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Prognostic predictivity of the pretreatment platelet-to-lymphocyte ratio, mean platelet volume and platelet distribution width in laryngeal squamous cell carcinoma: Analyses of 594 patients

Yıl 2025, Cilt: 58 Sayı: 1, 11 - 15, 04.05.2025

Sümeyra Doluoğlu , Gökhan Toptaş , Ömer Bayır , Emel Çadallı Tatar , Mehmet Hakan Korkmaz , Güleser Saylam

https://doi.org/10.20492/aeahtd.1602750

Öz

Amaç: Tedavi öncesi trombosit-lenfosit oranı (PLR), ortalama trombosit hacmi (MPV) ve trombosit dağılım genişliğinin (PDW) larenks skuamöz hücreli kanserli (LSCC) hastaların prognozu üzerindeki etkisini değerlendirmektir.

Gereç ve Yöntem: Çalışma popülasyonu iki gruba ayrıldı: sağ kalanlar (Grup 1) ve sağ kalmayanlar (Grup 2). Daha sonra, iki grup arasında yaş, cinsiyet, sigara içme durumu, lezyon lokalizasyonu, ön komissür tutulumu, tümör T evresi, N evresi, M evresi, erken/ileri evre ve tümör patolojik derecesi dahil olmak üzere çok sayıda değişken açısından kapsamlı bir karşılaştırma yapıldı. Genel sağkalımı (OS) tahmin etmek için ROC eğrisi analizi gerçekleştirildi. Daha sonra, kesme değerlerine göre gruplar oluşturuldu ve bu gruplar 3 ve 5 yıllık genel sağkalım (OS) oranları açısından karşılaştırıldı.

Bulgular: Çalışmaya dahil edilme kriterlerini karşılayan 594 hasta alındı. Sağ kalan grup yaş ortalaması 59.8±9.18 yıl olan 419 (%70.5) hastadan (Grup 1) ve sağ kalmayan grup yaş ortalaması 62.4±11.17 yıl olan 175 (%29.5) hastadan (Grup 2) oluşuyordu. PDW (kesme değeri 16,35 fL) %78,3 duyarlılık ve %52,2 özgüllük ile kanser prognozunu öngörme potansiyeline sahipti. Ayrıca, PLR (kesme değeri 123.64) kanser prognozunu %70.2 duyarlılık ve %51.1 özgüllük ile öngörebildi.

Sonuçlar: Tanı anında PDW >16.35 fL ve PLR >%123.64 olan LSCC hastalarının tedavi seçimi ve takibinde daha dikkatli olunmalıdır.

Aim: The objective of this study was to assess the impact of pre-treatment platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) on the prognosis of patients with laryngeal squamous cell cancer (LSCC).

Material and Method: The study population was divided into two groups: survivors (Group 1) and non-survivors (Group 2). Subsequently, we conducted a comprehensive comparison between the two groups with respect to a multitude of variables, including age, gender, smoking status, lesion localization, anterior commissure involvement, tumor T stage, N stage, M stage, early/advanced stage, and tumor pathological grade. ROC curve analysis was performed to estimate overall survival (OS). Then, groups were formed according to cut-off values and these groups were compared in terms of 3- and 5-year overall survival (OS) rates.

Results: The study included 594 patients who met the inclusion criteria. The survivor group consisted of 419 (70.5%) patients with a mean age of 59.8±9.18 years (Group 1) and the non-survivor group consisted of 175 (29.5%) patients with a mean age of 62.4±11.17 years (Group 2). PDW (cut-off value 16.35 fL) had the potential to predict cancer prognosis with a sensitivity of 78.3% and specificity of 52.2%. Furthermore, PLR (cut-off 123.64) could predict cancer prognosis with a sensitivity of 70.2% and specificity of 51.1%.

Conclusion: It was suggested that LSCC patients with PDW >16.35 fL and PLR >123.64% at the time of diagnosis should be more careful in treatment selection and follow-up.

