Derleme
Yıl 2025,
Cilt: 42 Sayı: 2, 101 - 108, 05.05.2025
Öz
Nanoteknoloji, nano boyutlu yapıların üretimi ve kullanımını kapsayan bir alan olarak tanımlanmaktadır. Teknolojideki gelişmeler sonucunda nanomateryaller diş hekimliği uygulamalarında daha fazla kullanılır hale gelmiştir. Malzemeler nano ölçekli boyutlarda farklı ve gelişmiş özelliklere sahip olabilirler. Bu özelliklerinden faydalanılarak tıpta ve diş hekimliğinde teşhis veya terapötik amaçlı olarak kullanılmış ve umut verici sonuçlar elde edilmiştir. Diş hekimliğinin her alanında kullanımı bulunan nanopartiküller, endodonti alanında da birçok amaçla kullanılmaktadır. Nanopartiküller, antibakteriyel özellik göstermeleri nedeniyle kök kanal tedavisinde kullanılan birçok materyale eklenebilir. Patlarda, obturasyon ve dolgu materyallerinde, kök onarım malzemelerinde, kanal içi ilaç veya dezenfeksiyon materyallerinde, dental enstrümanların kaplanmasında, pulpa rejenerasyonunda ve yapıların nano-test edilmesinde nanoteknolojiden faydalanılabilir. Yapılan çalışmalarda nanoteknolojinin, endodontiyi de içeren diş hekimliği alanına birçok yeni malzeme ve teknik getirdiği görülmektedir. Nano diş hekimliği sürekli gelişmekte olan bir alandır ve bu gelişmelerin endodontik tedaviyi de içeren dental tedavilerin başarısını artıracağı düşünülmektedir. Bu makale, nanoteknoloji ve nanomateryallerin endodonti uygulamalarındaki kullanımını tartışmakta ve örnekleriyle birlikte sunmaktadır.
Anahtar Kelimeler
Endodonti dezenfeksiyon kök kanal dolgu materyalleri nanopartiküller nanoteknoloji
Kaynakça
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- 3. Özdemir O, Kopac T. Recent Progress on the Applications of Nanomaterials and Nano-Characterization Techniques in Endodontics: A Review. Materials 2022;15:5109.
- 4. Allhoff F. On the autonomy and justification of nanoethics. Nanoethics 2007;1:185-210.
- 5. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The history of nanoscience and nanotechnology: from chemical–physical applications to nanomedicine. Molecules 2019;25:112.
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- 12. Iijima S. Helical microtubules of graphitic carbon. Nature 1991;354:56-8.
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- 15. Kim YH, Lee DK, Cha HG, Kim CW, Kang YC, Kang YS. Preparation and characterization of the antibacterial Cu nanoparticle formed on the surface of SiO2 nanoparticles. J Phys Chem B 2006;110:24923-8.
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- 18. Lynch I, Dawson KA. Protein-nanoparticle interactions. Nano Today 2008;3:40-7.
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- 44. Dasgupta D, Peddi S, Saini DK, Ghosh A. Mobile Nanobots for Prevention of Root Canal Treatment Failure. Adv Healthc Mater 2022;11:e2200232.
- 45. Guo X, Sun Y, Wang Z, Ren B, Xu HHK, Peng X, et al. The Preventive Effect of A Magnetic Nanoparticle-Modified Root Canal Sealer on Persistent Apical Periodontitis. Int J Mol Sci 2022;23:13137.
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- 48. Slenters TV, Hauser-Gerspach I, Daniels AU, Fromm KM. Silver coordination compounds as light-stable, nano-structured and anti-bacterial coatings for dental implant and restorative materials. J Mater Chem 2008;18:5359-62.
- 49. Percival SL, Bowler PG, Russell D. Bacterial resistance to silver in wound care. J Hosp Infect 2005;60:1-7.
- 50. Afkhami F, Akbari S, Chiniforush N. Entrococcus faecalis elimination in root canals using silver nanoparticles, photodynamic therapy, diode laser, or laser-activated nanoparticles: an in vitro study. J Endod 2017;43:279-82.
- 51. Chan EL, Zhang C, Cheung GS. Cytotoxicity of a novel nano-silver particle endodontic irrigant. Clin Cosmet Investig Dent 2015;7:65-74.
