KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI

Erhan Nalçacı

Derleme

KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI

Yıl 1993, Cilt: 46 Sayı: 3, 493 - 511, 30.09.1993

Erhan Nalçacı

Öz

Kan beyin bariyeri (KBB)nin proteinlere karşı permeabilitesinin çok düşük olduğu bilinmektedir. Bu düşük permeabilite; beyin kapiller endotel hücreleri arasında bulunan sıkı fenestraların yokluğuna ve pinositotik aktivitenin düşüklüğüne bağlanmıştır. Ancak iskemi, soğuk yaralanması, akut hipertansiyon ve konvülsiyonlar gibi patolojik olaylar esnasında KBB'i yıkılmaktadır. KBB'de proteinlere karşı artmış permeabilitedenj pinositotik aktivite artışı sorumlu tutulmuş ve histaminden araşidonik asit metabolizması ürünlerine kadar çeşitli faktörlerin rolü incelenmiştir. Sunulan derlemede, KBB permeabilite artışına yol açan, histamin salınımı, araşidonik asit metabolizması ve oksidan stres arasındaki ilişki tartışılmıştır.

Anahtar Kelimeler

: Kan-beyin bariyeri, Pinositotik aktivite, histamin, oksidan stres, Drostaglandinler, hipertansiyon, epileptik atak.

