New Approachesin the Diagnosis and Treatment of Infantile Colic

Filiz Şimşek Orhon

Derleme

İnfantil Kolik Tanı ve Tedavisinde Güncel Yaklaşımlar

Yıl 2016, Cilt: 69 Sayı: 3, 159 - 166, 21.12.2016

Filiz Şimşek Orhon

Öz

Bebeklik döneminde ağlama düzenleyici bir işlevdir. İnfantil kolik; sağlıklı büyüyen bir bebekte günün belirli
saatlerinde meydana gelen, 3-4. aya kadar devam eden ve hiçbir nedene bağlanamayan ağlama krizleridir.
İnfantil kolik sıklığı %10-40 arasında olup kesin nedeni bilinmemektedir. Etiyolojide; gastrointestinal, nörogelişimsel ve psikososyal nedenler tartışılmaktadır. Kolikli bebeklerde fiziksel istismar riskinin artmış olduğu, hiperaktivite ve akademik zorluklar gibi davranışsal sorunların görüldüğü bildirilmektedir. Ayrıca kolikli bebeğin
ebeveyninde tükenmişlik, yorgunluk ve depresyon gibi bulguların gelişebileceği bildirilmektedir. İnfantil kolikli bebeğe yaklaşımda; bebeğin ağlamasının süresi ve şiddeti ve ağlama krizine eşlik eden özellikler ayrıntılı
olarak değerlendirilmelidir. Bebeğin ayrıntılı bir muayenesi yapılmalı, büyüme ve gelişimi değerlendirilmelidir. Diğer hastalıkların dışlanması sonucunda infantil kolik tanısı konduğunda aileler ayrıntılı olarak bilgilendirilmelidir. İnfantil kolik tedavisinde uygulanan yaklaşımlar; beslenme önerileri, alternatif besinler, farmakolojik
tedavi, fiziksel destek tedavileri ve davranışsal tedavilerdir. Çalışmalarda; infantil koliğin tedavisinde etkinliği
kesin olarak kanıtlanmış bir tedavi yöntemi bulunmamaktadır. Ailelerin koliğin genellikle geçici bir durum olduğu konusunda bilgilendirilmesi, rahatlatılması ve desteklenmesi çok önemlidir.

