Öz
Bu çalışma, medetomidinin Scottish Fold kedilerinde vertebral kalp skoru (VHS) üzerindeki etkisini değerlendirmeyi amaçlamıştır. VHS yöntemi, veteriner hekimlikte yaygın olarak kullanılan ve radyografik görüntüleme yoluyla kalp büyüklüğünü güvenilir bir şekilde değerlendiren bir yöntemdir. Sedatif ilaçların bu tür ölçümler üzerindeki etkilerini anlamak özellikle kardiyak sorunları olan hayvanlar için önemlidir. Çalışmaya, 8 ile 48 ay arasında ve 2.8-5.9 kg ağırlığında 20 Scottish Fold kedisi dahil edilmiştir. Sedasyon, kedilere intramüsküler olarak 80 µg/kg dozunda medetomidin enjeksiyonu ile sağlanmıştır ve radyografik görüntüler sedasyon öncesinde (T0) ve sedasyon sonrası 5, 10, 30 ve 45. dakikalarda (T1-T4) elde edilmiştir. VHS, sol laterolateral (LL) ve ventrodorsal (VD) radyografilerden değerlendirilmiş ve bu zaman dilimleri arasında istatistiksel karşılaştırmalar yapılmıştır. Sedasyon öncesi (T0) ile 45. dakika (T4) arasındaki VHS'de istatistiksel olarak anlamlı bir artış gözlenmiştir (P<0.05). Ancak, daha erken zaman noktalarında (T1, T2 ve T3) anlamlı bir fark bulunmamıştır. Ayrıca, sedasyon sonrası kalp kısa ekseni (CSA) boyutunda hafif bir artış gözlenmiş (P=0.06), ancak kalp uzun ekseni (CLA) değişmemiştir (P=0.40). Medetomidin, hem LL hem de VD radyografilerinde VHS artışına neden olmuş, özellikle sedasyondan 45 dakika sonra belirgin hale gelmiştir. Bu değişiklik hem kardiyolojik değerlendirmeyi hem de anestezi güvenliğini etkilediğinden, bu bulguların rapor edilmesi klinik karar alma süreçlerini iyileştirmek açısından kritik öneme sahiptir. Kalp siluetindeki bu değişiklikler göz önünde bulundurulduğunda, medetomidinin klinik kardiyak değerlendirmeleri etkileyebildiği ve mevcut kalp rahatsızlıkları olan Scottish Fold kedilerine uygulanırken dikkatli olunması önerilmektedir.
Anahtar Kelimeler
Kalp büyüklüğü medetomidin radyografi Scottish Fold kedileri vertebral kalp skoru
Kaynakça
- Litster AL, Buchanan JW (2000). Vertebral scale system to measure heart size in radiographs of cats. J Am Vet Med Assoc., 216(2):210-214.
- Buchanan JW, Bücheler J (1995). Vertebral scale system to measure canine heart size in radiographs. J Am Vet Med Assoc., 206(2):194-199.
- Spasojević-Kosić L, Krstić N, Trailović R (2007). Comparison of three methods of measuring vertebral heart size in German shepherd dogs. Acta Vet-Beograd., 57(2-3):133-141.
- Doğan E, Okur S, Hayirli A, Okumuş Z (2022). Vertebral heart score and cardiothoracic ratio in Wistar rats. Ankara Univ Vet Fak Derg., 1-16.
- Ghadiri A, Avizeh R, Rasekh A, Yadegari A (2008). Radiographic measurement of vertebral heart size in healthy stray cats. J Feline Med Surg., 10(1):61-65.
- Grimm K, Lamont L, Tranquilli WJ, Greene SA, Robertson S (Eds.) (2015). Veterinary anesthesia and analgesia. John Wiley & Sons, Hoboken.
- Sinclair MD (2003). A review of the physiological effects of α2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J., 44(11):885-897.
- Guzel O, Kaya DA, Altunatmaz K, Sevim G, Sezer D, Erdikmen DO (2018). Evaluation of the cardiorespiratory effects of the alpha-2 adrenoceptor agonists xylazine, medetomidine, and dexmedetomidine in combination with ketamine in dogs. Vet Med., 63(12):546-554.
- Zwicker LA, Matthews AR, Côté E, Andersen E (2016). The effect of dexmedetomidine on radiographic cardiac silhouette size in healthy cats. Vet Radiol Ultrasound., 57(3):230-236.
- Yaygingül R, Belge A (2018). The comparison of clinical and cardiopulmonary effects of xylazine, medetomidine, and detomidine in dogs. Ankara Univ Vet Fak Derg., 65(3):313-322.
- Wang HC, Hung CT, Lee WM, Chang KM, Chen KS (2016). Effects of intravenous dexmedetomidine on cardiac characteristics measured using radiography and echocardiography in six healthy dogs. Vet Radiol Ultrasound., 57(1):8-15.
- Gutiérrez A, Ezquerra LJ, Rodríguez PL, Jiménez J (2022). Cardiac radiographic measurements in ferrets using the Osirix MD programme. Front Vet Sci., 8:795947.
- Tangpakornsak T, Saisawart P, Sutthigran S, et al. (2023). Thoracic vertebral length-to-height ratio: A promising parameter to predict the vertebral heart score in normal Welsh Corgi Pembroke dogs. Vet Sci., 10(2):168.
- Lemke KA (2004). Perioperative use of selective alpha-2 agonists and antagonists in small animals. Can Vet J., 45(6):475.
- Guan M, Fanelli D, Verbeek T, Warfield DJ, Liu H (2023). Alpha-2 adrenergic agonists. In: Li J, Jiang W, Vadivelu N (eds). First Aid Perioperative Ultrasound. Springer, Cham.
