Araştırma Makalesi
Comparison of changes in blood group, hemogram and biochemical parameters in healthcare workers with and without COVID-19
Öz
Objective: This study aimed to evaluate blood groups and some hematologic and biochemical parameters in healthcare workers with and without COVID-19.
Methods: The sample consisted of 1232 healthcare workers who consented to participate in the study after being informed about its purpose and methodology. The study's case group consisted of 704 individuals who got COVID-19, whereas the control group consisted of 528 individuals who didn't get the virus. A survey conducted online was used to gather data. The study was conducted with adherence to ethical norms.
Results: Participants in the case and control groups showed a significant difference in their vitamin D level variables, and those with low vitamin D levels were 1.9 times more likely to contract COVID-19 than those with normal levels. Blood glucose, lactate dehydrogenase (LDH), ferritin, troponin-I, D-dimer, C-reactive protein (CRP), anti- human immunodeficiency virüs (HIV), white blood cell, hemoglobulin, platelets, lymphocyte, and neutrophil averages were significantly different between the case and control groups when the biochemistry values of the participants were compared (P<0.05).
Conclusions: Vitamin D level, blood glucose, LDH, ferritin, troponin I, D-dimer, CRP, and anti-HIV among the significant biochemistry parameters in our study; leukocyte, hemoglobin, platelets, lymphocyte, and neutrophil levels among hemogram parameters are in parallel with the literature data in predicting the diagnosis of COVID-19. The use of these parameters in the clinic will contribute to the early detection of the diagnosis, early isolation of patients, and early initiation of the treatment process.
Anahtar Kelimeler
Biochemistry COVID-19 hemogram blood group healthcare worker
Etik Beyan
The study was approved by the Bursa City Hospital Clinical Research Ethics Committee (Decision no: KAEK/2021-5/2 and date: 17.03.2021) before to its commencement. At every stage of the study, the Declaration of Helsinki was followed, and participants were informed using a "voluntary consent form" that the researchers had created.
Kaynakça
- 1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
- 2. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8.
- 3. Pyrc K, Dijkman R, Deng L, et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J Mol Biol. 2006;364(5):964-973. doi: 10.1016/j.jmb.2006.09.074.
- 4. Budak F, Korkmaz Ş. [An Overall Evaluatıon for the Covıd-19 Pandemıc Process: The Case Of Turkey]. Sosyal Araştırmalar ve Yönetim Dergisi (SAYOD). 2020;(1):62-79. doi:10.35375/sayod.738657. [Article in Turkish]
- 5. İnce F, Evcil FY. [The First Three Weeks of the Covid-19 in Turkey]. 2020 Mar ;11(2):236-41. doi:10.22312/sdusbed.719168. [Article in Turkish]
- 6. Imran N, Zeshan M, Pervaiz Z. Mental health considerations for children & adolescents in COVID-19 Pandemic. Pak J Med Sci. 2020;36(COVID19-S4):S67-S72. doi: 10.12669/pjms.36.COVID19-S4.2759.
- 7. Li X, Liu C, Mao Z, et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2020;24(1):647. doi: 10.1186/s13054-020-03374-8.
- 8. Yang M, Ng MH, Li CK. Thrombocytopenia in patients with severe acute respiratory syndrome (review). Hematology. 2005;10(2):101-105. doi: 10.1080/10245330400026170.
- 9. Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi: 10.1056/NEJMoa2002032.
- 10. Muñiz-Diaz E, Llopis J, Parra R, et al. Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients. Blood Transfus. 2021;19(1):54-63. doi: 10.2450/2020.0256-20.
- 11. Almadhi MA, Abdulrahman A, Alawadhi A, Rabaan AA, Atkin S, AlQahtani M. The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes. Sci Rep. 2021;11(1):5745. doi: 10.1038/s41598-021-84810-9.
- 12. Hussein AD, Bakr EA, Al-Jumaili MHA. Association between ABO blood groups and the risk of infection with SARS-CoV-2 in Iraq. J Int Med Res. 2022;50(11):3000605221133147. doi: 10.1177/03000605221133147.
- 13. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220-223. doi: 10.1016/j.cca.2020.06.026.
- 14. Nalbant A, Aydın A, Yaylacı S, Kaya T, Wermeulen CL, Cinemre H. Association of ABO blood group and age with COVID-19 positive test. Rev Assoc Med Bras (1992). 2021;67 Suppl 1(Suppl 1):46-50. doi: 10.1590/1806-9282.67.
- 15. Robinson LE, van Soeren MH. Insulin resistance and hyperglycemia in critical illness: role of insulin in glycemic control. AACN Clin Issues. 2004;15(1):45-62. doi: 10.1097/00044067-200401000-00004.
