Araştırma Makalesi
BibTex RIS Kaynak Göster

Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?

Yıl 2019, Cilt: 72 Sayı: 1, 106 - 110, 13.06.2019

Ahmet Cem Dural

Öz

Objectives: The purpose of this study was to calculate the long-axis-to-short axis ratio of breast masses pre-diagnosed as fibroadenoma (FA) on ultrasonography and determine its role in predicting malignancy.

Materials and Methods: Between January 2011 and March 2014, 1,154 patients who underwent tru-cut biopsy for the evaluation of solid breast masses encountered on imaging were evaluated. Of these, patients with breast masses that were diagnosed as FA based on ultrasonographic findings were included (n=707) into the study. The long axis ratio of lesions with only 1-2 lobulations or had well circumscribed borders, homogenous echogenicity was measured parallel to the skin. The patient’s clinical characteristics and demographic data, imaging and pathology findings were reviewed.

Results: Pathology findings revealed malignancy in 13 (1.8%) patients. Two of these were <40 years and 11 of them were >40 years (p=0.003). The long axis-short axis ratio was 1.8 for the benign cases and 1.4 for the malignant cases. The cut off value of the two ratios was calculated to be 1.4 (p=0.001). Most of the lesions were on right side and upper outer quadrant (n=394, 55.7% and n=389, 55% respectively). The rate of malignancy was similar according to location.

Conclusion: Breast masses diagnosed as FA based on imaging with a long axis to short axis ratio less than 1.4 may be at an increased risk for malignancy despite the presence of benign sonographic features. In patients older than 40 with notable risk factors, a detailed review of pathological findings is strongly encouraged.

Anahtar Kelimeler

Fibroadenoma Benign Breast Mass Breast Imaging

Etik Beyan

Ethics Committee Approval: Bakırkoy Dr. Sadi Konuk Training and Research Hospital Ethical Committee for Clinical Research (Nr: 2014/09/26). Informed Consent: A written consent was obtained from all patients. Peer-review: Externally peer-reviewed. Authorship Contributions Surgical and Medical Practices: A.S., M.G.Ü., E.Ö., H.F.B., Concept: A.S., M.F.Ç., A.C.D., H.A., Design: M.G.Ü., A.S., M.F.Ç.,S.K., Data Collection or Processing: A.S., H.F.B., E.Ö., Analysis or Interpretation: S.K., H.A., A.C.D., Literature Search: A.C.D., H.F.B., Writing: A.S., M.G.Ü. Conflict of Interest: No conflict of interest was declared by the authors. Financial Disclosure: The authors declared that this study received no financial support.

