BibTex RIS Kaynak Göster

The effect of serum 25(OH) vitamin D on hemogram parameters

Yıl 2014, Cilt: 41 Sayı: 2, 332 - 336, 01.06.2014

Gülfer Öztürk Erdem Bulut Sümeyya Akyol Mine Yavuz Taşlıpınar Zeynep Giniş Fatma Uçar Gönül Erden

https://doi.org/10.5798/diclemedj.0921.2014.02.0426
Cited By: 2

Öz

Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin. In general, vitamin D is known to be associated with rickets, but the studies show that vitamin D also acts on tissues and cells other than bone itself. In this study, we aimed to investigate if vitamin D has any effects on hemogram parameters or not. Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients. Vitamin D level and hemogram parameters [(red blood cell (RBC), hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW)] of patients were obtained. Patients were divided into 4 groups according to their levels of vitamin D: Group 1: < 10 ng/mL; Group 2: 10-19 ng/mL; Group 3: 20-29 ng/mL, and Group 4: 30-60 ng/mL. Results: There were no significant differences in RBC, Hb, WBC, PLT, MPV, and RDW between the groups (p>0.05). Also, there was no correlation between the hemogram parameters and vitamin D. Conclusion: According to the literature, there are a lot of studies that show the relationship between vitamin D and WBC, RBC, and PLT. However, contrary to the previous studies, we were unable to find any significant relationship between vitamin D and hemogram parameters. These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.

Anahtar Kelimeler

Vitamin D WBC RBC PLT Hemoglobin

Kaynakça

  • Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
  • Bogunia-Kubik K, Middleton P, Norden J, et al. Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Int J Immunogenet 2008;35:207-213.
  • Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1,25-dihy- droxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181-1183.
  • Baeke F, Gysemans C, Korf H, et al. Vitamin D insufficien- cy: implications for the immune system. Pediatr Nephrol 2010;25:1597-1606.
  • Yilmaz M, Yilmaz N. D vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. J Clin Exp Invest 2013; 4:411-415.
  • Çidem M, Kara S, Sarı H, et al. Yaygın kas-iskelet ağrısı olan hastalarda D vitamini eksikliği prevalansı ve risk faktörleri. J Clin Exp Invest 2013; 4:488-491.
  • Köse N. Fibromiyalji hastalarında kan vitamin D düzey- leri ve D vitamini tedavisinin etkinliği. Dicle Med J 2013; 40:583-588.
  • Wallis DE, Penckofer S, Sizemore GW. The “sunshine defi- cit” and cardiovascular disease. Circulation 2008;118:1476- 1485.
  • Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovas- cular disease and vitamin D insufficiency into perspective. Br J Nutr 2005;94:483-492.
  • Kıdır V. D vitamininin kardiyovasküler ve metabolik et- kileri. J Clin Exp Invest 2013; 4:398-404.
  • Martins D, Wolf M, Pan D, et al. Prevalence of cardiovas- cular risk factors and the serum levels of 25-hydroxyvita- min D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007;167:1159-1165.
  • von Hurst PR, Stonehouse W, Coad J. Vitamin D supple- mentation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomized, placebo-controlled trial. Br J Nutr 2010;103:549-555.
  • Bunce CM, Brown G, Hewison M. Vitamin D and hemato- poiesis. Trends Endocrinol Metab 1997;8:245-251.
  • Grande A, Montanari M, Tagliafico E, et al. Physiological levels of 1alpha, 25 dihydroxyvitamin D3 induce the mono- cytic commitment of CD34+ hematopoietic progenitors. J Leukoc Biol 2002;71:641-651.
  • Stach K, Kalsch AI, Nguyen XD, et al. 1alpha,25-dihy- droxyvitamin D3 attenuates platelet activation and the ex- pression of VCAM-1 and MT1-MMP in human endothelial cells. Cardiology. 2011;118:107-115.
  • Muller K, Diamant M, Bendtzen K. Inhibition of produc- tion and function of interleukin-6 by 1,25-dihydroxyvita- min D3. Immunol Lett 1991;28:115-120.
  • Cantorna MT, Woodward WD, Hayes CE. 1,25-dihy- droxyvitamin D3 is a positive regulator for the two anti-en- cephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol 1998;160:5314-5319.
  • Icardi A, Paoletti E, De Nicola L, et al. Renal anaemia and EPO hyporesponsiveness associated with vitamin D defi- ciency: the potential role of inflammation. Nephrol Dial Transplant 2013;28:1672-1679.
  • Luong QT, Koeffler HP. Vitamin D compounds in leukemia. J Steroid Biochem Mol Biol 2005;97:195-202.
  • O’Kelly J, Hisatake J, Hisatake Y, et al. Normal myelopoi- esis but abnormal T lymphocyte responses in vitamin D re- ceptor knockout mice. J Clin Invest 2002;109:1091-1099.
  • Yu S, Cantorna MT. Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice. J Im- munol 2011;186:1384-1390.
  • Yu S, Zhao J, Cantorna MT. Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. J Immunol 2011;187:4907-4912.
  • Kebapcilar AG, Kulaksizoglu M, Ipekci SH, et al. Relation- ship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency. Arch Gynecol Obstet 2013;288:207-212.
  • Yildirim I, Hur E, Kokturk F. Inflammatory markers: C- reactive protein, erythrocyte sedimentation rate, and leuko- cyte count in vitamin D deficient patients with and without chronic kidney disease. Int J Endocrinol 2013;2013:802165.
  • Bockow B, Kaplan TB. Refractory immune thrombocyto- penia successfully treated with high-dose vitamin D sup- plementation and hydroxychloroquine: two case reports. J Med Case Rep 2013;7:91.
  • Norman AW. Minireview: vitamin D receptor: new as- signments for an already busy receptor. Endocrinology 2006;147:5542-5548.
  • Patel NM, Gutierrez OM, Andress DL, et al. Vitamin D de- ficiency and anemia in early chronic kidney disease. Kid- ney Int 2010;77:715-720.
  • Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta 2013;421:177-180.
  • Goicoechea M, Vazquez MI, Ruiz MA, et al. Intravenous calcitriol improves anaemia and reduces the need for eryth- ropoietin in haemodialysis patients. Nephron 1998;78:23- 27.
  • Carvalho C, Isakova T, Collerone G, et al. Hepcidin and disordered mineral metabolism in chronic kidney disease. Clin Nephrol 2011;76:90-98.
  • Toxqui L, Perez-Granados AM, Blanco-Rojo R, et al. Ef- fects of an iron or iron and vitamin D-fortified flavored skim milk on iron metabolism: a randomized controlled double-blind trial in iron-deficient women. J Am Coll Nutr 2013;32:312-320.

Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi

Yıl 2014, Cilt: 41 Sayı: 2, 332 - 336, 01.06.2014

Gülfer Öztürk Erdem Bulut Sümeyya Akyol Mine Yavuz Taşlıpınar Zeynep Giniş Fatma Uçar Gönül Erden

https://doi.org/10.5798/diclemedj.0921.2014.02.0426
Cited By: 2

Öz

Amaç: D vitamini pleitropik hormon özellikleri olan yağda çözünen bir vitamindir. Genel anlamda rikets ile beraber anılır ancak yapılan araştırmalar D vitamininin kemik dışı dokularda da etkin olduğunu göstermektedir. Biz de bu çalışmada serum D vitamini düzeyinin hemogram parametrelerine etkisi olup olmadığını araştırmayı amaçladık. Yöntemler: Bu retrospektif çalışma, 243 kadın 59 erkek toplam 302 hastanın verileri değerlendirilerek gerçekleştirildi. Hastaların D vitamini düzeyi ve hemogram [eritrosit sayısı (RBC), hemoglobin (Hb), beyaz küre sayısı (WBC), trombosit sayısı (PLT), ortalama trombosit volümü (MPV) ve eritrosit dağılım genişliği (RDW)] parametreleri elde edildi. Hastalar D vitamini düzeylerine göre 4 gruba ayrıldı: Grup 1: < 10 ng/mL; Grup 2: 10-19 ng/mL; Grup 3: 20-29 ng/mL ve Grup 4: 30-60 ng/mL. Bulgular: Gruplar arası RBC, Hb, WBC, PLT, MPV ve RDW değerleri arasında anlamlı bir farklılık saptanmadı (p>0.05). Ayrıca, D vitamini ile hemogram parametreleri arasında herhangi bir korelasyon tespit edilmedi. Sonuçlar: Literatüre bakıldığında D vitamini ile WBC, RBC ve PLT arasında ilişki olduğunu gösteren çok sayıda yayın bulunmaktadır. Ancak, bizim çalışmamızda literatürün aksine D vitamini ile hemogram parametreleri arasında herhangi bir ilişki tespit edilemedi. Bu sonuçlar D vitamininin hematopoietik sistem üzerindeki etkilerinin deneysel ve klinik olarak daha iyi araştırılması gerektiği fikrini vermektedir.