Anahtar Kelimeler

Blood Platelets Laryngeal neoplasms Mean platelet volume Platelet distribution width Survival Analysis

Kaynakça

  • 1. Bray F, Ferlay J, Soarjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov; 68(6): 394-424. https://doi.org/10.3322/caac.21492
  • 2. Howlader N, Noone A, Krapcho M, Miller D, Bishop K, Altekruse S. www.impactjournals.com/oncotarget 60526 Oncotarget Mariotto A. SEER Cancer Statistics Review, 1975-2013, National Cancer Institute.
  • 3. Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin. 2017 Mar;67(2):93-99. doi: 10.3322/caac.21388
  • 4. Çelik EK, Han Ü, Mutlu M, Saylam G, Keseroğlu K, Bayır Ö, et al. Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis. B-ENT 2022;18(3),184-189.
  • 5. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001; 357: 539–45. https://doi.org/10.1016/S0140-6736(00)04046-0
  • 6. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420:860–67. https://doi.org/10.1038/nature01322
  • 7. Sabrkhany S, Griffioen AW, Oude Egbrink MGA. The role of blood platelets in tumor angiogenesis. Biochim Biophys Acta 2011; 1815: 189–196. https://doi.org/10.1016/j.bbcan.2010.12.001
  • 8. Shen XM, Xia YY, Lian L, Zhou C, Li XL, Han SG, et al. Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer. Oncol Lett. 2016; 12: 2501-6. https://doi.org/10.3892/ol.2016.4913
  • 9. Kemal Y, Demirağ G, Ekiz K, Yücel I. Mean platelet volume could be a useful biomarker for monitoring epithelial ovarian cancer. J Obstet Gynaecol. 2014; 34: 515-8. https://doi.org/10.3109/01443615.2014.912620
  • 10. Kumagai S, Tokuno J, Ueda Y, Marumo S, Shoji T, Nishimura T, et al. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer. Mol Clin Oncol. 2015; 3: 197-201. https://doi.org/10.3892/mco.2014.436
  • 11. Tanriverdi O, Menekse S, Teker F, Oktay E, Nur Pilanc K, Gunaldi M, et al. The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG). J BUON. 2016; 21: 840-50. (PMID: 27685904)
  • 12. Anand A, Raju K, Azeem Mohiyuddin SM. Significance of platelet parameters in squamous cell carcinoma of oral cavity - A case-control study. J Cancer Res Ther. 2022 Jul-Sep;18(4):1036-1041. doi: 10.4103/jcrt.jcrt_786_21
  • 13. Li C, Zhang H, Li S, Zhang D, Li J, Dionigi G, et al. Prognostic Impact of Inflammatory Markers PLR, LMR, PDW, MPV in Medullary Thyroid Carcinoma. Front Endocrinol (Lausanne). 2022 Mar 8;13:861869. doi: 10.3389/fendo.2022.861869.
  • 14. Zhang H, Liu L, Fu S, Liu YS, Wang C, Liu T, et al. Higher platelet distrubition width predicts poor prognosis in laryngeal cancer. Oncotarget 2017; 8(29): 48138-44. https://doi.org/10.18632/oncotarget.18306
  • 15. Hsueh C, Tao L, Zhang M, Cao W, Gong H, Zhou J, et al. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget. 2017 Mar 15;8(36):60514-60527. https://doi.org/10.18632/oncotarget.16234
  • 16. Zhang X, Lv Z, Yu H, Zhu J. The clinicopathological and prognostic role of thrombocytosis in patients with cancer: a meta-analysis. Oncol Lett. 2017;13:5002–8. https://doi.org/10.3892/ol.2017.6054
  • 17. Meikle CK, Kelly CA, Garg P, Wuescher LM, Ali RA, Worth RG. Cancer and thrombosis: the platelet perspective. Front Cell Dev Biol. 2016;2012 4:147. https://doi.org/10.3389/fcell.2016.00147
  • 18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation. Curr Pharm Des. 2011;17:47–58. https://doi.org/10.2174/138161211795049804
  • 19. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost. 2004;10:175–8. https://doi.org/10.1177/107602960401000208
  • 20. Bambace NM, Holmes CE. The platelet contribution to cancer progression. J Thromb Haemost. 2011;9:237–49. https://doi.org/10.1111/j.1538-7836.2010.04131.x
  • 21. Ye J, Liao B, Jiang X, Dong Z, Hu S, Liu Y, et al. Prognosis value of platelet counts, albumin and neutrophil-lymphocyte ratio of locoregional recurrence in patients with operable head and neck squamous cell carcinoma. Cancer Manag Res. 2020;12:731–41. https://doi.org/10.17.2147/CMAR.S234618
  • 22. Pardo L, Valero C, López M, García J, Camacho M, Quer M, et al. The prognostic value of pretreatment platelet count in patients with head and neck squamous cell carcinoma. Auris Nasus Larynx 2017;44:313–8. https://doi.org/10.1016/j.anl.2016.06.009
  • 23. Fu S, Liu L, Zhang X, Liu ZP, Wang RT. Platelet indices in laryngeal cancer. Cancer Biomark. 2018;21:675–80. https://doi.org/10.3233/CBM-170751
  • 24. Guo E, Zhang C, Guo L, Song K, Wang G, Duan C, et al. Prognostic value of platelet distribution width and mean platelet volume in patients with laryngeal cancer. Future Oncol. 2021;17:1025–37. https://doi.org/10.2217/fon-2020-0658
  • 25. Sheng X, Zhang H, Ge P, Chen L, Zhang S. A retrospective study of the prognostic significance of preoperative plasma fibrinogen, mean platelet volume, and the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Med Sci Monit. 2019;25:4527–34. https://doi.org/10.12659/MSM.914426
  • 26. Kara A, Guven M, Demir D, Yilmaz MS, Gundogan ME, Genc S. Are calculated ratios and red blood cell and platelet distribution width really important for the laryngeal cancer and precancerous larynx lesions. Niger J Clin Pract. 2019;22:701–6. https://doi.org/10.4103/njcp.njcp_478_18
  • 27. Sierko E, Wojtukiewicz MZ. Platelets and angiogenesis in malignancy. Semin Thromb Hemost. 2004;30:95–108. https://doi.org/10.1055/s-2004-822974
  • 28. Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas. 2004;29:132–40. https://doi.org/10.1097/00006676-200408000-00008
  • 29. Jain S, Harris J, Ware J. Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol. 2010;30:2362–7. https://doi.org/10.1161/ATVBAHA.110.207514
  • 30. Atasever Akkas E, Yucel B. Prognostic value of systemic immune inflammation index in patients with laryngeal cancer. Eur Arch Otorhinolaryngol. 2021;278:1945–55. https://doi.org/10.1007/s00405-021-06798-2
  • 31. Kara M, Uysal S, Altinisik U, Cevizci S, Güclü O, Dereköy FS. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2017;274:535–42. https://doi.org/10.1007/s00405-016-4250-8
  • 32. Wang J, Wang S, Song X, Zeng W, Wang S, Chen F, et al. The prognostic value of systemic and local inflammation in patients with laryngeal squamous cell carcinoma. Onco Targets Ther. 2016;9:7177–85. https://doi.org/10.2147/OTT.S113307
  • 33. Zhong B, Gu DY, Du JT, Chen F, Liu YF, Liu SX. May the change of platelet to lymphocyte ratio be a prognostic factor for T3–T4 laryngeal squamous cell carcinoma: a retrospective study. PLoS One. 2018;13:e0210033. https://doi.org/10.1371/journal.pone.0210033

