Real-World Experience with Canakinumab in Familial Mediterranean Fever: A Single-Center Study

Tuğba Ocak; Ayşe Bulur; Burcu Yağız; Belkis Nihan Coskun; Hüseyin Ediz Dalkılıç; Yavuz Pehlivan

doi:10.32708/uutfd.1649876

Research Article

Ailevi Akdeniz Ateşinde Kanakinumab ile Gerçek Yaşam Deneyimi: Tek Merkezli Bir Çalışma

Year 2025, Volume: 51 Issue: 1, 87 - 92, 27.05.2025

Tuğba Ocak , Ayşe Bulur , Burcu Yağız , Belkis Nihan Coskun , Hüseyin Ediz Dalkılıç , Yavuz Pehlivan

https://doi.org/10.32708/uutfd.1649876

Abstract

Ailesel Akdeniz ateşi (AAA), Mediterranean Fever (MEFV) geninde mutasyonların neden olduğu ve aşırı interlökin-1 beta (IL-1β) üretimine yol açan otoinflamatuar bir hastalıktır. Kolşisin AAA için ana tedavi olsa da, hastaların bir alt grubu direnç veya intolerans göstererek alternatif tedavi stratejilerine ihtiyaç duymaktadır. Selektif bir IL-1β inhibitörü olan kanakinumab, potansiyel bir tedavi seçeneği olarak ortaya çıkmıştır. Bu çalışma, kolşisine dirençli veya kolşisine intoleransı olan AAA hastalarında kanakinumabın gerçek yaşamdaki etkinliğini ve güvenliğini değerlendirmeyi amaçlamaktadır. Ocak 2013 ve Ekim 2023 tarihleri arasında kanakinumab tedavisine başlayan 18 yaş üstü AAA hastalarında retrospektif, tek merkezli bir çalışmadır. Kolşisin direnci veya intoleransı kriterlerini karşılayan toplam 34 hasta analiz edildi. Pras skorları, eritrosit sedimantasyon hızı (ESR), C-reaktif protein (CRP) ve serum amiloid A (SAA) dahil olmak üzere klinik ve laboratuvar parametreleri kanakinumab tedavisinden önce ve sonra değerlendirilmiştir. İstatistiksel analizler Wilcoxon testi ve eşleştirilmiş örneklem t-testi kullanılarak gerçekleştirilmiştir. Kanakinumab tedavisi Pras skorlarını (p<0,001), ESR (p<0,001), CRP (p<0,001) ve SAA düzeylerini (p<0,001) anlamlı ölçüde azaltmıştır. Proteinürisi olan hastalarda tedavi sonrasında istatistiksel olarak anlamlı olmasa da bir düşüş gözlenmiştir (p=0,140). Aktif hastalık veya yan etkiler nedeniyle üç hastada tedavi kesilmiştir. Hiçbir ciddi enfeksiyon bildirilmemiştir. Sonuç olarak, kanakinumab kolşisine dirençli veya kolşisine intoleranslı AAA hastalarında umut verici bir tedavi seçeneği olabilir.