Anahtar Kelimeler

D vitamini WBC RBC PLT hemoglobin.

Kaynakça

  • Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8.
  • Bogunia-Kubik K, Middleton P, Norden J, et al. Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Int J Immunogenet 2008;35:207-213.
  • Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1,25-dihy- droxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181-1183.
  • Baeke F, Gysemans C, Korf H, et al. Vitamin D insufficien- cy: implications for the immune system. Pediatr Nephrol 2010;25:1597-1606.
  • Yilmaz M, Yilmaz N. D vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. J Clin Exp Invest 2013; 4:411-415.
  • Çidem M, Kara S, Sarı H, et al. Yaygın kas-iskelet ağrısı olan hastalarda D vitamini eksikliği prevalansı ve risk faktörleri. J Clin Exp Invest 2013; 4:488-491.
  • Köse N. Fibromiyalji hastalarında kan vitamin D düzey- leri ve D vitamini tedavisinin etkinliği. Dicle Med J 2013; 40:583-588.
  • Wallis DE, Penckofer S, Sizemore GW. The “sunshine defi- cit” and cardiovascular disease. Circulation 2008;118:1476- 1485.
  • Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovas- cular disease and vitamin D insufficiency into perspective. Br J Nutr 2005;94:483-492.
  • Kıdır V. D vitamininin kardiyovasküler ve metabolik et- kileri. J Clin Exp Invest 2013; 4:398-404.
  • Martins D, Wolf M, Pan D, et al. Prevalence of cardiovas- cular risk factors and the serum levels of 25-hydroxyvita- min D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007;167:1159-1165.
  • von Hurst PR, Stonehouse W, Coad J. Vitamin D supple- mentation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomized, placebo-controlled trial. Br J Nutr 2010;103:549-555.
  • Bunce CM, Brown G, Hewison M. Vitamin D and hemato- poiesis. Trends Endocrinol Metab 1997;8:245-251.
  • Grande A, Montanari M, Tagliafico E, et al. Physiological levels of 1alpha, 25 dihydroxyvitamin D3 induce the mono- cytic commitment of CD34+ hematopoietic progenitors. J Leukoc Biol 2002;71:641-651.
  • Stach K, Kalsch AI, Nguyen XD, et al. 1alpha,25-dihy- droxyvitamin D3 attenuates platelet activation and the ex- pression of VCAM-1 and MT1-MMP in human endothelial cells. Cardiology. 2011;118:107-115.
  • Muller K, Diamant M, Bendtzen K. Inhibition of produc- tion and function of interleukin-6 by 1,25-dihydroxyvita- min D3. Immunol Lett 1991;28:115-120.
  • Cantorna MT, Woodward WD, Hayes CE. 1,25-dihy- droxyvitamin D3 is a positive regulator for the two anti-en- cephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol 1998;160:5314-5319.
  • Icardi A, Paoletti E, De Nicola L, et al. Renal anaemia and EPO hyporesponsiveness associated with vitamin D defi- ciency: the potential role of inflammation. Nephrol Dial Transplant 2013;28:1672-1679.
  • Luong QT, Koeffler HP. Vitamin D compounds in leukemia. J Steroid Biochem Mol Biol 2005;97:195-202.
  • O’Kelly J, Hisatake J, Hisatake Y, et al. Normal myelopoi- esis but abnormal T lymphocyte responses in vitamin D re- ceptor knockout mice. J Clin Invest 2002;109:1091-1099.
  • Yu S, Cantorna MT. Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice. J Im- munol 2011;186:1384-1390.
  • Yu S, Zhao J, Cantorna MT. Invariant NKT cell defects in vitamin D receptor knockout mice prevents experimental lung inflammation. J Immunol 2011;187:4907-4912.
  • Kebapcilar AG, Kulaksizoglu M, Ipekci SH, et al. Relation- ship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency. Arch Gynecol Obstet 2013;288:207-212.
  • Yildirim I, Hur E, Kokturk F. Inflammatory markers: C- reactive protein, erythrocyte sedimentation rate, and leuko- cyte count in vitamin D deficient patients with and without chronic kidney disease. Int J Endocrinol 2013;2013:802165.
  • Bockow B, Kaplan TB. Refractory immune thrombocyto- penia successfully treated with high-dose vitamin D sup- plementation and hydroxychloroquine: two case reports. J Med Case Rep 2013;7:91.
  • Norman AW. Minireview: vitamin D receptor: new as- signments for an already busy receptor. Endocrinology 2006;147:5542-5548.
  • Patel NM, Gutierrez OM, Andress DL, et al. Vitamin D de- ficiency and anemia in early chronic kidney disease. Kid- ney Int 2010;77:715-720.
  • Shin JY, Shim JY. Low vitamin D levels increase anemia risk in Korean women. Clin Chim Acta 2013;421:177-180.
  • Goicoechea M, Vazquez MI, Ruiz MA, et al. Intravenous calcitriol improves anaemia and reduces the need for eryth- ropoietin in haemodialysis patients. Nephron 1998;78:23- 27.
  • Carvalho C, Isakova T, Collerone G, et al. Hepcidin and disordered mineral metabolism in chronic kidney disease. Clin Nephrol 2011;76:90-98.
  • Toxqui L, Perez-Granados AM, Blanco-Rojo R, et al. Ef- fects of an iron or iron and vitamin D-fortified flavored skim milk on iron metabolism: a randomized controlled double-blind trial in iron-deficient women. J Am Coll Nutr 2013;32:312-320.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Yazıları
Yazarlar

