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CLINICAL EVALUATION OF THE EFFECTS OF A PROBIOTIC LOZENGE ON CHILDREN'S SALIVARY PARAMETERS

Yıl 2025, Cilt: 34 Sayı: 2, 171 - 179, 15.08.2025

Ecem Akbeyaz Şivet , Betul Kargul

https://doi.org/10.34108/eujhs.1583684

Öz

This double-blind, randomized, placebo-controlled clinical trial aimed to evaluate the effects of Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges on various salivary parameters, including flow rate, volume, consistency, pH, and buffering capacity. A total of 40 children, aged 8-13, participated in the study and were randomly assigned to either the treatment or placebo group. The treatment group received Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges for 56 days, while the placebo group received placebo lozenges without active ingredients. Salivary flow rate, consistency, pH, and buffering capacity were assessed using the Saliva-Check BUFFER kit at baseline and after 56 days. Descriptive statistics, independent and paired t-tests, Chi-square tests, and Mc Nemar tests were employed for analysis, with statistical significance set at p<0.05. Results indicated a statistically significant increase in both salivary flow rate and pH in the treatment group compared to the placebo group at the end of 56 days (p<0.05). However, no significant changes were observed in buffering capacity, volume, or consistency between the two groups (p>0.05). These findings suggest that Casein phosphopeptide-amorphous calcium phosphate containing probiotic lozenges may have potential in supporting oral health in children.

Anahtar Kelimeler

Casein phosphopeptide-amorphous calcium phosphate probiotics saliva

Etik Beyan

This study was approved by the Yeditepe University Clinical Research Ethics Committee with protocol number 22.04.2014-421.

Teşekkür

We would like to thank all children and families who participated in our study.

