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Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri

Yıl 2025, , 113 - 130, 29.05.2025

Tuğba Topal , İlknur Tosun

https://doi.org/10.63716/guffd.1594101

Öz

Hücre dışı matris, canlı gelişimini, doku homeostazını ve doku organizasyonu kontrol ederken hücre proliferasyonunu, migrasyonunu ve farklılaşmasını düzenler; bu yüzden bu matrisin bozulması kanserin ilerlemesine yol açar. Tümör gelişimi, metastaz ve terapötik direnç hem biyokimyasal sinyallerden hem de ekstrasellüler matristeki fiziksel sinyallerden etkilenir. İntegrinler, HDM proteinleri ve HDM’i yeniden şekillendirme hücreleri gibi HDM sensörlerini hedefleyen anti-kanser ilaçların keşfi için, tümör mikro çevresini ve HDM sertliği gibi mekanik etkilerin stromal hücreler ile kanser arasındaki karmaşık bağlantıları aydınlatma üzerindeki etkilerini araştırmamıza yardımcı olacaktır. Kanser hücreleri arasındaki geri bildirim ve HDM yeniden şekillemdirme süreçlerini anlamak, kanser hastaları için etkili tedaviler geliştirmek adına tümör mikro çevresininin temel mekanizmalarını derinlemesine anlamak için esastır.

Anahtar Kelimeler

Hücre dışı matris Tümör mikro çevresi Kanserde Mekanotransduksiyon

Kaynakça

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Toplam 72 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Hücre Gelişimi, Proliferasyon ve Ölümü, Hücresel Etkileşimler , Reseptörler ve Membran Biyolojisi
Bölüm Derlemeler
Yazarlar

Tuğba Topal 0000-0002-8865-9656

İlknur Tosun 0009-0008-8069-5506

Yayımlanma Tarihi 29 Mayıs 2025
Gönderilme Tarihi 2 Aralık 2024
Kabul Tarihi 14 Nisan 2025
Yayımlandığı Sayı Yıl 2025

Kaynak Göster

APA Topal, T., & Tosun, İ. (2025). Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi, 6(1), 113-130. https://doi.org/10.63716/guffd.1594101
AMA Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. Mayıs 2025;6(1):113-130. doi:10.63716/guffd.1594101
Chicago Topal, Tuğba, ve İlknur Tosun. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 6, sy. 1 (Mayıs 2025): 113-30. https://doi.org/10.63716/guffd.1594101.
EndNote Topal T, Tosun İ (01 Mayıs 2025) Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi 6 1 113–130.
IEEE T. Topal ve İ. Tosun, “Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”, GÜFFD, c. 6, sy. 1, ss. 113–130, 2025, doi: 10.63716/guffd.1594101.
ISNAD Topal, Tuğba - Tosun, İlknur. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 6/1 (Mayıs 2025), 113-130. https://doi.org/10.63716/guffd.1594101.
JAMA Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. 2025;6:113–130.
MLA Topal, Tuğba ve İlknur Tosun. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 6, sy. 1, 2025, ss. 113-30, doi:10.63716/guffd.1594101.
Vancouver Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. 2025;6(1):113-30.