Destekleyen Kurum

-

Proje Numarası

-

Teşekkür

-

Kaynakça

  • 1. Amin AL, Purdy AC, Mattingly JD, et al. Benign breast disease. Surg Clin North Am. 2013;93:299-308.
  • 2. Jayasinghe Y, Simmons PS. Fibroadenomas in adolescence. Curr Opin Obstet Gynecol. 2009;21:402-406.
  • 3. Rosen PP. Fibroepithelial lesions. Rosen’s Breast Pathology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001;p.163-200.
  • 4. Kuijper A, Mommers EC, van der Wall E, et al. Histopathology of fibroadenoma of the breast. Am J Clin Pathol. 2001;115:736-742.
  • 5. Malt RA. Morris PJ. Benign condition of breast. Oxford Textbook of Surgery. New York: Oxford University Press. 1994;p.796-799.
  • 6. Bland KI, Copeland EM. The Breast. 4th ed. Philadelphia: Saunders; 2009.
  • 7. Sikora K. Genes, dreams and cancer. BMJ. 1994;308:1217-1221
  • 8. Moy L, Heller SL, Bailey L, et al. ACR Appropriateness Criteria® Palpable Breast Masses. J Am Coll Radiol. 2017 May;14(5S):S203-S224.
  • 9. Greenberg R, Skornick Y, Kaplan O. Management of breast fibroadeomas. J Gen Intern Med. 1998;13: 640-645.
  • 10. Dixon JM . Cystic disease and fibroadenoma of the breast: natural history and relation to breast cancer risk. Br Med Bull. 1991;47:258-271.
  • 11. Dupont WD, Page DL, Parl FF et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med. 1994; 331:10-15
  • 12. Markopoulos C, Kouskos E, Mantas D, et al. Fibroadenomas of the breast: is there any association with breast cancer? Eur J Gynaecol Oncol. 2004;25:495-497.
  • 13. Rosen PR. Rosen’s Breast Pathology. 3nd ed. Philadelphia: Lippincott Williams & Wilkins 2009;p.1-32.
  • 14. Heywang-Kobrunner SH. Diagnostic Breast Imaging. 2nd ed. New York: Thieme, 2001;p.162-208.
  • 15. Stavros AT, Thickman D, Rapp CL, et al. Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. Radiology. 1995;196:123-134.
  • 16. Dewitt JE. Benign disorders of the breast in older women. Surg Gynecol Obstet. 1986;162:340-342.
  • 17. Mansel RE, Webster DJT, Sweetland HM et al. Fibroadenoma and related tumors. Benign Disorders and Diseases of the Breast. 3rd ed. Edinburgh: Saunders. 2009;p.81-106.
  • 18. Jonhson AT, Henry-Tillman RS, Smith LF, et al. Percutaneous excisional breast biopsy. Am J Surg. 2002;184:550-554.
  • 19. Trapido EJ, Brinton LA, Schairer C, et al. Estrogen replacement therapy and benign breast disease. J Natl Cancer Inst. 1984;73:1101-1105.
  • 20. Yu H, Rohan TE, Cook MG, et al. Risk factors for fibroadenoma: a casecontrol study in Australia. Am J Epidemiol. 1992;135:247-258.
  • 21. Hindle WH, Alonzo LJ. Conservative management of breast fibroadenomas. Am J Obstet Gynecol. 1991;164:1647-1650.
  • 22. McDivitt RW, Stevens JA, Lee NC, et al. Histologic types of benign breast disease and the risk for breast cancer. The Cancer and Steroid Hormone Study Group. Cancer. 1992;69:1408-1414.
  • 23. Levi F, Randimbison L, Te VC, et al. Incidence of breast cancer in women with fibroadenoma. Int J Cancer. 1994;57:681-683.
  • 24. Cant PJ, Madden MV, Coleman MG, et al. Non-operative management of breast masses diagnosed as fibroadenoma. Br J Surg. 1995;82:792-794.
  • 25. American College of Radiology. Breast Imaging Reporting and Data System, Breast Imaging Atlas. First ed. Reston, VA:American College of Radiology;2003.
  • 26. Malik G, Waqar F, Buledi GQ. Sonomammography for evaluation of solid breast masses in young patients. J Ayub Med Coll Abbottabad. 2006;18:34-37.
  • 27. Clavel-Chapelon F, Gerber M. Reproductive factors and breast cancer risk. Do they differ according to age at diagnosis? Breast Cancer Res Treat. 2002;72:107-115.
  • 28. Rogers C, Thompson K, Robinson S. Intoducing A Breast Health Strategy into Schools. Health Education 2002;12:106-112.