Kaynakça

  • Peng X, Cheng L, You Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci. 2022;14(1):14. doi:10.1038/s41368-022-00163-7
  • Giacaman RA, Fernández CE, Muñoz-Sandoval C, et al. Understanding dental caries as a non-communicable and behavioral disease: Management implications. Front Oral Health.2022;3:764479. doi:10.3389/froh.2022.764479
  • Philip N. State of the art enamel remineralization systems: the next frontier in caries management. Caries Res. 2019;53(3):284-95. doi:10.1159/000493031
  • Fontana M. Enhancing fluoride: clinical human studies of alternatives orboosters for caries management. Caries Res. 2016;50(suppl 1):22–37. doi: 10.1159/000439059
  • Giacaman RA, Maturana CA, Molina J, Volgenant CMC, Fernández CE. Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate Added to Milk, Chewing Gum, and Candy on Dental Caries: A Systematic Review. Caries Res. 2023;57(2):106-118. doi:10.1159/000530638
  • Salminen S, Collado MC, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021;18(9):649-667. doi:10.1038/s41575-021-00440-6
  • Gao J, Li X, Zhang G, et al. Probiotics in the dairy industry-Advances and opportunities. Compr Rev Food Sci Food Saf. 2021 Jul;20(4):3937-3982. doi: 10.1111/1541-4337.12755.
  • How YH, Yeo SK. Oral probiotic and its delivery carriers to improve oral health: A review. Microbiology (Reading). 2021;167(8):10.1099/mic.0.001076. doi: 10.1099/mic.0.001076.
  • Salim HP, Mallikarjun SB, Raju S, Surendranath AR. Randomized Clinical Trial of Oral Probiotic Streptococcussalivarius M18 on Salivary Streptococcusmutans in Preprimary Children. Int J Clin Pediatr Dent. 2023;16(2):259-263. doi:10.5005/jp-journals-10005-2527
  • Malavalli PL, Shetty SB, Thimmaiah C, et al. Evaluation of the Effect of Probiotic Yogurt Consumption on Salivary pH, Buffering Capacity and Calcium Level in 6-12-year-old Children: An In Vivo Study. Int J Clin Pediatr Dent. 2022;15(2):194. doi:10.5005/jp-journals-10005-2368
  • Srinivasan M, Nivedhitha MS, Poorni S. Comparing the effect of probiotic Streptococcussalivarius K12 and M18 on the Streptococcusmutans Count, salivary pH and buffercapacity: a randomized double blinded clinical trial. Cumhuriyet Dent J. 2022;24(4):346-354. doi:10.7126/cumudj.941928
  • Natassa SE, Pintauli S, Ilyas S. Effectivity of Probiotic and Non-Probiotic Milk Consumption on Salivary pH and Streptococcusmutans Count. IOSR J Dent Med Sci. 2019;18(6):67-72. doi:10.9790/0853-1806106772
  • Villavicencio J, Villegas LM, Arango MC, Arias S, Triana F. Effects of a foodenriched with probiotics on Streptococcusmutans and Lactobacillus spp. Salivary counts in preschool children: a cluster randomized trial. J Appl Oral Sci. 2018;26:e20170318. doi:10.1590/1678-7757-2017-0318
  • Nishihara T, Suzuki N, Yoneda M, Hirofuji T. Effects of Lactobacillussalivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health. 2014;14:110. doi:10.1186/1472-6831-14-110
  • Alkarad L, Alkhouli M, Dashash M. Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow. BDJ Open. 2023;9(1):16. doi:10.1038/s41405-023-00141-z
  • Padminee K, Poorni S, Diana D, Duraivel D, Srinivasan MR. Effectiveness of casein phosphopeptide-amorphous calcium phosphate and xylitol chewing gums on salivary pH, buffer capacity, and Streptococcus mutans levels: An interventional study. Indian J Dent Res. 2018;29(5):616-621. doi:10.4103/ijdr.IJDR_166_17
  • Plint AC, Moher D, Morrison A, et al. Doesthe CONSORT check list improve the quality of reports of randomised controlled trials? A systematic review. Med J Aust. 2006;185(5):263-267. doi:10.5694/j.1326-5377.2006.tb00557.x
  • Random.org. Randomness and Integrity Services Ltd. https://www.random.org. Erişim tarihi: 17.11.2024.
  • Petersen PE, Baez RJ. Oral Health Surveys: Basic Methods. New York. World Health Organization; 2013:47.
  • GC Europe. Saliva Check Buffer Broşürü. https://www.gc.dental/europe/sites/europe.gc.dental/files/products/downloads/salivacheckbuffer/leaflet/LFL_SCB_Test_Mat_en.pdf. Erişim tarihi: 19.02.2025
  • K S A, P Puranik M, S R U. Association between dental caries experience and salivary profile among autoimmune thyroid disease subjects - a cross-sectional comparative study. F1000Res. 2023;12:833. doi:10.12688/f1000research.135684.1
  • Prathima GS, Narmatha M, Selvabalaji A, Adimoulame S, Ezhumalai G. Effects of Xylitol and CPP-ACP Chewing Gum on Salivary Properties of Children with Molar Incisor Hypomineralization. Int J Clin Pediatr Dent. 2021;14(3):412-415. doi:10.5005/jp-journals-10005-1779
  • Baker JL, Mark Welch JL, Kauffman KM, McLean JS, He X. The oral microbiome: diversity, biogeography and human health. Nat Rev Microbiol. 2024;22(2):89-104. doi:10.1038/s41579-023-00963-6
  • Rm VR, Singh N, Murmu S, et al. Salivary physicochemical characteristics and antimicrobial human peptid eamong Indian children with dental caries. Bioinformation. 2023;19(4):428-432. doi:10.6026/97320630019428
