Araştırma Makalesi
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Yıl 2025, Cilt: 7 Sayı: 2, 177 - 183, 21.03.2025

Hilal Ünsal , Beyza Akalın Ertürk

https://doi.org/10.38053/acmj.1625706

Öz

Kaynakça

  • Liva GA, Karatzanis AD, Prokopakis EP. Review of rhinitis: classification, types, pathophysiology. J Clin Med. 2021;10(14):3183. doi: 10.3390/jcm10143183
  • Papadopoulos NG, Guibas GV. Rhinitis subtypes, endotypes, and definitions. Immunol Allergy Clin North Am. 2016;36(2):215-233. doi:10. 1016/j.iac.2015.12.001
  • Özdemir Ö, Elmas B. New Developments in the diagnosis and therapy of allergic rhinitis. Asthma Allergy Immunol. 2022;15(1):001-016. doi:10. 21911/aai.5033
  • Reyes-Angel J, Kaviany P, Rastogi D, Forno E. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health. 2022;6(10):713-724. doi:10.1016/S2352-4642(22)00185-7
  • Permaul P, Kanchongkittiphon W, Phipatanakul W. Childhood asthma and obesity—what is the true link? Ann Allergy Asthma Immunol. 2014; 113(3):244-246. doi:10.1016/j.anai.2014.07.001
  • Vatankhah V, Khazraei H, Iranpoor H, Lotfizadeh M. Impact of high body-mass index on allergic rhinitis patients. Revue Française d'Allergologie. 2017;57(5):370-374. doi:10.1016/j.reval.2017.05.001
  • Han Y-Y, Forno E, Gogna M, Celedón JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137(5):1460-1465. doi:10.1016/j.jaci.2015.12.1307
  • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115(5):911-920. doi:10.1016/j.jaci.2005.02.023
  • Ciprandi G, Caimmi D, Raschetti R, et al. Adipokines and their role in allergies. Int J Immunopathol Pharmacol. 2011;24(4 Suppl):13-16. doi:10. 1177/03946320110240S403
  • Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007;62(10):1205-1213. doi:10.1111/j.1398-9995.2007.01506.x
  • Zmora N, Bashiardes S, Levy M, Elinav E. The role of the immune system in metabolic health and disease. Cell Metab. 2017;25(3):506-521. doi:10.1016/j.cmet.2017.02.006
  • Hellings PW, Klimek L, Cingi C, et al. Non-allergic rhinitis: position paper of the European Academy of allergy and clinical immunology. Allergy. 2017;72(11):1657-1665. doi:10.1111/all.13200
  • Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(5 Suppl):S147-S334. doi:10.1067/mai.2001.118891
  • Cavkaytar O, Buyuktiryaki B, Sag E, Soyer O, Sekerel BE. What we miss if standard panel is used for skin prick testing? Asian Pac J Allergy Immunol. 2015;33(3):211-221. doi:10.12932/AP0564.33.3.2015
  • Şahiner UM, Civelek E, Yavuz ST, Büyüktiryaki AB, Tuncer A, Şekerel BE. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol. 2012; 157(4):391-398. doi:10.1159/000329870
  • AnthroPlus WHO (World Health Organization) for personal computers. 2009. mamaproject.org
  • Settipane RA. Demographics and epidemiology of allergic and nonallergic rhinitis. Allergy Asthma Proc. 2001;22(4):185-189.
  • Greiner AN, Hellings PW, Rotiroti G, Scadding GK. Allergic rhinitis. Lancet. 2011;378(9809):2112-2122. doi:10.1016/S0140-6736(11)60130-X
  • Kaliner MA. Nonallergic rhinopathy (formerly known as vasomotor rhinitis). Immunol Allergy Clin North Am. 2011;31(3):441-455. doi:10. 1016/j.iac.2011.05.007
  • Matheson MC, Dharmage SC, Abramson MJ, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study—an international population-based cohort study. J Allergy Clin Immunol. 2011;128(4):816-823.e5. doi:10.1016/j.jaci. 2011.05.039
  • Saulyte J, Regueira C, Montes-Martínez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS Med. 2014;11(3):e1001611. doi:10.1371/journal.pmed.1001611
  • Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. Allergy Clin Immunol. 2002;109(3):419-425. doi:10.1067/mai.2002.121701
  • Shaaban R, Zureik M, Soussan D, et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet. 2008;372(9643):1049-1057. doi:10.1016/S0140-6736(08)61446-4
  • Eriksson J, Bjerg A, Lötvall J, et al. Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma. Respir Med. 2011;105(11):1611-1621. doi:10.1016/j.rmed.2011.06.004
  • Bedolla-Barajas M, Kestler-Gramajo A, Alcalá-Padilla G, Morales-Romero J. Prevalence of oral allergy syndrome in children with allergic diseases. Allergol Immunopathol (Madr). 2017;45(2):127-133. doi:10. 1016/j.aller.2016.04.017
  • Vichyanond P, Suratannon C, Lertbunnaphong P, Jirapongsananuruk O, Visitsunthorn N. Clinical characteristics of children with non-allergic rhinitis vs with allergic rhinitis. Asian Pac J Allergy Immunol. 2010;28(4):270-274.
  • Evcimik MF, Dogru M, Cirik AA, Nepesov MI. Adenoid hypertrophy in children with allergic disease and influential factors. Int J Pediatr Otorhinolaryngol. 2015;79(5):694-697. doi:10.1016/j.ijporl.2015.02.017
  • Westman M, Stjärne P, Asarnoj A, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol. 2012;129(2):403-408. doi:10.1016/j.jaci.2011.09.036
  • Schuler IV CF, Montejo JM. Allergic rhinitis in children and adolescents. Immunol Allergy Clin North Am. 2021;41(4):613-625. doi:10.1016/j.iac. 2021.07.010
  • Li AR, Zhang K, Reddy PD, et al. Systematic review of measures of disease severity in rhinitis. Int Forum Allergy Rhinol. 2021;11(9):1367-1377. doi:10.1002/alr.22794
  • Saadeh D, Salameh P, Caillaud D, et al. High body-mass index and allergies in schoolchildren: the French six cities study. BMJ Open Respir Res. 2014;1(1):e000054. doi:10.1136/bmjresp-2014-000054
  • Han MW, Kim SH, Oh I, Kim YH, Lee J. Obesity can contribute to severe persistent allergic rhinitis in children through leptin and interleukin-1β. Int Arch Allergy Immunol. 2021;182(6):546-552. doi:10.1159/000512920
  • Zhou J, Luo F, Han Y, Lou H, Tang X, Zhang L. Obesity/overweight and risk of allergic rhinitis: a meta-analysis of observational studies. Allergy. 2020;75(5):1272-1275. doi:10.1111/all.14143
  • Hsueh KC, Lin YJ, Lin HC, Lin CY. Serum leptin and adiponectin levels correlate with severity of allergic rhinitis. Pediatr Allergy Immunol. 2010;21(1 Pt 2):e155-e159. doi:10.1111/j.1399-3038.2009.00878.x
  • Sybilski AJ, Raciborski F, Lipiec A, et al. Obesity–a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization. Public Health Nutr. 2015;18(3):530-536. doi:10.1017/S1368980014000676
  • Kusunoki T, Morimoto T, Nishikomori R, et al. Obesity and the prevalence of allergic diseases in schoolchildren. Pediatr Allergy Immunol. 2008;19(6):527-534. doi:10.1111/j.1399-3038.2007.00686.x
  • Yao TC, Ou LS, Yeh KW, et al. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011;48(5):503-510. doi:10.3109/02770903.2011.576743

