Araştırma Makalesi
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Yıl 2022, Cilt: 75 Sayı: 2, 199 - 203, 30.06.2022

Emra Asfuroğlu Kalkan

Öz

Anahtar Kelimeler

Çölyak Hastalığı Marsh Sınıflaması Platelet İndeksleri Platelet/Lenfosit Oranı

Proje Numarası

-

Kaynakça

  • 1. Lundin KE, Sollid LM. Advances in coeliac disease. Curr Opin Gastroenterol. 2014;30:154-162.
  • 2. Bai D, Brar P, Holleran D, et al. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005;40:183-187.
  • 3. Sategna C, Solerio E, Scaglione N, et al. Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders. Gut. 2001;49:502-505.
  • 4. Niewinski MM. Advences in Celiac Disease and Gluten-Free Diet. J Am Diet Assoc. 2008;108:661-672.
  • 5. Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012;107:1538-44; quiz 1537, 1545.
  • 6. Ciclitera PJ, Evans DJ, Fagg NL, et al. Clinical testing of gliadin fractions on coeliac disease. Clin Science. 2004;66:357-364.
  • 7. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology. 1992;102:330-354.
  • 8. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636-651.
  • 9. Ifran A, Haşimi A, Kaptan K, et al. Evaluation of platelet parameters in healthy apheresis donors using the ADVIA 120. Transfus Apher Sci. 2005;33:87-90.
  • 10. Proctor MJ, Morrison DS, Talwar D, et al. A comparison of inflammationbased prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 2011;47:2633-2641.
  • 11. Bao F, Green P, Bhagat G, et al. An update on celiac disease histopathology and the road ahead. Arch Pathol Lab Med. 2012;136:735-745.
  • 12. Lebwohl B, Rubio-Tapia A, Assiri A, et al. Diagnosis of celiac disease. Gastrointest Endosc Clin N Am. 2012;22:661-677.
  • 13. Goldman L, Schafer AI. Goldman-Cecil Medicine 25th edition vol: 1, Chapter: 140;929-931, 2016.
  • 14. Freeman HJ, Chopra A, Clandinin MT, et al. Recent advances in celiac disease. World J Gastroenterol. 2011;17:2259-2272.
  • 15. Kaplan MJ. Role of neutrophils in systemic autoimmune diseases. Arthritis Res Ther. 2013;15:219-228.
  • 16. Yıldız F, Gökmen O. Haematologic indices and disease activity index in primary Sjogren’s syndrome. Int J Clin Pract. 2021;75:e13992. Epub 2021 Jan 19
  • 17. Tezcan D, Körez MK, Gülcemal S et al. Evaluation of diagnostic performance of haematological parameters in Behçet’s disease. Int J Clin Pract. 2021;75:e14638.
  • 18. Sen BB, Rifaioglu EN, Ekiz O, et al. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol. 2014;33:223-227.
  • 19. Qin B, Ma N, Tang Q, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26:372-376.
  • 20. Fu H, Qin B, Hu Z, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269-273.
  • 21. Yuri Gasparyan A, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47- 58.
  • 22. Carrol ED, Thomson APJ, Hart CA. Procalcitonin as a marker of sepsis. Int JAntimicrob Agents. 2002;20:1-9.

Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients

Yıl 2022, Cilt: 75 Sayı: 2, 199 - 203, 30.06.2022

Emra Asfuroğlu Kalkan

Öz

Objectives: Celiac disease is an autoimmune and inflammatory disease induced by dietary gluten in genetically susceptible individuals. The most important diagnostic method in celiac disease is histopathological examination, and Marsh classification. It is known that in some inflammatory diseases, systemic inflammatory response markers such as mean platelet volume (MPV), plateletcrit (PCT) and platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) are of diagnostic importance. Our aim in this study is to investigate the importance of systemic inflammatory response markers in determining the Marsh classification

Materials and Methods: Two hundred and fifty patients with gluten sensitive enteropathy were investigated by using MPV, PCT, PLR, and NLR. Patients were stratified into five groups; Group I: Marsh type 1, Group II: Marsh type 2, Group III: Marsh type 3, Group IV: increased intraepithelial lymphocytes, and also one group involving control group (Group V). Results: 250 newly diagnosed celiac patients were divided into 3 groups as Group I (Marsh type 1, n=109), Group II (type 2, n=11) and Group III (type
3, n=130) according to the Marsh classification. Fifty patients with increased intraepithelial lymphocytes (Group IV) and 150 patients with normal duodenal biopsy were taken as the control group (Group V). Patients and control groups were compared in terms of MPV, PCT, PLR, and NLR values.

Conclusion: MPV (8.7±1.07 vs 8.7±1.2 fL, p=0.922), PCT (0.24±0.06 vs 0.22±0.07, p=0.145) and PLR (144.28±61.54 vs 148.59±89.71, p=0.711) values
did not differ compared to the controls. As a result, it is not appropriate to use MPV, PCT, PLR, and NLR in determining the Marsh classification.