Etik Beyan

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

KAYNAKLAR 1. Adam G Joo F Temesvari, P Dux E Szerdehelvi P : Effects of acute hypoxia on the adenylate cyclase and Avans blue transport of brain microvessels. Neurochem. Int. 10 (4) 529-532, 1987.
2. Bazan NG : Arachidonic acid in the modullation of exitable membrane function and at the onset of brain damage. In : Ed : Barkai, Al., Bazan N.G. Arachidonic acid metabolism in the nervous system physiological and pathological significance. New York Academy of Science. 559 : 1 16* 1989,
3. Betz AL Goldstein GA/V Specialized properties and solute transport in brain, cappilleries. Ann. Rev. Physiol, 48 : 241-250 1886.
4. Burkhaliter A brick OL : Histamin, serotonin, & the ergot alkoloids. In : Ed Katzung, B.G. Basic and Clinical Pharynacology. Printed in USA. 3. Edition. S 183-200, 1987.
5. Burns EM Kruckeberg TW The ultrastructural basis of capillary permeability. In : Ed Battaini, F. , Gova.ni, S., Magnoni M.S., Trabucchi, M. Regulatory Mechamsms of Neuron to Vessel Communication in the Brain. NATO Series, Series H : cell Biology. Springer-Verlag Berlin Heidelberg. vol. 33, S, 1-16, 1989.
6. Chan PH Yurko M Fishman RA : Phospholipid degradetion and cellular edema induced by free radicals in bram cortical slices. J. Neurochem. 38 : 525-531, 1982.
7. Chuieh CC sun CL Kopin IJ Fredericks, WR Rapoport Sl : Entry of PHI norepinephrine, 1 125 1 1 albumin and Evans blue from blood into brain fol lowing unilateral osmotic opening of the blood-brain barrier. Brain Research. 145 : 291-301, 1978
8. Claudio L Kress Y Norton WT Brosan CF : Incresed vesicular transport and decreased miotchondrial content in blood-brain barrier andothelial cells during experimental autoimmune encephalomyel itis. ARE Jour. of Pathology. 135 (6) 1157-1168, 1989.
9. Cornford EM Oldendorf WH : Epilepsi and the blood-brain barrier, In Ed Delgado-Escavata, A. V., Ward, A.A., Woodbury, Porter, J. Advances in Neurology. Raven Press, New York, S. 787-812, 1986.
10. Cotran RS Kumar V Robbins SL Celluler Injury and adaptation. In : Robbins, Pathologic basis of Disease. 4. Edition. Saunders Company. Printed in Canada, S. 1-38, 1989 504
11. Cserr I-IF Bundgaard, M : Blood-brain interfaces in vertebrates a comparative approach. Am. J. Physiol. 246 : R277-R288, 1984.
12. Dobbin J Crockard HA Ross-Russel R : Transient blood-brain barrier permeability following profound temporary global ischaemia : An experimental study using 14C-AIB. Journal of Cerebral Blood Flow and Metabolism. 9 : 71-78, 1989.
13. Dropp JJ : Mast cells in the central nervous system of several rodents. Anat. Rec. 174 : 227-238, 1972.
14. Dux E Joo F : Effects of histamine on brain capillaries. Experimental Brain Research. 47 : 252-258, 1982.
15. Ellison MD Povlishock JT Hages RL : Examination of the blood-to-brain transfer of a-aminoisobutyrik acid and horseradish peroxidase : regional alterations in blood-brain barrier function following acute hypertention. Journal of Cerebral Blood Flow and Metabolism. 6 (4) : 471-480, 1986.
16. Frank L ; Protection from 02 toxicity by preexposure to hypoxia : Lung antioxidant enzyme role. J. Appl. Physiol. 53 (2) : 475-482, 1982
17. Freeman BA Crapo JD : Biology of disease, free radicals and tissue injury. Laboratory Invastigation. 47 (5) : 412-426, 1982.
18. Granger DN : Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am. J. Physioli 255 H1269-H1275, 1988.
19. Gross PM Teasdale GM Angerson WJ Harper AM : Hrreceptors mediate increases in permeability of the blood-brain barrier during arterial histamine infusion. Brain Research. 210 : 396-400, 1981.
20. Guy J Ellis EA Hope GM Rao NA : Antioxidant enzymes reduce loss of bloodbrain barrier integrity in experimental optic neuritis. Arch. Ophtalmol+ 107 (sept) : 1359-1363, 1989.
21. Hedley-M/hyte ET Lorenzo Av- Hsu DV Protein transport across cerebral vessels during metrazole-induced convulsions. Am. J. Physiol, 233 (2) i74-c85, 1977.