- 52. Moghadas L, Narimani T, Shahmoradi M. Antimicrobial activity of a new nanobased endodontic irrigation solution: in vitro study. Dent Hypotheses 2012;3:142-6.
- 53. Barreras US, Méndez FT, Martínez REM, Valencia CS, Rodríguez PRM, Rodríguez JPL. Chitosan nanoparticles enhance the antibacterial activity of chlorhexidine in collagen membranes used for periapical guided tissue regeneration. Mater Sci Eng C Mater Biol Appl 2016;58:1182-7.
- 54. Savitha A, SriRekha A, Vijay R, Ashwija, Champa C, Jaykumar T. An in vivo comparative evaluation of antimicrobial efficacy of chitosan, chlorhexidine gluconate gel and their combination as an intracanal medicament against Enterococcus faecalis in failed endodontic cases using real time polymerase chain reaction (qPCR). Saudi Dent J 2019;31:360-6.
- 55. Wu C, Chang J, Fan W. Bioactive mesoporous calcium–silicate nanoparticles with excellent mineralization ability, osteostimulation, drug-delivery and antibacterial properties for filling apex roots of teeth. J Mater Chem 2012;22:16801-9.
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- 57. Khetawat S, Lodha S. Nanotechnology (Nanohydroxyapatite Crystals): Recent Advancement in Treatment of Dentinal Hypersensitivity. J Interdiscipl Med Dent Sci 2015;3:181.
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Yıl 2025,
Cilt: 42 Sayı: 2, 101 - 108, 05.05.2025
Öz
Nanotechnology is defined as a field that encompasses the production and use of nano-sized structures. With advances in technology, nanomaterials have become increasingly used in dentistry applications. Materials at the nano-scale can exhibit different and advanced properties, which have been utilized for diagnostic or therapeutic purposes in medicine and dentistry, with promising results. Nanoparticles, which are used in every field of dentistry, are also used for many purposes in the field of endodontics. Nanoparticles can be added to many materials used in root canal treatment due to their antibacterial properties. Nanotechnology can also be utilized in sealers, obturation and filling materials, root repair materials, intra-canal medication or disinfection applications, coating dental instruments, pulp regeneration, and nano-testing of structures. Studies have shown that nanotechnology has brought many new materials and techniques to the field of dentistry, including endodontics. Nano dentistry is a continuously developing field, and it is believed that these developments will increase the success of dental treatments, including endodontic therapy. This article discusses the use of nanotechnology and nanomaterials in endodontic applications, and provides examples.
Anahtar Kelimeler
Disinfection endodontics nanoparticles nanotechnology root canal filling materials
Kaynakça
- 1. Dağlıoğlu Y, Yavuz MC. Dişhekimliğinde nanoteknoloji ve uygulamaları. EÜ Dişhek Fak Derg 2020;41:149-60.
- 2. Kaehler T. Nanotechnology: basic concepts and definitions. Clin Chem 1994;40:1797-9.
- 3. Özdemir O, Kopac T. Recent Progress on the Applications of Nanomaterials and Nano-Characterization Techniques in Endodontics: A Review. Materials 2022;15:5109.
- 4. Allhoff F. On the autonomy and justification of nanoethics. Nanoethics 2007;1:185-210.
- 5. Bayda S, Adeel M, Tuccinardi T, Cordani M, Rizzolio F. The history of nanoscience and nanotechnology: from chemical–physical applications to nanomedicine. Molecules 2019;25:112.
- 6. European Commission. Commission recommendation of 18 October 2011 on the definition of nanomaterial. J Eur Union 2011;275:38-40.
- 7. National Nanotechnology Initiative. Nanotechnology: Big Things from a Tiny World [Internet]. Alexandria (VA): National Nanotechnology Coordination Office; c2018 [cited 2023 Mar 30]. Available from: https://www.nano.gov/big-things-from-a-tiny-world.
- 8. Raura N, Garg A, Arora A, Roma M. Nanoparticle technology and its implications in endodontics: a review. Biomater Res 2020;24:21.
- 9. Freitas RA Jr. Nanodentistry. J Am Dent Assoc 2000;131:1559-65.
- 10. Taniguchi N. On the basic concept of ‘nano-technology’. Proceedings of the International Conference of Production Engineering; 1974; Tokyo, Japan.
- 11. Drexler EK, Peterson C, Pergamit G. Unbounding the Future: The Nanotechnology Revolution. 1st ed. New York: William Morrow and Company; 1991.
