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Yıl 2025, Cilt: 7 Sayı: 2, 234 - 238, 21.03.2025

Fatma Özgüç Çömlek , Ahmet Fatih Yılmaz

https://doi.org/10.38053/acmj.1621956

Öz

Kaynakça

  • Wu WC, Lai YW, Chou YC, et al. Serum uric acid level as a harbinger of type 2 diabetes: a prospective observation. Int J Environ Res Public Health. 2020;17(7):2277. doi:10.3390/ijerph17072277
  • Thomazini F, de Carvalho BS, de Araujo PX, Franco MDC. High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? J Pediatr Endocrinol Metab. 2021;34(11):1435-1441. doi: 10.1515/jpem-2021-0211
  • Han T, Lan L, Qu R, et al. Temporal relationship between hyperuricemia and insulin resistance and its impact on future risk of hypertension. Hypertension. 2017;70(4):703e11. doi:10.1161/HYPERTENSIONAHA. 117.09508
  • Wei F, Li J, Chen C, et al. Higher serum uric acid level predicts non-alcoholic fatty liver disease: a 4-year prospective cohort study. Front Endocrinol (Lausanne). 2020;11:179. doi:10.3389/fendo.2020.00179
  • Sirota JC, McFann K, Targher G, et al. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013;62(3):392-399. doi:10.1016/j.metabol.2012.08.013
  • Cardoso AS, Gonzaga NC, Medeiros CC, et al. Association of uric acid levels with components of metabolic syndrome and nonalcoholic fatty liver disease in overweight or obese children and adolescents. J Pediatr (Rio J). 2013;89(4):412-418. doi:10.1016/j.jped.2012.12.008
  • Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44(235):291-303. doi:10.1136/adc.44.235.291
  • Marzuillo P, Del Giudice EM, Santoro N. Pediatric non-alcoholic fatty liver disease: new insights and future directions. World J Hepatol. 2014; 6(4):217-225. doi:10.4254/wjh.v6.i4.217
  • Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U.  Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN hepatology committee. J Pediatr Gastroenterol Nutr. 2012;54(5):700-713. doi:10. 1097/MPG.0b013e318252a13f
  • Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One. 2015; 10(10):e0140908. doi:10.1371/journal.pone.0140908
  • Barrera F, George J. The role of diet and nutritional intervention in managing patients with NAFLD. Clin Liver Dis. 2014;18(1):91-112. doi: 10.1016/j.cld.2013.09.009
  • Rupasinghe K, Hind J, Hegarty R. Updates in metabolic dysfunction-associated fatty liver disease (MAFLD) in children. J Pediatr Gastroenterol Nutr. 2023;77(5):583-591. doi:10.1097/MPG.0000000000003919
  • Jensen T, Abdelmalek MF, Sullivan S, et al. Fructose and sugar: a central mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68(5):1063-1075. doi:10.1016/j.jhep.2018.01.019
  • Muriel P, López-Sánchez P, Ramos-Tovar E. Fructose and the liver. Int J Mol Sci. 2021;22(13):6969. doi:10.3390/ijms22136969
  • Darmawan G, Hamijoyo L, Hasan I. Association between serum uric acid and non-alcoholic fatty liver disease: a meta-analysis. Acta Med Indones. 2017;49(2):136-147.
  • Wu SJ, Zhu GQ, Ye BZ, et al. Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study. Medicine. 2015;94(17):e802. doi:10.1097/MD. 0000000000000802
  • Fan N, Zhang L, Xia Z, Peng L, Wang Y, Peng Y. Sex-specific associationbetween serumuric acid and nonalcoholic fatty liver disease in type 2 diabetic patients. J Diabetes Res. 2016;2016:3805372. doi:10.1155/2016/3805372
  • Ben-Aicha S, Badimon L, Vilahur G. Advances in HDL: much more than lipid transporters. Int J Mol Sci. 2020;21(3):732. doi:10.3390/ijms 21030732
  • Corey KE, Misdraji J, Gelrud L, Zheng H, Chung RT, Krauss RM. Nonalcoholic steatohepatitis is associated with an atherogenic lipoprotein subfraction profile. Lipids Health Dis. 2014;13(1):100. doi:10. 1186/1476-511X-13-100
  • Xie J, Huang H, Liu Z, et al. The associations between modifiable risk factors and nonalcoholic fatty liver disease: a comprehensive Mendelian randomization study. Hepatology. 2023;77(3):949-964. doi:10.1002/hep. 32728
  • de Alwis NM, Day CP. Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol. 2008;48(Suppl 1):S104–112. doi:10.1016/j.jhep.2008.01.009
  • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management. Hepatology. 2009;49(1):306-317. doi:10.1002/hep. 22603
  • Hamaguchi M, Kojima T, Itoh Y, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007; 102(12):2708-2715. doi:10.1111/j.1572-0241.2007.01526.x
  • Ballestri S, Lonardo A, Romagnoli D, et al. The ultrasonographic fatty liver indicator is a novel score that rules out NASH and correlates with metabolic parameters in NAFLD. Liver Int. 2012;32(8):1242-1252. doi: 10.1111/j.1478-3231.2012.02804.x
  • Dasarathy S, Dasarathy J, Khiyami A, et al. Validity of real-time ultrasound in diagnosing hepatic steatosis: a prospective study. J Hepatol. 2009;51(6):1061-1067. doi:10.1016/j.jhep.2009.09.001