  • Maldupa I, Brinkmane A, Mihailova A. Comparative analysis of CRT Buffer, GC saliva check buffer tests and laboratory titration to evaluatesaliva buffering capacity. Stomatologija. 2011;13(2):55-61.
  • Chandra HS, Johnson JS, Sagar L, et al. A Comparative Evaluation of Physical Parameters of Saliva and Correlation with Periodontal Condition in Down Syndrome Children and Healthy Controls. J Contemp Dent Pract. 2023;24(6):372-380. doi:10.5005/jp-journals-10024-3481
  • Vale GC, Cruz PF, Bohn AC, de Moura MS. Salivary fluoride levels after use of high-fluoride dentifrice. Scientific World Journal. 2015;2015:302717. doi:10.1155/2015/302717
  • Ferrer MD, López-López A, Nicolescu T, et al. Topic Application of the Probiotic Streptococcusdentisani Improves Clinical and Microbiological Parameters Associated With Oral Health. Front Cell Infect Microbiol. 2020;10:465. doi:10.3389/fcimb.2020.00465
  • Gill SK, Teixeira AM, Rosado F, Cox M, Costa RJ. High-Dose Probiotic Supplementation Containing Lactobacilluscaseifor 7 Days Does Not Enhance Salivary Antimicrobial Protein Responses to Exertional Heat Stress Compared With Placebo. Int J Sport Nutr Exerc Metab. 2016;26(2):150-160. doi:10.1123/ijsnem.2015-0171
  • Gueimonde L, Vesterlund S, García-Pola MJ, et al. Supplementation of xylitol-containing chewing gum with probiotics: a double blind, randomised pilot study focusing on saliva flow and saliva properties. Food Funct. 2016;7(3):1601-1609. doi:10.1039/c5fo01497b
  • Babina K, Salikhova D, Polyakova M, et al. The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial. Nutrients. 2022;14(5):1124. doi:10.3390/nu14051124
  • Hegde RJ, Thakkar JB. Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: An in vivo study. J Indian Soc Pedod Prev Dent. 2017;35(4):332-337. doi:10.4103/JISPPD.JISPPD_147_17
  • Curtis C, Qian F, Bowers RD. CPP-ACP paste's effect on salivary conditions in patients with removable dentures. J Prosthodont. 2024;33(5):427-435. doi:10.1111/jopr.13797
  • Biria M, Eslami G, Taghipour E, Akbarzadeh Baghban A. Effects of Three Mastic Gums on the Number of Mutans Streptococci, Lactobacilli and PH of the Saliva. J Dent (Tehran). 2014;11(6):672-679.
  • Park HR. Effect of Salivary Streptococcimutans and Lactobacilli levels after up take of the Probiotic for Clinical Trial. Research Journal of Pharmacy and Technology. 2017;10(9), 2984-2988.
  • Campanella V, Syed J, Santacroce L, et al. Oral probiotics influence oral and respiratory tract infections in pediatric population: a randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2018;22(22):8034-8041. doi:10.26355/eurrev_201811_16433
  • Marsh PD, Do T, Beighton D, Devine DA. Influence of saliva on the oral microbiota. Periodontol 2000. 2016;70(1):80-92. doi:10.1111/prd.12098
  • Rusu LC, Roi A, Roi CI, Tigmeanu CV, Ardelean LC. The influence of salivary pH on the prevalence of dental caries. Intech Open. doi:10.5772/intechopen.106154.
  • Farooq I, Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a narrative review. F1000Res. 2020;9:171. doi:10.12688/f1000research.22499.3
  • Borrell García C, Ribelles Llop M, García Esparza MÁ, et al. The use of Lactobacillusreuteri DSM 17938 and ATCC PTA 5289 on oral health indexes in a school population: A pilot randomized clinical trial. Int J Immunopathol Pharmacol. 2021;35:20587384211031107. doi:10.1177/20587384211031107
  • Manikandan S, Behera S, Karthikeyan R, et al. Effect of Green Tea Extract Mouthrinse and Probiotic Mouthrinse on Salivary pH in a Group of School children: An In Vivo Study. J Pharm Bioallied Sci. 2020;12(Suppl 1):404-409. doi:10.4103/jpbs.JPBS_119_20
  • Sakhare S, Shantanu C, Mopagar V, et al. A comparative evaluation of probiotic formulations in prevention of dental caries: A clinical study. J Indian Soc Pedod Prev Dent. 2021;39(4):416-422. doi:10.4103/jisppd.jisppd_236_21
  • Hao S, Wang J, Wang Y. Effectiveness and safety of Bifido bacterium in preventing dental caries: a systematic review and meta- analysis. Acta Odontol Scand. 2021;79(8):613-622. doi:10.1080/00016357.2021.1921259.
  • Shen P, Fernando JR, Walker GD, et al. Addition of CPP-ACP toyogurtinhibits enamel subsurface demineralization. J Dent. 2020;103:103506. doi:10.1016/j.jdent.2020.103506
  • Huq NL, Myroforidis H, Cross KJ, et al. The Interactions of CPP-ACP with Saliva. Int J Mol Sci. 2016;17(6):915. doi:10.3390/ijms17060915
  • Peric T, Markovic D, Petrovic B, et al. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjögren's syndrome. Clin Oral Investig. 2015;19(9):2153-2165. doi:10.1007/s00784-015-1444-1
  • Alamoudi NM, Almabadi ES, El Ashiry EA, El Derwi DA. Effect of Probiotic Lactobacillusreuteri on Salivary Cariogenic Bacterial Countsamong Groups of Preschool Children in Jeddah, Saudi Arabia: A Randomized Clinical Trial. J Clin Pediatr Dent. 2018;42(5):331-338. doi:10.17796/1053-4625-42.5.2

PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ

Yıl 2025, Cilt: 34 Sayı: 2, 171 - 179, 15.08.2025

Ecem Akbeyaz Şivet , Betul Kargul

https://doi.org/10.34108/eujhs.1583684

Öz

Bu çift kör, randomize, plasebo kontrollü klinik çalışmada, Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastillerin tükürük akış hızı, miktarı, kıvamı, pH’ı ve tamponlama kapasitesi üzerine etkileri incelenmiştir. Çalışmaya, 8-13 yaş arası 40 çocuk katılmış ve katılımcılar çift kör randomize yöntemiyle tedavi ve plasebo gruplarına ayrılmıştır. Tedavi grubuna 56 gün boyunca Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastil verilmiş, plasebo grubu ise aynı süre boyunca plasebo pastil kullanmıştır. Tükürük akış hızı, kıvamı, pH değeri ve tamponlama kapasitesi başlangıçta ve 56. günde Saliva-Check BUFFER kiti kullanılarak ölçülmüştür. Tanımlayıcı istatistiklerin yanı sıra bağımsız ve eşleştirilmiş örneklem t-testi, Ki-kare testi ve Mc Nemar testi kullanılarak analiz yapılmıştır. İstatistiksel anlamlılık düzeyi olarak p<0.05 kabul edilmiştir. Bulgular, 56 gün sonunda tedavi grubunda plasebo grubuna göre tükürük akış hızı ve pH'ın da istatistiksel olarak anlamlı bir artış olduğunu göstermiştir (p<0.05). Tükürük tamponlama kapasitesi, miktarı ve kıvamı açısından ise 56 gün sonunda anlamlı bir fark bulunamamıştır (p>0.05). Sonuçlar, çocuklarda Kazein fosfopeptit-amorf kalsiyum fosfat içeren probiyotik pastilin ağız sağlığını destekleme potansiyeline sahip olabileceğine işaret etmektedir

Anahtar Kelimeler

: Kazein fosfopeptid-amorf kalsiyum fosfat probiyotikler tükürük

Etik Beyan

Bu çalışma Yeditepe Üniversitesi Fakültesi Klinik Araştırmalar Etik Kurulu tarafından 22.04.2014-421 protokol numarası ile etik olarak onaylanmıştır.

Teşekkür

Çalışmamıza katılan tüm çocuklara ve ailelerine teşekkür ederiz.

