Araştırma Makalesi
BibTex RIS Kaynak Göster

AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ'IN YERİ

Yıl 1993, Cilt: 46 Sayı: 1, 119 - 128, 31.03.1993

Ayşenaz Taşkın

Öz

Küçük hücreli akciğer kanser (KHAK)i kemoterapi ve radyoterapiden yararlandığı için tanınması ve tümör belirleyiciler büyük önem taşır, Birçok tümör belirleyici çalışılmış fakat yeterli spesifiteye 2,ahip olmadıklarından değerleri sınırlı kamıştır. KHAK'lerinde, NSE'ın tanı değerinin araştırılması için 33 KHAK'li (11'i sınırlı, 22'si yaygın hastalık) hastanın serum NSE değerleri, küçük hücreli dışı akciğer kanserli, kanser dışı akciğer hastalığı olan, akciğer dışı malignitesi olan hastaların ve sağlıklı kontrollerin NSE değerleri ile karşılaştırıldl. KHAK'lerinde serum İNSE tayininin % 83 spesifiyete sahip bir tesl olduğu, sensitivitesinin hastalığın evresi ile ilişkili olduğu saptandı.

Anahtar Kelimeler

Akciğer kanseri Nöron - spesifik enolaz radyoterapi

Kaynakça

  • 1. Addis BJ Hamid Q tbrahim NB et al : Immunohlstochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung. J Pathol 153 : 13750, 1987.
  • 2. Akoun GM Scarna HM Milleron BJ et al Serum neuronspecifia enolase, Chest 87 : 39-43, 1985.
  • 3. Bepler G Jaques G Koehler A et al : Markers and characteristics of human SCLC cell lines. J Cancer Res Clin Oncol 113 : 253-9, 1987.
  • 4. Buamah PK Drake SR Smedley HM et al Neuron-specific enolase during chemotherapy of small cell lung cancer. J Surg Onco 144 (IJ • 1-4, 1990.
  • 5. Burghuber OC Worofka B Schernthaner G et al : Serum neuron-specific enolase is a useful tumor marker for small cell lung cancer, Cancer 65 1386-90* 1990.
  • 6. Carney DN Marangos PJ Ihde DC et al : Serum neuronspecific enolase : A marker for disease extent and response to therapy of small-cell lung cancer. Lancet 1 : 583-5, 1982
  • 7. Carney DN Gazdar AF : Bepler G et al : Estabilishment and identification of small cell lung cancer cell lines having celssic and variant features. Cancer Res 45 : 2913-23, 1985
  • 8. Cooper EH Splinter TAW Brown DA et al Evaluation of a radioimmunoassay for neuron specific enolase in small cell lung cancer. Br J Cancer 52 : 333-8, 1985.
  • 9. Esscher T Steinholtz L J ct al Neurone specific enolase : a useful diagnostic serum marker for small cell carscinoma of the lung. Thorax 40 : 85-90, 1985.
  • 10. Esscher T Bergh J Steinholtz L et al : Neuron-specific enolase in small-cell carcinoma of the lung : The value of combined immunocytochemistry and serum determination. Anticancer Res 9 ; 1717-20, 1989
  • 11. Gerbitz KD Summer J Schumacher I et al : Enolase isoenzymes as tumour markers. J Clin Chem Clin Biochem 24 : 1009-16, 1986.
  • 12. Johnson BE Minna JD Small cell lung cancer In : Fishman AP (Ed) Pulmonary Disease and Disorders, Volume 3. 1988 Mc Graw Hill Book Company, New York, sayfa ; 1971-82.
  • 13. Jorgensen LGM Hansen HH Cooper EH : Neuron specific enolase, carcinoembryonic antigen and lactate dehydrogenase as indicators of disease activity in small cell lung cancer. Eur J Cancer Clin Oncol 25 ; 123-8, 1989.
  • 14. Linnoila RI Mul shine JL Steinberg SM et al Neuroendocrine differantiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol 90 : 641-52, 1988*
  • 15. Mizushima Y Hirata H Izumi S et al : Clinical significance of the number of positive tumor markers in assisting the diagnosis of lung cancer with multiple tumor marker assay. Oncology 47 : 43-8, 1990.
  • 16. Patterson GA ; Lung Cancer Staging. Chest 100 : 520-22, 1991.
  • 17. Scagliotti GV Piani M Gatti E et al : Combined measurements of neuron specific enoJase and bombesin/gastrin releasing peptide in lung cancer. Eur Respir J 2 746-50, 1989.
  • 18. Splinter TAW Cooper EH Kho GS et al : Neuron-specific enolase as a guide to the treatment of small cell lung cancer. Eur J Cancer Oncol 23 (2) • 1716-, 1987.

THE PLACE OF NEURON SPECIFIC ENOLAS IN THE DIAGNOSIS OF LUNG CANCERS

Yıl 1993, Cilt: 46 Sayı: 1, 119 - 128, 31.03.1993

Ayşenaz Taşkın

Öz

Since small cell lung cancer (SCLC) benefits from chemotherapy and radiotherapy, its recognition and tumor markers are of great importance. Many tumor markers have been studied, but their values ​​are limited because they do not have sufficient specificity2. In order to investigate the diagnostic value of NSE in SCLC, serum NSE values ​​of 33 patients with SCLC (11 with limited and 22 with extensive disease) were compared with NSE values ​​of non-small cell lung cancer, non-cancerous lung disease, extrapulmonary malignancies and healthy controls. It was determined that serum INSE determination in SCLC had a specificity of 83% and its sensitivity was related to the stage of the disease.

