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REAKTİF ARTRİTLİ HASTALARIN SERUMLARINDA ADENOZİN DEAMİNAZ AKTİVİTESİ TAYİNİ

Yıl 1993, Cilt: 46 Sayı: 4, 631 - 638, 31.12.1994

Orhan Canbolat

Öz

Otuzddrt reaktif artritli hastanın serumlarında ADA aktivitesi tayin edildi. 34 hasta tutulan eklem sayısına göre sınıflandırılmış ayrıca bu hastaların 27 tanesi sedimentasyon hızlarına göre gruplandırılmıştır. Bütün gruplarda ADA aktivitesi kontrole göre düşük bulunmustur. En düşük değer iki eklem tutulumu olan hastalarda belirlenmiştir (p< 0.005). Tek eklem tutulumu olan grupta ise sonuçlar yine anlamh bulunmustur (p< 0.01). Ug eklem tutulumu olan hastalarda ise ADA aktivitesindeki azalma anlamsiz bulunmustur (p>>0.05). Sedimantasyon degeri 30 - 60 mm/saat olan hasta grubunda ADA aktivitesindeki düşüş kontrole gére anlamsiz bulunmasına karsiik (p> 0.05), sedimantasyon hızı 0-30 ve 80’ Uzerinde olan gruplarda kontrole gére anlamh sonuglar elde edilmistir (sırasıyla (p< 0.25 ve p< 005). ADA aktivitesindeki azalma ile eklem tutulumu sayisi ve sedimantasyon hızı arasinda bir farklılık gozlenememistir. ADA aktivietesindeki bu düşüşün rezktif artritte immiin sistem baskılanmasının bir gostergesi olarak degerlendirilebilecegi düşünülmektedir

Anahtar Kelimeler

Reaktif Artrit Adenozin Deaminaz. v

Etik Beyan

-

Destekleyen Kurum

-

Proje Numarası

-

Teşekkür

-

Kaynakça

  • 1. adrin GS Hutton JS : Adenosine dsaminase messenger ENAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency. The J. Clin. Invest. 71 : 1649-1660, 1983,
  • 2.Aho K : Pathogenesis of Reither's Syndrome and reactive arthrits. Scand J Rheumatol suppl. 52 : 30-36, 1984
  • 3. Balis ME : Adenosine deaminase and malignant cells. Ann. NY Acad. Scien. 45 : 142-149, 1985.
  • 4. Brenner MB Kabayashi S Weisenhutter CW Huberman AK : In vitro T Iympho cyte proliferative response to Yersinia enterocolitica in Reiter's Syndrome. Arth Rheum. 27 : 250-255, 1984
  • 5. Bonet M Mayoma J Arnev D : Adenosine deaminase activity in rheumatoid plevral effusion. An. Rheum. Dis. 48 : 789-791, 1989
  • 6.Chechik BE Schrader WP Fernandes B et al : Association of adenosine deaminase with differentiation of normal and leukemic T and B lymphocytes. Annals New York Academy of Sciences 451 : 169-179, 1985,
  • 7.Chester WF : Reactive Arthritis. Pediatr Infect Dis J 7 (1) : 58-65, 1988.
  • 8.Denys KF : Reactive arthritis : A wiev point ratber than a rewiev. Clinic in Rheumatic Diseases. 12 (2) ; 389-401, 1986.
  • 9.Dornand J Bonnafous JC Favero J et al : Ecto-5-nucleotidase and adenosine deaminase activities of lymphoid cells. Biochemical Medicine 28 : 144-156, 1982.
  • 10.Forster SM Seifert MH Keat ACS : Inflamatery joint disease and human immunedificiency virus infection. Br Med J 296 : 1625-27, 1988,
  • 11.Gary S Fristein MD Nathan J Zvaifler MD : Reactive arthritis Ann Rev Med 38 : 351-60, 1987.
  • 12.Gib'ett ER Anderson JE Cohen F et al : Adenosine deaminase deficiency in two patients with severely impaired collular immunity. The Lancet 18 : 1067-1069, 1972,
  • 13.Granfors K Toivanen A : IgA-anti-yersinia anti bedies in yersinia triggered reactive avthritis, Ann Rheum Dis 45 : 561-65, 1986.
  • 14.Grever MR Coleman MS Balcerzak SP : Adenosine deaminase and deoxynucleotidyl transferase : Biochemical markers in the wmanagement of chronic myelogenous leukemia, Cancer Research 43 : 1442-1445, 1983
  • 15.Guisti G : Adenosine deaminase. Bergmeyer H.U. Ed. Methods of enzymatic analysis 3rd english Ed. Academic Press New York. 1092-1099, 1974
  • 16.Ho A D and Ganeshaguru K : Enzyms of purin metabolism in lymphoid neoplasms. Clinical relevance for treatmenti with enzym inhibitors. Clin Wochenscher 86 : 467-477, 1988.
  • 17.Kaplan AM Gerrad TL Strawson J et al : Role of adenosine dcaminase in human monocyte differentiation and tumor cell ctotoxicity. Annals New York Academy of Sciences 451 : 264-77, 1985.
  • 18.Keat A : Reithers syndrome and reactive arthritis in perspective. N Engl J Med 309 : 1606-1615, 1983.
  • 19.Kingsley G Pitzalis C Kyriazis N Pan«yi G: Abnormal herper-inducer/supressor - inducer T-cell activation status are cominon to all types of chronic synovitis. Scand J Immunol 28 : 225, 1988.
  • 20.Konttinen YT Nodstrom D Bergroth V : Cell mediated immune response in the diseased joints in patients with reactive arthritis. Scand J Immunol 23 : 68-91, 1986.
  • 21.Kottinenen YT Nodstrom DC Bergroth V : Reactive arthritis British Medical J 296 : 1644, 1986

ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS

Yıl 1993, Cilt: 46 Sayı: 4, 631 - 638, 31.12.1994

Orhan Canbolat

Öz

n this study, adenosine deaminase activity was determined in sera from 24 patients with reactive arthritis. The patients were classified according to the sedimentation rafes and number of joints affected. ADA activities was found lower in the patient groups than control group. We found that the lowest values of ADA were in the patients having two joints affected (p< 0.005) and results were also meaningful in the patients having one joint affected (p< 0.01). Decreases in ADA activities however were not meaningful in the patients having three joints affected (p> 0.05) ADA activities was not meaningful in the patients with sedimantation rates between 30 and 60 mm/hr. However, we obtained meaningful results in the groups with sedimantation rates of 0-30 and >60 (p< 0:025 and p< 0.05 respectively). We found no meaningful differences between ADA activity, and sedimantation rates and number of joints affected. We suggest that decreased ADA activities might be an indicator of the immune system depression in reactive arthritis.

Anahtar Kelimeler

Reactive Arthritis Adenosine Deaminase. v

Etik Beyan

-

Destekleyen Kurum

-

Proje Numarası

-

Teşekkür

-

Kaynakça

  • 1. adrin GS Hutton JS : Adenosine dsaminase messenger ENAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency. The J. Clin. Invest. 71 : 1649-1660, 1983,
  • 2.Aho K : Pathogenesis of Reither's Syndrome and reactive arthrits. Scand J Rheumatol suppl. 52 : 30-36, 1984
  • 3. Balis ME : Adenosine deaminase and malignant cells. Ann. NY Acad. Scien. 45 : 142-149, 1985.
  • 4. Brenner MB Kabayashi S Weisenhutter CW Huberman AK : In vitro T Iympho cyte proliferative response to Yersinia enterocolitica in Reiter's Syndrome. Arth Rheum. 27 : 250-255, 1984
  • 5. Bonet M Mayoma J Arnev D : Adenosine deaminase activity in rheumatoid plevral effusion. An. Rheum. Dis. 48 : 789-791, 1989
  • 6.Chechik BE Schrader WP Fernandes B et al : Association of adenosine deaminase with differentiation of normal and leukemic T and B lymphocytes. Annals New York Academy of Sciences 451 : 169-179, 1985,
  • 7.Chester WF : Reactive Arthritis. Pediatr Infect Dis J 7 (1) : 58-65, 1988.
  • 8.Denys KF : Reactive arthritis : A wiev point ratber than a rewiev. Clinic in Rheumatic Diseases. 12 (2) ; 389-401, 1986.
  • 9.Dornand J Bonnafous JC Favero J et al : Ecto-5-nucleotidase and adenosine deaminase activities of lymphoid cells. Biochemical Medicine 28 : 144-156, 1982.
  • 10.Forster SM Seifert MH Keat ACS : Inflamatery joint disease and human immunedificiency virus infection. Br Med J 296 : 1625-27, 1988,
  • 11.Gary S Fristein MD Nathan J Zvaifler MD : Reactive arthritis Ann Rev Med 38 : 351-60, 1987.
