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Kansere Mikrobiyal Bakış: Postbiyotikler

Yıl 2025, , 151 - 160, 26.04.2025

Mert Aşit , Hasan Ergenç , Sinem Uysal

https://doi.org/10.58605/bingolsaglik.1600034

Öz

Dünya genelinde meydana gelen ölümlerin nedenleri arasında kanser ikinci sırada yer almaktadır. Gelişmekte olan tedavi yöntemleri ile kanser hastalarının prognozunda olumlu yönde ilerleme kat edilmiş olsada vakaların büyük bir kısmında hala daha kötüdür. Antikanser tedavisine olan karmaşık yaklaşımlar araştırmacıları bu konuda da yeni yollar aramaya teşvik etmektedir. Bağırsak mikrobiyotası bu amaçla araştırılması gereken geniş alanlardan biridir. Mikrobiyotanın insan vücudunda önemli bir yeri vardır. Mikrobiyal kompozisyonun dengesizleşmesi sonucu meydana gelen disbiyosiz tümorijenik yolu etkileyerek bazı kanser türlerini tetikleyebilir. Probiyotikler, prebiyotikler, sinbiyotikler ve postbiyotikler bağırsak mikrobiyotasını etkileyerek mikrobiyota dengesinin yeniden sağlanmasına yardımcı olabilmektedir. Bağırsak mikrobiyomu için biyotik ailesinin bir üyesi olan postbiyotiklerin kullanımı son zamanlarda ilgi çekmektedir. Postbiyotikler konakçı sağlığına faydalı etkileri bulunan mikrobiyal metabolitlerdir. Postbiyotikler bazı kanser türlerini önleme veya tedavisine potansiyel olarak yardımcı olan antibakteriyel, antikanser ve antikanserojenik özelliklere sahiptir. Bu etkileri ile postbiyotikler kanser üzerinde oldukça önemlidir. Bu derleme postbiyotiklerin bazı kanser türleri üzerine etkilerini incelemek amacıyla yazılmıştır.

Anahtar Kelimeler

Gastrointestinal kanser Mikrobiyal yaşayabilirlik Oral kanser.

