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Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature

Year 2015, Volume: 22 Issue: 2, 125 - 127, 11.12.2015

Öztun Temelli Cemal Ekici

Abstract

Pleomorphic adenoma is the most common benign salivary gland neoplasm (%75-80). It is found mostly in the parotid gland in middle-aged women. The optimal treatment is superficial or total parotidectomy with facial nerve preservation, which results in local control rates of 95% or higher. Radiotherapy (RT) is indicated for ositive margins, unresectable tumours, and multifocal recurrences after prior resection. Local control rates after RT for microscopic and gross residual tumour are approximately 80% to 85% and 40% to 60%, respectively. In this article, we share our experience of 2 cases of recurrent pleomorphic adenoma.

Key Words: Pleomorphic Adenoma; Radiotherapy; Treatment.

Keywords

-

References

  • Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP. Salivary gland pleomorphic adenoma. Am J Clin Oncol 2008;31(1):95-9.
  • Laccourreye H, Laccourreye O, Cauchois R, et al. Total conservative parotidectomy for primary benign pleomorphic adenoma of the parotid gland: a 25-year experience with 229 patients. Laryngoscope 1994;104:1487-94.
  • Satar B, Gerek M, Yetişer S, Akkaya A, Özkaptan Y. Major Tükrük Bezi Tümörleri: 93 Olgunun Analizi. Turkiye Klinikleri J E.N.T 2001;1(3):123-8.
  • Ohtake S, Cheng J, Ida H, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med 2002;31:590-7.
  • Nouraei SA, Ferguson MS, Clarke PM, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 2006;132:788-93.
  • Alves FA, Perez DE, Almeida OP, et al. Pleomorphic adenoma of the submandibula gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg 2002;128:1400-03.
  • Hamada T, Matsukita S, Goto M,et al. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004;57:813-21.
  • Wallace AS, Morris CG, Kirwan JM, Werning JW, Mendenhall WM. Radiotherapy for pleomorphic adenoma. Am J Otolaryngol 2013;34(1):36-40.
  • Wittekindt C, Streubel K, Arnold G, et al. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck 2007;29:822-8.
  • Dawson AK, Orr JA. Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 1985;11(3):451-5.
  • Chen AM, Garcia J, Bucci MK, et al. Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys 2006;66:1031-5.
  • Liu FF, Rotstein L, Davison AJ, et al. Benign parotid adenomas: a review of the Princess Margaret Hospital experience. Head Neck 1995;17:177-83.
  • Makeieff M, Pelliccia P, Letois F, et al. Recurrent pleomorphic adenoma: results of surgical treatment. Ann Surg Oncol 2010;17:3308-13.
  • Ravasz LA, Terhaard CH, Hordijk GJ. Radiotherapy in epithelial tumors of the parotid gland: case presentation and literature review. Int J Radiat Oncol Biol Phys 1990;19(1):55-9.
  • Barton J, Slevin NJ, Gleave EN. Radiotherapy for pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 1992;22(5):925-8.
  • Samson MJ, Metson R, Wang CC, et al. Preservation of the facial nevre in the management of recurrent pleomorphic adenoma. Laryngoscope 1991;101:1060-2.
  • Hodge CW, Morris CG, Werning JW, et al. Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 2005;28:148-51.
  • Douglas JG, Einck J,Austin-Seymour M,et al. Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands. Head Neck 2001;23:1037-42.

Journal of Turgut Ozal Medical Center

Year 2015, Volume: 22 Issue: 2, 125 - 127, 11.12.2015

Öztun Temelli Cemal Ekici

Abstract

Pleomorfik adenomlar tükrük bezlerinin en sık görülen iyi huylu neoplazmlarıdır . Genelde orta yaşlı kadınlarda ve parotis bezinde bulunur. Optimal tedavi şekli fasial siniri koruyarak yapılan superfisyal veya total parotidektomidir. Cerrahi ile %95 ve üzerinde başarı vardır. Radyoterapi(RT) pozitif cerrahi sınırda, unrezektabl hastalıkta ve cerrahi sonrası multifokal nüksde kullanılır. RT sonrası lokal kontrol mikroskopik hastalıkta %80-85 ve gros rezidüel hastalıkta %40-60 arasındadır. Biz de bu makalede cerrahi sonrası nüks eden 2 olguyu adjuvan RT deneyimimizi paylaştık

