Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?

Özlem Ergin Beton

doi:10.4274/atfm.galenos.2023.47568

Araştırma Makalesi

Migren Atağı Kognitif Bozukluğa ve Beyaz Cevher Lezyonlarına Neden Olur mu?

Yıl 2023, Cilt: 76 Sayı: 3, 238 - 243, 24.10.2023

Özlem Ergin Beton

Öz

Amaç: Çalışmanın amacı migren atağı sırasındaki kognitif bozulma ile beyaz cevher lezyonları arasındaki ilişkinin yanı sıra migrenin, beyaz cevher lezyonlarının anatomik lokalizasyonları ile ilişkisini ortaya koymaktır.

Gereç ve Yöntem: Çalışma anketleri rutin muayene sırasında dolduruldu. Kognitif işlevleri değerlendirilmek için standartize mini-mental durum muayenesinden yararlanıldı. Hastaların demografik özellikleri ve migren özellikleri kaydedildi. Migrenin şiddetini test etmek için Migraine Disability Assessment Score, Headache Impact Test, ve Mig-Scog anketleri kullanıldı. Beyin manyetik rezonans görüntülemeleri (MRG) değerlendirildi; Beyaz cevher lezyonlarının tespiti ve skorlanması için Scheltens skorlama sistemi kullanıldı. Beyin MRG’sinde hiperintens lezyonların varlığına veya yokluğuna bağlı olarak hastalar iki alt gruba ayrıldı.

Bulgular: Yüz yirmi kadın (%86) ve 19 (%14) erkek hasta değerlendirildi. İki grup arasında demografik özellikler, yaş ve eğitim düzeylerine ilişkin istatistiksel olarak anlamlı farklılıklar ortaya çıktı. MRG’i normal olan hastaların hastalık süresi, beyaz cevher lezyonlarının olduğu grupla karşılaştırıldığında daha kısaydı. Mig-SCog anketlerine göre migren atakları sırasındaki bilişsel yakınmalar beyaz cevher lezyonları olan grupta istatistiksel olarak anlamlıydı. Migren süreleri daha uzun olan ve daha yüksek Mig-SCog skorları, derin beyaz cevher hiperintensiteleri ile koreleydi.

Sonuç: Migren atakları sırasında, altında yatan patofizyolojik süreç kognitif bozulmaya ve beyaz cevher değişikliklerine neden olabilir.

Anahtar Kelimeler: Migren, Kognisyon, Beyaz Cevher

Anahtar Kelimeler

Migren, Kognisyon, Beyaz Cevher

Etik Beyan

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

1. Dodick DW. Migraine. Lancet. 2018;391:1315-1330.
2. Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37:631-649.
3. Ertaş M, Siva A, Dalkara T, et al. Validity and reliability of the Turkish Migraine Disability Assessment (MIDAS) questionnaire. Headache. 2004;44:786-793.
4. Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain. 2012;13:147-157.
5. Herricks JR, Hotez PJ, Wanga V, et al. The global burden of disease study 2013: What does it mean for the NTDs? PLoS Negl Trop Dis. 2017;11:e0005424
6. Gil-Gouveia R, Oliveira AG, Martins IP. The impact of cognitive symptoms on migraine attack-related disability. Cephalalgia. 2016;36:422-430.
7. Polat B, Özge A, Yılmaz N, et al. Validity and reliability of the Turkish version of the mig-scog scale in migraine patients. Neurol Sci Neurophysiol. 2020;37:29.
8. Gil-Gouveia R, Martins IP. Cognition and Cognitive Impairment in Migraine. Curr Pain Headache Rep. 2019;23:84.
9. Tolner EA, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in migraine. Cephalalgia. 2019;39:1683-1699.
10. Huang L, Juan Dong H, Wang X, et al. Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials. J Headache Pain. 2017;18:54.
11. Vuralli D, Ayata C, Bolay H. Cognitive dysfunction and migraine. J Headache Pain. 2018;19:109.
12. Kruit MC, van Buchem MA, Hofman PA, et al. Migraine as a risk factor for subclinical brain lesions. JAMA. 2004;291:427-434.
13. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004;61:1366-1368.
14. Eikermann-Haerter K, Huang SY. White Matter Lesions in Migraine. Am J Pathol. 2021;191:1955-1962.
15. Güngen C, Ertan T, Eker E, et al. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği [Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg. 2002;13:273-281.
16. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1-211.
17. Stewart WF, Lipton RB, Kolodner K, et al. Reliability of the migraine disability assessment score in a population-based sample of headache sufferers. Cephalalgia. 1999;19:107-114.
18. Yang M, Rendas-Baum R, Varon SF, et al. Validation of the Headache Impact Test (HIT-6™) across episodic and chronic migraine. Cephalalgia. 2011;31:357-367.
19. Dikmen PY, Bozdağ M, Güneş M, et al. Reliability and Validity of Turkish Version of Headache Impact Test (HIT-6) in Patients with Migraine. Noro Psikiyatr Ars. 2020;58:300-307.
20. Gil-Gouveia R, Oliveira AG, Martins IP. A subjective cognitive impairment scale for migraine attacks. The MIG-SCOG: development and validation. Cephalalgia. 2011;31:984-991.
21. Palm-Meinders IH, Koppen H, Terwindt GM, et al. Structural brain changes in migraine. JAMA. 2012;308:1889-1897.
22. Gil-Gouveia R, Oliveira AG, Pavão Martins I. Clinical Utility of the Mig-SCog. Headache. 2016;56:941-951.
23. Trauninger A, Leél-Ossy E, Kamson DO, et al. Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients. J Headache Pain. 2011;12:97-103.
24. Rist PM, Dufouil C, Glymour MM, et al. Migraine and cognitive decline in the population-based EVA study. Cephalalgia. 2011;31:1291-1300.
25. Gaist D, Garde E, Blaabjerg M, et al. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study. Brain. 2016;139:2015-2023.
26. Fernando MS, Simpson JE, Matthews F, et al. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391-1398.
27. Caplan LR, Hennerici M. Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol. 1998;55:1475-1482.
28. Sam K, Crawley AP, Conklin J, et al. Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity. Ann Neurol. 2016;80:277-285.
29. Gil-Gouveia R, Oliveira AG, Martins IP. Assessment of cognitive dysfunction during migraine attacks: a systematic review. J Neurol. 2015;262:654-665.

Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?

Yıl 2023, Cilt: 76 Sayı: 3, 238 - 243, 24.10.2023

Özlem Ergin Beton

Öz

Objectives: The aim of the study is to better assess the association between cognitive impairment during migraine attacks and white matter lesions, in conjunction with the relation of anatomical localizations in migraineurs with white matter lesions.

Materials and Methods: Study questionnaires were filled during routine medical visitations. In the context of cognitive functions evaluation, the standardized mini-mental status examination was utilized. Patient demographics and migraine characteristics were carefully recorded. The Migraine Disability Assessment Score, the Headache Impact Test, and the Mig-SCog questionnaires were used to test the ultimate severity of the migraine. Brain magnetic resonance imaging (MRI) scans were evaluated with the benefit of hindsight; for detecting and scoring white matter lesions, the Scheltens scoring system was brought into play. Depending upon perceived presence or absence of hyperintense lesions in brain MRI, the patients were divided into a pair of specific subsections.

Results: One hundred twenty female (86%) and 19 (14%) male patients were evaluated, respectively. Statistically significant differences were uncovered between the two groupings related to their intrinsic demographics, age, and educational levels. Patients demonstrating normal MRI had shorter disease duration when juxtaposed with the grouping possessed of white matter lesions. As per Mig-SCog questionnaires, cognitive complaints during migraine attacks were statistically significant within the tranche with white matter lesions. Interestingly, longer durations of migraine and higher Mig-SCog scores were correlated with deep white matter hyperintensities.

Conclusion: During instances of migraine attack, the underlying migraine pathophysiological process can significantly influence cognitive impairment and noticeable alterations to white matter.

Key Words: Migraine, Cognition, White Matter

Anahtar Kelimeler

Migraine, Cognition, White Matter

Etik Beyan

Ethics Committee Approval: The study was approved by the Ankara City Hospital No: 1 Clinical Research Ethics Committee (date: 02.17.2021, decision no: E1/1476/2021). Informed Consent: Retrospective cross-sectional study. Peer-review: Externally peer-reviewed.