Anahtar Kelimeler

İnfantil Kolik, Tanı, Tedavi

Etik Beyan

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

1. Newman JD. Neural circuits underlying crying and cry responding in mammals. Behavioral Brain Resarch 2007;182:155- 165.
2. Hiscock H, Jordan B. Problem crying in infancy. Med J Aust 2004;181:507-512.
3. Fleisher DR. Infant colic. In: Faure C et al. editors. Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children, Clinical Gastroenterology, DOI 10.1007/978-1-60761-709- 9_31, New York: Springer Science Business Media; 2013. p. 347-354.
4. Kaley F, Reid V, Flynn EG. The psychology of infant colic: a review of current research. Infant Mental Health J 2011;32: 526–541.
5. Wessel MA, Cobb JC, Jackson EB, et al. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954;14:421-435.
6. Milla P, Hyman PE, Benninga M, et al. Infant colic. Functional gastrointestinal disorders-Rome III. McLean, VA: Degnon Associates, Inc.; 2006. p. 699–7703.
7. Akhnikh S, Engelberts AC, van Sleuwen BE, et al. The excessively crying infant: etiology and treatment . Pediatric Annals 2014;43:e69-e75.
8. Engler AC, Etzioni T, Pillar G. Sleep and Colic. In: Sheldon SH, Kryger MH, Ferber R, Gozal D editors. Principles and Practice of Pediatric Sleep Medicine. 2nd ed. New York: Elsevier Saunders; 2014. p. 77-82.
9. Lucassen PLBJ, Assendelft WJ, van Eijk JT, et al. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child 2001;84:398–403
10. Burns AJ, Thapar N. Developmental and postnatal changes in the enteric nervous system. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S4–8.
11. Roberts DM, Ostapchuk M, O’Brien JG. Infantile colic. Am Fam Physician 2004;70:735–739.
12. Shamir R. Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms JPGN 2013;57:S1-S2.
13. Indrio F, Riezzo G, Di Mauro A, et al. Gut motility alterations in neonates and young infants: relation to colic? J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S9–11.
14. Rhoads JM, Fatheree NY, Norori J, et al. Altered fecal microflora and increased calprotectin in infants with colic. J Pediatr 2009;155:823–882.
15. Heine RG. Cow’s-milk allergy and lactose malabsorption in infants with colic. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S25–7.
16. Nocerino R, Pezzella V, Cosenza L, et al. The controversial role of food allergy in infantile colic: evidence and clinical management. Nutrients 2015;7: 2015-2025.
17. Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Aller Clin Immunol 2006;6:220–222
18. Verduci E, Arrizza C, Riva E, et al. Microbiota and infantile colic: what’s new? Int J Probiot Prebiot 2013;8:25-28.
19. De Weerth C, Fuentes S, de Vos WM. Crying in infants. Gut Microbes 2013;4: 416–421.
20. Indrio F, Riezzo G, Raimondi F, et al. Microbiota involvement in the gut–brain axis. J Pediatr Gastroenterol Nutr 2013;57 (Suppl 1):S11–5.
21. Ha-Vinh Leuchter R, Darque A, Hüppi PS. Brain maturation, early sensory processing and infant colic. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S18–25.
22. Milidou I, Sondergaard C, Sondergaard Jensen M, et al. Gestational age, small for gestational age, and infantile colic. Paediatr Perinat Epidemiol 2014;28:138–145.
23. Canivet CA, Ostergren PO, Rosen AS, et al. Infantile colic and the role of trait anxiety during pregnancy in relation to psychosocial and socioeconomic factors. Scand J Public Health 2005;33:26–34.
24. Kurth E, Kennedy HP, Spichiger E, et al. Crying babies, tired mothers: What do we know? A systematic review. Midwifery 2011;27:187–1.
25. Vik T, Grote V, Escribano J, European Childhood Obesity Trial Study Group, et al. Infantile colic, prolonged crying and maternal postnatal depression. Acta Paediatr 2009;98:1344–1348.
26. Reijneveld SA, van der Wal MF, Brugman E, et al. Infant crying and abuse. Lancet 2004;364:1340–1342.
27. Fujiwara T, Barr RG, Brant R, et al. Infant distress at five weeks of age and caregiver frustration. J Pediatr 2011;159:425-430.
28. Clifford TJ, Campbell MK, Speechley KN, et al. Sequelae of infant colic: evidence of transient infant distress and absence of lasting effects on maternal mental health. Arch Pediatr Adolesc Med 2002;156: 1183–8.
29. Di Lorenzo C. Impact of early life events on pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S15–8.
30. Heine RG. Gastrointestinal food allergy and intolerance in infants and young children. J Pediatr Gastroenterol Nutr 2013; 57(Suppl 1):S38–41.
31. Indrio F, Di Mauro A, Riezzo G, et al. Infantile colic, regurgitation, and constipation: an early traumatic insult in the development of functional gastrointestinal disorders in children? Eur J Pediatr 2015; 174:841–842
32. Wolke D, Rizzo P, Woods S. Persistent infant crying and hyperactivity problems in middle childhood. Pediatrics 2002;109: 1054–1060.
33. Rao MR, Brenner RA, Schisterman EF, et al. Long term cognitive development in children with prolonged crying. Arch Dis Child Fetal Neonat Ed 2004;89:989–992.
34. Gelfand AA. Infant Colic. Semin Pediatr Neurol 10.1016/j.spen.2015.08.003 DOI: http://dx.doi.org/10.1016/j.spen.2015.0 8.003
35. Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: A systematic review and meta-analysis. Cephalalgia 2015;35:63-72.
36. Freedman SB, Al-Harthy N, Thull-Freedman J. The crying infant:Diagnosis testing an frequency of serious underlying disease. Pediatrics 2009;123:841-848.
37. Savino F, Benetti S, Ceratto S. Infantile colic: from symptoms to diagnosis - A practical approach. J Symptoms and Signs 2013;2:248-252.
38. Savino F, Ceratto S, De Marco A, et al. Looking for new treatments of infantile colic Italian J Pediatr 2014,40:53.
39. NICE. Diagnosis and assessment of food allergy in children and young people in primary care and community settings: CG116 [online]. 2011. Available at: www.nice.org. uk/guidance/CG116
40. Bhatia J, Greer F; American Academy of Pediatrics, Committee on Nutrition. Use of soy protein-based formulas in infant feeding. Pediatrics 2008;121:1062-1068.
41. Chau K, Lau E, Greenberg S, et al. Probiotics for infantile colic: randomized, double-blind placebo-controlled trial investigating lactobacillus reuteri DSM 17938. J Pediatr 2015;166:74-78.
42. Sung V, Hiscock H, Tang MLK, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebocontrolled randomised trial. BMJ 2014; 348:g2107.
43. Anabrees J, Indrio F, Paes B, et al. Probiotics for infantile colic: a systematic review BMC Pediatrics 2013,13:186.
44. Critch JN. Infantile colic: Is there a role for dietary interventions? Paediatr Child Health 2011;16:47-49.
45. Waddell L. Management of infantile colic an update. J Fam Health Care 2015;23:17-22.
46. Markestad T. Use of sucrose as a treatment for infant colic. Arch Dis Child 1997;76:356–358.
47. Aviner S, Berkovitch M, Dalkian H, et al. Use of a homeopathic preparation for infantile colic and an apparent life-threatening event. Pediatrics 2010;125:e318–323.
48. Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics 2011;127:720–733.
49. Ernst E. Chiropractic spinal manipulation for infant colic: a systematic review of randomised clinical trials. Int J Clin Prac 2009;63:1351–1353.
50. Dobson D, Lucassen PL, Miller JJ, et al. Manipulative therapies for infantile colic. Cochrane Database Syst Rev 2012;12:CD004796.
51. Skjeie H, Skonnord T, Fetveit A, et al. Acupuncture for infantile colic: a blindingvalidated, randomized controlled multicentre trial in general practice Scand J Primary Health Care 2013;31:190–196.
52. van Sleuwen BE, Engelberts AC, BoereBoonekamp MM, et al. Swaddling: a systematic review. Pediatrics 2007;120:e1097- 1106.
53. Hall B, Chesters J, Robinson A. Infantile colic: A systematic review of medical and conventional therapies. J Paediatr and Child Health 2012;48:128–137.
54. Bellaiche M, Levy M, Jung C. Treatments for infant colic. JPGN 2013;57:S27-S29.