Destekleyen Kurum

yoktur

Proje Numarası

yoktur

Kaynakça

  • Rodríguez, JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, et al. The composition of the gut microbiota throughout life, with an emphasis on early life. Microbial Ecology in Health and Disease. 2015;26(1), 26050. https://doi:10.3402/mehd.v26.26050
  • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285), 59-65. https://doi:10.1038/nature08821
  • Açar Y, Sökülmez KP. Postbiyotikler ve sağlık üzerine etkileri: Sistematik derleme. Literatür Eczacılık Bilimleri Dergisi. 2021;10(2), 276 – 284. https://doi:10.5336/pharmsci.2021-82004
  • FAO/WHO. (2001). Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report, 1-34.
  • O’Toole PW, Marchesi JR, Hill C. Next-Generation probiotics: The spectrum from probiotics to live biotherapeutics. Nature Microbiology. 2017;2(5), 1-6. https://doi:10.1038/nmicrobiol.2017.57
  • Sánchez B, Delgado S, Blanco-Míguez A, Lourenço A, Gueimonde M, Margolles A. Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food Research. 2017;61(1), 1600240. https://doi:10.1002/mnfr.201600240
  • Kvakova M, Kamlarova A, Stofilova J, Benetinova V, Bertkova I. Probiotics and postbiotics in colorectal cancer: prevention and complementary therapy. World Journal of Gastroenterology. 2022;28(27), 3370. https://doi:10.3748/wjg.v28.i27.3370
  • Mohd Fuad AS, Amran NA, Nasruddin NS, Burhanudin NA, Dashper S, Arzmi MH. The mechanisms of probiotics, prebiotics, synbiotics, and postbiotics in oral cancer management. Probiotics and Antimicrobial Proteins. 2022; 1-14. https://doi:10.1007/s12602-022-09985-7
  • Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey Jr G, Goh YJ, et al. Prebiotics: Why definitions matter. Current Opinion in Biotechnology. 2016;37, 1-7. https://doi:10.1016/j.copbio.2015.09.001
  • Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, et al. Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods. 2019;8(3), 92. https://doi:10.3390/foods8030092
  • Ashwini A, Ramya HN, Ramkumar C, Reddy KR, Kulkarni RV, Abinaya V, et al. Reactive mechanism and the applications of bioactive prebiotics for human health. Journal of Microbiological Methods. 2019;159, 128-137. https://doi:10.1016/j.mimet.2019.02.019
  • Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9(9), 1021. https://doi:10.3390/nu9091021
  • Pandey K, Naik S, Vakil B. Probiotics, prebiotics and synbiotics-a review. Journal of Food Science and Technology. 2015;52(12), 7577-7587. https://doi:10.1007/s13197-015-1921-1
  • Nikbakht E, Khalesi S, Singh I, Williams LT, West NP, Colson N. Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials. European Journal of Nutrition. 2018;57(1), 95-106. https://doi:10.1007/s00394-016-1300-3
  • Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, Mata-Haro V, González-Córdova AF, Vallejo-Cordoba B, et al. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018;75, 105-114. https://doi:10.1016/j.tifs.2018.03.009
  • Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2024;74(3), 229-263. https://doi.org/10.3322/caac.21834
  • Sharma M, Shukla G. Metabiotics: One step ahead of probiotics; an insight into mechanisms involved in anticancerous effect in colorectal cancer. Frontiers in Microbiology. 2016;7, 1940. https://doi:10.3389/fmicb.2016.01940
  • Verma A, Shukla G. Modulation of apoptosis and immune response by synbiotic in experimental colorectal cancer. International Journal of Pharma and Biological Sciences. 2015;6, 529-43.
  • 19.Tiptiri-Kourpeti A, Spyridopoulou K, Santarmaki V, Aindelis G, Tompoulidou E, Lamprianidou EE, et al. Lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of traıl in colon carcinoma cells. PloS one. 2016;11(2), e0147960. https://doi:10.1371/journal.pone.0147960
  • Wang B, Yao M, Lv L, Ling Z, Li L. The human microbiota in health and disease. Engineering, 2017;3(1), 71-82. https://doi:10.1016/J.ENG.2017.01.008
  • 21.Gao J, Li Y, Wan Y, Hu T, Liu L, Yang S, et al. A novel postbiotic from lactobacillus rhamnosus gg with a beneficial effect on ıntestinal barrier function. Frontiers in Microbiology. 2019;10, 477. https://doi:10.3389/fmicb.2019.00477
  • 22. Escamilla J, Lane MA, Maitin V. Cell-Free supernatants from probiotic lactobacillus casei and lactobacillus rhamnosus gg decrease colon cancer cell invasion in vitro. Nutrition and Cancer. 2012;64(6), 871-878. https://doi:10.1080/01635581.2012.700758
  • 23. Lupton JR. Is fiber protective against colon cancer? Where the research is leading us. Nutrition (Burbank, Los Angeles County, Calif.). 2000;16(7-8), 558-561. https://doi:10.1016/s0899-9007(00)00350-6
  • 24. Hijova E, Chmelarova A. Short chain fatty acids and colonic health. Bratislavské lekárske Listy. 2007;108(8), 354.
  • 25. de LeBlanc ADM, LeBlanc JG, Perdigon G, Miyoshi A, Langella P, Azevedo V, et al. Oral administration of a catalase-producing lactococcus lactis can prevent a chemically induced colon cancer in mice. Journal of Medical Microbiology. 2008;57(1), 100-105. https://doi:10.1099/jmm.0.47403-0
  • 26. Choe DW, Foo HL, Loh TC, Hair-Bejo M, Awis QS. Inhibitory property of metabolite combinations produced from lactobacillus plantarum strains. Pertanika Journal of Tropical Agricultural Science. 2013;36(1).
  • 27. Wang K, Li W, Rui X, Chen X, Jiang M, Dong M. Characterization of a novel exopolysaccharide with antitumor activity from lactobacillus plantarum 70810. International Journal of Biological Macromolecules. 2014;63, 133-139. https://doi:10.1016/j.ijbiomac.2013.10.036
  • 28.Tang HY, Cao YZ, Zhou YW, Ma YS, Jiang H, Zhang H, et al. The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer. Journal of Advanced Research. 2024. https://doi.org/10.1016/j.jare.2024.01.014
  • 29. Sobocki BK, Kaźmierczak-Siedlecka K, Folwarski M, Hawryłkowicz V, Makarewicz W, Stachowska E. Pancreatic cancer and gut microbiome-related aspects: A comprehensive review and dietary recommendations. Nutrients. 2021;13(12), 4425. https://doi.org/10.3390/nu13124425
  • 30. Luan C, Xie L, Yang X, Miao H, Lv N, Zhang R, et al. Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas. Scientific Reports. 2015;5(1), 1-9. https://doi:10.1038/srep07980
  • 31. Jones SE, Versalovic J. Probiotic lactobacillus reuteribiofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiology. 2009;9(1), 1-9. https://doi:10.1186/1471-2180-9-35
  • 32. Jung JI, Baek SM, Nguyen TH, Kim JW, Kang CH, Kim S, et al. Effects of probiotic culture supernatant on cariogenic biofilm formation and RANKL-Induced osteoclastogenesis in RAW 264.7 macrophages. Molecules. 2021;26(3), 733. https://doi:10.3390/molecules26030733
  • 33. Vrzáčková N, Ruml T, Zelenka J. Postbiotics, metabolic signaling, and cancer. Molecules. 2021;26(6), 1528. https://doi:10.3390/molecules26061528
  • 34. Cakmak YO. Provotella-derived hydrogen sulfide, constipation, and neuroprotection in parkinson's disease. Movement Disorders. 2015;8(30), 1151-1151. https://doi.org/10.1002/mds.26258

