Experimental Therapeutics, 1999, 289, 219-223.
  • [6] American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care, 2014, 37 Supplement 1, S14-S80.
  • [7] Slyper, A. H. Childhood Obesity, Adipose Tissue Distribution, and the Pediatric Practitioner. Pediatrics, 1998, 102, e4-e4.
  • [8] Stone, P. H., Lloyd-Jones, D. M., Kinlay, S., Frei, B., Carlson, W., Rubenstein, J.,Orav, J. Effect of İntensive Lipid Lowering, with or without Antioxidant Vitamins, Compared with Moderate Lipid Lowering on Myocardial is Chemia in Patients with Stable Coronary Artery Disease: the Vascular Basis for the Treatment of Myocardial Ischemia Study. Circulation, 2005, 111(14), 1747-1755.
  • [9] Randall, O. S., Feseha, H. B., Illoh, K., Xu, S., Ketete, M., Kwagyan, J., Wrenn, M. Response of Lipoprotein (a) Levels to Therapeutic Life-style Change in Obese African–Americans. Atherosclerosis, 2004, 172(1), 155-160.
  • [10] Onat, A., Yıldırım, B., Erer, B., Başar, Ö., Çetinkaya, A., Ceyhan, K., Sansoy, V. Total Kolesterol/HDL-Kolesterol Oranı Koroner Hastalığın En İyi Lipid Öngördürücüsü: Trigliserid Ortalama Düzeyimiz Yılda 1 Mg Yükselme Gösteriyor. Türk Kardiyoloji Derneği Arşivi, 2001, 29, 334-343.
  • [11] Li, Z., McNamara, J. R., Fruchart, J. C., Luc, G., Bard, J. M., Ordovas, J. M., Schaefer, E. J. Effects of Gender and Menopausal Status on Plasma Lipoprotein Subspecies and Particle Sizes. Journal of Lipid Research, 1996, 37, 1886-1896.
  • [12] Tremollieres, F. A., Pouilles, J. M., Cauneille, C., Ribot, C. Coronary Heart Disease Risk Factors and Menopause, a Study in 1684 French Women. Atherosclerosis, 1999, 142(2), 415-423.
  • [13] Haverkate, E., Thompson, S. G., Pyke, S. D., Gallimore, J. R. Production of C-reactive protein and risk of coronary events in stable and unstable angina. The Lancet, 1997, 349(9050), 462-466.
  • [14] Bahceci, M., Gokalp, D., Bahceci, S., Tuzcu, A., Atmaca, S., Arikan, S. The Correlation Between Adiposity and Adiponectin, Tumor Necrosis Factor α, Interleukin-6 and High Sensitivity C-reactive Protein Levels. Is Adipocyte Size Associated with Inflammation in Adults?. Journal of Endocrinological Investigation, 2007, 30(3), 210-214.
  • [15] Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Rifai, N. Markers of Inflammation and Cardiovascular Disease, Application to Clinical and Public Health Practice, A Statement for Healthcare Professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 2003, 107(3), 499-511.
  • [16] Haddy, N., Sass, C., Droesch, S., Zaiou, M., Siest, G., Ponthieux, A., Visvikis, S. IL-6, TNF-α and AtherosclerosisRisk İndicators in a Healthy Family Population: the STANISLAS Cohort. Atherosclerosis, 2003,170(2), 277-283.
  • [17] Wilding, J. P. H. Neuropeptides and Appetite Control. Diabetic Medicine, 2002, 19(8), 619-627.
  • [18] Yamanaka, A., Sakurai, T., Katsumoto, T., Yanagisawa, M., Goto, K. Chronic Intracerebroventricular Administration of Orexin-A to Rats Increases Food Intake in Daytime, but has no Effect on Body Weight. Brain Research, 1999, 849(1-2), 248-252.
  • [19] Haynes, A. C., Jackson, B., Overend, P., Buckingham, R. E., Wilson, S., Tadayyon, M., Arch, J. R. Effects of Single and Chronic Intracerebroventricular Administration of the Orexins on Feeding in the Rat. Peptides, 1999, 20(9), 1099-1105.
  • [20] Rodgers, R. J., Ishii, Y., Halford, J. C. G., Blundell, J. E. Orexins and Appetite Regulation. Neuropeptides, 2002, 36(5), 303-325.
  • [21] Iqbal, J., Henry, B. A., Pompolo, S., Rao, A., Clarke, I. J. Long-term Alteration in Bodyweight and Food Restriction does not affect the Gene Expression of Either Preproorexin or Prodynorphin in the Sheep. Neuroscience, 2003, 118(1), 217-226.
  • [22] Baranowska, B., Wolinska-Witort, E., Martynska, M., Chmielowska, M., Baranowska-Bik, A. Plasma Orexin A, Orexin B, Leptin, Neuropeptide Y (NPY) and Insulin in Obese Women. Neuroendocrinology Letters, 2005, 26(4), 293-296.
  • [23] Adam, J. A., Menheere, P. P. C. A., Van Dielen, F. M. H., Soeters, P. B., Buurman, W. A., Greve, J. W. M. Decreased Plasma Orexin-A Levels in Obese Individuals. International Journal of Obesity, 2002, 26(2), 274.
  • [24] Beck, B., Richy, S. Hypothalamic Hypocretin/Orexin and Neuropeptide Y: Divergent Interaction with Energy Depletion and Leptin. Biochemical and Biophysical Research Communications, 1999, 258(1), 119-122.
  • [25] Horvath, T. L., Diano, S., Van Den Pol, A. N. Synaptic Interaction Between Hypocretin, Orexin and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus, a Novel Circuit Implicated in Metabolic and Endocrine Regulations. Journal of Neuroscience, 1999, 19(3), 1072-1087.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Araştırma Articlesi
Authors

Ayşe Bülbül

Eda Evgen Tülüceoğlu

Önder Öztürk

Nilüfer Şahin Calapoğlu

Taner Gonca

Mustafa Calapoğlu

Publication Date December 25, 2018
Submission Date April 20, 2018
Published in Issue Year 2018 Volume: 9 Issue: 4

Cite

Vancouver Bülbül A, Evgen Tülüceoğlu E, Öztürk Ö, Şahin Calapoğlu N, Gonca T, Calapoğlu M. Serum oreksin seviyelerinin obezite ile ilişkisi: kesitsel ilişkilendirme çalışması. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2018;9(4):37-43.
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