Kaynakça

  • Peng X, Cheng L, You Y, et al. Oral microbiota in human systematic diseases. Int J Oral Sci. 2022;14(1):14. doi:10.1038/s41368-022-00163-7
  • Giacaman RA, Fernández CE, Muñoz-Sandoval C, et al. Understanding dental caries as a non-communicable and behavioral disease: Management implications. Front Oral Health.2022;3:764479. doi:10.3389/froh.2022.764479
  • Philip N. State of the art enamel remineralization systems: the next frontier in caries management. Caries Res. 2019;53(3):284-95. doi:10.1159/000493031
  • Fontana M. Enhancing fluoride: clinical human studies of alternatives orboosters for caries management. Caries Res. 2016;50(suppl 1):22–37. doi: 10.1159/000439059
  • Giacaman RA, Maturana CA, Molina J, Volgenant CMC, Fernández CE. Effect of Casein Phosphopeptide-Amorphous Calcium Phosphate Added to Milk, Chewing Gum, and Candy on Dental Caries: A Systematic Review. Caries Res. 2023;57(2):106-118. doi:10.1159/000530638
  • Salminen S, Collado MC, Endo A, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021;18(9):649-667. doi:10.1038/s41575-021-00440-6
  • Gao J, Li X, Zhang G, et al. Probiotics in the dairy industry-Advances and opportunities. Compr Rev Food Sci Food Saf. 2021 Jul;20(4):3937-3982. doi: 10.1111/1541-4337.12755.
  • How YH, Yeo SK. Oral probiotic and its delivery carriers to improve oral health: A review. Microbiology (Reading). 2021;167(8):10.1099/mic.0.001076. doi: 10.1099/mic.0.001076.
  • Salim HP, Mallikarjun SB, Raju S, Surendranath AR. Randomized Clinical Trial of Oral Probiotic Streptococcussalivarius M18 on Salivary Streptococcusmutans in Preprimary Children. Int J Clin Pediatr Dent. 2023;16(2):259-263. doi:10.5005/jp-journals-10005-2527
  • Malavalli PL, Shetty SB, Thimmaiah C, et al. Evaluation of the Effect of Probiotic Yogurt Consumption on Salivary pH, Buffering Capacity and Calcium Level in 6-12-year-old Children: An In Vivo Study. Int J Clin Pediatr Dent. 2022;15(2):194. doi:10.5005/jp-journals-10005-2368
  • Srinivasan M, Nivedhitha MS, Poorni S. Comparing the effect of probiotic Streptococcussalivarius K12 and M18 on the Streptococcusmutans Count, salivary pH and buffercapacity: a randomized double blinded clinical trial. Cumhuriyet Dent J. 2022;24(4):346-354. doi:10.7126/cumudj.941928
  • Natassa SE, Pintauli S, Ilyas S. Effectivity of Probiotic and Non-Probiotic Milk Consumption on Salivary pH and Streptococcusmutans Count. IOSR J Dent Med Sci. 2019;18(6):67-72. doi:10.9790/0853-1806106772
  • Villavicencio J, Villegas LM, Arango MC, Arias S, Triana F. Effects of a foodenriched with probiotics on Streptococcusmutans and Lactobacillus spp. Salivary counts in preschool children: a cluster randomized trial. J Appl Oral Sci. 2018;26:e20170318. doi:10.1590/1678-7757-2017-0318
  • Nishihara T, Suzuki N, Yoneda M, Hirofuji T. Effects of Lactobacillussalivarius-containing tablets on caries risk factors: a randomized open-label clinical trial. BMC Oral Health. 2014;14:110. doi:10.1186/1472-6831-14-110
  • Alkarad L, Alkhouli M, Dashash M. Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow. BDJ Open. 2023;9(1):16. doi:10.1038/s41405-023-00141-z
  • Padminee K, Poorni S, Diana D, Duraivel D, Srinivasan MR. Effectiveness of casein phosphopeptide-amorphous calcium phosphate and xylitol chewing gums on salivary pH, buffer capacity, and Streptococcus mutans levels: An interventional study. Indian J Dent Res. 2018;29(5):616-621. doi:10.4103/ijdr.IJDR_166_17
  • Plint AC, Moher D, Morrison A, et al. Doesthe CONSORT check list improve the quality of reports of randomised controlled trials? A systematic review. Med J Aust. 2006;185(5):263-267. doi:10.5694/j.1326-5377.2006.tb00557.x
  • Random.org. Randomness and Integrity Services Ltd. https://www.random.org. Erişim tarihi: 17.11.2024.
  • Petersen PE, Baez RJ. Oral Health Surveys: Basic Methods. New York. World Health Organization; 2013:47.
  • GC Europe. Saliva Check Buffer Broşürü. https://www.gc.dental/europe/sites/europe.gc.dental/files/products/downloads/salivacheckbuffer/leaflet/LFL_SCB_Test_Mat_en.pdf. Erişim tarihi: 19.02.2025
  • K S A, P Puranik M, S R U. Association between dental caries experience and salivary profile among autoimmune thyroid disease subjects - a cross-sectional comparative study. F1000Res. 2023;12:833. doi:10.12688/f1000research.135684.1
  • Prathima GS, Narmatha M, Selvabalaji A, Adimoulame S, Ezhumalai G. Effects of Xylitol and CPP-ACP Chewing Gum on Salivary Properties of Children with Molar Incisor Hypomineralization. Int J Clin Pediatr Dent. 2021;14(3):412-415. doi:10.5005/jp-journals-10005-1779
  • Baker JL, Mark Welch JL, Kauffman KM, McLean JS, He X. The oral microbiome: diversity, biogeography and human health. Nat Rev Microbiol. 2024;22(2):89-104. doi:10.1038/s41579-023-00963-6
  • Rm VR, Singh N, Murmu S, et al. Salivary physicochemical characteristics and antimicrobial human peptid eamong Indian children with dental caries. Bioinformation. 2023;19(4):428-432. doi:10.6026/97320630019428
