Abstract
2.5 yaşlı erkek, English Cocker Spaniel ırkı bir köpek sol eksenli kendi etrafında dönme, vokalizasyonda artış, vestibular ataksi semptomları ile kliniğimize başvurdu. Hastanın sağlık geçmişinde sol arka ekstremitenin malign tümör kaynaklı ampute edildiği, tümör tipinin patoloji raporu ile hemanjiyosarkom olarak doğrulandığı bilgisi alındı. Yapılan fiziksel, nörolojik ve radyografik muayeneler sonucunda hastada sol arka ekstremite primer kökenli, intrakraniyal tümör metastazından şüphelenildi. Hastadan alınan beyin omurilik sıvısının yapılan incelemelerinde anormal bulguya rastlanılmadı. Tedavinin planlanması için gereken ileri görüntüleme teknikleri (bilgisayarlı tomografi ve manyetik rezonans görüntüleme) ve biyopsi işlemleri hasta sahibi tarafından reddedildi ve 4 gün sonra hasta ex oldu. Hastanın makroskobik nekropsi bulgularında başta beyin olmak üzere, dalak, karaciğer, diyafram ve akciğerde değişken boyutlarda kitlesel odaklar olduğu görüldü. Yapılan histopatolojik incelemede beyinde 0.2.x0.1 cm boyularında hemanjiosarkom metastazı görüldü. Elde edilen post-mortem bulgular klinik bulgular ile eşleşmektedir. Cocker spaniel ırkı bir köpekte hemanjiyosarkomun beyin metastazının görülmesi, olgumuzun ender olduğunu göstermektedir.
Keywords
References
- Brown N, Patnaik A, MacEwen E. Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc. 1985;186(1):56-8.
- Griffin MA, Culp WTN, Rebhun RB. Canine and feline haemangiosarcoma. Vet Rec. 2021;e585.
- Oksanen A. Haemangiosarcoma in dogs. J Comp Pathol. 1978;88(4):585-95.
- Sorenmo KU, Jeglum KA, Helfand SC. Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. J Vet Intern Med. 1993;7(6):370-6.
- Clifford CA, Mackin AJ, Henry CJ. Treatment of canine hemangiosarcoma: 2000 and beyond. J Vet Intern Med. 2000;14(5):479-85.
- Smith AN. Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract. 2003;33(3):533-52.
- Waters DJ, Hayden DW, Walter PA. Intracranial lesions in dogs with hemangiosarcoma. J Vet Intern Med. 1989;3(4):222-30.
- Long S. Neoplasia of the nervous system [Internet]. 2006 [cited 2014 Aug 15]. Available from: (kaynağın URL'si varsa eklenmeli)
- Tamburini BA, Trapp S, Phang TL, Schappa JT, Hunter LE, Modiano JF. Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS One. 2009;4(5):e5549.
- Yamamoto S, Hoshi K, Hirakawa A, Chimura S, Kobayashi M, Machida N. Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases. J Vet Med Sci. 2013;75(11):1433-41.
- De Nardi AB, de Oliveira Massoco Salles Gomes C, Fonseca-Alves CE, de Paiva FN, Linhares LCM, Carra GJU, et al. Diagnosis, prognosis, and treatment of canine hemangiosarcoma: a review based on a consensus organized by the Brazilian association of veterinary oncology, ABROVET. Cancers (Basel). 2023;15(7):2025.
- Gabor L, Vanderstichel R. Primary cerebral hemangiosarcoma in a 6-week-old dog. Vet Pathol. 2006;43(5):782-4.
- Withrow SJ, Page R, Vail DM. Withrow and MacEwen's small animal clinical oncology. Elsevier Health Sciences; 2012.
- Mallol C, Gutierrez-Quintana R, Hammond G, Schweizer-Gorgas D, De Decker S, Novellas R, et al. MRI features of canine hemangiosarcoma affecting the central nervous system. Vet Radiol Ultrasound. 2022;63(2):185-96.
- Dennler M, Lange EM, Schmied O, Kaser-Hotz B. Imaging diagnosis—metastatic hemangiosarcoma causing cerebral hemorrhage in a dog. Vet Radiol Ultrasound. 2007;48(2):138-40.
- Uçmak Günay Z, Öztürk Yüzbaşıoğlu G, Kırşan İ, Baykal A, Gülçubuk A, Mahzunlar E. A rare case of perivulvar hemangiosarcoma in a bitch. Vet Hekim Der Derg. 2024;95(1):60-5.
- Sarı S. Kliniğimize getirilen kedi ve köpeklerde karşılaşılan tümör olguları ve sağaltım olanakları [tez]. [Yayınlanmamış yüksek lisans tezi]. 2017.
- Karabağlı G, Düzgün O, Yıldar E, Erdoğan Ö, Gürel A. A hemangiosarcoma case in a dog. İstanbul Üniversitesi Vet Fak Derg. 2011;37(2):161-5.
