3 Tesla MRI Kullanılarak Normal Beyin Dokusunda Bölgesel Manyetizasyon Transfer Oranı Haritalaması: Beyaz ve Gri Madde Farklılıklarının İncelenmesi
Öz
Amaç: Bu çalışmanın amacı, sağlıklı yetişkin deneklerde 3 Tesla manyetik rezonans görüntüleme (MRG) kullanarak beyaz ve gri cevherde normal bölgesel Manyetizasyon Transfer Oranı (MTO) değerlerini, özellikle kortikal ve derin beyin yapılarına odaklanarak belirlemek, bu değerlerin değişkenliğini değerlendirmek ve daha ileri patolojik çalışma-lar için bir temel oluşturmaktır.
Materyal ve metod: Çalışmaya dahil edilen 70 sağlıklı gönüllünün (28 kadın, 42 erkek, ortalama yaş 28) MRG tarama-ları 3.0 Tesla MRG tarayıcısı kullanılarak gerçekleştirildi. Konvansiyonel kranial MRG sekanslar elde edilmiş, ardından rezonans dışı darbelerle Manyetizasyon Transfer Görüntüleme yapıldı. MTR haritaları, manyetizasyon transferi ön darbeleriyle ve bunlar olmadan elde edilen proton yoğunluk ağırlıklı görüntülerden oluşturuldu. Ölçümler, gürültü kontrolü için ek BOS değerlendirmeleriyle birlikte 31 beyaz cevher ve 9 gri cevher bölgesinde gerçekleştirildi. Farklı beyin bölgelerindeki MTO değerlerini karşılaştırmak için istatistiksel analiz yapıldı.
Bulgular: Ortalama MTO değeri beyaz cevherde (23,9 ± 0,21) gri cevhere (17,3 ± 0,77) kıyasla önemli ölçüde daha yüksekti. Korpus kallozum, beyaz cevher içinde, özellikle spleniumda en yüksek MTO değerlerine sahipken, talamus gri cevherde en yüksek MTO değerleri saptandı. Oksipital ve temporal loblarda daha yüksek MTO değerleri ve frontal ve parietal loblarda daha düşük değerlerle bölgesel farklılıklar gözlendi. MTO ölçümleri mükemmel gözlemci içi (ICC > 0,9) ve gözlemciler arası iyi güvenilirlik (ICC 0,80–0,90) gösterdi.
Sonuç: Bu çalışma, normal beyin dokusunun ayrıntılı MTO haritalamasını sunarak beyaz ve gri cevher arasındaki önemli bölgesel farklılıkları vurgulamaktadır. Bulgular, MSS hastalıklarındaki yapısal değişiklikleri değerlendirmek ve terapötik müdahalelerin etkinliğini değerlendirmek için değerli temel veriler sunmaktadır. MTO ölçümleri yüksek tek-rarlanabilirlik gösterir ve bu tekniği merkezi sinir sistemindeki patolojik değişiklikleri izlemek için klinik ve araştırma uygulamalarında güvenilir bir araç haline getirir.
Anahtar Kelimeler
Manyetizasyon Transfer Oranı MTR 3.0 Tesla Manyetizasyon Transfer Görüntüleme beyin.
Kaynakça
- 1. Silver NC, Barker GJ, MacManus DG, Tofts PS, Miller DH. Magnetisation transfer ratio of normal brain white matter: a normative database spanning four decades of life. J Neurol Neurosurg Psychiatry. 1997;62:223-228.
- 2. Van Gelderen P, Duyn JH. Background suppressed magnetiza-tion transfer MRI. Magn Reson Med. 2020;83(3):883-891.
- 3. Henkelman RM, Stanisz GJ, Graham SJ. Magnetization trans-fer in MRI: a review. NMR Biomed. 2001;14(2):57-64.
- 4. Wolff SD, Balaban RS. Magnetisation transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med. 1989;10:135-144.
- 5. Dousset V, Grossman RI, Ramer KN, Schnall MD, Young LH, Gonzalez-Scarano F, et al. Experimental allergic encephalo-myelitis and multiple sclerosis: lesion characterisation with magnetization transfer imaging. Radiology. 1992;182:483-491.
- 6. Gass A, Barker GJ, Kidd D, Thorpe JW, MacManus D, Brennan A, et al. Correlation of magnetization transfer ratio with clin-ical disability in multiple sclerosis. Ann Neurol. 1994;36:62-67.
- 7. Tomiak MM, Rosenblum JD, Prager JM, Metz CE. Magnetiza-tion transfer: a potential method to determine the age of multiple sclerosis lesions. AJNR Am J Neuroradiol. 1994;15:1569-1574.