Gülfer Öztürk

Erdem Bulut

Sümeyya Akyol

Mine Yavuz Taşlıpınar

Zeynep Giniş

Fatma Uçar

Gönül Erden

Yayımlanma Tarihi 1 Haziran 2014
Gönderilme Tarihi 2 Mart 2015
Yayımlandığı Sayı Yıl 2014 Cilt: 41 Sayı: 2

Kaynak Göster

APA Öztürk, G., Bulut, E., Akyol, S., Taşlıpınar, M. Y., vd. (2014). Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi. Dicle Medical Journal, 41(2), 332-336. https://doi.org/10.5798/diclemedj.0921.2014.02.0426
AMA Öztürk G, Bulut E, Akyol S, Taşlıpınar MY, Giniş Z, Uçar F, Erden G. Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi. diclemedj. Haziran 2014;41(2):332-336. doi:10.5798/diclemedj.0921.2014.02.0426
Chicago Öztürk, Gülfer, Erdem Bulut, Sümeyya Akyol, Mine Yavuz Taşlıpınar, Zeynep Giniş, Fatma Uçar, ve Gönül Erden. “Serum 25(OH) D Vitamini düzeyinin Hemogram Parametreleri üzerine Etkisi”. Dicle Medical Journal 41, sy. 2 (Haziran 2014): 332-36. https://doi.org/10.5798/diclemedj.0921.2014.02.0426.
EndNote Öztürk G, Bulut E, Akyol S, Taşlıpınar MY, Giniş Z, Uçar F, Erden G (01 Haziran 2014) Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi. Dicle Medical Journal 41 2 332–336.
IEEE G. Öztürk, E. Bulut, S. Akyol, M. Y. Taşlıpınar, Z. Giniş, F. Uçar, ve G. Erden, “Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi”, diclemedj, c. 41, sy. 2, ss. 332–336, 2014, doi: 10.5798/diclemedj.0921.2014.02.0426.
ISNAD Öztürk, Gülfer vd. “Serum 25(OH) D Vitamini düzeyinin Hemogram Parametreleri üzerine Etkisi”. Dicle Medical Journal 41/2 (Haziran 2014), 332-336. https://doi.org/10.5798/diclemedj.0921.2014.02.0426.
JAMA Öztürk G, Bulut E, Akyol S, Taşlıpınar MY, Giniş Z, Uçar F, Erden G. Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi. diclemedj. 2014;41:332–336.
MLA Öztürk, Gülfer vd. “Serum 25(OH) D Vitamini düzeyinin Hemogram Parametreleri üzerine Etkisi”. Dicle Medical Journal, c. 41, sy. 2, 2014, ss. 332-6, doi:10.5798/diclemedj.0921.2014.02.0426.
Vancouver Öztürk G, Bulut E, Akyol S, Taşlıpınar MY, Giniş Z, Uçar F, Erden G. Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi. diclemedj. 2014;41(2):332-6.

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