- 12. Iijima S. Helical microtubules of graphitic carbon. Nature 1991;354:56-8.
- 13. Neoh KG, Li M, Kang ET. Characterization of Nanomaterials/Nanoparticles. In: Kishen A, editor. Nanotechnology in endodontics: current and potential clinical applications. 1st ed. Switzerland: Springer Cham; 2015. p. 23-44.
- 14. Bhushan J, Maini C. Nanoparticles: a promising novel adjunct for dentistry. Indian J Dent 2019;11:167-73.
- 15. Kim YH, Lee DK, Cha HG, Kim CW, Kang YC, Kang YS. Preparation and characterization of the antibacterial Cu nanoparticle formed on the surface of SiO2 nanoparticles. J Phys Chem B 2006;110:24923-8.
- 16. Wang D, Lin Z, Wang T, Yao Z, Qin M, Zheng S, et al. Where does the toxicity of metal oxide nanoparticles come from: the nanoparticles, the ions, or a combination of both? J Hazard Mater 2016;308:328-34.
- 17. Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311:622-7.
- 18. Lynch I, Dawson KA. Protein-nanoparticle interactions. Nano Today 2008;3:40-7.
- 19. Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia MA, McNeil SE. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 2009;61:428-37.
- 20. Giannousi K, Lafazanis K, Arvanitidis J, Pantazaki A, Dendrinou-Samara C. Hydrothermal synthesis of copper based nanoparticles: Antimicrobial screening and interaction with DNA. J Inorg Biochem 2014;133:24-32.
- 21. Arakha M, Pal S, Samantarrai D, Panigrahi TK, Mallick BC, Pramanik K, et al. Antimicrobial activity of iron oxide nanoparticle upon modulation of nanoparticle-bacteria interface. Sci Rep 2015;5:14813.
- 22. Kirstein J, Turgay K. A new tyrosine phosphorylation mechanism involved in signal transduction in Bacillus subtilis. J Mol Microbiol Biotechnol 2005;9:182-8.
- 23. Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P, Dash D. Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 2007;18:225103.
- 24. Chen WJ, Chen YC. Fe3O4/TiO2 core/shell magnetic nanoparticle-based photokilling of pathogenic bacteria. Nanomedicine (Lond) 2010;5:1585-93.
- 25. Hall JB, Dobrovolskaia MA, Patri AK, McNeil SE. Characterization of nanoparticles for therapeutics. Nanomedicine (Lond) 2007;2:789-803.
- 26. Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther 2008;83:761-9.
- 27. Sampathkumar SG, Yarema KJ. Dendrimers in cancer treatment and diagnosis. Nanotechnol Life Sci. In: Kumar CSSR, editor. Nanomaterials for Cancer Diagnosis. Weinheim: Wiley-VCH; 2007. Vol 7. p. 1-43.
- 28. Patil M, Mehta DS, Guvva S. Future impact of nanotechnology on medicine and dentistry. J Indian Soc Periodontol 2008;12:34-40.
- 29. European Science Foundation Policy Briefing. ESF Scientific Forward Look on Nanomedicine. France: European Science Foundation; 2005 Feb.
- 30. Freitas RA Jr. Nanotechnology, nanomedicine and nanosurgery. Int J Surg 2005;3:243-6.
- 31. Gupta J. Nanotechnology applications in medicine and dentistry. J Investig Clin Dent 2011;2:81-8.
- 32. Roig-Soriano X, Souto EB, Elmsmari F, Garcia ML, Espina M, Duran-Sindreu F, et al. Nanoparticles in Endodontics Disinfection: State of the Art. Pharmaceutics 2022;14:1519.
- 33. Zakrzewski W, Dobrzynski M , Dobrzynski W , Zawadzka-Knefel A , Janecki M, Kurek K , et al. Nanomaterials Application in Orthodontics. Nanomaterials (Basel). 2021;28:337.
- 34. Chandki R, Kala M, Kumar KN, Brigit B, Banthia P, Banthia R. ‘Nanodentistry’: exploring the beauty of miniature. J Clin Exp Dent 2012;4:e119-24.
- 35. Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 2007;23:844-54.
- 36. Jain KK. Nanodiagnostics: application of nanotechnology in molecular diagnostics. Expert Rev Mol Diagn 2003;3:153-61.