Microbial Perspective on Cancer: Postbiotics

Yıl 2025, , 151 - 160, 26.04.2025

Mert Aşit , Hasan Ergenç , Sinem Uysal

https://doi.org/10.58605/bingolsaglik.1600034

Öz

Cancer is the second leading cause of death worldwide. Although there has been positive progress in the prognosis of cancer patients with developing treatment methods, it is still poor in the majority of cases. Complex approaches to anticancer treatment encourage researchers to seek new ways in this regard. Intestinal microbiota is one of the large areas that need to be investigated for this purpose. Microbiota has an important place in the human body. Dysbiosis, which occurs as a result of imbalance in microbial composition, can trigger some types of cancer by affecting the tumorigenic pathway. Probiotics, prebiotics, synbiotics and postbiotics can help restore the microbiota balance by affecting the intestinal microbiota. The use of postbiotics, a member of the biotic family for the intestinal microbiome, has recently attracted attention. Postbiotics are microbial metabolites that have beneficial effects on host health. Postbiotics have antibacterial, anticancer and anticarcinogenic properties that potentially help prevent or treat some types of cancer. With these effects, postbiotics are very important on cancer. This review was written to examine the effects of postbiotics on some types of cancer.

Anahtar Kelimeler

Gastrointestinal cancer Microbial viability Oral cancer.