Can levels of serum uric acid and HDL cholesterol effectively predict the presence of fatty liver in children with obesity?

Yıl 2025, Cilt: 7 Sayı: 2, 234 - 238, 21.03.2025

Fatma Özgüç Çömlek , Ahmet Fatih Yılmaz

https://doi.org/10.38053/acmj.1621956

Öz

Aims: Our study aimed to evaluate the relationship between biochemical parameters such as high uric acid and low HDL levels and metabolic dysfunction-associated steatohepatitis (MDAS) in children with obesity.
Methods: The records of 81 obese children with a body mass index above two standard deviations for their age who underwent fasting lipids, liver enzymes, uric acid level, oral glucose tolerance tests (OGTT), and abdominal ultrasounds to assess fatty liver were reviewed retrospectively. The findings from physical examinations and results from laboratory and imaging tests were documented. The relationship between laboratory data and MDAS was examined.
Results: The study included 81 children, 27 males and 54 females. Fifty-six out of the total participants, accounting for 69.2%, were diagnosed with steatohepatitis. the MDAS and non-MDAS subjects' SUA levels were 6.34±1.36 mg/dl and 5.26±1.09 mg/ dl, respectively. HDL levels were significantly lower in MDAS children than in non-MDAS children (39.90±7.89 vs. 45.23±7.32, p=.005,). Moreover, the MDAS and non-MDAS subjects' SUA levels were 6.34±1.36 mg/dl and 5.26±1.09 mg/dl, respectively. There was a statistical difference between the two groups (p<.001,).To assess the diagnostic performance of each marker and
predictive model, we conducted a receiver operating characteristics (ROC) analysis. As individual predictors, SUA (AUC=0.729 [95% CI, 0.619–0.822], cut-off >6.89, sensitivity=37.5, specificity=100) and HDL (AUC=0.699 [95% CI, 0.587–0.796], cut-off ≤39.2, sensitivity=51.8, specificity=84) showed similar diagnostic performance in discriminating MDAS from non-MDAS patients.
Conclusion: Elevated SUA levels with low HDL levels may significantly predict MDAS.

Anahtar Kelimeler

Uric acid HDL obesity children fatty liver

Etik Beyan

Approval for the study was obtained from the local ethics committee of XXXX University Medical faculty. (Protocol No: 2024/509)