Evaluation of children with allergic and non-allergic rhinitis and the effect of obesity/overweight in patients with allergic rhinitis

Yıl 2025, Cilt: 7 Sayı: 2, 177 - 183, 21.03.2025

Hilal Ünsal , Beyza Akalın Ertürk

https://doi.org/10.38053/acmj.1625706

Öz

Aims: Allergic rhinitis (AR) and obesity are two of the most prevalent chronic health diseases in children. This report aims to investigate to types of allergic and non-allergic rhinitis (NAR) and the association between the frequency and severity of rhinitis symptoms in AR patients with and without overweight/obesity.
Methods: Patients aged 5-18 years with rhinitis symptoms who were referred to Sincan Training and Research Hospital pediatric immunology and allergy outpatient clinic were retrospectively evaluated. Demographic, clinical and laboratory characteristics of patients were recorded.
Results: The study included 385 children with a median age of 11 years (IQR8-14) (53.5% males). 31 (8.1%) of patients had atopic dermatitis and 22 (5.7 %) of patients had asthma. 283 (73.5%) patients were in the AR group. Total IgE level and eosinophil count were found significantly higher in AR group [256 (113-995) vs. 280 (160-480)] than NAR group [64 (25.5-210) vs. 170 (90-310)] (p=0.002 vs. p=<0.001). 61.3 % of patients were sensitized to grass pollen, 21% to cat, and 9.9% to house dust-mite. The number of patients with moderate-to-severe rhinitis were higher in AR group (65%) compared to NAR group (35%) (p=0.005). Nasal congestion (77.7%), sneezing (75.3%), rhinorrhea (42.6%) were more common symptoms. Postnasal drip, snoring-mouth breathing and adenoid hypertrophy were more common in the NAR group compared to AR group (p=0.011, p=0.013 and p<0.001, respectively). Among patients with AR, there were 79 (28%) patients with overweight/obesity. The rate of moderate-tosevere rhinitis was 68.4% in obese/overweight group and 63.7% in the non-obese/overweight group.
Conclusion: Our study found that moderate-to-severe rhinitis was higher in the AR group than the NAR group. No difference was found between the frequency and severity of rhinitis symptoms and aeroallergen sensitivities in patients with and without obesity/overweight.