Yıl 2019, Cilt: 72 Sayı: 1, 106 - 110, 13.06.2019

Ahmet Cem Dural

Öz

Proje Numarası

-

Kaynakça

  • 1. Amin AL, Purdy AC, Mattingly JD, et al. Benign breast disease. Surg Clin North Am. 2013;93:299-308.
  • 2. Jayasinghe Y, Simmons PS. Fibroadenomas in adolescence. Curr Opin Obstet Gynecol. 2009;21:402-406.
  • 3. Rosen PP. Fibroepithelial lesions. Rosen’s Breast Pathology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001;p.163-200.
  • 4. Kuijper A, Mommers EC, van der Wall E, et al. Histopathology of fibroadenoma of the breast. Am J Clin Pathol. 2001;115:736-742.
  • 5. Malt RA. Morris PJ. Benign condition of breast. Oxford Textbook of Surgery. New York: Oxford University Press. 1994;p.796-799.
  • 6. Bland KI, Copeland EM. The Breast. 4th ed. Philadelphia: Saunders; 2009.
  • 7. Sikora K. Genes, dreams and cancer. BMJ. 1994;308:1217-1221
  • 8. Moy L, Heller SL, Bailey L, et al. ACR Appropriateness Criteria® Palpable Breast Masses. J Am Coll Radiol. 2017 May;14(5S):S203-S224.
  • 9. Greenberg R, Skornick Y, Kaplan O. Management of breast fibroadeomas. J Gen Intern Med. 1998;13: 640-645.
  • 10. Dixon JM . Cystic disease and fibroadenoma of the breast: natural history and relation to breast cancer risk. Br Med Bull. 1991;47:258-271.
  • 11. Dupont WD, Page DL, Parl FF et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med. 1994; 331:10-15
  • 12. Markopoulos C, Kouskos E, Mantas D, et al. Fibroadenomas of the breast: is there any association with breast cancer? Eur J Gynaecol Oncol. 2004;25:495-497.
  • 13. Rosen PR. Rosen’s Breast Pathology. 3nd ed. Philadelphia: Lippincott Williams & Wilkins 2009;p.1-32.
  • 14. Heywang-Kobrunner SH. Diagnostic Breast Imaging. 2nd ed. New York: Thieme, 2001;p.162-208.
  • 15. Stavros AT, Thickman D, Rapp CL, et al. Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. Radiology. 1995;196:123-134.
  • 16. Dewitt JE. Benign disorders of the breast in older women. Surg Gynecol Obstet. 1986;162:340-342.
  • 17. Mansel RE, Webster DJT, Sweetland HM et al. Fibroadenoma and related tumors. Benign Disorders and Diseases of the Breast. 3rd ed. Edinburgh: Saunders. 2009;p.81-106.
  • 18. Jonhson AT, Henry-Tillman RS, Smith LF, et al. Percutaneous excisional breast biopsy. Am J Surg. 2002;184:550-554.
  • 19. Trapido EJ, Brinton LA, Schairer C, et al. Estrogen replacement therapy and benign breast disease. J Natl Cancer Inst. 1984;73:1101-1105.
  • 20. Yu H, Rohan TE, Cook MG, et al. Risk factors for fibroadenoma: a casecontrol study in Australia. Am J Epidemiol. 1992;135:247-258.
  • 21. Hindle WH, Alonzo LJ. Conservative management of breast fibroadenomas. Am J Obstet Gynecol. 1991;164:1647-1650.
  • 22. McDivitt RW, Stevens JA, Lee NC, et al. Histologic types of benign breast disease and the risk for breast cancer. The Cancer and Steroid Hormone Study Group. Cancer. 1992;69:1408-1414.
  • 23. Levi F, Randimbison L, Te VC, et al. Incidence of breast cancer in women with fibroadenoma. Int J Cancer. 1994;57:681-683.
  • 24. Cant PJ, Madden MV, Coleman MG, et al. Non-operative management of breast masses diagnosed as fibroadenoma. Br J Surg. 1995;82:792-794.
  • 25. American College of Radiology. Breast Imaging Reporting and Data System, Breast Imaging Atlas. First ed. Reston, VA:American College of Radiology;2003.
  • 26. Malik G, Waqar F, Buledi GQ. Sonomammography for evaluation of solid breast masses in young patients. J Ayub Med Coll Abbottabad. 2006;18:34-37.
  • 27. Clavel-Chapelon F, Gerber M. Reproductive factors and breast cancer risk. Do they differ according to age at diagnosis? Breast Cancer Res Treat. 2002;72:107-115.
  • 28. Rogers C, Thompson K, Robinson S. Intoducing A Breast Health Strategy into Schools. Health Education 2002;12:106-112.
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Genel Cerrahi
Bölüm Makaleler
Yazarlar

Ahmet Cem Dural 0000-0003-3479-725X

Proje Numarası -
Yayımlanma Tarihi 13 Haziran 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 72 Sayı: 1

Kaynak Göster

APA Dural, A. C. (2019). Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 72(1), 106-110. https://doi.org/10.4274/atfm.galenos.2019.47966
AMA Dural AC. Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Haziran 2019;72(1):106-110. doi:10.4274/atfm.galenos.2019.47966
Chicago Dural, Ahmet Cem. “Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed As Fibroadenomas on Ultrasonography. Can It Be a Useful Tool in Predicting Malignancy?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72, sy. 1 (Haziran 2019): 106-10. https://doi.org/10.4274/atfm.galenos.2019.47966.
EndNote Dural AC (01 Haziran 2019) Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72 1 106–110.
IEEE A. C. Dural, “Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 72, sy. 1, ss. 106–110, 2019, doi: 10.4274/atfm.galenos.2019.47966.
ISNAD Dural, Ahmet Cem. “Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed As Fibroadenomas on Ultrasonography. Can It Be a Useful Tool in Predicting Malignancy?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 72/1 (Haziran 2019), 106-110. https://doi.org/10.4274/atfm.galenos.2019.47966.
JAMA Dural AC. Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2019;72:106–110.
MLA Dural, Ahmet Cem. “Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed As Fibroadenomas on Ultrasonography. Can It Be a Useful Tool in Predicting Malignancy?”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 72, sy. 1, 2019, ss. 106-10, doi:10.4274/atfm.galenos.2019.47966.
Vancouver Dural AC. Long Axis to Short Axis Ratio of Breast Masses Pre-Diagnosed as Fibroadenomas on Ultrasonography. Can it Be a Useful Tool in Predicting Malignancy?. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2019;72(1):106-10.
 Kapak Resmi İndir