Abstract
A 2.5 years old male English Cocker Spaniel dog was admitted to our clinic with symptoms of left axis circling, increased vocalization and vestibular ataxia. The patient's medical history revealed that the left hind limb was amputated due to a malignant tumor and the tumor type was confirmed as hemangiosarcoma by pathology report. As a result of physical, neurological and radiographic examinations, intracranial tumor metastasis of primary origin in the left hind limb was suspected. No abnormal findings were found in the cerebrospinal fluid obtained from the patient. Advanced imaging techniques (computed tomography and magnetic resonance imaging) and biopsy procedures required for treatment planning were refused by the owner and the patient died 4 days later. Macroscopic necropsy findings revealed mass foci of varying sizes in the brain, spleen, liver, diaphragm and lung. Histopathologic examination revealed hemangiosarcoma metastasis of 0.2.x0.1 cm in the brain. The post-mortem findings were consistent with the clinical findings. Brain metastasis of hemangiosarcoma in a cocker spaniel dog shows that our case is rare.
Keywords
References
- Brown N, Patnaik A, MacEwen E. Canine hemangiosarcoma: retrospective analysis of 104 cases. J Am Vet Med Assoc. 1985;186(1):56-8.
- Griffin MA, Culp WTN, Rebhun RB. Canine and feline haemangiosarcoma. Vet Rec. 2021;e585.
- Oksanen A. Haemangiosarcoma in dogs. J Comp Pathol. 1978;88(4):585-95.
- Sorenmo KU, Jeglum KA, Helfand SC. Chemotherapy of canine hemangiosarcoma with doxorubicin and cyclophosphamide. J Vet Intern Med. 1993;7(6):370-6.
- Clifford CA, Mackin AJ, Henry CJ. Treatment of canine hemangiosarcoma: 2000 and beyond. J Vet Intern Med. 2000;14(5):479-85.
- Smith AN. Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract. 2003;33(3):533-52.
- Waters DJ, Hayden DW, Walter PA. Intracranial lesions in dogs with hemangiosarcoma. J Vet Intern Med. 1989;3(4):222-30.
- Long S. Neoplasia of the nervous system [Internet]. 2006 [cited 2014 Aug 15]. Available from: (kaynağın URL'si varsa eklenmeli)
- Tamburini BA, Trapp S, Phang TL, Schappa JT, Hunter LE, Modiano JF. Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed. PLoS One. 2009;4(5):e5549.
- Yamamoto S, Hoshi K, Hirakawa A, Chimura S, Kobayashi M, Machida N. Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases. J Vet Med Sci. 2013;75(11):1433-41.
- De Nardi AB, de Oliveira Massoco Salles Gomes C, Fonseca-Alves CE, de Paiva FN, Linhares LCM, Carra GJU, et al. Diagnosis, prognosis, and treatment of canine hemangiosarcoma: a review based on a consensus organized by the Brazilian association of veterinary oncology, ABROVET. Cancers (Basel). 2023;15(7):2025.
- Gabor L, Vanderstichel R. Primary cerebral hemangiosarcoma in a 6-week-old dog. Vet Pathol. 2006;43(5):782-4.
- Withrow SJ, Page R, Vail DM. Withrow and MacEwen's small animal clinical oncology. Elsevier Health Sciences; 2012.
- Mallol C, Gutierrez-Quintana R, Hammond G, Schweizer-Gorgas D, De Decker S, Novellas R, et al. MRI features of canine hemangiosarcoma affecting the central nervous system. Vet Radiol Ultrasound. 2022;63(2):185-96.
- Dennler M, Lange EM, Schmied O, Kaser-Hotz B. Imaging diagnosis—metastatic hemangiosarcoma causing cerebral hemorrhage in a dog. Vet Radiol Ultrasound. 2007;48(2):138-40.
- Uçmak Günay Z, Öztürk Yüzbaşıoğlu G, Kırşan İ, Baykal A, Gülçubuk A, Mahzunlar E. A rare case of perivulvar hemangiosarcoma in a bitch. Vet Hekim Der Derg. 2024;95(1):60-5.
- Sarı S. Kliniğimize getirilen kedi ve köpeklerde karşılaşılan tümör olguları ve sağaltım olanakları [tez]. [Yayınlanmamış yüksek lisans tezi]. 2017.
- Karabağlı G, Düzgün O, Yıldar E, Erdoğan Ö, Gürel A. A hemangiosarcoma case in a dog. İstanbul Üniversitesi Vet Fak Derg. 2011;37(2):161-5.
Details
| Primary Language | English |
|---|---|
| Subjects | Veterinary Sciences (Other) |
| Journal Section | CASE REPORT |
| Authors | |
| Early Pub Date | June 13, 2025 |
| Publication Date | June 15, 2025 |
| Submission Date | November 19, 2024 |
| Acceptance Date | December 30, 2024 |
| Published in Issue | Year 2025 Volume: 96 Issue: 2 |
Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society) is an open access publication, and the journal’s publication model is based on Budapest Access Initiative (BOAI) declaration. All published content is licensed under a Creative Commons CC BY-NC 4.0 license, available online and free of charge. Authors retain the copyright of their published work in Veteriner Hekimler Derneği Dergisi (Journal of Turkish Veterinary Medical Society).
Veteriner Hekimler Derneği / Turkish Veterinary Medical Society