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Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi

Yıl 1982, Cilt: 35 Sayı: 3, 487 - 502, 30.09.1982

Gürbüz Erdoğan

Öz

Bu çalışmada galaktore ile başvuran 41 olguda prolaktin patolojisi ve bromokriptin tedavisi ile elde edilen sonuçlar üzerine ön gözlemlerimizi sunduk. Ayrı ayrı ele alınan akromegali, hirsutizm ve hipogonadizm vakalarında bromokriptin tedavisinin etkisi konusunda net bir sonuca varmak için henüz erkendir, Bromokriptin 497 Bununla birlikte galaktore ile ilişkili akromegaliklerde galaktore genellikle kısa sürede azalmıştır. Ayrıca amenore ve galaktore olan kadın hastalarımızdan biri fertilizasyon kapasitesi kazanarak gebe kalmıştır. Hipogonadizm olan erkek hastalarımızdan birinde bromokriptin tedavisi ile spermatogenetik fonksiyon başlamıştır.

Anahtar Kelimeler

prolaktin galaktore akromegali hipogonadizm

Kaynakça

  • 1. Adler, R.A., Noel, G.L., et al : Failure of oral water loading and intravenous hypotonic saline to suppress plasma prolaetin in man. J. Clin Endocrinol Metab, 41 : 383-389, 1975.
  • 2. Ben-david, M. et al : Evidence of antagonism between prolaetin and gonadotrophin secretion effect of methalikure in perphenezine induced prolactin secretion in ovariectomised rats. Journal of Endocrinology, 51 710-715, 1971.
  • 3. Besser-G. M, et al : Galactorrhea : Succesful treatment with reduction of plasma pro lactin levels by Bromergocriptine, British Medical Journal, ii : 669-673, 1972.
  • 4. Besser; G.M., Thorner, M.C. : Bromocript.ine in the treatmeut of the hyperprolactinemie hypogonadism syndromes postgraduate. Medical Journal, 52 (supp : l) 64-69, 1976.
  • 5. Besser-G.M , Wase, J.A., Hanel Thorner, M.C. : Acromegaly-results of long term treat ment with BromocrÏptine, Acta Endocrinologica supp : 216 : 187-218, 1972.
  • 6. Bohnet, H.O., et al : Hyperprolaetinemic anovulatory syndrome. J: of Clinical Endoc. and Metab. 42 : 132-139, 1976,
  • 7. Cammanni, F, et al : Effect of dopamine on plasma Growth hormone and prolactin Icvels in normal and acromegalic subject. J. Clin, Endoe. 44 : 465-470, 1977 .
  • DelPozo, et al : hormonal response to bromocriptine in the galactorrhea syndromes. J. of. Clinical Endoc. and Metab. 39 : 18-23, 1974.
  • 9. ErðoEan, G. : idiopatik hirsutizmde gonadotropinler ye androjen hormonlar ile prolaktinemi arasmdaki korelasyon, iizerinde arastLrtna. AiÜi TIP Fak. Mec. XXX/IV 882-827, 1977.
  • 10. Franka, S, et al : Incidence and significance of hyperprolactinemia in women with amenorrhea. Clin Endocrinology. 4 : 597-601 1975.
  • 11, Frinsen, I-LG. : Clinical Endocrinology. p. 53-59 ed Ewin, C, et al Apprectan-Century Crafta-Newyork* 1977.
  • 12. Gibson, Norymbcrsky, Stubbs : Bioehemic. J. 60 : 453-461, 1975.
  • 13. Gomez, F. Reyen, F.L, Faiman, •C. : Non-puerperal galactorrhea and hyperprolactine Amer, J, Med, 62 : 648-653, 1977,
  • 14. Hershan, Ü.M. : Endocrine pathopsiology : A patient, oeriented approach Lea and Febriger Philadelphiav 1977, 15, Hökleft, B., Millius, J S. : The dopamine agonist bromoeriptine, sandoz A.H. Sweden, 1978.
  • 16. Jacobs. TïS. et al : Diagnosis and treatment of hyperprolactinemic amenorrhea. Grange press, soutlwick, Sussex, 1976.
  • 17. Kleinberg, D.L et al : Galactorrhea, A study of 235 cases inCIuding 4 With pituitary tumors. New Eng. r. Med. 296, 589-593, 1977.
  • 18. Koloälu, S. ErdoEan, G. Hipersomatotropinizmin tedavisinde hipofiz 19tnlanmas1mn degeri tedavi sonuçlarltnn takibinde faydall clan kriteryumlar ve kobaltoterapi için hasta seleksiyenu. A.Ü Tgp Fak. No. 37/3-4 : 797-801, 1975.
  • 19, Lunden, L, et al : Bromocriptine therapy Ein eleven patients acromegaly. Acta Endocrinologica supp, 216 : 207-216, 1,978.
  • 20. Mortimer, CC, et al : Luteinising hormon and follicle stimiilating hormone redeasing hormone test in patients with hypotalamic-pituitary-gonadal dysfunction British Med your. iv. 73-78, 1973.
  • 21. Nillius. J.S. Prolactin. Acta Endocrinologica. Supp. 216 99-104 1978.
  • 22 Neryherskyt et al : Lancet 264 1276-1283, 1963.
  • 23. Nilson, A Experienced with bromocriptinc treatment in aeromegaly. A preliminary re port. Acta Endocrinologia. Supp. 216 : 217-224, 1978.
  • 24 Rayer. RI, et al : Pituitary-ovarian interrelationships during the puerperium. Amer• J. af obstet And gynecology. 111 : 589-596, 1972.
  • 25. Sehpali, M, et al : Raised serum prolactin levels in amenorrhea, British Med J ii, 305312, 1975.
  • 26, Thorner, MC.. Besser G.M. et al : Long term treatment of galactorrhea and hypogonadism with bromocriptine, British Med. J. ii. 419-424, 1974,
  • 27. Thorner, MO, Prolactin, Clinics in Endocrinology and Met. 6 (1) : 201-203, 1977.
  • 28. Thorner, MO, Besser, G.M. : Hyperprolactinemia and gonadažl. function. Results of bromocriptinc treatment. •prolactine and human reproduction» proceeding serono symp posia vcl, 2, Academic press Inc. London Ltd. 1977.
  • 29 Thorner, MO., Besser, S.G.M. : Hyperprolactinemia and gonadal function. Results of bromoeriptine treatment in prolactin and human reproduction. Ed. Crosingnani et al Academic Press, London. 1977.
  • 30. Tolis, G. : Galactorrhea-amenorrhea and hyperprolactinemia : Pathophysiological aspeets and diagnostic tests. Clina Endoe. Supp. XXX-6 : 81-87, 1977.
  • 31. Werner, S. : Regulation of growth hormone secretion during normal conditions and in patients With acromcgaly. Acta Endocrinologica. Supp. 216 : 179-186, 1978.
  • 32. Werner, S. et al Bromocriptine therapy in patients with acromega.ly. Acta Endocrinuologica. Supp. 216 : 199-205, 1978.