Larenks skuamöz hücreli karsinomunda tedavi öncesi trombosit/lenfosit oranı, ortalama trombosit hacmi ve trombosit dağılım genişliğinin prognostik öngörülebilirliği: 594 hastanın analizi

Yıl 2025, Cilt: 58 Sayı: 1, 11 - 15, 04.05.2025

Sümeyra Doluoğlu , Gökhan Toptaş , Ömer Bayır , Emel Çadallı Tatar , Mehmet Hakan Korkmaz , Güleser Saylam

https://doi.org/10.20492/aeahtd.1602750

Öz

Aim: The objective of this study was to assess the impact of pre-treatment platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and platelet distribution width (PDW) on the prognosis of patients with laryngeal squamous cell cancer (LSCC).

Material and Method: The study population was divided into two groups: survivors (Group 1) and non-survivors (Group 2). Subsequently, we conducted a comprehensive comparison between the two groups with respect to a multitude of variables, including age, gender, smoking status, lesion localization, anterior commissure involvement, tumor T stage, N stage, M stage, early/advanced stage, and tumor pathological grade. ROC curve analysis was performed to estimate overall survival (OS). Then, groups were formed according to cut-off values and these groups were compared in terms of 3- and 5-year overall survival (OS) rates.

Results: The study included 594 patients who met the inclusion criteria. The survivor group consisted of 419 (70.5%) patients with a mean age of 59.8±9.18 years (Group 1) and the non-survivor group consisted of 175 (29.5%) patients with a mean age of 62.4±11.17 years (Group 2). PDW (cut-off value 16.35 fL) had the potential to predict cancer prognosis with a sensitivity of 78.3% and specificity of 52.2%. Furthermore, PLR (cut-off 123.64) could predict cancer prognosis with a sensitivity of 70.2% and specificity of 51.1%.

Conclusion: It was suggested that LSCC patients with PDW >16.35 fL and PLR >123.64% at the time of diagnosis should be more careful in treatment selection and follow-up.