22. Jarasch Ed Bruder G Heid HW Significance of xanthine oxidase in capillary endothelial cells. Acta. Physiol. Scand. (Suppl.), 548 : 39-46, 1986.
23. Joo F Szucs A Csanda E : Metiamide-treatment of brain oedema in animals exposed to 90Yttrium irradiation. J. Pharm. Pharmacol. 28 : 162-163, 1976.
24 Joo F : Physiological and pathological events metiated by capillary neurotransmitter receptors. In : Ed : Battaini, F., Govani, S., Magnoni M.S. Trabucchi, M. Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, Series H : Cell Biology. Springer-Verlag Berlin Heidelberg. Vol. 33, S. 145-164, 1989.
25. Jungueira LC Carneiro J Long JA Basic Histology. 5. Edition. Lange, printed in in Lebanon. S. 199-201, 1986.
2B. Kiwak KJ Moskowitz MA Levine L : Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrage, and concussive injury. J. Neurosurg. 62 : 865-869, 1985.
27. Koenig H Goldstone AD Lu CY : Blood-brain barrier breakdown in cold-injured brain is Iniked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis : Both are coordinately inhibited by verapamil, dexametr hasone, and aspirin. J. Neurochemistry, 52 : 101-109, 1989.
28. Kontos HA wei EP Dietrich WD Navari RM Povlishock JT Ghatal< NR Ellis EF Patterson JL : Mechanism of cerebral arteriolar abnormalities after acute hypertantion. Am. J. Physiol. 240 : 1-1511-H527, 1981.
29. Kontos HA : Oxygen radicals in cerebral vasculer injury. Circ. Res. 57 : 508-516, 1985.
30. Kontos HA Wei EP Ellis EF Jenkins, IW Povlishock JT Rowe GT Hess ML : Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circ. Res. 57 : 142-151, 1981.
31. Lorenzo AV Hadley-Weit ET Eisenberg HM Hsu DW : Increased penetration of horseradish peroxidase acrose the blood-brain barrier induced by metrazol seizures. Brain Research. 88 : 136-140, 1975.
32. Methews CK Van Holde KE Biological oxidations, electron transport, and oxidatvie phosphorylation. In Biochemistry. Benjamin/ Cummings Publishing Company, In California, S. 504-537, 1990.
33. Meisenberg G Simmons WH : Peptides and the blood brain barrier. Life Sciences. 32 : 2611-2623, 1983.
34. Moskowitz MA Kiwak KJ Mekimian K Levine L Synthesis of coumpounds with properties of leukotrienes C4 and in gerbil brains after ischemia and reperfusion, Science, 224 : 886-889, 1984.
135. Nag S : Localisation of calcium-activated adenosinetriphosphatase (Ca ATPase) in intracerebral. arterioles in acute hypertention. Acta Neuropatol. (Berl), 75 547-553, 1988.
36. Nitsch C Klatzo I : Regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by varius convulsive agents. J Neurological Sci ences. 59 305-322, 1983.
37. Olesen SP : Free oxygen radicals decrease electrical resistance of microvascular endothelium. Acta. Physiol. Scand. 129 : 181-187, 1987.
38, Palmer GC McCreedy SA Freedman LR Neurotransmitter coupled responses in the microvasculature of the brain under normal and pathological conditions. In Ed : Battaini, Fij Govani, S., Magnoni M.S., Trabucchi M, Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, Series H Cell Biology. Springer-Verlag Berlin Heidelberg. Vol. 33, s. 113-141, 1989.
39. Papadopoulos SM Black KL Hoff J T : Cerebral edema induced by arachidonic acid : Role of leukocytes and 5-lipooxygenase products. Neurosurgery. 25 (3) 319-372, 1989.
40. Pardrige WM Oldendorf W Cancilla P Frank L : Blood-brain barrier ; Interface between internal medicine and the brain. Annals of Internal Medicine. 105 82 95, 1986.
41. Pardrige WM ; Recent advences in blood-brain barrier transport. Ann, Rev. Pharmacol. Toxicol. 28 : 25-39* 1988.
42. Petito CK Schaefer JA Pl um F : Ultrastructural characteristics of the blood-brain barrier in experimental seizures. Brain Research. 127 : 251-267, 1977.
43, Petito CK Levy DE : The importance of cerebral arterioles in alterations of the blood-brain barrier. Laboratory Investigation, 43 (3) 262-268, 1980.
44 Pryor WA : Oxy-radicals and related species, Ann. Rev. Physiol. 48 657-667, 1986,