Anahtar Kelimeler

Çölyak Hastalığı Marsh Sınıflaması Platelet İndeksleri Platelet/Lenfosit Oranı

Etik Beyan

Ethics Committee Approval: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ankara City Hospital Ethics Committee (approval no: E2- 22-1447). Informed Consent: Retrospective study. Peer-reviewed: Externally peer-reviewed. Financial Disclosure: The author received no financial support for the research and/or authorship of this article.

Destekleyen Kurum

-

Proje Numarası

-

Teşekkür

-

Kaynakça

  • 1. Lundin KE, Sollid LM. Advances in coeliac disease. Curr Opin Gastroenterol. 2014;30:154-162.
  • 2. Bai D, Brar P, Holleran D, et al. Effect of gender on the manifestations of celiac disease: evidence for greater malabsorption in men. Scand J Gastroenterol. 2005;40:183-187.
  • 3. Sategna C, Solerio E, Scaglione N, et al. Duration of gluten exposure in adult coeliac disease does not correlate with the risk for autoimmune disorders. Gut. 2001;49:502-505.
  • 4. Niewinski MM. Advences in Celiac Disease and Gluten-Free Diet. J Am Diet Assoc. 2008;108:661-672.
  • 5. Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol. 2012;107:1538-44; quiz 1537, 1545.
  • 6. Ciclitera PJ, Evans DJ, Fagg NL, et al. Clinical testing of gliadin fractions on coeliac disease. Clin Science. 2004;66:357-364.
  • 7. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (‘celiac sprue’). Gastroenterology. 1992;102:330-354.
  • 8. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology. 2001;120:636-651.
  • 9. Ifran A, Haşimi A, Kaptan K, et al. Evaluation of platelet parameters in healthy apheresis donors using the ADVIA 120. Transfus Apher Sci. 2005;33:87-90.
  • 10. Proctor MJ, Morrison DS, Talwar D, et al. A comparison of inflammationbased prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 2011;47:2633-2641.
  • 11. Bao F, Green P, Bhagat G, et al. An update on celiac disease histopathology and the road ahead. Arch Pathol Lab Med. 2012;136:735-745.
  • 12. Lebwohl B, Rubio-Tapia A, Assiri A, et al. Diagnosis of celiac disease. Gastrointest Endosc Clin N Am. 2012;22:661-677.
  • 13. Goldman L, Schafer AI. Goldman-Cecil Medicine 25th edition vol: 1, Chapter: 140;929-931, 2016.
  • 14. Freeman HJ, Chopra A, Clandinin MT, et al. Recent advances in celiac disease. World J Gastroenterol. 2011;17:2259-2272.
  • 15. Kaplan MJ. Role of neutrophils in systemic autoimmune diseases. Arthritis Res Ther. 2013;15:219-228.
  • 16. Yıldız F, Gökmen O. Haematologic indices and disease activity index in primary Sjogren’s syndrome. Int J Clin Pract. 2021;75:e13992. Epub 2021 Jan 19
  • 17. Tezcan D, Körez MK, Gülcemal S et al. Evaluation of diagnostic performance of haematological parameters in Behçet’s disease. Int J Clin Pract. 2021;75:e14638.
  • 18. Sen BB, Rifaioglu EN, Ekiz O, et al. Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis. Cutan Ocul Toxicol. 2014;33:223-227.
  • 19. Qin B, Ma N, Tang Q, et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26:372-376.
  • 20. Fu H, Qin B, Hu Z, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269-273.
  • 21. Yuri Gasparyan A, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47- 58.
  • 22. Carrol ED, Thomson APJ, Hart CA. Procalcitonin as a marker of sepsis. Int JAntimicrob Agents. 2002;20:1-9.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gastroenteroloji ve Hepatoloji
Bölüm Makaleler
Yazarlar

Emra Asfuroğlu Kalkan 0000-0002-6017-6142

Proje Numarası -
Yayımlanma Tarihi 30 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 75 Sayı: 2

Kaynak Göster

APA Asfuroğlu Kalkan, E. (2022). Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 75(2), 199-203. https://doi.org/10.4274/atfm.galenos.2022.62207
AMA Asfuroğlu Kalkan E. Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Haziran 2022;75(2):199-203. doi:10.4274/atfm.galenos.2022.62207
Chicago Asfuroğlu Kalkan, Emra. “Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75, sy. 2 (Haziran 2022): 199-203. https://doi.org/10.4274/atfm.galenos.2022.62207.
EndNote Asfuroğlu Kalkan E (01 Haziran 2022) Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75 2 199–203.
IEEE E. Asfuroğlu Kalkan, “Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 75, sy. 2, ss. 199–203, 2022, doi: 10.4274/atfm.galenos.2022.62207.
ISNAD Asfuroğlu Kalkan, Emra. “Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 75/2 (Haziran 2022), 199-203. https://doi.org/10.4274/atfm.galenos.2022.62207.
JAMA Asfuroğlu Kalkan E. Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75:199–203.
MLA Asfuroğlu Kalkan, Emra. “Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 75, sy. 2, 2022, ss. 199-03, doi:10.4274/atfm.galenos.2022.62207.
Vancouver Asfuroğlu Kalkan E. Platelet Indices in Determination of Marsh Classification in New Diagnosed Celiac Patients. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2022;75(2):199-203.
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