Anahtar Kelimeler

Kan Trombositleri Laringeal neoplazmlar Ortalama trombosit hacmi Trombosit dağılım genişliği Sağkalım Analizi

Kaynakça

  • 1. Bray F, Ferlay J, Soarjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov; 68(6): 394-424. https://doi.org/10.3322/caac.21492
  • 2. Howlader N, Noone A, Krapcho M, Miller D, Bishop K, Altekruse S. www.impactjournals.com/oncotarget 60526 Oncotarget Mariotto A. SEER Cancer Statistics Review, 1975-2013, National Cancer Institute.
  • 3. Amin MB, Greene FL, Edge SB, Compton CC, Gershenwald JE, Brookland RK, et al. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging. CA Cancer J Clin. 2017 Mar;67(2):93-99. doi: 10.3322/caac.21388
  • 4. Çelik EK, Han Ü, Mutlu M, Saylam G, Keseroğlu K, Bayır Ö, et al. Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis. B-ENT 2022;18(3),184-189.
  • 5. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001; 357: 539–45. https://doi.org/10.1016/S0140-6736(00)04046-0
  • 6. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002; 420:860–67. https://doi.org/10.1038/nature01322
  • 7. Sabrkhany S, Griffioen AW, Oude Egbrink MGA. The role of blood platelets in tumor angiogenesis. Biochim Biophys Acta 2011; 1815: 189–196. https://doi.org/10.1016/j.bbcan.2010.12.001
  • 8. Shen XM, Xia YY, Lian L, Zhou C, Li XL, Han SG, et al. Mean platelet volume provides beneficial diagnostic and prognostic information for patients with resectable gastric cancer. Oncol Lett. 2016; 12: 2501-6. https://doi.org/10.3892/ol.2016.4913
  • 9. Kemal Y, Demirağ G, Ekiz K, Yücel I. Mean platelet volume could be a useful biomarker for monitoring epithelial ovarian cancer. J Obstet Gynaecol. 2014; 34: 515-8. https://doi.org/10.3109/01443615.2014.912620
  • 10. Kumagai S, Tokuno J, Ueda Y, Marumo S, Shoji T, Nishimura T, et al. Prognostic significance of preoperative mean platelet volume in resected non-small-cell lung cancer. Mol Clin Oncol. 2015; 3: 197-201. https://doi.org/10.3892/mco.2014.436
  • 11. Tanriverdi O, Menekse S, Teker F, Oktay E, Nur Pilanc K, Gunaldi M, et al. The mean platelet volume may predict the development of isolated bone metastases in patients with breast cancer: a retrospective study of the Young Researchers Committee of the Turkish Oncology Group (TOG). J BUON. 2016; 21: 840-50. (PMID: 27685904)
  • 12. Anand A, Raju K, Azeem Mohiyuddin SM. Significance of platelet parameters in squamous cell carcinoma of oral cavity - A case-control study. J Cancer Res Ther. 2022 Jul-Sep;18(4):1036-1041. doi: 10.4103/jcrt.jcrt_786_21
  • 13. Li C, Zhang H, Li S, Zhang D, Li J, Dionigi G, et al. Prognostic Impact of Inflammatory Markers PLR, LMR, PDW, MPV in Medullary Thyroid Carcinoma. Front Endocrinol (Lausanne). 2022 Mar 8;13:861869. doi: 10.3389/fendo.2022.861869.
  • 14. Zhang H, Liu L, Fu S, Liu YS, Wang C, Liu T, et al. Higher platelet distrubition width predicts poor prognosis in laryngeal cancer. Oncotarget 2017; 8(29): 48138-44. https://doi.org/10.18632/oncotarget.18306
  • 15. Hsueh C, Tao L, Zhang M, Cao W, Gong H, Zhou J, et al. The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer. Oncotarget. 2017 Mar 15;8(36):60514-60527. https://doi.org/10.18632/oncotarget.16234
  • 16. Zhang X, Lv Z, Yu H, Zhu J. The clinicopathological and prognostic role of thrombocytosis in patients with cancer: a meta-analysis. Oncol Lett. 2017;13:5002–8. https://doi.org/10.3892/ol.2017.6054
  • 17. Meikle CK, Kelly CA, Garg P, Wuescher LM, Ali RA, Worth RG. Cancer and thrombosis: the platelet perspective. Front Cell Dev Biol. 2016;2012 4:147. https://doi.org/10.3389/fcell.2016.00147
  • 18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: a link between thrombosis and inflammation. Curr Pharm Des. 2011;17:47–58. https://doi.org/10.2174/138161211795049804
  • 19. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Appl Thromb Hemost. 2004;10:175–8. https://doi.org/10.1177/107602960401000208