Prolactin Pathology And Bromocriptine Therapy In Galactorrhea Syndromes

Yıl 1982, Cilt: 35 Sayı: 3, 487 - 502, 30.09.1982

Gürbüz Erdoğan

Öz

In this study, we presented our preliminary observations on prolactin pathology and on the results obtained with bromocriptine therapy in 41 cases with galactorrhea. It is still early to have a clear conclusion on the effect of bromocriptine therapy on the cases of acromegaly, hirsutism and hypogonadism which were taken up separately, Bromocriptine 497 Nevertheless, in acromegalic associated with galactorhea, galactorrhea usu ally decreased in a short period. In addition, one of our female cases with amenorrhea and galactorrhea gained hlr capacity for fertilisaticn and became pregnant, In one of our male cases with hypogonadism, spermatogenetic function started with bromocriptine therapy.

Anahtar Kelimeler

prolactin galactorhea acromegaly hypogonadism

Kaynakça

  • 1. Adler, R.A., Noel, G.L., et al : Failure of oral water loading and intravenous hypotonic saline to suppress plasma prolaetin in man. J. Clin Endocrinol Metab, 41 : 383-389, 1975.
  • 2. Ben-david, M. et al : Evidence of antagonism between prolaetin and gonadotrophin secretion effect of methalikure in perphenezine induced prolactin secretion in ovariectomised rats. Journal of Endocrinology, 51 710-715, 1971.
  • 3. Besser-G. M, et al : Galactorrhea : Succesful treatment with reduction of plasma pro lactin levels by Bromergocriptine, British Medical Journal, ii : 669-673, 1972.
  • 4. Besser; G.M., Thorner, M.C. : Bromocript.ine in the treatmeut of the hyperprolactinemie hypogonadism syndromes postgraduate. Medical Journal, 52 (supp : l) 64-69, 1976.
  • 5. Besser-G.M , Wase, J.A., Hanel Thorner, M.C. : Acromegaly-results of long term treat ment with BromocrÏptine, Acta Endocrinologica supp : 216 : 187-218, 1972.
  • 6. Bohnet, H.O., et al : Hyperprolaetinemic anovulatory syndrome. J: of Clinical Endoc. and Metab. 42 : 132-139, 1976,
  • 7. Cammanni, F, et al : Effect of dopamine on plasma Growth hormone and prolactin Icvels in normal and acromegalic subject. J. Clin, Endoe. 44 : 465-470, 1977 .
  • DelPozo, et al : hormonal response to bromocriptine in the galactorrhea syndromes. J. of. Clinical Endoc. and Metab. 39 : 18-23, 1974.
  • 9. ErðoEan, G. : idiopatik hirsutizmde gonadotropinler ye androjen hormonlar ile prolaktinemi arasmdaki korelasyon, iizerinde arastLrtna. AiÜi TIP Fak. Mec. XXX/IV 882-827, 1977.
  • 10. Franka, S, et al : Incidence and significance of hyperprolactinemia in women with amenorrhea. Clin Endocrinology. 4 : 597-601 1975.
  • 11, Frinsen, I-LG. : Clinical Endocrinology. p. 53-59 ed Ewin, C, et al Apprectan-Century Crafta-Newyork* 1977.
  • 12. Gibson, Norymbcrsky, Stubbs : Bioehemic. J. 60 : 453-461, 1975.
  • 13. Gomez, F. Reyen, F.L, Faiman, •C. : Non-puerperal galactorrhea and hyperprolactine Amer, J, Med, 62 : 648-653, 1977,
  • 14. Hershan, Ü.M. : Endocrine pathopsiology : A patient, oeriented approach Lea and Febriger Philadelphiav 1977, 15, Hökleft, B., Millius, J S. : The dopamine agonist bromoeriptine, sandoz A.H. Sweden, 1978.
  • 16. Jacobs. TïS. et al : Diagnosis and treatment of hyperprolactinemic amenorrhea. Grange press, soutlwick, Sussex, 1976.
  • 17. Kleinberg, D.L et al : Galactorrhea, A study of 235 cases inCIuding 4 With pituitary tumors. New Eng. r. Med. 296, 589-593, 1977.