Anahtar Kelimeler

Lung cancer Neuron-specific enolase radyoterapi

Kaynakça

  • 1. Addis BJ Hamid Q tbrahim NB et al : Immunohlstochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung. J Pathol 153 : 13750, 1987.
  • 2. Akoun GM Scarna HM Milleron BJ et al Serum neuronspecifia enolase, Chest 87 : 39-43, 1985.
  • 3. Bepler G Jaques G Koehler A et al : Markers and characteristics of human SCLC cell lines. J Cancer Res Clin Oncol 113 : 253-9, 1987.
  • 4. Buamah PK Drake SR Smedley HM et al Neuron-specific enolase during chemotherapy of small cell lung cancer. J Surg Onco 144 (IJ • 1-4, 1990.
  • 5. Burghuber OC Worofka B Schernthaner G et al : Serum neuron-specific enolase is a useful tumor marker for small cell lung cancer, Cancer 65 1386-90* 1990.
  • 6. Carney DN Marangos PJ Ihde DC et al : Serum neuronspecific enolase : A marker for disease extent and response to therapy of small-cell lung cancer. Lancet 1 : 583-5, 1982
  • 7. Carney DN Gazdar AF : Bepler G et al : Estabilishment and identification of small cell lung cancer cell lines having celssic and variant features. Cancer Res 45 : 2913-23, 1985
  • 8. Cooper EH Splinter TAW Brown DA et al Evaluation of a radioimmunoassay for neuron specific enolase in small cell lung cancer. Br J Cancer 52 : 333-8, 1985.
  • 9. Esscher T Steinholtz L J ct al Neurone specific enolase : a useful diagnostic serum marker for small cell carscinoma of the lung. Thorax 40 : 85-90, 1985.
  • 10. Esscher T Bergh J Steinholtz L et al : Neuron-specific enolase in small-cell carcinoma of the lung : The value of combined immunocytochemistry and serum determination. Anticancer Res 9 ; 1717-20, 1989
  • 11. Gerbitz KD Summer J Schumacher I et al : Enolase isoenzymes as tumour markers. J Clin Chem Clin Biochem 24 : 1009-16, 1986.
  • 12. Johnson BE Minna JD Small cell lung cancer In : Fishman AP (Ed) Pulmonary Disease and Disorders, Volume 3. 1988 Mc Graw Hill Book Company, New York, sayfa ; 1971-82.
  • 13. Jorgensen LGM Hansen HH Cooper EH : Neuron specific enolase, carcinoembryonic antigen and lactate dehydrogenase as indicators of disease activity in small cell lung cancer. Eur J Cancer Clin Oncol 25 ; 123-8, 1989.
  • 14. Linnoila RI Mul shine JL Steinberg SM et al Neuroendocrine differantiation in endocrine and nonendocrine lung carcinomas. Am J Clin Pathol 90 : 641-52, 1988*
  • 15. Mizushima Y Hirata H Izumi S et al : Clinical significance of the number of positive tumor markers in assisting the diagnosis of lung cancer with multiple tumor marker assay. Oncology 47 : 43-8, 1990.
  • 16. Patterson GA ; Lung Cancer Staging. Chest 100 : 520-22, 1991.
  • 17. Scagliotti GV Piani M Gatti E et al : Combined measurements of neuron specific enoJase and bombesin/gastrin releasing peptide in lung cancer. Eur Respir J 2 746-50, 1989.
  • 18. Splinter TAW Cooper EH Kho GS et al : Neuron-specific enolase as a guide to the treatment of small cell lung cancer. Eur J Cancer Oncol 23 (2) • 1716-, 1987.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Göğüs Hastalıkları
Bölüm Makaleler
Yazarlar

Ayşenaz Taşkın

Yayımlanma Tarihi 31 Mart 1993
Yayımlandığı Sayı Yıl 1993 Cilt: 46 Sayı: 1

Kaynak Göster

APA Taşkın, A. (1993). AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 46(1), 119-128.
AMA Taşkın A. AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Mart 1993;46(1):119-128.
Chicago Taşkın, Ayşenaz. “AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46, sy. 1 (Mart 1993): 119-28.
EndNote Taşkın A (01 Mart 1993) AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46 1 119–128.
IEEE A. Taşkın, “AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 1, ss. 119–128, 1993.
ISNAD Taşkın, Ayşenaz. “AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 46/1 (Mart 1993), 119-128.
JAMA Taşkın A. AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1993;46:119–128.
MLA Taşkın, Ayşenaz. “AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 46, sy. 1, 1993, ss. 119-28.
Vancouver Taşkın A. AKCİĞER KANSERLERİNİN TANISINDA NÖRON SPESİFİK ENOLAZ’IN YERİ. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1993;46(1):119-28.
 Kapak Resmi İndir