  • 20. Bambace NM, Holmes CE. The platelet contribution to cancer progression. J Thromb Haemost. 2011;9:237–49. https://doi.org/10.1111/j.1538-7836.2010.04131.x
  • 21. Ye J, Liao B, Jiang X, Dong Z, Hu S, Liu Y, et al. Prognosis value of platelet counts, albumin and neutrophil-lymphocyte ratio of locoregional recurrence in patients with operable head and neck squamous cell carcinoma. Cancer Manag Res. 2020;12:731–41. https://doi.org/10.17.2147/CMAR.S234618
  • 22. Pardo L, Valero C, López M, García J, Camacho M, Quer M, et al. The prognostic value of pretreatment platelet count in patients with head and neck squamous cell carcinoma. Auris Nasus Larynx 2017;44:313–8. https://doi.org/10.1016/j.anl.2016.06.009
  • 23. Fu S, Liu L, Zhang X, Liu ZP, Wang RT. Platelet indices in laryngeal cancer. Cancer Biomark. 2018;21:675–80. https://doi.org/10.3233/CBM-170751
  • 24. Guo E, Zhang C, Guo L, Song K, Wang G, Duan C, et al. Prognostic value of platelet distribution width and mean platelet volume in patients with laryngeal cancer. Future Oncol. 2021;17:1025–37. https://doi.org/10.2217/fon-2020-0658
  • 25. Sheng X, Zhang H, Ge P, Chen L, Zhang S. A retrospective study of the prognostic significance of preoperative plasma fibrinogen, mean platelet volume, and the neutrophil-to-lymphocyte ratio in patients with laryngeal squamous cell carcinoma. Med Sci Monit. 2019;25:4527–34. https://doi.org/10.12659/MSM.914426
  • 26. Kara A, Guven M, Demir D, Yilmaz MS, Gundogan ME, Genc S. Are calculated ratios and red blood cell and platelet distribution width really important for the laryngeal cancer and precancerous larynx lesions. Niger J Clin Pract. 2019;22:701–6. https://doi.org/10.4103/njcp.njcp_478_18
  • 27. Sierko E, Wojtukiewicz MZ. Platelets and angiogenesis in malignancy. Semin Thromb Hemost. 2004;30:95–108. https://doi.org/10.1055/s-2004-822974
  • 28. Suzuki K, Aiura K, Ueda M, Kitajima M. The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas. 2004;29:132–40. https://doi.org/10.1097/00006676-200408000-00008
  • 29. Jain S, Harris J, Ware J. Platelets: linking hemostasis and cancer. Arterioscler Thromb Vasc Biol. 2010;30:2362–7. https://doi.org/10.1161/ATVBAHA.110.207514
  • 30. Atasever Akkas E, Yucel B. Prognostic value of systemic immune inflammation index in patients with laryngeal cancer. Eur Arch Otorhinolaryngol. 2021;278:1945–55. https://doi.org/10.1007/s00405-021-06798-2
  • 31. Kara M, Uysal S, Altinisik U, Cevizci S, Güclü O, Dereköy FS. The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2017;274:535–42. https://doi.org/10.1007/s00405-016-4250-8
  • 32. Wang J, Wang S, Song X, Zeng W, Wang S, Chen F, et al. The prognostic value of systemic and local inflammation in patients with laryngeal squamous cell carcinoma. Onco Targets Ther. 2016;9:7177–85. https://doi.org/10.2147/OTT.S113307
  • 33. Zhong B, Gu DY, Du JT, Chen F, Liu YF, Liu SX. May the change of platelet to lymphocyte ratio be a prognostic factor for T3–T4 laryngeal squamous cell carcinoma: a retrospective study. PLoS One. 2018;13:e0210033. https://doi.org/10.1371/journal.pone.0210033
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kulak Burun Boğaz
Bölüm Araştırma Makalesi
Yazarlar

Sümeyra Doluoğlu 0000-0002-7264-6578

Gökhan Toptaş 0000-0003-2444-4450

Ömer Bayır 0000-0001-9445-6129

Emel Çadallı Tatar 0000-0003-3365-6308

Mehmet Hakan Korkmaz 0000-0001-8732-3061

Güleser Saylam 0000-0002-6499-7140

Yayımlanma Tarihi 4 Mayıs 2025
Gönderilme Tarihi 16 Aralık 2024
Kabul Tarihi 10 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 58 Sayı: 1

Kaynak Göster

AMA Doluoğlu S, Toptaş G, Bayır Ö, Çadallı Tatar E, Korkmaz MH, Saylam G. Prognostic predictivity of the pretreatment platelet-to-lymphocyte ratio, mean platelet volume and platelet distribution width in laryngeal squamous cell carcinoma: Analyses of 594 patients. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. Mayıs 2025;58(1):11-15. doi:10.20492/aeahtd.1602750
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