Keywords

Kanakinumab, Kolşsin intolreansı, Kolşissin direnci, Ailevi Akdeniz ateşi

References

1. Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol. 2009;27: 621–68. doi: 10.1146/annurev.immunol.25.022106.141627
2. Ozen S, Bilginer Y. A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin. Nat Rev Rheumatol. 2014;10(3):135–47. doi: 10.1038/nrrheum.2013.174
3. Ozen S, Demirkaya E, Erer B et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016;75:644–51. doi: 10.1136/annrheumdis-2015-208690
4. Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D. Amyloidosis and glomerular diseases in familial Mediterranean fever. Medicina (Kaunas). 2021;57(10):1049. doi: 10.3390/medicina57101049
5. Özen S, Batu ED, Demir S. Familial Mediterranean fever: recent developments in pathogenesis and new recommendations for management. Front Immunol. 2017;8:253. doi: 10.3389/fimmu.2017.00253
6. Ben-Zvi I, Livneh A. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 2011;7:105-12. doi: 10.1038/nrrheum.2010.181
7. Eren Akarcan S, Dogantan S, Edeer Karaca N, Aksu G, Kutukculer N. Successful management of colchicine resistant familial Mediterranean fever patients with a standardized canakinumab treatment protocol: a case series and literature review. Rheumatol Int. 2020;40:161–8. doi: 10.1007/s00296-019-04366-w
8. Hentgen V, Grateau G, Kone-Paut I et al. Evidence-based recommendations for the practical management of familial Mediterranean fever. Semin Arthritis Rheum. 2013;43:387–91. doi: 10.1016/j.semarthrit.2013.04.011
9. Satis¸ H, Armagan B, Bodakc¸i E et al. Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turk J MedSci. 2020;50:1337–43. doi: 10.3906/sag-2001-261
10. van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics. 2016; 10:75. doi: 10.2147/BTT.S102954
11. Atas N, Eroglu GA, Sodan HN, et al. Long-term safety and efficacy of anakinra and canakinumab in patients with familial Mediterranean fever: a single-centre real-life study with 101 patients. Clin Exp Rheumatol. 2021;39 Suppl 132(5):30-36. doi: 10.55563/clinexprheumatol/815tdt
12. Fautrel B. Adult-onset Still disease. Best Pract Res Clin Rheumatol. 2008;22:773-92. doi: 10.1016/j.berh.2008.08.006
13. Mitroulis I, Skendros P, Oikonomou A, Tzioufas AG, Ritis K. The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and long-standing destructive arthritis. Ann Rheum Dis. 2011;70(7):1347–8. doi: 10.1136/ard.2010.146878
14. Eroglu FK, Besbas N, Topaloglu R, Ozen S. Treatment of colchicine-resistant familial Mediterranean fever in children and adolescents. Rheumatol Int. 2015;35(10):1733-7. doi: 10.1007/s00296-015-3293-2
15. Basaran O, Uncu N, Celikel BA, et al. Interleukin-1 targeting treatment in familial Mediterranean fever: an experience of pediatric patients. Mod Rheumatol. 2015;25(4):621-4. doi: 10.3109/14397595.2014.987437
16. Ozcakar ZB, Ozdel S, Yılmaz S, et al. Anti-IL-1 treatment in familial Mediterranean fever and related amyloidosis. Clin Rheumatol. 2016;35(2):441–6. doi: 10.1007/s10067-014-2772-2
17. Cetin P, Sari I, Sozeri B, et al. Efficacy of interleukin-1 targeting treatments in patients with familial Mediterranean fever. Inflammation. 2015;38(1):27-31. doi: 10.1007/s10753-014-0004-1
18. Kacar M, Savic S, van der Hilst JCh. The Efficacy, Safety and Tolerability of Canakinumab in the Treatment of Familial Mediterranean Fever: A Systematic Review of the Literature J Inflamm Res. 2020;13:141–149. doi: 10.2147/JIR.S206204
19. Sener S, Cam V, Batu ED. Feasibility of canakinumab withdrawal in colchicine-resistant familial Mediterranean fever. Rheumatology. 2023;62(11):3700-3705. doi: 10.1093/rheumatology/kead128
20. Çakan M, Karadağ ŞG, Ayaz NA. Canakinumab in colchicine resistant familial Mediterranean fever and other pediatric rheumatic diseases. Turk J Pediatr. 2020;62(2):167-174. doi: 10.24953/turkjped.2020.02.001