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

1. Dodick DW. Migraine. Lancet. 2018;391:1315-1330.
2. Burch RC, Buse DC, Lipton RB. Migraine: Epidemiology, Burden, and Comorbidity. Neurol Clin. 2019;37:631-649.
3. Ertaş M, Siva A, Dalkara T, et al. Validity and reliability of the Turkish Migraine Disability Assessment (MIDAS) questionnaire. Headache. 2004;44:786-793.
4. Ertas M, Baykan B, Orhan EK, et al. One-year prevalence and the impact of migraine and tension-type headache in Turkey: a nationwide home-based study in adults. J Headache Pain. 2012;13:147-157.
5. Herricks JR, Hotez PJ, Wanga V, et al. The global burden of disease study 2013: What does it mean for the NTDs? PLoS Negl Trop Dis. 2017;11:e0005424
6. Gil-Gouveia R, Oliveira AG, Martins IP. The impact of cognitive symptoms on migraine attack-related disability. Cephalalgia. 2016;36:422-430.
7. Polat B, Özge A, Yılmaz N, et al. Validity and reliability of the Turkish version of the mig-scog scale in migraine patients. Neurol Sci Neurophysiol. 2020;37:29.
8. Gil-Gouveia R, Martins IP. Cognition and Cognitive Impairment in Migraine. Curr Pain Headache Rep. 2019;23:84.
9. Tolner EA, Chen SP, Eikermann-Haerter K. Current understanding of cortical structure and function in migraine. Cephalalgia. 2019;39:1683-1699.
10. Huang L, Juan Dong H, Wang X, et al. Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials. J Headache Pain. 2017;18:54.
11. Vuralli D, Ayata C, Bolay H. Cognitive dysfunction and migraine. J Headache Pain. 2018;19:109.
12. Kruit MC, van Buchem MA, Hofman PA, et al. Migraine as a risk factor for subclinical brain lesions. JAMA. 2004;291:427-434.
13. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004;61:1366-1368.
14. Eikermann-Haerter K, Huang SY. White Matter Lesions in Migraine. Am J Pathol. 2021;191:1955-1962.
15. Güngen C, Ertan T, Eker E, et al. Standardize Mini Mental test’in türk toplumunda hafif demans tanisinda geçerlik ve güvenilirliği [Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population]. Turk Psikiyatri Derg. 2002;13:273-281.
16. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1-211.
17. Stewart WF, Lipton RB, Kolodner K, et al. Reliability of the migraine disability assessment score in a population-based sample of headache sufferers. Cephalalgia. 1999;19:107-114.
18. Yang M, Rendas-Baum R, Varon SF, et al. Validation of the Headache Impact Test (HIT-6™) across episodic and chronic migraine. Cephalalgia. 2011;31:357-367.
19. Dikmen PY, Bozdağ M, Güneş M, et al. Reliability and Validity of Turkish Version of Headache Impact Test (HIT-6) in Patients with Migraine. Noro Psikiyatr Ars. 2020;58:300-307.
20. Gil-Gouveia R, Oliveira AG, Martins IP. A subjective cognitive impairment scale for migraine attacks. The MIG-SCOG: development and validation. Cephalalgia. 2011;31:984-991.
21. Palm-Meinders IH, Koppen H, Terwindt GM, et al. Structural brain changes in migraine. JAMA. 2012;308:1889-1897.
22. Gil-Gouveia R, Oliveira AG, Pavão Martins I. Clinical Utility of the Mig-SCog. Headache. 2016;56:941-951.
23. Trauninger A, Leél-Ossy E, Kamson DO, et al. Risk factors of migraine-related brain white matter hyperintensities: an investigation of 186 patients. J Headache Pain. 2011;12:97-103.
24. Rist PM, Dufouil C, Glymour MM, et al. Migraine and cognitive decline in the population-based EVA study. Cephalalgia. 2011;31:1291-1300.
25. Gaist D, Garde E, Blaabjerg M, et al. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study. Brain. 2016;139:2015-2023.
26. Fernando MS, Simpson JE, Matthews F, et al. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391-1398.
27. Caplan LR, Hennerici M. Impaired clearance of emboli (washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol. 1998;55:1475-1482.
28. Sam K, Crawley AP, Conklin J, et al. Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity. Ann Neurol. 2016;80:277-285.
29. Gil-Gouveia R, Oliveira AG, Martins IP. Assessment of cognitive dysfunction during migraine attacks: a systematic review. J Neurol. 2015;262:654-665.

Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Beyin ve Sinir Cerrahisi (Nöroşirurji), Nöroloji ve Nöromüsküler Hastalıklar
Bölüm	Makaleler
Yazarlar	Özlem Ergin Beton 0000-0002-9982-3650
Proje Numarası	-
Yayımlanma Tarihi	24 Ekim 2023
Yayımlandığı Sayı	Yıl 2023 Cilt: 76 Sayı: 3

Kaynak Göster

APA	Ergin Beton, Ö. (2023). Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 76(3), 238-243. https://doi.org/10.4274/atfm.galenos.2023.47568
AMA	Ergin Beton Ö. Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Ekim 2023;76(3):238-243. doi:10.4274/atfm.galenos.2023.47568
Chicago	Ergin Beton, Özlem. “Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 76, sy. 3 (Ekim 2023): 238-43. https://doi.org/10.4274/atfm.galenos.2023.47568.
EndNote	Ergin Beton Ö (01 Ekim 2023) Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?. Ankara Üniversitesi Tıp Fakültesi Mecmuası 76 3 238–243.
IEEE	Ö. Ergin Beton, “Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 76, sy. 3, ss. 238–243, 2023, doi: 10.4274/atfm.galenos.2023.47568.
ISNAD	Ergin Beton, Özlem. “Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 76/3 (Ekim 2023), 238-243. https://doi.org/10.4274/atfm.galenos.2023.47568.
JAMA	Ergin Beton Ö. Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2023;76:238–243.
MLA	Ergin Beton, Özlem. “Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 76, sy. 3, 2023, ss. 238-43, doi:10.4274/atfm.galenos.2023.47568.
Vancouver	Ergin Beton Ö. Does Migraine Attack Cause Cognitive Impairment and White Matter Lesions?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2023;76(3):238-43.

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