  • 12.Gib'ett ER Anderson JE Cohen F et al : Adenosine deaminase deficiency in two patients with severely impaired collular immunity. The Lancet 18 : 1067-1069, 1972,
  • 13.Granfors K Toivanen A : IgA-anti-yersinia anti bedies in yersinia triggered reactive avthritis, Ann Rheum Dis 45 : 561-65, 1986.
  • 14.Grever MR Coleman MS Balcerzak SP : Adenosine deaminase and deoxynucleotidyl transferase : Biochemical markers in the wmanagement of chronic myelogenous leukemia, Cancer Research 43 : 1442-1445, 1983
  • 15.Guisti G : Adenosine deaminase. Bergmeyer H.U. Ed. Methods of enzymatic analysis 3rd english Ed. Academic Press New York. 1092-1099, 1974
  • 16.Ho A D and Ganeshaguru K : Enzyms of purin metabolism in lymphoid neoplasms. Clinical relevance for treatmenti with enzym inhibitors. Clin Wochenscher 86 : 467-477, 1988.
  • 17.Kaplan AM Gerrad TL Strawson J et al : Role of adenosine dcaminase in human monocyte differentiation and tumor cell ctotoxicity. Annals New York Academy of Sciences 451 : 264-77, 1985.
  • 18.Keat A : Reithers syndrome and reactive arthritis in perspective. N Engl J Med 309 : 1606-1615, 1983.
  • 19.Kingsley G Pitzalis C Kyriazis N Pan«yi G: Abnormal herper-inducer/supressor - inducer T-cell activation status are cominon to all types of chronic synovitis. Scand J Immunol 28 : 225, 1988.
  • 20.Konttinen YT Nodstrom D Bergroth V : Cell mediated immune response in the diseased joints in patients with reactive arthritis. Scand J Immunol 23 : 68-91, 1986.
  • 21.Kottinenen YT Nodstrom DC Bergroth V : Reactive arthritis British Medical J 296 : 1644, 1986
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Metabolik Tıp
Bölüm Makaleler
Yazarlar

Orhan Canbolat

Proje Numarası -
Yayımlanma Tarihi 31 Aralık 1994
Yayımlandığı Sayı Yıl 1993 Cilt: 46 Sayı: 4

Kaynak Göster

APA Canbolat, O. (1994). ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 46(4), 631-638.
AMA Canbolat O. ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Aralık 1994;46(4):631-638.
Chicago Canbolat, Orhan. “ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46, sy. 4 (Aralık 1994): 631-38.
EndNote Canbolat O (01 Aralık 1994) ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46 4 631–638.
IEEE O. Canbolat, “ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 4, ss. 631–638, 1994.
ISNAD Canbolat, Orhan. “ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46/4 (Aralık 1994), 631-638.
JAMA Canbolat O. ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1994;46:631–638.
MLA Canbolat, Orhan. “ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 4, 1994, ss. 631-8.
Vancouver Canbolat O. ESTABLISHMENT OF ADENOSINE DEAMINASE ACTIVITY IN SERA FROM PATIENTS WITH REACTIVE ARTHRITIS. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1994;46(4):631-8.