  • Maldupa I, Brinkmane A, Mihailova A. Comparative analysis of CRT Buffer, GC saliva check buffer tests and laboratory titration to evaluatesaliva buffering capacity. Stomatologija. 2011;13(2):55-61.
  • Chandra HS, Johnson JS, Sagar L, et al. A Comparative Evaluation of Physical Parameters of Saliva and Correlation with Periodontal Condition in Down Syndrome Children and Healthy Controls. J Contemp Dent Pract. 2023;24(6):372-380. doi:10.5005/jp-journals-10024-3481
  • Vale GC, Cruz PF, Bohn AC, de Moura MS. Salivary fluoride levels after use of high-fluoride dentifrice. Scientific World Journal. 2015;2015:302717. doi:10.1155/2015/302717
  • Ferrer MD, López-López A, Nicolescu T, et al. Topic Application of the Probiotic Streptococcusdentisani Improves Clinical and Microbiological Parameters Associated With Oral Health. Front Cell Infect Microbiol. 2020;10:465. doi:10.3389/fcimb.2020.00465
  • Gill SK, Teixeira AM, Rosado F, Cox M, Costa RJ. High-Dose Probiotic Supplementation Containing Lactobacilluscaseifor 7 Days Does Not Enhance Salivary Antimicrobial Protein Responses to Exertional Heat Stress Compared With Placebo. Int J Sport Nutr Exerc Metab. 2016;26(2):150-160. doi:10.1123/ijsnem.2015-0171
  • Gueimonde L, Vesterlund S, García-Pola MJ, et al. Supplementation of xylitol-containing chewing gum with probiotics: a double blind, randomised pilot study focusing on saliva flow and saliva properties. Food Funct. 2016;7(3):1601-1609. doi:10.1039/c5fo01497b
  • Babina K, Salikhova D, Polyakova M, et al. The Effect of Oral Probiotics (Streptococcus Salivarius k12) on the Salivary Level of Secretory Immunoglobulin A, Salivation Rate, and Oral Biofilm: A Pilot Randomized Clinical Trial. Nutrients. 2022;14(5):1124. doi:10.3390/nu14051124
  • Hegde RJ, Thakkar JB. Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: An in vivo study. J Indian Soc Pedod Prev Dent. 2017;35(4):332-337. doi:10.4103/JISPPD.JISPPD_147_17
  • Curtis C, Qian F, Bowers RD. CPP-ACP paste's effect on salivary conditions in patients with removable dentures. J Prosthodont. 2024;33(5):427-435. doi:10.1111/jopr.13797
  • Biria M, Eslami G, Taghipour E, Akbarzadeh Baghban A. Effects of Three Mastic Gums on the Number of Mutans Streptococci, Lactobacilli and PH of the Saliva. J Dent (Tehran). 2014;11(6):672-679.
  • Park HR. Effect of Salivary Streptococcimutans and Lactobacilli levels after up take of the Probiotic for Clinical Trial. Research Journal of Pharmacy and Technology. 2017;10(9), 2984-2988.
  • Campanella V, Syed J, Santacroce L, et al. Oral probiotics influence oral and respiratory tract infections in pediatric population: a randomized double-blinded placebo-controlled pilot study. Eur Rev Med Pharmacol Sci. 2018;22(22):8034-8041. doi:10.26355/eurrev_201811_16433
  • Marsh PD, Do T, Beighton D, Devine DA. Influence of saliva on the oral microbiota. Periodontol 2000. 2016;70(1):80-92. doi:10.1111/prd.12098
  • Rusu LC, Roi A, Roi CI, Tigmeanu CV, Ardelean LC. The influence of salivary pH on the prevalence of dental caries. Intech Open. doi:10.5772/intechopen.106154.
  • Farooq I, Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a narrative review. F1000Res. 2020;9:171. doi:10.12688/f1000research.22499.3
  • Borrell García C, Ribelles Llop M, García Esparza MÁ, et al. The use of Lactobacillusreuteri DSM 17938 and ATCC PTA 5289 on oral health indexes in a school population: A pilot randomized clinical trial. Int J Immunopathol Pharmacol. 2021;35:20587384211031107. doi:10.1177/20587384211031107
  • Manikandan S, Behera S, Karthikeyan R, et al. Effect of Green Tea Extract Mouthrinse and Probiotic Mouthrinse on Salivary pH in a Group of School children: An In Vivo Study. J Pharm Bioallied Sci. 2020;12(Suppl 1):404-409. doi:10.4103/jpbs.JPBS_119_20
  • Sakhare S, Shantanu C, Mopagar V, et al. A comparative evaluation of probiotic formulations in prevention of dental caries: A clinical study. J Indian Soc Pedod Prev Dent. 2021;39(4):416-422. doi:10.4103/jisppd.jisppd_236_21
  • Hao S, Wang J, Wang Y. Effectiveness and safety of Bifido bacterium in preventing dental caries: a systematic review and meta- analysis. Acta Odontol Scand. 2021;79(8):613-622. doi:10.1080/00016357.2021.1921259.
  • Shen P, Fernando JR, Walker GD, et al. Addition of CPP-ACP toyogurtinhibits enamel subsurface demineralization. J Dent. 2020;103:103506. doi:10.1016/j.jdent.2020.103506
  • Huq NL, Myroforidis H, Cross KJ, et al. The Interactions of CPP-ACP with Saliva. Int J Mol Sci. 2016;17(6):915. doi:10.3390/ijms17060915
  • Peric T, Markovic D, Petrovic B, et al. Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjögren's syndrome. Clin Oral Investig. 2015;19(9):2153-2165. doi:10.1007/s00784-015-1444-1
  • Alamoudi NM, Almabadi ES, El Ashiry EA, El Derwi DA. Effect of Probiotic Lactobacillusreuteri on Salivary Cariogenic Bacterial Countsamong Groups of Preschool Children in Jeddah, Saudi Arabia: A Randomized Clinical Trial. J Clin Pediatr Dent. 2018;42(5):331-338. doi:10.17796/1053-4625-42.5.2
Toplam 47 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Çocuk Diş Hekimliği
Bölüm Araştırma Makalesi
Yazarlar