New Approachesin the Diagnosis and Treatment of Infantile Colic

Yıl 2016, Cilt: 69 Sayı: 3, 159 - 166, 21.12.2016

Filiz Şimşek Orhon

Öz

Crying during infancy is a regulatory function. Infantile colic may be defined as crying episodes in healthy children, which occurs during some hours a day, lasts for 3 to 4 hours, and cannot be linked to any cause. The frequency of infantile colic is 10-40% with an unknown precise cause. In terms of etiology, the points under discussion
are gastrointestinal, neurodevelopmental, and psychosocial causes. It is reported that colicy infants have increased risk of physical abuse and are observed to have behavioral problems like hyperactivity and academic difficulties. It is further reported that findings such as exhaustion, weariness and depression are likely to develop in the
parents of colicy infants. In the treatment of infants with infantile colic,the duration and severity of crying, as well
as other features which accompany a crying episode should be evaluated in detail. An affected infant should be
examined in detail and evaluated in terms of growth and development. When a diagnosis of infantile colic is
made following the exclusion of other possible diseases, the families should be advised accordingly. The approaches in the treatment of infantile colic are dietary recommendations, alternative foods, pharmacologic therapies, physical supportive treatments, and behavioral therapies. There is no such treatment available for infantile
colic, which has a proven efficacy. It is quite significant to advise the affected families in that colic is typically a
temporary condition and to relieve and support them accordingly.