Keywords

Pleomorfik Adenom Radyoterapi Tedavi

References

  • Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP. Salivary gland pleomorphic adenoma. Am J Clin Oncol 2008;31(1):95-9.
  • Laccourreye H, Laccourreye O, Cauchois R, et al. Total conservative parotidectomy for primary benign pleomorphic adenoma of the parotid gland: a 25-year experience with 229 patients. Laryngoscope 1994;104:1487-94.
  • Satar B, Gerek M, Yetişer S, Akkaya A, Özkaptan Y. Major Tükrük Bezi Tümörleri: 93 Olgunun Analizi. Turkiye Klinikleri J E.N.T 2001;1(3):123-8.
  • Ohtake S, Cheng J, Ida H, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med 2002;31:590-7.
  • Nouraei SA, Ferguson MS, Clarke PM, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 2006;132:788-93.
  • Alves FA, Perez DE, Almeida OP, et al. Pleomorphic adenoma of the submandibula gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg 2002;128:1400-03.
  • Hamada T, Matsukita S, Goto M,et al. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004;57:813-21.
  • Wallace AS, Morris CG, Kirwan JM, Werning JW, Mendenhall WM. Radiotherapy for pleomorphic adenoma. Am J Otolaryngol 2013;34(1):36-40.
  • Wittekindt C, Streubel K, Arnold G, et al. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck 2007;29:822-8.
  • Dawson AK, Orr JA. Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 1985;11(3):451-5.
  • Chen AM, Garcia J, Bucci MK, et al. Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys 2006;66:1031-5.
  • Liu FF, Rotstein L, Davison AJ, et al. Benign parotid adenomas: a review of the Princess Margaret Hospital experience. Head Neck 1995;17:177-83.
  • Makeieff M, Pelliccia P, Letois F, et al. Recurrent pleomorphic adenoma: results of surgical treatment. Ann Surg Oncol 2010;17:3308-13.
  • Ravasz LA, Terhaard CH, Hordijk GJ. Radiotherapy in epithelial tumors of the parotid gland: case presentation and literature review. Int J Radiat Oncol Biol Phys 1990;19(1):55-9.
  • Barton J, Slevin NJ, Gleave EN. Radiotherapy for pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 1992;22(5):925-8.
  • Samson MJ, Metson R, Wang CC, et al. Preservation of the facial nevre in the management of recurrent pleomorphic adenoma. Laryngoscope 1991;101:1060-2.
  • Hodge CW, Morris CG, Werning JW, et al. Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 2005;28:148-51.
  • Douglas JG, Einck J,Austin-Seymour M,et al. Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands. Head Neck 2001;23:1037-42.
There are 18 citations in total.

Details

Primary Language Tr
Journal Section Articles
Authors

Öztun Temelli

Cemal Ekici

Publication Date December 11, 2015
Published in Issue Year 2015 Volume: 22 Issue: 2

Cite

APA Temelli, Ö., & Ekici, C. (2015). Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Journal of Turgut Ozal Medical Center, 22(2), 125-127.
AMA Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. J Turgut Ozal Med Cent. December 2015;22(2):125-127.
Chicago Temelli, Öztun, and Cemal Ekici. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center 22, no. 2 (December 2015): 125-27.
EndNote Temelli Ö, Ekici C (December 1, 2015) Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Journal of Turgut Ozal Medical Center 22 2 125–127.
IEEE Ö. Temelli and C. Ekici, “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”, J Turgut Ozal Med Cent, vol. 22, no. 2, pp. 125–127, 2015.
ISNAD Temelli, Öztun - Ekici, Cemal. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center 22/2 (December 2015), 125-127.
JAMA Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. J Turgut Ozal Med Cent. 2015;22:125–127.
MLA Temelli, Öztun and Cemal Ekici. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center, vol. 22, no. 2, 2015, pp. 125-7.
Vancouver Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. J Turgut Ozal Med Cent. 2015;22(2):125-7.
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