Öz
Kaynakça
- Ighilahriz-Boubchir, K., Benazzouz-Touami, A. & Makhloufi-Chebli, M. (2024). Design, synthesis and in silico studies of new 2-methyl quinazolin-4(3h)-ones derivatives. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics (EPSTEM), 28, 519-525.
Öz
The concept of the green chemistry consists in the development of an environmentally friendly approach for organic synthesis using ecological and efficient protocols. In order to develop a methodology that could fit into the green chemistry field, for the synthesis of new quinazolin-4(3H)-ones derivatives via benzoxazinone, the choice was made on the use of both as catalysts, known for their efficiency, and microwave irradiations for time saving.The quinazolinone core and its derivatives form an important class of compounds, as they are present in a large family of products with broad biological activities. They generally display useful therapeutic and pharmacological properties such as anti-inflammatory, anti-convulsant, antihypertensive and antimalarial activity.The derivatives of the 2-metylquinazolin-4(3H)-ones 3a-d series was synthesized from 2- methyl benzoxazin-4(3H)-one 1 and aniline in the presence of H3PW12O40 (PW12) under microwave irradiation and solvent free conditions. The compound structures were established using IR, 1H-NMR, 13C-NMR and mass spectroscopy. The toxicity of the hydrazone derivatives was studied through ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) simulations using ADMET Lab 2.0 server.
Anahtar Kelimeler
Keggin-type heteropolyacids Quinazolin-4(3H)-ones Benzoxazin-4(3H)-one
Kaynakça
- Ighilahriz-Boubchir, K., Benazzouz-Touami, A. & Makhloufi-Chebli, M. (2024). Design, synthesis and in silico studies of new 2-methyl quinazolin-4(3h)-ones derivatives. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics (EPSTEM), 28, 519-525.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Yazılım Mühendisliği (Diğer) |
| Bölüm | Makaleler |
| Yazarlar | |
| Erken Görünüm Tarihi | 29 Temmuz 2024 |
| Yayımlanma Tarihi | 1 Ağustos 2024 |
| Gönderilme Tarihi | 10 Ocak 2024 |
| Kabul Tarihi | 15 Nisan 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 28 |
Kaynak Göster