- 8. Hiehle JF, Grossman RI, Ramer KN, Gonzales-Scarano F, Co-hen JA. Magnetization transfer effects in MR-detected multi-ple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and non-enhanced T1-weighted images. AJNR Am J Neuroradiol. 1995;16:69-77.
- 9. Ordidge RJ, Helpem JA, Knight RA, Quing Z, Welch KMA. Investigation of cerebral ischaemia using magnetization transfer (MTC) MR imaging. Magn Reson Imaging. 1991;9:895-902.
- 10. Dousset V, Armand JP, Degreze P, Mieze S, Lafon P, Caille JM. Progressive multifocal leucoencephalopathy studied by magnetization transfer imaging. In: Proceedings of the Socie-ty of Magnetic Resonance and the European Society for Magnetic Resonance in Medicine and Biology; 1995; Nice, France. p. 284.
- 11. Boorstein JM, Wong KT, Grossman RI, Bolinger L, McGowan JC. Metastatic lesions of the brain: imaging with magnetiza-tion transfer. Radiology. 1994;191:799-803.
- 12. Wong KT, Grossman RI, Boorstein JM, Lexa FJ, McGowan JC. Magnetization transfer imaging of periventricular hyperin-tense white matter in the elderly. AJNR Am J Neuroradiol. 1995;16:253-258.
- 13. Pirpamer L, Kincses B, Kincses ZT, Kiss C, Damulina A, Khalil M, et al. Periventricular magnetisation transfer abnormali-ties in early multiple sclerosis. Neuroimage Clin. 2022;34:103012.
- 14. Tahtabasi M, Kilicaslan N, Akin Y, Karaman E, Gezer M, Icen YK, et al. The Prognostic Value of Vertebral Bone Density on Chest CT in Hospitalized COVID-19 Patients. J Clin Densitom. 2021;24(4):506–515.
- 15. Kaya V, Tahtabasi M, Akin Y, Karaman E, Gezer M, Kilicaslan N. Prognostic Value of Vertebral Bone Density in the CT Scans of Sepsis Patients Admitted to the Intensive Care Unit. J Clin Densitom. 2023;26(3):101417.
- 16. Tahtabasi M, Erturk SM, Basak M. Comparison of MRI and 18F-FDG PET/CT in the Liver Metastases of Gastrointestinal and Pancreaticobiliary Tumors. Sisli Etfal Hastan Tip Bul. 2021;55(1):12-17.
- 17. Mehta RC, Pike GB, Enzmann DR. Magnetization transfer MR of the normal adult brain. AJNR Am J Neuroradiol. 1995;16:2085-2091.
- 18. Steens SC, van Buchem MA. MT: Magnetization Transfer. In: Quantitative MRI of the Brain: Measuring Changes Caused by Disease. John Wiley & Sons; 2003. p. 257-298.
- 19. Tofts PS, Sisodiya S, Barker GJ, Webb S, MacManus D, Fish D, Shorvon S. MR magnetization transfer measurements in temporal lobe epilepsy: a preliminary study. AJNR Am J Neu-roradiol. 1995;16:1862-1863.
- 20. Hiehle JF Jr, Grossman RI, Ramer KN, Gonzalez-Scarano F, Cohen JA. Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and non-enhanced T1-weighted images. AJNR Am J Neuroradiol. 1995;16:69-77.
- 21. van Buchem MA, Steens SC, Vrooman HA, Zwinderman AH, McGowan JC, Rassek M, et al. Global estimation of mye-lination in the developing brain on the basis of magnetiza-tion transfer imaging: a preliminary study. AJNR Am J Neuro-radiol. 2001;22:762-766.
- 22. Engelbrecht V, Rassek M, Preiss S, Wald C, Modder U. Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain. AJNR Am J Neuroradiol. 1998;19:1923-1929.
- 23. Steens SC, van Buchem MA. MT: Magnetization Transfer. In: Quantitative MRI of the Brain: Measuring Changes Caused by Disease. John Wiley & Sons; 2003. p. 257-298.
- 24. Berry I, Barker GJ, Barkhof F, Campi A, Dousset V, Franconi JM, et al. A multicenter measurement of magnetization transfer ratio in normal white matter. J Magn Reson Imaging. 1999;9:441-446.
- 25. Garcia M, Gloor M, Bieri O, Wetzel SG, Radue EW, Scheffler K. MTR variations in normal adult brain structures using bal-anced steady-state free precession. Neuroradiology. 2011;53:159-167.
- 26. Barr ML, Kieman JA. The human nervous system: an anatomi-cal viewpoint. Philadelphia: JB Lippincott; 1993. p. 251-268.
- 27. Tozer D, Ramani A, Barker GJ, Davies GR, Miller DH, Tofts PS. Quantitative magnetization transfer mapping of bound pro-tons in multiple sclerosis. Magn Reson Med. 2003;50(1):83-91.