- 16. Lymperaki E, Kazeli K, Variti G, et al. Potential Role of Certain Biomarkers Such as Vitamin B12, ROS, Albumin, as Early Predictors for Prognosis of COVID-19 Outcomes. Medicines (Basel). 2022;9(6):36. doi: 10.3390/medicines9060036.
- 17. Thapa A, Malla R, Koirala R, et al. Comparison of Biochemical Parameters in COVID-19 and non-COVID-19 Individuals in Gandaki Province, Nepal. Fortune J Health Sci. 2023;6(3):246-252. doi: 10.26502/fjhs.122.
- 18. Hussein MM. Comparison between Alterations in some Hematological and Biochemical Parameters in COVID-19 and non-COVID-19 Patients Albaida, Libya. Sci J Faculty Sci-Sirte Univ. 2022;2(1):33-37. doi: 10.37375/sjfssu.v2i1.170.
- 19. Rostam SRK, Shekhany KAM, Smail HO. Comparative study of some biochemical parameters among of COVID-19 symptoms and non COVID-19 symptoms individuals. Biovalentia: Biol Res J. 2020;6(2):9-14. doi: 10.24233/biov.6.2.2020.180.
- 20. García LF. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. Front Immunol. 2020;11:1441. doi: 10.3389/fimmu.2020.01441.
- 21. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. doi: 10.3389/fimmu.2018.00754.
- 22. Ahmed HS, Nanakali NMQ, Ali KA. Comparison of Biochemical Parameters in Vaccinated and Non-vaccinated SARS-COV-2 Patients in Erbil-City. Cihan Univ-Erbil Sci J. 2024;8(1):46-57. doi: 10.24086/cuesj.v8n1y2024.pp46-57.
- 23. Tersalvi G, Vicenzi M, Calabretta D, Biasco L, Pedrazzini G, Winterton D. Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms. J Card Fail. 2020;26(6):470-475. doi: 10.1016/j.cardfail.2020.04.009.
- 24. Soraya GV, Ulhaq ZS. Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis. Med Clin (Engl Ed). 2020;155(4):143-151. doi: 10.1016/j.medcle.2020.05.004.
- 25. Kiss S, Gede N, Hegyi P, et al. Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a systematic review and meta-analysis. Med Microbiol Immunol. 2021;210(1):33-47. doi: 10.1007/s00430-020-00696-w.
- 26. Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84:106504. doi: 10.1016/j.intimp.2020.106504.
- 27. Wang X, Liu W, Zhao J, et al. Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. J Hosp Infect. 2020;105(3):399-403. doi: 10.1016/j.jhin.2020.04.019.
- 28. Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943. doi: 10.1001/jamainternmed.2020.0994.
Yıl 2025,
Cilt: 11 Sayı: 3, 480 - 489, 04.05.2025
Öz
Kaynakça
- 1. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5.
- 2. Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8.
- 3. Pyrc K, Dijkman R, Deng L, et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J Mol Biol. 2006;364(5):964-973. doi: 10.1016/j.jmb.2006.09.074.
- 4. Budak F, Korkmaz Ş. [An Overall Evaluatıon for the Covıd-19 Pandemıc Process: The Case Of Turkey]. Sosyal Araştırmalar ve Yönetim Dergisi (SAYOD). 2020;(1):62-79. doi:10.35375/sayod.738657. [Article in Turkish]
- 5. İnce F, Evcil FY. [The First Three Weeks of the Covid-19 in Turkey]. 2020 Mar ;11(2):236-41. doi:10.22312/sdusbed.719168. [Article in Turkish]
- 6. Imran N, Zeshan M, Pervaiz Z. Mental health considerations for children & adolescents in COVID-19 Pandemic. Pak J Med Sci. 2020;36(COVID19-S4):S67-S72. doi: 10.12669/pjms.36.COVID19-S4.2759.
- 7. Li X, Liu C, Mao Z, et al. Predictive values of neutrophil-to-lymphocyte ratio on disease severity and mortality in COVID-19 patients: a systematic review and meta-analysis. Crit Care. 2020;24(1):647. doi: 10.1186/s13054-020-03374-8.
- 8. Yang M, Ng MH, Li CK. Thrombocytopenia in patients with severe acute respiratory syndrome (review). Hematology. 2005;10(2):101-105. doi: 10.1080/10245330400026170.
- 9. Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi: 10.1056/NEJMoa2002032.
- 10. Muñiz-Diaz E, Llopis J, Parra R, et al. Relationship between the ABO blood group and COVID-19 susceptibility, severity and mortality in two cohorts of patients. Blood Transfus. 2021;19(1):54-63. doi: 10.2450/2020.0256-20.