Anahtar Kelimeler

Rhinitis allergic severity children obesity

Etik Beyan

Ethics committee approval was obtained for this retrospective study (Decision number: 2024-BÇEK/151)

Destekleyen Kurum

no

Teşekkür

no

Kaynakça

  • Liva GA, Karatzanis AD, Prokopakis EP. Review of rhinitis: classification, types, pathophysiology. J Clin Med. 2021;10(14):3183. doi: 10.3390/jcm10143183
  • Papadopoulos NG, Guibas GV. Rhinitis subtypes, endotypes, and definitions. Immunol Allergy Clin North Am. 2016;36(2):215-233. doi:10. 1016/j.iac.2015.12.001
  • Özdemir Ö, Elmas B. New Developments in the diagnosis and therapy of allergic rhinitis. Asthma Allergy Immunol. 2022;15(1):001-016. doi:10. 21911/aai.5033
  • Reyes-Angel J, Kaviany P, Rastogi D, Forno E. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health. 2022;6(10):713-724. doi:10.1016/S2352-4642(22)00185-7
  • Permaul P, Kanchongkittiphon W, Phipatanakul W. Childhood asthma and obesity—what is the true link? Ann Allergy Asthma Immunol. 2014; 113(3):244-246. doi:10.1016/j.anai.2014.07.001
  • Vatankhah V, Khazraei H, Iranpoor H, Lotfizadeh M. Impact of high body-mass index on allergic rhinitis patients. Revue Française d'Allergologie. 2017;57(5):370-374. doi:10.1016/j.reval.2017.05.001
  • Han Y-Y, Forno E, Gogna M, Celedón JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137(5):1460-1465. doi:10.1016/j.jaci.2015.12.1307
  • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol. 2005;115(5):911-920. doi:10.1016/j.jaci.2005.02.023
  • Ciprandi G, Caimmi D, Raschetti R, et al. Adipokines and their role in allergies. Int J Immunopathol Pharmacol. 2011;24(4 Suppl):13-16. doi:10. 1177/03946320110240S403
  • Hersoug LG, Linneberg A. The link between the epidemics of obesity and allergic diseases: does obesity induce decreased immune tolerance? Allergy. 2007;62(10):1205-1213. doi:10.1111/j.1398-9995.2007.01506.x
  • Zmora N, Bashiardes S, Levy M, Elinav E. The role of the immune system in metabolic health and disease. Cell Metab. 2017;25(3):506-521. doi:10.1016/j.cmet.2017.02.006
  • Hellings PW, Klimek L, Cingi C, et al. Non-allergic rhinitis: position paper of the European Academy of allergy and clinical immunology. Allergy. 2017;72(11):1657-1665. doi:10.1111/all.13200
  • Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 2001;108(5 Suppl):S147-S334. doi:10.1067/mai.2001.118891
  • Cavkaytar O, Buyuktiryaki B, Sag E, Soyer O, Sekerel BE. What we miss if standard panel is used for skin prick testing? Asian Pac J Allergy Immunol. 2015;33(3):211-221. doi:10.12932/AP0564.33.3.2015
  • Şahiner UM, Civelek E, Yavuz ST, Büyüktiryaki AB, Tuncer A, Şekerel BE. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol. 2012; 157(4):391-398. doi:10.1159/000329870
  • AnthroPlus WHO (World Health Organization) for personal computers. 2009. mamaproject.org
  • Settipane RA. Demographics and epidemiology of allergic and nonallergic rhinitis. Allergy Asthma Proc. 2001;22(4):185-189.
  • Greiner AN, Hellings PW, Rotiroti G, Scadding GK. Allergic rhinitis. Lancet. 2011;378(9809):2112-2122. doi:10.1016/S0140-6736(11)60130-X
  • Kaliner MA. Nonallergic rhinopathy (formerly known as vasomotor rhinitis). Immunol Allergy Clin North Am. 2011;31(3):441-455. doi:10. 1016/j.iac.2011.05.007
  • Matheson MC, Dharmage SC, Abramson MJ, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study—an international population-based cohort study. J Allergy Clin Immunol. 2011;128(4):816-823.e5. doi:10.1016/j.jaci. 2011.05.039
  • Saulyte J, Regueira C, Montes-Martínez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS Med. 2014;11(3):e1001611. doi:10.1371/journal.pmed.1001611
  • Guerra S, Sherrill DL, Martinez FD, Barbee RA. Rhinitis as an independent risk factor for adult-onset asthma. Allergy Clin Immunol. 2002;109(3):419-425. doi:10.1067/mai.2002.121701
  • Shaaban R, Zureik M, Soussan D, et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet. 2008;372(9643):1049-1057. doi:10.1016/S0140-6736(08)61446-4