21. Gülez N, Makay B, Sözeri B. Long-term effectiveness and safety of canakinumab in pediatric familial Mediterranean fever patients. Mod Rheumatol. 2020;30(1):166-171. doi: 10.1080/14397595.2018.1559488
22. Livneh A, Langevitz P, Zemer D, et al. The changing face of familial Mediterranean fever. Semin Arthritis Rheum. 1996;26:613–27. doi: 10.1016/s0049-0172(96)80012-6
23. Gattorno M, Hofer M, Federici S, et al. Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019;78:1025–32. doi: 10.1136/annrheumdis-2019-215048
24. Özen S, Sag E, Ben-Chetrit E, et al. Defining colchicine resistance/intolerance in patients with familial Mediterranean fever: a modified-Delphi consensus approach. Rheumatology. 2021, 60, 3799-3808. doi: 10.1093/rheumatology/keaa863
25. Pras E, Livneh A, Balow Jr, JE, et al. Clinical differences between North African and Iraqi Jews with familial Mediterranean fever. Am J Med Genet. 1998;75(2):216-9. doi: 10.1002/(sici)1096-8628(19980113)75:2<216::aid-ajmg20>3.0.co;2-r
26. Ozen S, Kone-Paut I, Gül A. Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments. Semin Arthritis Rheum.2017;47(1):115-120. doi: 10.1016/j.semarthrit.2017.03.006
27. Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol. 2017;36(8):1707-1713. doi: 10.1007/s10067-017-3715-5
28.Ter Haar N, Lachmann H, Özen S, et al. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis. 2013;72(5):678-85. doi: 10.1136/annrheumdis-2011-201268
29. Gül A, Ozdogan H, Erer B, et al. Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Res Ther. 2015;17(1):243. doi: 10.1186/s13075-015-0765-4
30. Brik R, Butbul-Aviel Y, Lubin S, et al. Canakinumab for the treatment of children with colchicine-resistant familial Mediterranean fever: a 6-month open-label, single-arm pilot study. Arthritis Rheumatol.2014;66(11):3241-3. doi: 10.1002/art.38777
31. van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics.2016;10:75-80. doi: 10.2147/BTT.S102954. eCollection 2016
32. De Benedetti F, Gattorno M, Anton J, et al. Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes. N Engl J Med.2018;378(20):1908-1919. doi: 10.1056/NEJMoa1706314.
33. Atas N, Eroglu GA, Sodan HN, et al. Long-term safety and efficacy of anakinra and canakinumab in patients with familial Mediterranean fever: a single-centre real-life study with 101 patients. Clin Exp Rheumatol. 2021;39 Suppl 132(5):30-36. doi: 10.55563/clinexprheumatol/815tdt
34. Sevillano ÁM, Hernandez E, Gonzalez E, et al. Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis. Nefrologia. 2016;36(1):63-6. doi: 10.1016/j.nefro.2015.06.026.
35. Stankovic KS, Delmas Y, Torres PU, et al. Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure. Nephrol Dial Transplant. 2012;27(5):1898-901. doi: 10.1093/ndt/gfr528
36. Jesenak M, Hrubiskova K, Kapustova L, Kostkova M, Banovcin P. Canakinumab as monotherapy for treatment of familial Mediterranean fever - first report in Central and Eastern Europe region. Bratisl Lek Listy. 2018;119(4):198-200. doi:10.4149/BLL_2018_036
37. Kharouf F, Tsemach-Toren T, Ben-Chetrit E. IL-1 inhibition in familial Mediterranean fever: clinical outcomes and expectations. Clin Exp Rheumatol. 2022;40:1567. doi: 10.55563/clinexprheumatol/obb2ds
38. Eren Akarcan S, Dogantan S, Edeer Karaca N, Aksu G, Kutukculer N. Successful management of colchicine resistant familial mediterranean fever patients with a standardized canakinumab treatment protocol: a case series and literature review. Rheumatol Int. 40(1):161–168. doi:10. 1007/ s00296-019-04366-w
39. Hosono K, Okami N, Sasajima T. A 3-year interim analysis of post-marketing all-patient surveillance of canakinumab in Japanese patients with cryopyrin-associated periodic syndrome. Clin Exp Rheumatol.2022;40(8):1543-1553. doi:10.55563/clinexprheumatol/