- 11. Almadhi MA, Abdulrahman A, Alawadhi A, Rabaan AA, Atkin S, AlQahtani M. The effect of ABO blood group and antibody class on the risk of COVID-19 infection and severity of clinical outcomes. Sci Rep. 2021;11(1):5745. doi: 10.1038/s41598-021-84810-9.
- 12. Hussein AD, Bakr EA, Al-Jumaili MHA. Association between ABO blood groups and the risk of infection with SARS-CoV-2 in Iraq. J Int Med Res. 2022;50(11):3000605221133147. doi: 10.1177/03000605221133147.
- 13. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Chim Acta. 2020;509:220-223. doi: 10.1016/j.cca.2020.06.026.
- 14. Nalbant A, Aydın A, Yaylacı S, Kaya T, Wermeulen CL, Cinemre H. Association of ABO blood group and age with COVID-19 positive test. Rev Assoc Med Bras (1992). 2021;67 Suppl 1(Suppl 1):46-50. doi: 10.1590/1806-9282.67.
- 15. Robinson LE, van Soeren MH. Insulin resistance and hyperglycemia in critical illness: role of insulin in glycemic control. AACN Clin Issues. 2004;15(1):45-62. doi: 10.1097/00044067-200401000-00004.
- 16. Lymperaki E, Kazeli K, Variti G, et al. Potential Role of Certain Biomarkers Such as Vitamin B12, ROS, Albumin, as Early Predictors for Prognosis of COVID-19 Outcomes. Medicines (Basel). 2022;9(6):36. doi: 10.3390/medicines9060036.
- 17. Thapa A, Malla R, Koirala R, et al. Comparison of Biochemical Parameters in COVID-19 and non-COVID-19 Individuals in Gandaki Province, Nepal. Fortune J Health Sci. 2023;6(3):246-252. doi: 10.26502/fjhs.122.
- 18. Hussein MM. Comparison between Alterations in some Hematological and Biochemical Parameters in COVID-19 and non-COVID-19 Patients Albaida, Libya. Sci J Faculty Sci-Sirte Univ. 2022;2(1):33-37. doi: 10.37375/sjfssu.v2i1.170.
- 19. Rostam SRK, Shekhany KAM, Smail HO. Comparative study of some biochemical parameters among of COVID-19 symptoms and non COVID-19 symptoms individuals. Biovalentia: Biol Res J. 2020;6(2):9-14. doi: 10.24233/biov.6.2.2020.180.
- 20. García LF. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. Front Immunol. 2020;11:1441. doi: 10.3389/fimmu.2020.01441.
- 21. Sproston NR, Ashworth JJ. Role of C-Reactive Protein at Sites of Inflammation and Infection. Front Immunol. 2018;9:754. doi: 10.3389/fimmu.2018.00754.
- 22. Ahmed HS, Nanakali NMQ, Ali KA. Comparison of Biochemical Parameters in Vaccinated and Non-vaccinated SARS-COV-2 Patients in Erbil-City. Cihan Univ-Erbil Sci J. 2024;8(1):46-57. doi: 10.24086/cuesj.v8n1y2024.pp46-57.
- 23. Tersalvi G, Vicenzi M, Calabretta D, Biasco L, Pedrazzini G, Winterton D. Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms. J Card Fail. 2020;26(6):470-475. doi: 10.1016/j.cardfail.2020.04.009.
- 24. Soraya GV, Ulhaq ZS. Crucial laboratory parameters in COVID-19 diagnosis and prognosis: An updated meta-analysis. Med Clin (Engl Ed). 2020;155(4):143-151. doi: 10.1016/j.medcle.2020.05.004.
- 25. Kiss S, Gede N, Hegyi P, et al. Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a systematic review and meta-analysis. Med Microbiol Immunol. 2021;210(1):33-47. doi: 10.1007/s00430-020-00696-w.
- 26. Yang AP, Liu JP, Tao WQ, Li HM. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol. 2020;84:106504. doi: 10.1016/j.intimp.2020.106504.
- 27. Wang X, Liu W, Zhao J, et al. Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China. J Hosp Infect. 2020;105(3):399-403. doi: 10.1016/j.jhin.2020.04.019.
- 28. Wu C, Chen X, Cai Y, et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;180(7):934-943. doi: 10.1001/jamainternmed.2020.0994.
Toplam 28 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Halk Sağlığı (Diğer) |
| Bölüm | Original Article |
| Yazarlar | |
| Erken Görünüm Tarihi | 18 Şubat 2025 |
| Yayımlanma Tarihi | 4 Mayıs 2025 |
| Gönderilme Tarihi | 11 Aralık 2024 |
| Kabul Tarihi | 12 Ocak 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 11 Sayı: 3 |
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2025