Öz
Sarkoidoz, etiyolojisi tam olarak bilinmeyen, birçok sistemi tutan, non-kazeifiye granülomlarla karakterize bir hastalıktır. Deri sarkoidozunda spesifik lezyonların en nadir görülen formu subkutan sarkoidozdur. Subkutan sarkoidoz genellikle yaşamın dördüncü dekadında daha sık görülür ve kadınlarda erkeklerden daha yaygındır. Çoğunlukla ekstremitelerde, bilateral ve asimetrik bir şekilde yerleşen, çoklu asemptomatikten hafif ağrılıya kadar değişebilen, sert, hareketli, yuvarlak ila oval, deri renginde veya eritemli nodüller şeklinde görülür. Ayırıcı tanıda subkutan nodül ile seyreden diğer hastalıklar dışlanmalıdır. Bu çalışmada, topikal steroid tedavisine kısmen yanıt veren ve hidroksiklorokin ile başarılı bir şekilde tedavi edilen, hepatit B taşıyıcısı olan 51 yaşında bir kadın hastada görülen bir subkutan sarkoidoz olgusu sunulmaktadır. Subkutan sarkoidozda hastalar sistemik tutulum açısından da değerlendirilmelidir. Tedavi seçenekleri arasında hidroksiklorokin düşünülmelidir.
Anahtar Kelimeler
Kaynakça
- Koneti J, Cherukuri SP, Gadde S, Kalluru R, Chikatimalla R, Dasaradhan T. Sarcoidosis and its dermatological manifestations: A narrative review. Cureus. 2022;14(8):e28053.
- Sève P, Pacheco Y, Durupt F, Jamilloux Y, Gerfaud-Valentin M, Isaac S, et al. Sarcoidosis: A clinical overview from symptoms to diagnosis. Cells. 2021;10(4):766.
- Ezeh N, Caplan A, Rosenbach M, Imadojemu S. Cutaneous sarcoidosis. Dermatol Clin. 2023;41(3):455-70.
- Cohen E, Lheure C, Ingen-Housz-Oro S, Hotz C, Bettuzzi T, Chasset F, et al. Which first-line treatment for cutaneous sarcoidosis? A retrospective study of 120 patients. Eur J Dermatol. 2023;33(6):680-5.
- Lopez-Sundh AE, Maestre-Orozco T, Gonzalez-Vela MC, Fernandez-Ayala M. Subcutaneous sarcoidosis: A case series of 19 patients. J Postgrad Med. 2021;67(3):154-7.
- Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, et al. Diagnosis and detection of sarcoidosis. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2020;201(8):e26-e51.
- Dalle Vedove C, Colato C, Girolomoni G. Subcutaneous sarcoidosis: report of two cases and review of the literature. Clin Rheumatol. 2011;30(8):1123-8.
- Juratli HA, Hertl M, Gualtieri B. Sarcoidosis with concomitant hepatitis C infection treated successfully with adalimumab. J Dtsch Dermatol Ges. 2019;17(9):936-8.
- Marchetti M, Baker MG, Noland MM. Treatment of subcutaneous sarcoidosis with hydroxychloroquine: report of 2 cases. Dermatol Online J. 2014;20(1):21250.
- Youn P, Francis RJ, Preston H, Lake F. Subcutaneous sarcoidosis (Darier-Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature. Respirol Case Rep. 2022;10(5):e0949.
Treatment of Subcutaneous Sarcoidosis with Hydroxychloroquine in a Hepatitis B Carrier Patient: A Case Report
Öz
Sarcoidosis is a disorder of unknown etiology affecting many systems and characterized by non-caseating granulomas. Subcutaneous sarcoidosis is the rarest form of specific lesions in cutaneous sarcoidosis. It occurs more frequently in the fourth decade of life and is more common in females than in males. Multiple asymptomatic to slightly painful, firm, mobile, round to oval, skin-colored, or erythematous nodules frequently occur in a bilateral and asymmetric pattern on the extremities. In the differential diagnosis, other diseases presenting with subcutaneous nodules should be excluded. Here, a case of subcutaneous sarcoidosis in a 51-year-old female hepatitis B carrier patient who partially responded to topical steroid treatment and was successfully treated with hydroxychloroquine was presented. In subcutaneous sarcoidosis, patients should be evaluated for systemic involvement. Hydroxychloroquine should be considered among the treatment options.
Anahtar Kelimeler
Kaynakça
- Koneti J, Cherukuri SP, Gadde S, Kalluru R, Chikatimalla R, Dasaradhan T. Sarcoidosis and its dermatological manifestations: A narrative review. Cureus. 2022;14(8):e28053.
- Sève P, Pacheco Y, Durupt F, Jamilloux Y, Gerfaud-Valentin M, Isaac S, et al. Sarcoidosis: A clinical overview from symptoms to diagnosis. Cells. 2021;10(4):766.
- Ezeh N, Caplan A, Rosenbach M, Imadojemu S. Cutaneous sarcoidosis. Dermatol Clin. 2023;41(3):455-70.
- Cohen E, Lheure C, Ingen-Housz-Oro S, Hotz C, Bettuzzi T, Chasset F, et al. Which first-line treatment for cutaneous sarcoidosis? A retrospective study of 120 patients. Eur J Dermatol. 2023;33(6):680-5.
- Lopez-Sundh AE, Maestre-Orozco T, Gonzalez-Vela MC, Fernandez-Ayala M. Subcutaneous sarcoidosis: A case series of 19 patients. J Postgrad Med. 2021;67(3):154-7.
- Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, et al. Diagnosis and detection of sarcoidosis. An official American Thoracic Society clinical practice guideline. Am J Respir Crit Care Med. 2020;201(8):e26-e51.
- Dalle Vedove C, Colato C, Girolomoni G. Subcutaneous sarcoidosis: report of two cases and review of the literature. Clin Rheumatol. 2011;30(8):1123-8.
- Juratli HA, Hertl M, Gualtieri B. Sarcoidosis with concomitant hepatitis C infection treated successfully with adalimumab. J Dtsch Dermatol Ges. 2019;17(9):936-8.
- Marchetti M, Baker MG, Noland MM. Treatment of subcutaneous sarcoidosis with hydroxychloroquine: report of 2 cases. Dermatol Online J. 2014;20(1):21250.
- Youn P, Francis RJ, Preston H, Lake F. Subcutaneous sarcoidosis (Darier-Roussy sarcoidosis) with extensive disease on positron emission tomography: A case report and review of the literature. Respirol Case Rep. 2022;10(5):e0949.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Dermatoloji |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Erken Görünüm Tarihi | 31 Ocak 2025 |
| Yayımlanma Tarihi | 30 Nisan 2025 |
| Gönderilme Tarihi | 19 Eylül 2024 |
| Kabul Tarihi | 3 Ocak 2025 |
| Yayımlandığı Sayı | Yıl 2025 |
Kaynak Göster
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