  • Eriksson J, Bjerg A, Lötvall J, et al. Rhinitis phenotypes correlate with different symptom presentation and risk factor patterns of asthma. Respir Med. 2011;105(11):1611-1621. doi:10.1016/j.rmed.2011.06.004
  • Bedolla-Barajas M, Kestler-Gramajo A, Alcalá-Padilla G, Morales-Romero J. Prevalence of oral allergy syndrome in children with allergic diseases. Allergol Immunopathol (Madr). 2017;45(2):127-133. doi:10. 1016/j.aller.2016.04.017
  • Vichyanond P, Suratannon C, Lertbunnaphong P, Jirapongsananuruk O, Visitsunthorn N. Clinical characteristics of children with non-allergic rhinitis vs with allergic rhinitis. Asian Pac J Allergy Immunol. 2010;28(4):270-274.
  • Evcimik MF, Dogru M, Cirik AA, Nepesov MI. Adenoid hypertrophy in children with allergic disease and influential factors. Int J Pediatr Otorhinolaryngol. 2015;79(5):694-697. doi:10.1016/j.ijporl.2015.02.017
  • Westman M, Stjärne P, Asarnoj A, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol. 2012;129(2):403-408. doi:10.1016/j.jaci.2011.09.036
  • Schuler IV CF, Montejo JM. Allergic rhinitis in children and adolescents. Immunol Allergy Clin North Am. 2021;41(4):613-625. doi:10.1016/j.iac. 2021.07.010
  • Li AR, Zhang K, Reddy PD, et al. Systematic review of measures of disease severity in rhinitis. Int Forum Allergy Rhinol. 2021;11(9):1367-1377. doi:10.1002/alr.22794
  • Saadeh D, Salameh P, Caillaud D, et al. High body-mass index and allergies in schoolchildren: the French six cities study. BMJ Open Respir Res. 2014;1(1):e000054. doi:10.1136/bmjresp-2014-000054
  • Han MW, Kim SH, Oh I, Kim YH, Lee J. Obesity can contribute to severe persistent allergic rhinitis in children through leptin and interleukin-1β. Int Arch Allergy Immunol. 2021;182(6):546-552. doi:10.1159/000512920
  • Zhou J, Luo F, Han Y, Lou H, Tang X, Zhang L. Obesity/overweight and risk of allergic rhinitis: a meta-analysis of observational studies. Allergy. 2020;75(5):1272-1275. doi:10.1111/all.14143
  • Hsueh KC, Lin YJ, Lin HC, Lin CY. Serum leptin and adiponectin levels correlate with severity of allergic rhinitis. Pediatr Allergy Immunol. 2010;21(1 Pt 2):e155-e159. doi:10.1111/j.1399-3038.2009.00878.x
  • Sybilski AJ, Raciborski F, Lipiec A, et al. Obesity–a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization. Public Health Nutr. 2015;18(3):530-536. doi:10.1017/S1368980014000676
  • Kusunoki T, Morimoto T, Nishikomori R, et al. Obesity and the prevalence of allergic diseases in schoolchildren. Pediatr Allergy Immunol. 2008;19(6):527-534. doi:10.1111/j.1399-3038.2007.00686.x
  • Yao TC, Ou LS, Yeh KW, et al. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011;48(5):503-510. doi:10.3109/02770903.2011.576743
Toplam 37 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk İmmünolojisi ve Alerji Hastalıkları
Bölüm Research Articles
Yazarlar

Hilal Ünsal 0000-0002-7286-9210

Beyza Akalın Ertürk 0000-0002-6964-5515

Yayımlanma Tarihi 21 Mart 2025
Gönderilme Tarihi 23 Ocak 2025
Kabul Tarihi 25 Şubat 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 7 Sayı: 2

Kaynak Göster

AMA Ünsal H, Akalın Ertürk B. Evaluation of children with allergic and non-allergic rhinitis and the effect of obesity/overweight in patients with allergic rhinitis. Anatolian Curr Med J / ACMJ / acmj. Mart 2025;7(2):177-183. doi:10.38053/acmj.1625706
 Kapak Resmi İndir

Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]

-  Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.

Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamaktadır.

Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/3449/page/10809/update 

Dergi Dizin ve Platformları

TR Dizin ULAKBİM, Google Scholar, Crossref, Worldcat (OCLC), DRJI, EuroPub, OpenAIRE, Turkiye Citation Index, Turk Medline, ROAD, ICI World of Journal's, Index Copernicus, ASOS Index, General Impact Factor, Scilit.