Proje Numarası

yoktur

Kaynakça

  • Rodríguez, JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, et al. The composition of the gut microbiota throughout life, with an emphasis on early life. Microbial Ecology in Health and Disease. 2015;26(1), 26050. https://doi:10.3402/mehd.v26.26050
  • Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285), 59-65. https://doi:10.1038/nature08821
  • Açar Y, Sökülmez KP. Postbiyotikler ve sağlık üzerine etkileri: Sistematik derleme. Literatür Eczacılık Bilimleri Dergisi. 2021;10(2), 276 – 284. https://doi:10.5336/pharmsci.2021-82004
  • FAO/WHO. (2001). Evaluation of health and nutritional properties of powder milk and live lactic acid bacteria. Food and Agriculture Organization of the United Nations and World Health Organization Expert Consultation Report, 1-34.
  • O’Toole PW, Marchesi JR, Hill C. Next-Generation probiotics: The spectrum from probiotics to live biotherapeutics. Nature Microbiology. 2017;2(5), 1-6. https://doi:10.1038/nmicrobiol.2017.57
  • Sánchez B, Delgado S, Blanco-Míguez A, Lourenço A, Gueimonde M, Margolles A. Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food Research. 2017;61(1), 1600240. https://doi:10.1002/mnfr.201600240
  • Kvakova M, Kamlarova A, Stofilova J, Benetinova V, Bertkova I. Probiotics and postbiotics in colorectal cancer: prevention and complementary therapy. World Journal of Gastroenterology. 2022;28(27), 3370. https://doi:10.3748/wjg.v28.i27.3370
  • Mohd Fuad AS, Amran NA, Nasruddin NS, Burhanudin NA, Dashper S, Arzmi MH. The mechanisms of probiotics, prebiotics, synbiotics, and postbiotics in oral cancer management. Probiotics and Antimicrobial Proteins. 2022; 1-14. https://doi:10.1007/s12602-022-09985-7
  • Hutkins RW, Krumbeck JA, Bindels LB, Cani PD, Fahey Jr G, Goh YJ, et al. Prebiotics: Why definitions matter. Current Opinion in Biotechnology. 2016;37, 1-7. https://doi:10.1016/j.copbio.2015.09.001
  • Davani-Davari D, Negahdaripour M, Karimzadeh I, Seifan M, Mohkam M, Masoumi SJ, et al. Prebiotics: Definition, types, sources, mechanisms, and clinical applications. Foods. 2019;8(3), 92. https://doi:10.3390/foods8030092
  • Ashwini A, Ramya HN, Ramkumar C, Reddy KR, Kulkarni RV, Abinaya V, et al. Reactive mechanism and the applications of bioactive prebiotics for human health. Journal of Microbiological Methods. 2019;159, 128-137. https://doi:10.1016/j.mimet.2019.02.019
  • Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients. 2017;9(9), 1021. https://doi:10.3390/nu9091021
  • Pandey K, Naik S, Vakil B. Probiotics, prebiotics and synbiotics-a review. Journal of Food Science and Technology. 2015;52(12), 7577-7587. https://doi:10.1007/s13197-015-1921-1
  • Nikbakht E, Khalesi S, Singh I, Williams LT, West NP, Colson N. Effect of probiotics and synbiotics on blood glucose: a systematic review and meta-analysis of controlled trials. European Journal of Nutrition. 2018;57(1), 95-106. https://doi:10.1007/s00394-016-1300-3
  • Aguilar-Toalá JE, Garcia-Varela R, Garcia HS, Mata-Haro V, González-Córdova AF, Vallejo-Cordoba B, et al. Postbiotics: An evolving term within the functional foods field. Trends in Food Science & Technology. 2018;75, 105-114. https://doi:10.1016/j.tifs.2018.03.009
  • Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2024;74(3), 229-263. https://doi.org/10.3322/caac.21834
  • Sharma M, Shukla G. Metabiotics: One step ahead of probiotics; an insight into mechanisms involved in anticancerous effect in colorectal cancer. Frontiers in Microbiology. 2016;7, 1940. https://doi:10.3389/fmicb.2016.01940
  • Verma A, Shukla G. Modulation of apoptosis and immune response by synbiotic in experimental colorectal cancer. International Journal of Pharma and Biological Sciences. 2015;6, 529-43.
  • 19.Tiptiri-Kourpeti A, Spyridopoulou K, Santarmaki V, Aindelis G, Tompoulidou E, Lamprianidou EE, et al. Lactobacillus casei exerts anti-proliferative effects accompanied by apoptotic cell death and up-regulation of traıl in colon carcinoma cells. PloS one. 2016;11(2), e0147960. https://doi:10.1371/journal.pone.0147960
