Öz
Amaç: Bu çalışmada yaşa bağlı makula dejenerasyonu ile sarkopeni arasındaki ilişki en yaşlı popülasyonda (80 yaş ve üzeri) araştırılmıştır.
Gereç ve Yöntem: Bu retrospektif çalışma, 2023-2024 yılları arasında bir eğitim araştırma hastanesinin oftalmoloji ve geriatri bölümünde yürütülmüştür. Herhangi bir nedenle oftalmoloji polikliniğine başvuran 80 yaş ve üzeri katılımcılar bu çalışmaya dahil edilmiştir.
Bulgular: Çalışma popülasyonu 80 yaş ve üzeri 311 bireyden oluşmuştur ve yaşa bağlı makula dejenerasyonunun yaygınlığı %20,5'tir (n=64). Yaşa bağlı makula dejenerasyonu olan hastaların yaş ortalaması 85.9 (±3.8) iken kontrol grubunun yaş ortalaması 85.8(±3.9) idi. Yaşa bağlı makula dejenerasyonu olan hastaların 34 ü kadın, 30 u erkekti. Deyo-Charlson comorbidity index (D-CCI) değerleri yaşa bağlı makula dejenerasyonu grubunda 1.77 iken kontrol grubunda 1.85 idi. Sarkopeni prevalansının yaşa bağlı makula dejenerasyonu hastalarında belirgin şekilde daha yüksek olduğu gözlemlendi (%89,1'e karşı %52,6).
Sonuç: Çalışmamız, sarkopeninin en yaşlı bireylerde yaşa bağlı makula dejenerasyonu ile ilişkili bağımsız bir değişken olduğunu göstermektedir. Bu bulgular, sarkopeni yönetiminin yaşa bağlı makula dejenerasyonunun önlenmesi ve yönetimindeki önemini vurgulamaktadır.
Anahtar Kelimeler
oksidatif stres sarkopeni yaşa bağlı makula dejenerasyon inflamasyon
Etik Beyan
Approval was obtained from the Ethics Committee of Balıkesir Atatürk City Hospital (No: 2023/3/28).
Kaynakça
- Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392:1147-59.
- Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022;51:afac220.
- von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle. 2010;1:129-33..
- Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022; ;51:afac220..
- Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16-31.
- Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med. 2011;27:337-9.
- Dogac A, Yuksel M, Avcl A, Ceyhan B, Hülür Ü, Eryllmaz Z et al. Electronic health record interoperability as realized in the Turkish health information system. Methods Inf Med. 2011; 50:140-49.
- Bahat G, Aydin CO, Tufan A, Karan MA, Cruz-Jentoft AJ. Muscle strength cutoff values calculated from the young reference population to evaluate sarcopenia in Turkish population. Aging Clin Exp Res. 2021;33:2879-82..
- Bohannon RW. Reference values for the five-repetition sit-to-stand test: a descriptive meta-analysis of data from elders. Percept Mot Skills. 2006;103:215-22.
- Charlson ME, Carrozzino D, Guidi J, Patierno C. Charlson comorbidity index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91:8-35.
- Katipoglu B, Naharci MI. Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? Aging Clin Exp Res. 2022;34:1819-26.
- Southern DA, Quan H, Ghali WA. Comparison of the elixhauser and charlson/deyo methods of comorbidity measurement in administrative data. Med Care. 2004;42:355-60.
- Katipoğlu Z, Abay RN. The relationship between dry eye disease and anticholinergic burden. Eye. 2023;37:2921-5.
- Fleckenstein M, Keenan TD, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, et al. Age-related macular degeneration. Nat Rev Dis Primers.2021;7:31.
- Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health. 2014;2:e106-16.
- Kim BR, Yoo TK, Kim HK, Ryu IH, Kim JK, Lee IS et al. Oculomics for sarcopenia prediction: a machine learning approach toward predictive, preventive, and personalized medicine. EPMA J. 2022;13:367-82..
- Liang F-Q, Godley BF. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res. 2003;76:397-403.
- Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci. 2016;73:1765-86.
- Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Veréb Z, Salminen A. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy. 2013;9:973-84.
Öz
Purpose: The aim of this study was aimed to investigate the association between age-related macular degeneration and sarcopenia in the oldest-old population, constituting individuals aged ≥80 years.
Material and Methods: This retrospective study was conducted in the ophthalmology and geriatric departments of a training and research hospital in 2023 and 2024. Participants aged ≥80 years who were admitted to the ophthalmology outpatient clinic for any reason were included in the study.
Results: The study population comprised 311 individuals aged 80 years or older and the prevalence of age-related macular degeneration was 20.5% (n=64). The mean age of the patients diagnosed with age-related macular degeneration (AMD) was 85.9 years (±3.8), while the mean age of the control group was 85.8 years (±3.9). Of the patients diagnosed with age-related macular degeneration, 34 were female and 30 were male. The Deyo-Charlson Comorbidity Index (D-CCI) values were 1.77 in the age-related macular degeneration group and 1.85 in the control group. The prevalence of sarcopenia was significantly higher in patients with age-related macular degeneration (89.1% vs. 52.6%).
Conclusion: This study demonstrates that sarcopenia is independently associated with age-related macular degeneration in the oldest-old population. These findings highlight the significance of sarcopenia management in the prevention and management of age-related macular degeneration.
Anahtar Kelimeler
Sarcopenia Age-related macular degeneration Oxidative stress Inflammation Older adult
Etik Beyan
Approval was obtained from the Ethics Committee of Balıkesir Atatürk City Hospital (No: 2024-05/27) .
Kaynakça
- Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018;392:1147-59.
- Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022;51:afac220.
- von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle. 2010;1:129-33..
- Sayer AA, Cruz-Jentoft A. Sarcopenia definition, diagnosis and treatment: consensus is growing. Age Ageing. 2022; ;51:afac220..
- Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:16-31.
- Rosenberg IH. Sarcopenia: origins and clinical relevance. Clin Geriatr Med. 2011;27:337-9.
- Dogac A, Yuksel M, Avcl A, Ceyhan B, Hülür Ü, Eryllmaz Z et al. Electronic health record interoperability as realized in the Turkish health information system. Methods Inf Med. 2011; 50:140-49.
- Bahat G, Aydin CO, Tufan A, Karan MA, Cruz-Jentoft AJ. Muscle strength cutoff values calculated from the young reference population to evaluate sarcopenia in Turkish population. Aging Clin Exp Res. 2021;33:2879-82..
- Bohannon RW. Reference values for the five-repetition sit-to-stand test: a descriptive meta-analysis of data from elders. Percept Mot Skills. 2006;103:215-22.
- Charlson ME, Carrozzino D, Guidi J, Patierno C. Charlson comorbidity index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91:8-35.
- Katipoglu B, Naharci MI. Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? Aging Clin Exp Res. 2022;34:1819-26.
- Southern DA, Quan H, Ghali WA. Comparison of the elixhauser and charlson/deyo methods of comorbidity measurement in administrative data. Med Care. 2004;42:355-60.
- Katipoğlu Z, Abay RN. The relationship between dry eye disease and anticholinergic burden. Eye. 2023;37:2921-5.
- Fleckenstein M, Keenan TD, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, et al. Age-related macular degeneration. Nat Rev Dis Primers.2021;7:31.
- Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng C-Y. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. The Lancet Global Health. 2014;2:e106-16.
- Kim BR, Yoo TK, Kim HK, Ryu IH, Kim JK, Lee IS et al. Oculomics for sarcopenia prediction: a machine learning approach toward predictive, preventive, and personalized medicine. EPMA J. 2022;13:367-82..
- Liang F-Q, Godley BF. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res. 2003;76:397-403.
- Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell Mol Life Sci. 2016;73:1765-86.
- Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Veréb Z, Salminen A. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy. 2013;9:973-84.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Göz Hastalıkları |
| Bölüm | Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2025 |
| Gönderilme Tarihi | 23 Ocak 2025 |
| Kabul Tarihi | 15 Mayıs 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 50 Sayı: 2 |