Real-World Experience with Canakinumab in Familial Mediterranean Fever: A Single-Center Study

Year 2025, Volume: 51 Issue: 1, 87 - 92, 27.05.2025

Tuğba Ocak , Ayşe Bulur , Burcu Yağız , Belkis Nihan Coskun , Hüseyin Ediz Dalkılıç , Yavuz Pehlivan

https://doi.org/10.32708/uutfd.1649876

Abstract

Familial Mediterranean fever (FMF) is an autoinflammatory disorder caused by mutations in the Mediterranean fever gene (MEFV), leading to excessive interleukin-1 beta (IL-1β) production. While colchicine is the primary treatment for FMF, a subset of patients exhibits resistance or intolerance, necessitating alternative therapeutic strategies. Canakinumab, a selective IL-1β inhibitor, has emerged as a potential treatment option. This study aims to evaluate canakinumab's real-world efficacy and safety in colchicine-resistant or colchicine-intolerant FMF patients. A retrospective, single-center study was conducted on FMF patients aged over 18 who initiated canakinumab treatment between January 2013 and October 2023. A total of 34 patients experiencing colchicine resistance or intolerance criteria were analyzed. Clinical and laboratory parameters, including Pras scores, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum amyloid A (SAA), were assessed before and after canakinumab treatment. Statistical analyses were performed using the Wilcoxon test and paired sample t-test. Canakinumab treatment significantly reduced Pras scores (p<0.001), ESR (p<0.001), CRP (p<0.001), and SAA levels (p<0.001). A decrease was observed post-treatment among patients with proteinuria, though not statistically significant (p=0.140). Treatment was discontinued in three patients due to active disease or adverse effects. No serious infections were reported. In conclusion, canakinumab could be a promising treatment option in colchicine-resistant or colchicine-intolerant FMF patients.

Keywords

Canakinumab, Colchicine intolerant, Colchicine resistant, Familial Mediterranean fever