- Rolfe NG, Kerr CL, McDonell WN (2012). Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs. Am J Vet Res., 73(5):587-594.
Öz
This study aimed to evaluate the impact of medetomidine on the vertebral heart score (VHS) in Scottish Fold cats. The VHS method, commonly used in veterinary practice, provides a reliable means to assess cardiac size via radiographic imaging. Understanding the effects of sedative drugs on such measurements is essential, particularly in clinical settings involving animals with potential cardiac concerns. A total of 20 Scottish Fold cats, aged between 8 and 48 months and weighing 2.8-5.9 kg, were included in the study. Sedation was induced using an intramuscular injection of medetomidine (80 µg/kg), and radiographic images were obtained at five time points: pre-sedation (T0) and at 5, 10, 30, and 45 minutes post-administration (T1-T4). The VHS was evaluated from left laterolateral (LL) and ventrodorsal (VD) X-rays, and statistical comparisons were performed between these intervals. There was a statistically significant increase in VHS between the pre-sedation (T0) and 45-minute (T4) measurements (P<0.05). However, no significant difference was observed at earlier time points (T1, T2, and T3). Additionally, while the cardiac short axis (CSA) showed a slight increase in size post-sedation (P=0.06), the cardiac long axis (CLA) remained unchanged (P=0.40). Medetomidine increased VHS in both LL and VD radiographs, particularly by the 45th minute post-administration. As this alteration impacts both cardiological evaluation and anesthesia safety, reporting these findings is critical for optimizing clinical decision-making. Given the potential for an altered cardiac silhouette, caution is advised when administering medetomidine in Scottish Fold cats with pre-existing heart conditions, as these changes may interfere with clinical assessments of cardiac health.
Anahtar Kelimeler
Cardiac size medetomidine radiography Scottish Fold cats vertebral heart score
Kaynakça
- Litster AL, Buchanan JW (2000). Vertebral scale system to measure heart size in radiographs of cats. J Am Vet Med Assoc., 216(2):210-214.
- Buchanan JW, Bücheler J (1995). Vertebral scale system to measure canine heart size in radiographs. J Am Vet Med Assoc., 206(2):194-199.
- Spasojević-Kosić L, Krstić N, Trailović R (2007). Comparison of three methods of measuring vertebral heart size in German shepherd dogs. Acta Vet-Beograd., 57(2-3):133-141.
- Doğan E, Okur S, Hayirli A, Okumuş Z (2022). Vertebral heart score and cardiothoracic ratio in Wistar rats. Ankara Univ Vet Fak Derg., 1-16.
- Ghadiri A, Avizeh R, Rasekh A, Yadegari A (2008). Radiographic measurement of vertebral heart size in healthy stray cats. J Feline Med Surg., 10(1):61-65.
- Grimm K, Lamont L, Tranquilli WJ, Greene SA, Robertson S (Eds.) (2015). Veterinary anesthesia and analgesia. John Wiley & Sons, Hoboken.
- Sinclair MD (2003). A review of the physiological effects of α2-agonists related to the clinical use of medetomidine in small animal practice. Can Vet J., 44(11):885-897.
- Guzel O, Kaya DA, Altunatmaz K, Sevim G, Sezer D, Erdikmen DO (2018). Evaluation of the cardiorespiratory effects of the alpha-2 adrenoceptor agonists xylazine, medetomidine, and dexmedetomidine in combination with ketamine in dogs. Vet Med., 63(12):546-554.
- Zwicker LA, Matthews AR, Côté E, Andersen E (2016). The effect of dexmedetomidine on radiographic cardiac silhouette size in healthy cats. Vet Radiol Ultrasound., 57(3):230-236.
- Yaygingül R, Belge A (2018). The comparison of clinical and cardiopulmonary effects of xylazine, medetomidine, and detomidine in dogs. Ankara Univ Vet Fak Derg., 65(3):313-322.
- Wang HC, Hung CT, Lee WM, Chang KM, Chen KS (2016). Effects of intravenous dexmedetomidine on cardiac characteristics measured using radiography and echocardiography in six healthy dogs. Vet Radiol Ultrasound., 57(1):8-15.
- Gutiérrez A, Ezquerra LJ, Rodríguez PL, Jiménez J (2022). Cardiac radiographic measurements in ferrets using the Osirix MD programme. Front Vet Sci., 8:795947.
- Tangpakornsak T, Saisawart P, Sutthigran S, et al. (2023). Thoracic vertebral length-to-height ratio: A promising parameter to predict the vertebral heart score in normal Welsh Corgi Pembroke dogs. Vet Sci., 10(2):168.
- Lemke KA (2004). Perioperative use of selective alpha-2 agonists and antagonists in small animals. Can Vet J., 45(6):475.
- Guan M, Fanelli D, Verbeek T, Warfield DJ, Liu H (2023). Alpha-2 adrenergic agonists. In: Li J, Jiang W, Vadivelu N (eds). First Aid Perioperative Ultrasound. Springer, Cham.
- Rolfe NG, Kerr CL, McDonell WN (2012). Cardiopulmonary and sedative effects of the peripheral α2-adrenoceptor antagonist MK 0467 administered intravenously or intramuscularly concurrently with medetomidine in dogs. Am J Vet Res., 73(5):587-594.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Veteriner Cerrahi |
| Bölüm | Araştıma |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2025 |
| Gönderilme Tarihi | 30 Eylül 2024 |
| Kabul Tarihi | 27 Ocak 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 18 Sayı: 1 |