  • 18. Koloälu, S. ErdoEan, G. Hipersomatotropinizmin tedavisinde hipofiz 19tnlanmas1mn degeri tedavi sonuçlarltnn takibinde faydall clan kriteryumlar ve kobaltoterapi için hasta seleksiyenu. A.Ü Tgp Fak. No. 37/3-4 : 797-801, 1975.
  • 19, Lunden, L, et al : Bromocriptine therapy Ein eleven patients acromegaly. Acta Endocrinologica supp, 216 : 207-216, 1,978.
  • 20. Mortimer, CC, et al : Luteinising hormon and follicle stimiilating hormone redeasing hormone test in patients with hypotalamic-pituitary-gonadal dysfunction British Med your. iv. 73-78, 1973.
  • 21. Nillius. J.S. Prolactin. Acta Endocrinologica. Supp. 216 99-104 1978.
  • 22 Neryherskyt et al : Lancet 264 1276-1283, 1963.
  • 23. Nilson, A Experienced with bromocriptinc treatment in aeromegaly. A preliminary re port. Acta Endocrinologia. Supp. 216 : 217-224, 1978.
  • 24 Rayer. RI, et al : Pituitary-ovarian interrelationships during the puerperium. Amer• J. af obstet And gynecology. 111 : 589-596, 1972.
  • 25. Sehpali, M, et al : Raised serum prolactin levels in amenorrhea, British Med J ii, 305312, 1975.
  • 26, Thorner, MC.. Besser G.M. et al : Long term treatment of galactorrhea and hypogonadism with bromocriptine, British Med. J. ii. 419-424, 1974,
  • 27. Thorner, MO, Prolactin, Clinics in Endocrinology and Met. 6 (1) : 201-203, 1977.
  • 28. Thorner, MO, Besser, G.M. : Hyperprolactinemia and gonadažl. function. Results of bromocriptinc treatment. •prolactine and human reproduction» proceeding serono symp posia vcl, 2, Academic press Inc. London Ltd. 1977.
  • 29 Thorner, MO., Besser, S.G.M. : Hyperprolactinemia and gonadal function. Results of bromoeriptine treatment in prolactin and human reproduction. Ed. Crosingnani et al Academic Press, London. 1977.
  • 30. Tolis, G. : Galactorrhea-amenorrhea and hyperprolactinemia : Pathophysiological aspeets and diagnostic tests. Clina Endoe. Supp. XXX-6 : 81-87, 1977.
  • 31. Werner, S. : Regulation of growth hormone secretion during normal conditions and in patients With acromcgaly. Acta Endocrinologica. Supp. 216 : 179-186, 1978.
  • 32. Werner, S. et al Bromocriptine therapy in patients with acromega.ly. Acta Endocrinuologica. Supp. 216 : 199-205, 1978.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Endokrinoloji
Bölüm Makaleler
Yazarlar

Gürbüz Erdoğan

Yayımlanma Tarihi 30 Eylül 1982
Yayımlandığı Sayı Yıl 1982 Cilt: 35 Sayı: 3

Kaynak Göster

APA Erdoğan, G. (1982). Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 35(3), 487-502.
AMA Erdoğan G. Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. Eylül 1982;35(3):487-502.
Chicago Erdoğan, Gürbüz. “Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35, sy. 3 (Eylül 1982): 487-502.
EndNote Erdoğan G (01 Eylül 1982) Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35 3 487–502.
IEEE G. Erdoğan, “Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 35, sy. 3, ss. 487–502, 1982.
ISNAD Erdoğan, Gürbüz. “Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 35/3 (Eylül 1982), 487-502.
JAMA Erdoğan G. Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35:487–502.
MLA Erdoğan, Gürbüz. “Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, c. 35, sy. 3, 1982, ss. 487-02.
Vancouver Erdoğan G. Galaktore Sendromlarında Prolaktin Patolojisi Ve Bromocriptine Tedavisi. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1982;35(3):487-502.
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