References

1. Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol. 2009;27: 621–68. doi: 10.1146/annurev.immunol.25.022106.141627
2. Ozen S, Bilginer Y. A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin. Nat Rev Rheumatol. 2014;10(3):135–47. doi: 10.1038/nrrheum.2013.174
3. Ozen S, Demirkaya E, Erer B et al. EULAR recommendations for the management of familial Mediterranean fever. Ann Rheum Dis. 2016;75:644–51. doi: 10.1136/annrheumdis-2015-208690
4. Siligato R, Gembillo G, Calabrese V, Conti G, Santoro D. Amyloidosis and glomerular diseases in familial Mediterranean fever. Medicina (Kaunas). 2021;57(10):1049. doi: 10.3390/medicina57101049
5. Özen S, Batu ED, Demir S. Familial Mediterranean fever: recent developments in pathogenesis and new recommendations for management. Front Immunol. 2017;8:253. doi: 10.3389/fimmu.2017.00253
6. Ben-Zvi I, Livneh A. Chronic inflammation in FMF: markers, risk factors, outcomes and therapy. Nat Rev Rheumatol 2011;7:105-12. doi: 10.1038/nrrheum.2010.181
7. Eren Akarcan S, Dogantan S, Edeer Karaca N, Aksu G, Kutukculer N. Successful management of colchicine resistant familial Mediterranean fever patients with a standardized canakinumab treatment protocol: a case series and literature review. Rheumatol Int. 2020;40:161–8. doi: 10.1007/s00296-019-04366-w
8. Hentgen V, Grateau G, Kone-Paut I et al. Evidence-based recommendations for the practical management of familial Mediterranean fever. Semin Arthritis Rheum. 2013;43:387–91. doi: 10.1016/j.semarthrit.2013.04.011
9. Satis¸ H, Armagan B, Bodakc¸i E et al. Colchicine intolerance in FMF patients and primary obstacles for optimal dosing. Turk J MedSci. 2020;50:1337–43. doi: 10.3906/sag-2001-261
10. van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics. 2016; 10:75. doi: 10.2147/BTT.S102954
11. Atas N, Eroglu GA, Sodan HN, et al. Long-term safety and efficacy of anakinra and canakinumab in patients with familial Mediterranean fever: a single-centre real-life study with 101 patients. Clin Exp Rheumatol. 2021;39 Suppl 132(5):30-36. doi: 10.55563/clinexprheumatol/815tdt
12. Fautrel B. Adult-onset Still disease. Best Pract Res Clin Rheumatol. 2008;22:773-92. doi: 10.1016/j.berh.2008.08.006
13. Mitroulis I, Skendros P, Oikonomou A, Tzioufas AG, Ritis K. The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and long-standing destructive arthritis. Ann Rheum Dis. 2011;70(7):1347–8. doi: 10.1136/ard.2010.146878
14. Eroglu FK, Besbas N, Topaloglu R, Ozen S. Treatment of colchicine-resistant familial Mediterranean fever in children and adolescents. Rheumatol Int. 2015;35(10):1733-7. doi: 10.1007/s00296-015-3293-2
15. Basaran O, Uncu N, Celikel BA, et al. Interleukin-1 targeting treatment in familial Mediterranean fever: an experience of pediatric patients. Mod Rheumatol. 2015;25(4):621-4. doi: 10.3109/14397595.2014.987437
16. Ozcakar ZB, Ozdel S, Yılmaz S, et al. Anti-IL-1 treatment in familial Mediterranean fever and related amyloidosis. Clin Rheumatol. 2016;35(2):441–6. doi: 10.1007/s10067-014-2772-2
17. Cetin P, Sari I, Sozeri B, et al. Efficacy of interleukin-1 targeting treatments in patients with familial Mediterranean fever. Inflammation. 2015;38(1):27-31. doi: 10.1007/s10753-014-0004-1
18. Kacar M, Savic S, van der Hilst JCh. The Efficacy, Safety and Tolerability of Canakinumab in the Treatment of Familial Mediterranean Fever: A Systematic Review of the Literature J Inflamm Res. 2020;13:141–149. doi: 10.2147/JIR.S206204
19. Sener S, Cam V, Batu ED. Feasibility of canakinumab withdrawal in colchicine-resistant familial Mediterranean fever. Rheumatology. 2023;62(11):3700-3705. doi: 10.1093/rheumatology/kead128
20. Çakan M, Karadağ ŞG, Ayaz NA. Canakinumab in colchicine resistant familial Mediterranean fever and other pediatric rheumatic diseases. Turk J Pediatr. 2020;62(2):167-174. doi: 10.24953/turkjped.2020.02.001
21. Gülez N, Makay B, Sözeri B. Long-term effectiveness and safety of canakinumab in pediatric familial Mediterranean fever patients. Mod Rheumatol. 2020;30(1):166-171. doi: 10.1080/14397595.2018.1559488
22. Livneh A, Langevitz P, Zemer D, et al. The changing face of familial Mediterranean fever. Semin Arthritis Rheum. 1996;26:613–27. doi: 10.1016/s0049-0172(96)80012-6
23. Gattorno M, Hofer M, Federici S, et al. Classification criteria for autoinflammatory recurrent fevers. Ann Rheum Dis. 2019;78:1025–32. doi: 10.1136/annrheumdis-2019-215048