Anahtar Kelimeler

Infantile Colic, Diagnosis, Treatment

Etik Beyan

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

1. Newman JD. Neural circuits underlying crying and cry responding in mammals. Behavioral Brain Resarch 2007;182:155- 165.
2. Hiscock H, Jordan B. Problem crying in infancy. Med J Aust 2004;181:507-512.
3. Fleisher DR. Infant colic. In: Faure C et al. editors. Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children, Clinical Gastroenterology, DOI 10.1007/978-1-60761-709- 9_31, New York: Springer Science Business Media; 2013. p. 347-354.
4. Kaley F, Reid V, Flynn EG. The psychology of infant colic: a review of current research. Infant Mental Health J 2011;32: 526–541.
5. Wessel MA, Cobb JC, Jackson EB, et al. Paroxysmal fussing in infancy, sometimes called colic. Pediatrics 1954;14:421-435.
6. Milla P, Hyman PE, Benninga M, et al. Infant colic. Functional gastrointestinal disorders-Rome III. McLean, VA: Degnon Associates, Inc.; 2006. p. 699–7703.
7. Akhnikh S, Engelberts AC, van Sleuwen BE, et al. The excessively crying infant: etiology and treatment . Pediatric Annals 2014;43:e69-e75.
8. Engler AC, Etzioni T, Pillar G. Sleep and Colic. In: Sheldon SH, Kryger MH, Ferber R, Gozal D editors. Principles and Practice of Pediatric Sleep Medicine. 2nd ed. New York: Elsevier Saunders; 2014. p. 77-82.
9. Lucassen PLBJ, Assendelft WJ, van Eijk JT, et al. Systematic review of the occurrence of infantile colic in the community. Arch Dis Child 2001;84:398–403
10. Burns AJ, Thapar N. Developmental and postnatal changes in the enteric nervous system. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S4–8.
11. Roberts DM, Ostapchuk M, O’Brien JG. Infantile colic. Am Fam Physician 2004;70:735–739.
12. Shamir R. Infant crying, colic, and gastrointestinal discomfort in early childhood: a review of the evidence and most plausible mechanisms JPGN 2013;57:S1-S2.
13. Indrio F, Riezzo G, Di Mauro A, et al. Gut motility alterations in neonates and young infants: relation to colic? J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S9–11.
14. Rhoads JM, Fatheree NY, Norori J, et al. Altered fecal microflora and increased calprotectin in infants with colic. J Pediatr 2009;155:823–882.
15. Heine RG. Cow’s-milk allergy and lactose malabsorption in infants with colic. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S25–7.
16. Nocerino R, Pezzella V, Cosenza L, et al. The controversial role of food allergy in infantile colic: evidence and clinical management. Nutrients 2015;7: 2015-2025.
17. Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Aller Clin Immunol 2006;6:220–222
18. Verduci E, Arrizza C, Riva E, et al. Microbiota and infantile colic: what’s new? Int J Probiot Prebiot 2013;8:25-28.
19. De Weerth C, Fuentes S, de Vos WM. Crying in infants. Gut Microbes 2013;4: 416–421.
20. Indrio F, Riezzo G, Raimondi F, et al. Microbiota involvement in the gut–brain axis. J Pediatr Gastroenterol Nutr 2013;57 (Suppl 1):S11–5.
21. Ha-Vinh Leuchter R, Darque A, Hüppi PS. Brain maturation, early sensory processing and infant colic. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S18–25.
22. Milidou I, Sondergaard C, Sondergaard Jensen M, et al. Gestational age, small for gestational age, and infantile colic. Paediatr Perinat Epidemiol 2014;28:138–145.
23. Canivet CA, Ostergren PO, Rosen AS, et al. Infantile colic and the role of trait anxiety during pregnancy in relation to psychosocial and socioeconomic factors. Scand J Public Health 2005;33:26–34.
24. Kurth E, Kennedy HP, Spichiger E, et al. Crying babies, tired mothers: What do we know? A systematic review. Midwifery 2011;27:187–1.
25. Vik T, Grote V, Escribano J, European Childhood Obesity Trial Study Group, et al. Infantile colic, prolonged crying and maternal postnatal depression. Acta Paediatr 2009;98:1344–1348.
26. Reijneveld SA, van der Wal MF, Brugman E, et al. Infant crying and abuse. Lancet 2004;364:1340–1342.
27. Fujiwara T, Barr RG, Brant R, et al. Infant distress at five weeks of age and caregiver frustration. J Pediatr 2011;159:425-430.
28. Clifford TJ, Campbell MK, Speechley KN, et al. Sequelae of infant colic: evidence of transient infant distress and absence of lasting effects on maternal mental health. Arch Pediatr Adolesc Med 2002;156: 1183–8.
29. Di Lorenzo C. Impact of early life events on pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr 2013;57(Suppl 1):S15–8.
30. Heine RG. Gastrointestinal food allergy and intolerance in infants and young children. J Pediatr Gastroenterol Nutr 2013; 57(Suppl 1):S38–41.
31. Indrio F, Di Mauro A, Riezzo G, et al. Infantile colic, regurgitation, and constipation: an early traumatic insult in the development of functional gastrointestinal disorders in children? Eur J Pediatr 2015; 174:841–842
32. Wolke D, Rizzo P, Woods S. Persistent infant crying and hyperactivity problems in middle childhood. Pediatrics 2002;109: 1054–1060.
33. Rao MR, Brenner RA, Schisterman EF, et al. Long term cognitive development in children with prolonged crying. Arch Dis Child Fetal Neonat Ed 2004;89:989–992.
34. Gelfand AA. Infant Colic. Semin Pediatr Neurol 10.1016/j.spen.2015.08.003 DOI: http://dx.doi.org/10.1016/j.spen.2015.0 8.003
35. Gelfand AA, Goadsby PJ, Allen IE. The relationship between migraine and infant colic: A systematic review and meta-analysis. Cephalalgia 2015;35:63-72.
36. Freedman SB, Al-Harthy N, Thull-Freedman J. The crying infant:Diagnosis testing an frequency of serious underlying disease. Pediatrics 2009;123:841-848.
37. Savino F, Benetti S, Ceratto S. Infantile colic: from symptoms to diagnosis - A practical approach. J Symptoms and Signs 2013;2:248-252.
38. Savino F, Ceratto S, De Marco A, et al. Looking for new treatments of infantile colic Italian J Pediatr 2014,40:53.
39. NICE. Diagnosis and assessment of food allergy in children and young people in primary care and community settings: CG116 [online]. 2011. Available at: www.nice.org. uk/guidance/CG116
40. Bhatia J, Greer F; American Academy of Pediatrics, Committee on Nutrition. Use of soy protein-based formulas in infant feeding. Pediatrics 2008;121:1062-1068.
41. Chau K, Lau E, Greenberg S, et al. Probiotics for infantile colic: randomized, double-blind placebo-controlled trial investigating lactobacillus reuteri DSM 17938. J Pediatr 2015;166:74-78.
42. Sung V, Hiscock H, Tang MLK, et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebocontrolled randomised trial. BMJ 2014; 348:g2107.
43. Anabrees J, Indrio F, Paes B, et al. Probiotics for infantile colic: a systematic review BMC Pediatrics 2013,13:186.
44. Critch JN. Infantile colic: Is there a role for dietary interventions? Paediatr Child Health 2011;16:47-49.
45. Waddell L. Management of infantile colic an update. J Fam Health Care 2015;23:17-22.
46. Markestad T. Use of sucrose as a treatment for infant colic. Arch Dis Child 1997;76:356–358.
47. Aviner S, Berkovitch M, Dalkian H, et al. Use of a homeopathic preparation for infantile colic and an apparent life-threatening event. Pediatrics 2010;125:e318–323.
48. Perry R, Hunt K, Ernst E. Nutritional supplements and other complementary medicines for infantile colic: a systematic review. Pediatrics 2011;127:720–733.
49. Ernst E. Chiropractic spinal manipulation for infant colic: a systematic review of randomised clinical trials. Int J Clin Prac 2009;63:1351–1353.
50. Dobson D, Lucassen PL, Miller JJ, et al. Manipulative therapies for infantile colic. Cochrane Database Syst Rev 2012;12:CD004796.
51. Skjeie H, Skonnord T, Fetveit A, et al. Acupuncture for infantile colic: a blindingvalidated, randomized controlled multicentre trial in general practice Scand J Primary Health Care 2013;31:190–196.
52. van Sleuwen BE, Engelberts AC, BoereBoonekamp MM, et al. Swaddling: a systematic review. Pediatrics 2007;120:e1097- 1106.
53. Hall B, Chesters J, Robinson A. Infantile colic: A systematic review of medical and conventional therapies. J Paediatr and Child Health 2012;48:128–137.
54. Bellaiche M, Levy M, Jung C. Treatments for infant colic. JPGN 2013;57:S27-S29.