- 28. Van Gelderen P, Duyn JH. Background suppressed magnetiza-tion transfer MRI. Magn Reson Med. 2020;83(3):883-891. doi:10.1002/mrm.27978.
3T MRI-Based Regional Mapping of Magnetization Transfer Ratio in Normal Brain Tissue: A Study of White and Grey Matter Differences
Öz
Background: This study aimed to establish normal regional Magnetization Transfer Ratio (MTR) values in white and grey matter using 3-Tesla MRI in healthy adult subjects, with a particular focus on cortical and deep brain structures. It also aims to assess the variability of these values and provide a baseline for further pathological studies.
Materials and Methods: Seventy healthy volunteers (28 females, 42 males, mean age 28 years) were included. MRI scans were performed using a 3.0 Tesla MRI scanner. Conventional cranial MRI sequences were acquired, followed by Magnetization Transfer Imaging (MTI) with off-resonance pulses. MTR maps were generated from proton density-weighted images obtained with and without magnetization transfer pre-pulses. Measurements were performed in 31 white matter and 9 grey matter regions, with additional assessments of CSF for noise control. Statistical analysis was carried out to compare MTR values across different brain regions.
Results: The mean MTR value was significantly higher in white matter (23.9 ± 0.21) compared to grey matter (17.3 ± 0.77). The corpus callosum had the highest MTR values within the white matter, particularly in the splenium, while the thalamus exhibited the highest MTR values in the grey matter. Regional variations were observed, with higher MTR values in the occipital and temporal lobes and lower values in the frontal and parietal lobes. MTR measurements showed excellent intra-observer (ICC > 0.9) and good inter-observer reliability (ICC 0.80–0.90).
Conclusions: This study provides detailed MTR mapping of normal brain tissue, highlighting significant regional dif-ferences between white and grey matter. The findings offer valuable baseline data for assessing structural changes in CNS diseases and for evaluating the efficacy of therapeutic interventions. MTR measurements demonstrate high reproducibility, making this technique a reliable tool in clinical and research applications for monitoring pathological alterations in the central nervous system.
Anahtar Kelimeler
Magnetization Transfer Ratio MTR 3.0 Tesla Magnetization Transfer Imaging brain.
Etik Beyan
Sağlık bilimleri Üniversitesi, Dr. Sadi Konuk Eğitim ve Araştırma Hastanesinin Etik kurulundan onam alındı (Tarih:23.02.2015, NO: 2015/39)
Destekleyen Kurum
Yok
Teşekkür
Yok
Kaynakça
- 1. Silver NC, Barker GJ, MacManus DG, Tofts PS, Miller DH. Magnetisation transfer ratio of normal brain white matter: a normative database spanning four decades of life. J Neurol Neurosurg Psychiatry. 1997;62:223-228.
- 2. Van Gelderen P, Duyn JH. Background suppressed magnetiza-tion transfer MRI. Magn Reson Med. 2020;83(3):883-891.
- 3. Henkelman RM, Stanisz GJ, Graham SJ. Magnetization trans-fer in MRI: a review. NMR Biomed. 2001;14(2):57-64.
- 4. Wolff SD, Balaban RS. Magnetisation transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med. 1989;10:135-144.
- 5. Dousset V, Grossman RI, Ramer KN, Schnall MD, Young LH, Gonzalez-Scarano F, et al. Experimental allergic encephalo-myelitis and multiple sclerosis: lesion characterisation with magnetization transfer imaging. Radiology. 1992;182:483-491.
- 6. Gass A, Barker GJ, Kidd D, Thorpe JW, MacManus D, Brennan A, et al. Correlation of magnetization transfer ratio with clin-ical disability in multiple sclerosis. Ann Neurol. 1994;36:62-67.
- 7. Tomiak MM, Rosenblum JD, Prager JM, Metz CE. Magnetiza-tion transfer: a potential method to determine the age of multiple sclerosis lesions. AJNR Am J Neuroradiol. 1994;15:1569-1574.
- 8. Hiehle JF, Grossman RI, Ramer KN, Gonzales-Scarano F, Co-hen JA. Magnetization transfer effects in MR-detected multi-ple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and non-enhanced T1-weighted images. AJNR Am J Neuroradiol. 1995;16:69-77.
- 9. Ordidge RJ, Helpem JA, Knight RA, Quing Z, Welch KMA. Investigation of cerebral ischaemia using magnetization transfer (MTC) MR imaging. Magn Reson Imaging. 1991;9:895-902.
- 10. Dousset V, Armand JP, Degreze P, Mieze S, Lafon P, Caille JM. Progressive multifocal leucoencephalopathy studied by magnetization transfer imaging. In: Proceedings of the Socie-ty of Magnetic Resonance and the European Society for Magnetic Resonance in Medicine and Biology; 1995; Nice, France. p. 284.