24. Özen S, Sag E, Ben-Chetrit E, et al. Defining colchicine resistance/intolerance in patients with familial Mediterranean fever: a modified-Delphi consensus approach. Rheumatology. 2021, 60, 3799-3808. doi: 10.1093/rheumatology/keaa863
25. Pras E, Livneh A, Balow Jr, JE, et al. Clinical differences between North African and Iraqi Jews with familial Mediterranean fever. Am J Med Genet. 1998;75(2):216-9. doi: 10.1002/(sici)1096-8628(19980113)75:2<216::aid-ajmg20>3.0.co;2-r
26. Ozen S, Kone-Paut I, Gül A. Colchicine resistance and intolerance in familial mediterranean fever: Definition, causes, and alternative treatments. Semin Arthritis Rheum.2017;47(1):115-120. doi: 10.1016/j.semarthrit.2017.03.006
27. Alghamdi M. Familial Mediterranean fever, review of the literature. Clin Rheumatol. 2017;36(8):1707-1713. doi: 10.1007/s10067-017-3715-5
28.Ter Haar N, Lachmann H, Özen S, et al. Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review. Ann Rheum Dis. 2013;72(5):678-85. doi: 10.1136/annrheumdis-2011-201268
29. Gül A, Ozdogan H, Erer B, et al. Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Res Ther. 2015;17(1):243. doi: 10.1186/s13075-015-0765-4
30. Brik R, Butbul-Aviel Y, Lubin S, et al. Canakinumab for the treatment of children with colchicine-resistant familial Mediterranean fever: a 6-month open-label, single-arm pilot study. Arthritis Rheumatol.2014;66(11):3241-3. doi: 10.1002/art.38777
31. van der Hilst JCh, Moutschen M, Messiaen PE, Lauwerys BR, Vanderschueren S. Efficacy of anti-IL-1 treatment in familial Mediterranean fever: a systematic review of the literature. Biologics.2016;10:75-80. doi: 10.2147/BTT.S102954. eCollection 2016
32. De Benedetti F, Gattorno M, Anton J, et al. Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes. N Engl J Med.2018;378(20):1908-1919. doi: 10.1056/NEJMoa1706314.
33. Atas N, Eroglu GA, Sodan HN, et al. Long-term safety and efficacy of anakinra and canakinumab in patients with familial Mediterranean fever: a single-centre real-life study with 101 patients. Clin Exp Rheumatol. 2021;39 Suppl 132(5):30-36. doi: 10.55563/clinexprheumatol/815tdt
34. Sevillano ÁM, Hernandez E, Gonzalez E, et al. Anakinra induces complete remission of nephrotic syndrome in a patient with familial mediterranean fever and amyloidosis. Nefrologia. 2016;36(1):63-6. doi: 10.1016/j.nefro.2015.06.026.
35. Stankovic KS, Delmas Y, Torres PU, et al. Dramatic beneficial effect of interleukin-1 inhibitor treatment in patients with familial Mediterranean fever complicated with amyloidosis and renal failure. Nephrol Dial Transplant. 2012;27(5):1898-901. doi: 10.1093/ndt/gfr528
36. Jesenak M, Hrubiskova K, Kapustova L, Kostkova M, Banovcin P. Canakinumab as monotherapy for treatment of familial Mediterranean fever - first report in Central and Eastern Europe region. Bratisl Lek Listy. 2018;119(4):198-200. doi:10.4149/BLL_2018_036
37. Kharouf F, Tsemach-Toren T, Ben-Chetrit E. IL-1 inhibition in familial Mediterranean fever: clinical outcomes and expectations. Clin Exp Rheumatol. 2022;40:1567. doi: 10.55563/clinexprheumatol/obb2ds
38. Eren Akarcan S, Dogantan S, Edeer Karaca N, Aksu G, Kutukculer N. Successful management of colchicine resistant familial mediterranean fever patients with a standardized canakinumab treatment protocol: a case series and literature review. Rheumatol Int. 40(1):161–168. doi:10. 1007/ s00296-019-04366-w
39. Hosono K, Okami N, Sasajima T. A 3-year interim analysis of post-marketing all-patient surveillance of canakinumab in Japanese patients with cryopyrin-associated periodic syndrome. Clin Exp Rheumatol.2022;40(8):1543-1553. doi:10.55563/clinexprheumatol/

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Details

Primary Language	English
Subjects	Rheumatology and Arthritis
Journal Section	Research Article
Authors	Tuğba Ocak 0000-0002-4560-1569 Ayşe Bulur 0009-0007-7962-8472 Burcu Yağız 0000-0002-0624-1986 Belkis Nihan Coskun 0000-0003-0298-4157 Hüseyin Ediz Dalkılıç 0000-0001-8645-2670 Yavuz Pehlivan 0000-0002-7054-5351
Publication Date	May 27, 2025
Submission Date	March 3, 2025
Acceptance Date	April 13, 2025
Published in Issue	Year 2025 Volume: 51 Issue: 1

Cite

AMA	Ocak T, Bulur A, Yağız B, Coskun BN, Dalkılıç HE, Pehlivan Y. Real-World Experience with Canakinumab in Familial Mediterranean Fever: A Single-Center Study. Uludağ Tıp Derg. May 2025;51(1):87-92. doi:10.32708/uutfd.1649876

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