Toplam 54 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Çocuk Ürolojisi
Bölüm	Makaleler
Yazarlar	Filiz Şimşek Orhon
Proje Numarası	-
Yayımlanma Tarihi	21 Aralık 2016
Yayımlandığı Sayı	Yıl 2016 Cilt: 69 Sayı: 3

Kaynak Göster

APA	Şimşek Orhon, F. (2016). New Approachesin the Diagnosis and Treatment of Infantile Colic. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 69(3), 159-166.
AMA	Şimşek Orhon F. New Approachesin the Diagnosis and Treatment of Infantile Colic. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Aralık 2016;69(3):159-166.
Chicago	Şimşek Orhon, Filiz. “New Approachesin the Diagnosis and Treatment of Infantile Colic”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69, sy. 3 (Aralık 2016): 159-66.
EndNote	Şimşek Orhon F (01 Aralık 2016) New Approachesin the Diagnosis and Treatment of Infantile Colic. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69 3 159–166.
IEEE	F. Şimşek Orhon, “New Approachesin the Diagnosis and Treatment of Infantile Colic”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 69, sy. 3, ss. 159–166, 2016.
ISNAD	Şimşek Orhon, Filiz. “New Approachesin the Diagnosis and Treatment of Infantile Colic”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 69/3 (Aralık 2016), 159-166.
JAMA	Şimşek Orhon F. New Approachesin the Diagnosis and Treatment of Infantile Colic. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69:159–166.
MLA	Şimşek Orhon, Filiz. “New Approachesin the Diagnosis and Treatment of Infantile Colic”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 69, sy. 3, 2016, ss. 159-66.
Vancouver	Şimşek Orhon F. New Approachesin the Diagnosis and Treatment of Infantile Colic. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2016;69(3):159-66.

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