- 11. Boorstein JM, Wong KT, Grossman RI, Bolinger L, McGowan JC. Metastatic lesions of the brain: imaging with magnetiza-tion transfer. Radiology. 1994;191:799-803.
- 12. Wong KT, Grossman RI, Boorstein JM, Lexa FJ, McGowan JC. Magnetization transfer imaging of periventricular hyperin-tense white matter in the elderly. AJNR Am J Neuroradiol. 1995;16:253-258.
- 13. Pirpamer L, Kincses B, Kincses ZT, Kiss C, Damulina A, Khalil M, et al. Periventricular magnetisation transfer abnormali-ties in early multiple sclerosis. Neuroimage Clin. 2022;34:103012.
- 14. Tahtabasi M, Kilicaslan N, Akin Y, Karaman E, Gezer M, Icen YK, et al. The Prognostic Value of Vertebral Bone Density on Chest CT in Hospitalized COVID-19 Patients. J Clin Densitom. 2021;24(4):506–515.
- 15. Kaya V, Tahtabasi M, Akin Y, Karaman E, Gezer M, Kilicaslan N. Prognostic Value of Vertebral Bone Density in the CT Scans of Sepsis Patients Admitted to the Intensive Care Unit. J Clin Densitom. 2023;26(3):101417.
- 16. Tahtabasi M, Erturk SM, Basak M. Comparison of MRI and 18F-FDG PET/CT in the Liver Metastases of Gastrointestinal and Pancreaticobiliary Tumors. Sisli Etfal Hastan Tip Bul. 2021;55(1):12-17.
- 17. Mehta RC, Pike GB, Enzmann DR. Magnetization transfer MR of the normal adult brain. AJNR Am J Neuroradiol. 1995;16:2085-2091.
- 18. Steens SC, van Buchem MA. MT: Magnetization Transfer. In: Quantitative MRI of the Brain: Measuring Changes Caused by Disease. John Wiley & Sons; 2003. p. 257-298.
- 19. Tofts PS, Sisodiya S, Barker GJ, Webb S, MacManus D, Fish D, Shorvon S. MR magnetization transfer measurements in temporal lobe epilepsy: a preliminary study. AJNR Am J Neu-roradiol. 1995;16:1862-1863.
- 20. Hiehle JF Jr, Grossman RI, Ramer KN, Gonzalez-Scarano F, Cohen JA. Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and non-enhanced T1-weighted images. AJNR Am J Neuroradiol. 1995;16:69-77.
- 21. van Buchem MA, Steens SC, Vrooman HA, Zwinderman AH, McGowan JC, Rassek M, et al. Global estimation of mye-lination in the developing brain on the basis of magnetiza-tion transfer imaging: a preliminary study. AJNR Am J Neuro-radiol. 2001;22:762-766.
- 22. Engelbrecht V, Rassek M, Preiss S, Wald C, Modder U. Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain. AJNR Am J Neuroradiol. 1998;19:1923-1929.
- 23. Steens SC, van Buchem MA. MT: Magnetization Transfer. In: Quantitative MRI of the Brain: Measuring Changes Caused by Disease. John Wiley & Sons; 2003. p. 257-298.
- 24. Berry I, Barker GJ, Barkhof F, Campi A, Dousset V, Franconi JM, et al. A multicenter measurement of magnetization transfer ratio in normal white matter. J Magn Reson Imaging. 1999;9:441-446.
- 25. Garcia M, Gloor M, Bieri O, Wetzel SG, Radue EW, Scheffler K. MTR variations in normal adult brain structures using bal-anced steady-state free precession. Neuroradiology. 2011;53:159-167.
- 26. Barr ML, Kieman JA. The human nervous system: an anatomi-cal viewpoint. Philadelphia: JB Lippincott; 1993. p. 251-268.
- 27. Tozer D, Ramani A, Barker GJ, Davies GR, Miller DH, Tofts PS. Quantitative magnetization transfer mapping of bound pro-tons in multiple sclerosis. Magn Reson Med. 2003;50(1):83-91.
- 28. Van Gelderen P, Duyn JH. Background suppressed magnetiza-tion transfer MRI. Magn Reson Med. 2020;83(3):883-891. doi:10.1002/mrm.27978.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Radyoloji ve Organ Görüntüleme |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Erken Görünüm Tarihi | 26 Haziran 2025 |
| Yayımlanma Tarihi | 27 Haziran 2025 |
| Gönderilme Tarihi | 3 Mayıs 2025 |
| Kabul Tarihi | 25 Haziran 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 22 Sayı: 2 |
Harran Üniversitesi Tıp Fakültesi Dergisi / Journal of Harran University Medical Faculty