Ecem Akbeyaz Şivet 0000-0002-1890-7749

Betul Kargul 0000-0002-3294-8846

Erken Görünüm Tarihi 28 Temmuz 2025
Yayımlanma Tarihi 15 Ağustos 2025
Gönderilme Tarihi 18 Kasım 2024
Kabul Tarihi 6 Mart 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 34 Sayı: 2

Kaynak Göster

APA Akbeyaz Şivet, E., & Kargul, B. (2025). PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ. Sağlık Bilimleri Dergisi, 34(2), 171-179. https://doi.org/10.34108/eujhs.1583684
AMA Akbeyaz Şivet E, Kargul B. PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ. JHS. Ağustos 2025;34(2):171-179. doi:10.34108/eujhs.1583684
Chicago Akbeyaz Şivet, Ecem, ve Betul Kargul. “PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ”. Sağlık Bilimleri Dergisi 34, sy. 2 (Ağustos 2025): 171-79. https://doi.org/10.34108/eujhs.1583684.
EndNote Akbeyaz Şivet E, Kargul B (01 Ağustos 2025) PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ. Sağlık Bilimleri Dergisi 34 2 171–179.
IEEE E. Akbeyaz Şivet ve B. Kargul, “PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ”, JHS, c. 34, sy. 2, ss. 171–179, 2025, doi: 10.34108/eujhs.1583684.
ISNAD Akbeyaz Şivet, Ecem - Kargul, Betul. “PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ”. Sağlık Bilimleri Dergisi 34/2 (Ağustos 2025), 171-179. https://doi.org/10.34108/eujhs.1583684.
JAMA Akbeyaz Şivet E, Kargul B. PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ. JHS. 2025;34:171–179.
MLA Akbeyaz Şivet, Ecem ve Betul Kargul. “PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ”. Sağlık Bilimleri Dergisi, c. 34, sy. 2, 2025, ss. 171-9, doi:10.34108/eujhs.1583684.
Vancouver Akbeyaz Şivet E, Kargul B. PROBİYOTİK PASTİLİN ÇOCUKLARIN TÜKÜRÜK PARAMETRELERİ ÜZERİNE KLİNİK ETKİNLİĞİNİN DEĞERLENDİRİLMESİ. JHS. 2025;34(2):171-9.
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