  • Wang B, Yao M, Lv L, Ling Z, Li L. The human microbiota in health and disease. Engineering, 2017;3(1), 71-82. https://doi:10.1016/J.ENG.2017.01.008
  • 21.Gao J, Li Y, Wan Y, Hu T, Liu L, Yang S, et al. A novel postbiotic from lactobacillus rhamnosus gg with a beneficial effect on ıntestinal barrier function. Frontiers in Microbiology. 2019;10, 477. https://doi:10.3389/fmicb.2019.00477
  • 22. Escamilla J, Lane MA, Maitin V. Cell-Free supernatants from probiotic lactobacillus casei and lactobacillus rhamnosus gg decrease colon cancer cell invasion in vitro. Nutrition and Cancer. 2012;64(6), 871-878. https://doi:10.1080/01635581.2012.700758
  • 23. Lupton JR. Is fiber protective against colon cancer? Where the research is leading us. Nutrition (Burbank, Los Angeles County, Calif.). 2000;16(7-8), 558-561. https://doi:10.1016/s0899-9007(00)00350-6
  • 24. Hijova E, Chmelarova A. Short chain fatty acids and colonic health. Bratislavské lekárske Listy. 2007;108(8), 354.
  • 25. de LeBlanc ADM, LeBlanc JG, Perdigon G, Miyoshi A, Langella P, Azevedo V, et al. Oral administration of a catalase-producing lactococcus lactis can prevent a chemically induced colon cancer in mice. Journal of Medical Microbiology. 2008;57(1), 100-105. https://doi:10.1099/jmm.0.47403-0
  • 26. Choe DW, Foo HL, Loh TC, Hair-Bejo M, Awis QS. Inhibitory property of metabolite combinations produced from lactobacillus plantarum strains. Pertanika Journal of Tropical Agricultural Science. 2013;36(1).
  • 27. Wang K, Li W, Rui X, Chen X, Jiang M, Dong M. Characterization of a novel exopolysaccharide with antitumor activity from lactobacillus plantarum 70810. International Journal of Biological Macromolecules. 2014;63, 133-139. https://doi:10.1016/j.ijbiomac.2013.10.036
  • 28.Tang HY, Cao YZ, Zhou YW, Ma YS, Jiang H, Zhang H, et al. The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer. Journal of Advanced Research. 2024. https://doi.org/10.1016/j.jare.2024.01.014
  • 29. Sobocki BK, Kaźmierczak-Siedlecka K, Folwarski M, Hawryłkowicz V, Makarewicz W, Stachowska E. Pancreatic cancer and gut microbiome-related aspects: A comprehensive review and dietary recommendations. Nutrients. 2021;13(12), 4425. https://doi.org/10.3390/nu13124425
  • 30. Luan C, Xie L, Yang X, Miao H, Lv N, Zhang R, et al. Dysbiosis of fungal microbiota in the intestinal mucosa of patients with colorectal adenomas. Scientific Reports. 2015;5(1), 1-9. https://doi:10.1038/srep07980
  • 31. Jones SE, Versalovic J. Probiotic lactobacillus reuteribiofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiology. 2009;9(1), 1-9. https://doi:10.1186/1471-2180-9-35
  • 32. Jung JI, Baek SM, Nguyen TH, Kim JW, Kang CH, Kim S, et al. Effects of probiotic culture supernatant on cariogenic biofilm formation and RANKL-Induced osteoclastogenesis in RAW 264.7 macrophages. Molecules. 2021;26(3), 733. https://doi:10.3390/molecules26030733
  • 33. Vrzáčková N, Ruml T, Zelenka J. Postbiotics, metabolic signaling, and cancer. Molecules. 2021;26(6), 1528. https://doi:10.3390/molecules26061528
  • 34. Cakmak YO. Provotella-derived hydrogen sulfide, constipation, and neuroprotection in parkinson's disease. Movement Disorders. 2015;8(30), 1151-1151. https://doi.org/10.1002/mds.26258
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Kanser Tedavisi (Kemoterapi ve Radyoterapi hariç)
Bölüm Derlemeler
Yazarlar

Mert Aşit 0000-0003-2040-6924

Hasan Ergenç 0000-0003-0519-0264

Sinem Uysal 0009-0006-7279-8789

Proje Numarası yoktur
Erken Görünüm Tarihi 23 Nisan 2025
Yayımlanma Tarihi 26 Nisan 2025
Gönderilme Tarihi 11 Aralık 2024
Kabul Tarihi 28 Ocak 2025
Yayımlandığı Sayı Yıl 2025

Kaynak Göster

Vancouver Aşit M, Ergenç H, Uysal S. Kansere Mikrobiyal Bakış: Postbiyotikler. BÜSAD. 2025;6(1):151-60.