Kaynakça

  • Wu WC, Lai YW, Chou YC, et al. Serum uric acid level as a harbinger of type 2 diabetes: a prospective observation. Int J Environ Res Public Health. 2020;17(7):2277. doi:10.3390/ijerph17072277
  • Thomazini F, de Carvalho BS, de Araujo PX, Franco MDC. High uric acid levels in overweight and obese children and their relationship with cardiometabolic risk factors: what is missing in this puzzle? J Pediatr Endocrinol Metab. 2021;34(11):1435-1441. doi: 10.1515/jpem-2021-0211
  • Han T, Lan L, Qu R, et al. Temporal relationship between hyperuricemia and insulin resistance and its impact on future risk of hypertension. Hypertension. 2017;70(4):703e11. doi:10.1161/HYPERTENSIONAHA. 117.09508
  • Wei F, Li J, Chen C, et al. Higher serum uric acid level predicts non-alcoholic fatty liver disease: a 4-year prospective cohort study. Front Endocrinol (Lausanne). 2020;11:179. doi:10.3389/fendo.2020.00179
  • Sirota JC, McFann K, Targher G, et al. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013;62(3):392-399. doi:10.1016/j.metabol.2012.08.013
  • Cardoso AS, Gonzaga NC, Medeiros CC, et al. Association of uric acid levels with components of metabolic syndrome and nonalcoholic fatty liver disease in overweight or obese children and adolescents. J Pediatr (Rio J). 2013;89(4):412-418. doi:10.1016/j.jped.2012.12.008
  • Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969;44(235):291-303. doi:10.1136/adc.44.235.291
  • Marzuillo P, Del Giudice EM, Santoro N. Pediatric non-alcoholic fatty liver disease: new insights and future directions. World J Hepatol. 2014; 6(4):217-225. doi:10.4254/wjh.v6.i4.217
  • Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U.  Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN hepatology committee. J Pediatr Gastroenterol Nutr. 2012;54(5):700-713. doi:10. 1097/MPG.0b013e318252a13f
  • Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A. The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis. PLoS One. 2015; 10(10):e0140908. doi:10.1371/journal.pone.0140908
  • Barrera F, George J. The role of diet and nutritional intervention in managing patients with NAFLD. Clin Liver Dis. 2014;18(1):91-112. doi: 10.1016/j.cld.2013.09.009
  • Rupasinghe K, Hind J, Hegarty R. Updates in metabolic dysfunction-associated fatty liver disease (MAFLD) in children. J Pediatr Gastroenterol Nutr. 2023;77(5):583-591. doi:10.1097/MPG.0000000000003919
  • Jensen T, Abdelmalek MF, Sullivan S, et al. Fructose and sugar: a central mediator of non-alcoholic fatty liver disease. J Hepatol. 2018;68(5):1063-1075. doi:10.1016/j.jhep.2018.01.019
  • Muriel P, López-Sánchez P, Ramos-Tovar E. Fructose and the liver. Int J Mol Sci. 2021;22(13):6969. doi:10.3390/ijms22136969
  • Darmawan G, Hamijoyo L, Hasan I. Association between serum uric acid and non-alcoholic fatty liver disease: a meta-analysis. Acta Med Indones. 2017;49(2):136-147.
  • Wu SJ, Zhu GQ, Ye BZ, et al. Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study. Medicine. 2015;94(17):e802. doi:10.1097/MD. 0000000000000802
  • Fan N, Zhang L, Xia Z, Peng L, Wang Y, Peng Y. Sex-specific associationbetween serumuric acid and nonalcoholic fatty liver disease in type 2 diabetic patients. J Diabetes Res. 2016;2016:3805372. doi:10.1155/2016/3805372
  • Ben-Aicha S, Badimon L, Vilahur G. Advances in HDL: much more than lipid transporters. Int J Mol Sci. 2020;21(3):732. doi:10.3390/ijms 21030732
  • Corey KE, Misdraji J, Gelrud L, Zheng H, Chung RT, Krauss RM. Nonalcoholic steatohepatitis is associated with an atherogenic lipoprotein subfraction profile. Lipids Health Dis. 2014;13(1):100. doi:10. 1186/1476-511X-13-100
  • Xie J, Huang H, Liu Z, et al. The associations between modifiable risk factors and nonalcoholic fatty liver disease: a comprehensive Mendelian randomization study. Hepatology. 2023;77(3):949-964. doi:10.1002/hep. 32728
  • de Alwis NM, Day CP. Non-alcoholic fatty liver disease: the mist gradually clears. J Hepatol. 2008;48(Suppl 1):S104–112. doi:10.1016/j.jhep.2008.01.009
  • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management. Hepatology. 2009;49(1):306-317. doi:10.1002/hep. 22603
  • Hamaguchi M, Kojima T, Itoh Y, et al. The severity of ultrasonographic findings in nonalcoholic fatty liver disease reflects the metabolic syndrome and visceral fat accumulation. Am J Gastroenterol. 2007; 102(12):2708-2715. doi:10.1111/j.1572-0241.2007.01526.x
  • Ballestri S, Lonardo A, Romagnoli D, et al. The ultrasonographic fatty liver indicator is a novel score that rules out NASH and correlates with metabolic parameters in NAFLD. Liver Int. 2012;32(8):1242-1252. doi: 10.1111/j.1478-3231.2012.02804.x
  • Dasarathy S, Dasarathy J, Khiyami A, et al. Validity of real-time ultrasound in diagnosing hepatic steatosis: a prospective study. J Hepatol. 2009;51(6):1061-1067. doi:10.1016/j.jhep.2009.09.001
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Endokrinolojisi
Bölüm Research Articles
Yazarlar

Fatma Özgüç Çömlek 0000-0002-2752-3480

Ahmet Fatih Yılmaz 0000-0002-1085-8882

Yayımlanma Tarihi 21 Mart 2025
Gönderilme Tarihi 17 Ocak 2025
Kabul Tarihi 17 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 2

Kaynak Göster

AMA Özgüç Çömlek F, Yılmaz AF. Can levels of serum uric acid and HDL cholesterol effectively predict the presence of fatty liver in children with obesity?. Anatolian Curr Med J / ACMJ / acmj. Mart 2025;7(2):234-238. doi:10.38053/acmj.1621956
 Kapak Resmi İndir

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

-  Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.

Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamaktadır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/3449/page/10809/update 

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