The Permeahility Increase Mechanisms of Blood-Brain Barrier

Yıl 1993, Cilt: 46 Sayı: 3, 493 - 511, 30.09.1993

Erhan Nalçacı

Öz

İt is known that the permeability of bjood-brain barrier (BBB) againts the proteins is very Iow. Main reason for this Iow permeability is the existence of tight junctions between brain endothelial cells, a fcw pinocytotic activity and absence of fenestrae. However, during ArtbsSL Meleanizmalarl pathologic cases like ischemia, cold injury, acute hypertension and seizure activity, BBB breaks down. The reason for the permeability increace against the proteins on the BBB, is found to be the pinocytotic activity increase, and the role of various factors from histamine to the products of arachidonic acid metabolism has been studied. In the presented review, the relationship between histamine releasing, arachi-donic acid metabolism and oxidant stress, which lead to increase of BBB permeability is discussed.

Anahtar Kelimeler

Blood-brain barrier, histamine, oxidant stress, prostaglandins, hypertension, seizure

Etik Beyan

Destekleyen Kurum

Proje Numarası

Teşekkür

Kaynakça

KAYNAKLAR 1. Adam G Joo F Temesvari, P Dux E Szerdehelvi P : Effects of acute hypoxia on the adenylate cyclase and Avans blue transport of brain microvessels. Neurochem. Int. 10 (4) 529-532, 1987.
2. Bazan NG : Arachidonic acid in the modullation of exitable membrane function and at the onset of brain damage. In : Ed : Barkai, Al., Bazan N.G. Arachidonic acid metabolism in the nervous system physiological and pathological significance. New York Academy of Science. 559 : 1 16* 1989,
3. Betz AL Goldstein GA/V Specialized properties and solute transport in brain, cappilleries. Ann. Rev. Physiol, 48 : 241-250 1886.
4. Burkhaliter A brick OL : Histamin, serotonin, & the ergot alkoloids. In : Ed Katzung, B.G. Basic and Clinical Pharynacology. Printed in USA. 3. Edition. S 183-200, 1987.
5. Burns EM Kruckeberg TW The ultrastructural basis of capillary permeability. In : Ed Battaini, F. , Gova.ni, S., Magnoni M.S., Trabucchi, M. Regulatory Mechamsms of Neuron to Vessel Communication in the Brain. NATO Series, Series H : cell Biology. Springer-Verlag Berlin Heidelberg. vol. 33, S, 1-16, 1989.
6. Chan PH Yurko M Fishman RA : Phospholipid degradetion and cellular edema induced by free radicals in bram cortical slices. J. Neurochem. 38 : 525-531, 1982.
7. Chuieh CC sun CL Kopin IJ Fredericks, WR Rapoport Sl : Entry of PHI norepinephrine, 1 125 1 1 albumin and Evans blue from blood into brain fol lowing unilateral osmotic opening of the blood-brain barrier. Brain Research. 145 : 291-301, 1978
8. Claudio L Kress Y Norton WT Brosan CF : Incresed vesicular transport and decreased miotchondrial content in blood-brain barrier andothelial cells during experimental autoimmune encephalomyel itis. ARE Jour. of Pathology. 135 (6) 1157-1168, 1989.
9. Cornford EM Oldendorf WH : Epilepsi and the blood-brain barrier, In Ed Delgado-Escavata, A. V., Ward, A.A., Woodbury, Porter, J. Advances in Neurology. Raven Press, New York, S. 787-812, 1986.
10. Cotran RS Kumar V Robbins SL Celluler Injury and adaptation. In : Robbins, Pathologic basis of Disease. 4. Edition. Saunders Company. Printed in Canada, S. 1-38, 1989 504
11. Cserr I-IF Bundgaard, M : Blood-brain interfaces in vertebrates a comparative approach. Am. J. Physiol. 246 : R277-R288, 1984.
12. Dobbin J Crockard HA Ross-Russel R : Transient blood-brain barrier permeability following profound temporary global ischaemia : An experimental study using 14C-AIB. Journal of Cerebral Blood Flow and Metabolism. 9 : 71-78, 1989.
13. Dropp JJ : Mast cells in the central nervous system of several rodents. Anat. Rec. 174 : 227-238, 1972.
14. Dux E Joo F : Effects of histamine on brain capillaries. Experimental Brain Research. 47 : 252-258, 1982.
15. Ellison MD Povlishock JT Hages RL : Examination of the blood-to-brain transfer of a-aminoisobutyrik acid and horseradish peroxidase : regional alterations in blood-brain barrier function following acute hypertention. Journal of Cerebral Blood Flow and Metabolism. 6 (4) : 471-480, 1986.
16. Frank L ; Protection from 02 toxicity by preexposure to hypoxia : Lung antioxidant enzyme role. J. Appl. Physiol. 53 (2) : 475-482, 1982
17. Freeman BA Crapo JD : Biology of disease, free radicals and tissue injury. Laboratory Invastigation. 47 (5) : 412-426, 1982.
18. Granger DN : Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am. J. Physioli 255 H1269-H1275, 1988.
19. Gross PM Teasdale GM Angerson WJ Harper AM : Hrreceptors mediate increases in permeability of the blood-brain barrier during arterial histamine infusion. Brain Research. 210 : 396-400, 1981.
20. Guy J Ellis EA Hope GM Rao NA : Antioxidant enzymes reduce loss of bloodbrain barrier integrity in experimental optic neuritis. Arch. Ophtalmol+ 107 (sept) : 1359-1363, 1989.
21. Hedley-M/hyte ET Lorenzo Av- Hsu DV Protein transport across cerebral vessels during metrazole-induced convulsions. Am. J. Physiol, 233 (2) i74-c85, 1977.
22. Jarasch Ed Bruder G Heid HW Significance of xanthine oxidase in capillary endothelial cells. Acta. Physiol. Scand. (Suppl.), 548 : 39-46, 1986.