- 37. Pauwels EK, Kairemo K, Erba P, Bergstrom K. Nanoparticles in cancer. Curr Radiopharm 2008;1:30-6. 38. Kanaparthy R, Kanaparthy A. The changing face of dentistry: nanotechnology. Int J Nanomedicine 2011;6:2799-804.
- 39. Jhaveri HM, Balaji PR. Nanotechnology: The future of dentistry. J Indian Prosthodont Soc 2005;5:15-7.
- 40. Schleyer TL. Nanodentistry: Fact or fiction? J Am Dent Assoc 2000;131:1567-8.
- 41. Sujatha V, Suresh M, Mahalaxmi S. Nanorobotics-A futuristic approach. SRM Univ J Dent Sci 2010;1:86-90.
- 42. Aeran H, Kumar V, Uniyal S, Tanwer P. Nanodentistry: Is just a fiction or future. J Oral Biol Craniofacial Res 2015;5:207-11.
- 43. Arora R, Kapoor H. Nanotechnology in Dentistry - Hope or hype. OHDM 2014;13:928-33.
- 44. Dasgupta D, Peddi S, Saini DK, Ghosh A. Mobile Nanobots for Prevention of Root Canal Treatment Failure. Adv Healthc Mater 2022;11:e2200232.
- 45. Guo X, Sun Y, Wang Z, Ren B, Xu HHK, Peng X, et al. The Preventive Effect of A Magnetic Nanoparticle-Modified Root Canal Sealer on Persistent Apical Periodontitis. Int J Mol Sci 2022;23:13137.
- 46. Zakrzewski W, Dobrzyński M, Zawadzka-Knefel A, Lubojański A, Dobrzyński W, Janecki M, et al. Nanomaterials Application in Endodontics. Materials 2021;14:5296.
- 47. Rago I, Bregnocchi A, Zanni E, D’Aloia AG, De Angelis F, Bossu M, et al. Antimicrobial activity of graphene nanoplatelets against Streptococcus mutans. 2015 IEEE 15th International Conference on Nanotechnology (IEEE-NANO); 2015 July 27-30; Rome, Italy. IEEE; 2015. p. 9-12.
- 48. Slenters TV, Hauser-Gerspach I, Daniels AU, Fromm KM. Silver coordination compounds as light-stable, nano-structured and anti-bacterial coatings for dental implant and restorative materials. J Mater Chem 2008;18:5359-62.
- 49. Percival SL, Bowler PG, Russell D. Bacterial resistance to silver in wound care. J Hosp Infect 2005;60:1-7.
- 50. Afkhami F, Akbari S, Chiniforush N. Entrococcus faecalis elimination in root canals using silver nanoparticles, photodynamic therapy, diode laser, or laser-activated nanoparticles: an in vitro study. J Endod 2017;43:279-82.
- 51. Chan EL, Zhang C, Cheung GS. Cytotoxicity of a novel nano-silver particle endodontic irrigant. Clin Cosmet Investig Dent 2015;7:65-74.
- 52. Moghadas L, Narimani T, Shahmoradi M. Antimicrobial activity of a new nanobased endodontic irrigation solution: in vitro study. Dent Hypotheses 2012;3:142-6.
- 53. Barreras US, Méndez FT, Martínez REM, Valencia CS, Rodríguez PRM, Rodríguez JPL. Chitosan nanoparticles enhance the antibacterial activity of chlorhexidine in collagen membranes used for periapical guided tissue regeneration. Mater Sci Eng C Mater Biol Appl 2016;58:1182-7.
- 54. Savitha A, SriRekha A, Vijay R, Ashwija, Champa C, Jaykumar T. An in vivo comparative evaluation of antimicrobial efficacy of chitosan, chlorhexidine gluconate gel and their combination as an intracanal medicament against Enterococcus faecalis in failed endodontic cases using real time polymerase chain reaction (qPCR). Saudi Dent J 2019;31:360-6.
- 55. Wu C, Chang J, Fan W. Bioactive mesoporous calcium–silicate nanoparticles with excellent mineralization ability, osteostimulation, drug-delivery and antibacterial properties for filling apex roots of teeth. J Mater Chem 2012;22:16801-9.
- 56. Hannig M, Hannig C. Nanomaterials in preventive dentistry. Nat Nanotechnol 2010;5:565-9.