23. Joo F Szucs A Csanda E : Metiamide-treatment of brain oedema in animals exposed to 90Yttrium irradiation. J. Pharm. Pharmacol. 28 : 162-163, 1976.
24 Joo F : Physiological and pathological events metiated by capillary neurotransmitter receptors. In : Ed : Battaini, F., Govani, S., Magnoni M.S. Trabucchi, M. Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, Series H : Cell Biology. Springer-Verlag Berlin Heidelberg. Vol. 33, S. 145-164, 1989.
25. Jungueira LC Carneiro J Long JA Basic Histology. 5. Edition. Lange, printed in in Lebanon. S. 199-201, 1986.
2B. Kiwak KJ Moskowitz MA Levine L : Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrage, and concussive injury. J. Neurosurg. 62 : 865-869, 1985.
27. Koenig H Goldstone AD Lu CY : Blood-brain barrier breakdown in cold-injured brain is Iniked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis : Both are coordinately inhibited by verapamil, dexametr hasone, and aspirin. J. Neurochemistry, 52 : 101-109, 1989.
28. Kontos HA wei EP Dietrich WD Navari RM Povlishock JT Ghatal< NR Ellis EF Patterson JL : Mechanism of cerebral arteriolar abnormalities after acute hypertantion. Am. J. Physiol. 240 : 1-1511-H527, 1981.
29. Kontos HA : Oxygen radicals in cerebral vasculer injury. Circ. Res. 57 : 508-516, 1985.
30. Kontos HA Wei EP Ellis EF Jenkins, IW Povlishock JT Rowe GT Hess ML : Appearance of superoxide anion radical in cerebral extracellular space during increased prostaglandin synthesis in cats. Circ. Res. 57 : 142-151, 1981.
31. Lorenzo AV Hadley-Weit ET Eisenberg HM Hsu DW : Increased penetration of horseradish peroxidase acrose the blood-brain barrier induced by metrazol seizures. Brain Research. 88 : 136-140, 1975.
32. Methews CK Van Holde KE Biological oxidations, electron transport, and oxidatvie phosphorylation. In Biochemistry. Benjamin/ Cummings Publishing Company, In California, S. 504-537, 1990.
33. Meisenberg G Simmons WH : Peptides and the blood brain barrier. Life Sciences. 32 : 2611-2623, 1983.
34. Moskowitz MA Kiwak KJ Mekimian K Levine L Synthesis of coumpounds with properties of leukotrienes C4 and in gerbil brains after ischemia and reperfusion, Science, 224 : 886-889, 1984.
135. Nag S : Localisation of calcium-activated adenosinetriphosphatase (Ca ATPase) in intracerebral. arterioles in acute hypertention. Acta Neuropatol. (Berl), 75 547-553, 1988.
36. Nitsch C Klatzo I : Regional patterns of blood-brain barrier breakdown during epileptiform seizures induced by varius convulsive agents. J Neurological Sci ences. 59 305-322, 1983.
37. Olesen SP : Free oxygen radicals decrease electrical resistance of microvascular endothelium. Acta. Physiol. Scand. 129 : 181-187, 1987.
38, Palmer GC McCreedy SA Freedman LR Neurotransmitter coupled responses in the microvasculature of the brain under normal and pathological conditions. In Ed : Battaini, Fij Govani, S., Magnoni M.S., Trabucchi M, Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. NATO ASI Series, Series H Cell Biology. Springer-Verlag Berlin Heidelberg. Vol. 33, s. 113-141, 1989.
39. Papadopoulos SM Black KL Hoff J T : Cerebral edema induced by arachidonic acid : Role of leukocytes and 5-lipooxygenase products. Neurosurgery. 25 (3) 319-372, 1989.
40. Pardrige WM Oldendorf W Cancilla P Frank L : Blood-brain barrier ; Interface between internal medicine and the brain. Annals of Internal Medicine. 105 82 95, 1986.
41. Pardrige WM ; Recent advences in blood-brain barrier transport. Ann, Rev. Pharmacol. Toxicol. 28 : 25-39* 1988.
42. Petito CK Schaefer JA Pl um F : Ultrastructural characteristics of the blood-brain barrier in experimental seizures. Brain Research. 127 : 251-267, 1977.
43, Petito CK Levy DE : The importance of cerebral arterioles in alterations of the blood-brain barrier. Laboratory Investigation, 43 (3) 262-268, 1980.
44 Pryor WA : Oxy-radicals and related species, Ann. Rev. Physiol. 48 657-667, 1986,

Toplam 44 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Merkezi Sinir Sistemi
Bölüm	Makaleler
Yazarlar	Erhan Nalçacı
Proje Numarası	-
Yayımlanma Tarihi	30 Eylül 1993
Yayımlandığı Sayı	Yıl 1993 Cilt: 46 Sayı: 3

Kaynak Göster

APA	Nalçacı, E. (1993). KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 46(3), 493-511.
AMA	Nalçacı E. KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Eylül 1993;46(3):493-511.
Chicago	Nalçacı, Erhan. “KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46, sy. 3 (Eylül 1993): 493-511.
EndNote	Nalçacı E (01 Eylül 1993) KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46 3 493–511.
IEEE	E. Nalçacı, “KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 3, ss. 493–511, 1993.
ISNAD	Nalçacı, Erhan. “KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46/3 (Eylül 1993), 493-511.
JAMA	Nalçacı E. KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1993;46:493–511.
MLA	Nalçacı, Erhan. “KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 3, 1993, ss. 493-11.
Vancouver	Nalçacı E. KAN-BEYİN BARİYERİ PERMEABİLİTE ARTIŞI MEKANİZMALARI. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1993;46(3):493-511.

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