- 57. Khetawat S, Lodha S. Nanotechnology (Nanohydroxyapatite Crystals): Recent Advancement in Treatment of Dentinal Hypersensitivity. J Interdiscipl Med Dent Sci 2015;3:181.
- 58. Hosseinzade M, Soflou RK, Valian A, Nojehdehian H. Physicochemical properties of MTA, CEM, hydroxyapatite and nano hydroxyapatite-chitosan dental cements. Biomed Res 2016;27:442-8.
- 59. Priyadarsini S, Mukherjee S, Mishra M. Nanoparticles used in dentistry: A review. J Oral Biol Craniofac Res 2018;8:58-67.
- 60. Sathyanarayanan MB, Balachandranath R, Srinivasulu YG, Kannaiyan SK, Subbiahdoss G. The effect of gold and iron-oxide nanoparticles on biofilm-forming pathogens. ISRN Microbiol 2013;2013:272086.
- 61. Lughi V, Sergo V. Low temperature degradation -aging- of zirconia: A critical review of the relevant aspects in dentistry. Dent Mater 2010;26:807-20.
- 62. Ramesh TR, Gangaiah M, Harish PV, Krishnakumar U, Nandakishore B. Zirconia Ceramics as a Dental Biomaterial - An Over view. Trends Biomater Artif Organs 2012;26:154-60.
- 63. Hu C, Sun J, Long C, Wu L, Zhou C, Zhang X. Synthesis of nano zirconium oxide and its application in dentistry. Nanotechnol Rev 2019;8:396-404.
- 64. Guerreiro-Tanomaru JM, Trindade-Junior A, Costa BC, da Silva GF, Drullis Cifali L, Basso Bernardi MI, et al. Effect of zirconium oxide and zinc oxide nanoparticles on physicochemical properties and antibiofilm activity of a calcium silicate-based material. ScientificWorldJournal 2014;2014:975213.
- 65. Lubojanski A, Dobrzynski M, Nowak N, Rewak-Soroczynska J, Sztyler K, Zakrzewski W, et al. Application of Selected Nanomaterials and Ozone in Modern Clinical Dentistry. Nanomaterials (Basel) 2021;11:259.
- 66. Kishen A, Shi Z, Shrestha A, Neoh KG. An Investigation on the Antibacterial and Antibiofilm Efficacy of Cationic Nanoparticulates for Root Canal Disinfection. J Endod 2008;34:1515-20.
- 67. Monzavi A, Eshraghi S, Hashemian R, Momen-Heravi F. In vitro and ex vivo antimicrobial efficacy of nano-MgO in the elimination of endodontic pathogens. Clin Oral Investig 2015;19:349-56.
- 68. Keskin NB, Aydın ZU, Uslu G, Özyürek T, Erdönmez D, Gündoğar M. Antibacterial efficacy of copper-added chitosan nanoparticles: a confocal laser scanning microscopy analysis. Odontology 2021;109:868-73.
- 69. Eivazzadeh-Keihan R, Bahojb Noruzi E, Khanmohammadi Chenab K, Jafari A, Radinekiyan F, Hashemi SM, et al. Metal-based nanoparticles for bone tissue engineering. J Tissue Eng Regen Med 2020;14:1687-714.
- 70. Karkehabadi H, Rahmati A, Abbasi R, Farmany A, Najafi R, Behroozi R, et al. Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla. BMC Oral Health 2023;23:249.
- 71. Moradpoor H, Safaei M, Mozaffari HR, Sharifi R, Imani MM, Golshah A, et al. An overview of recent progress in dental applications of zinc oxide nanoparticles. RSC Adv 2021;11:21189-206.
- 72. Javidi M, Zarei M, Naghavi N, Mortazavi M, Nejat AH. Zinc oxide nano-particles as sealer in endodontics and its sealing ability. Contemp Clin Dent 2014;5:20-4.
- 73. Lee DK, Kim SV, Limansubroto AN, Yen A, Soundia A, Wang CY, et al. Nanodiamond–Gutta Percha Composite Biomaterials for Root Canal Therapy. ACS Nano 2015;9:11490-501.
- 74. Jamleh A, Sadr A, Nomura N, Yahata Y, Ebihara A, Hanawa T, et al. Nano-indentation testing of new and fractured nickel-titanium endodontic instruments. Int Endod J 2012;45:462-8.
Toplam 73 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Diş Hekimliği |
| Bölüm | Derleme |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Mayıs 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 42 Sayı: 2 |
