Kanser Tanısı Olan Çocuklara Uygulanan Terapötik Oyunun Yaşam Kalitesi Ve Semptom Kontrolüne Etkisi
Yıl 2025,
Cilt: 13 Sayı: 2, 294 - 312, 25.06.2025
Hatice Uzşen
,
Zümrüt Başbakkal
Öz
Kanser tanısı olan çocuklara uygulanan terapötik oyunun yaşam kalitesi ve semptom kontrolüne etkisinin incelenmesi amaçlanmıştır. Tek grup ön test-son test modelli yarı deneysel klinik bir araştırmadır. Çalışmanın verileri 2019-2021 tarihleri arasında, iki üniversite hastanesinde tedavi gören 15 kanser tanısı olan çocuktan toplanmıştır. Veri toplama araçları “Çocuk Hasta Bilgi Formu”, “PedsQL Kanser Modülü”, “Görsel Analog Semptom Tanılama Ölçeği”dir. Çocukların PedsQL Kanser Modülü/Çocuk toplam puan ortalaması terapötik oyun öncesinde 57.97±14.83, terapötik oyun sonrasında 62.08±12.97’dir. Çocukların PedsQL Kanser Modülünden aldıkları puanların medyanları arasında istatistiksel olarak anlamlı bir farklılık tespit edilmemiştir (p>0.05). Semptom değerlendirmek için kullanılan Görsel Analog Ölçeği’ne göre çocukların tüm semptom puanları arasında terapötik oyun öncesi ve sonrasında istatistiksel olarak anlamlı bir farklılık olduğu, terapötik oyun sonrası semptomların şiddetinin azaldığı belirlenmiştir (p˂0.05). Terapötik oyunun kemoterapi alan kanser tanısı olan çocukların deneyimlediği fiziksel ve duygusal semptomların şiddetinin azaltılmasında etkili bir yöntem olduğu, terapötik oyundan sonra çocukların yaşam kalitesi genel toplam puanları arasında istatistiksel olarak anlamlı bir değişim belirlenmemesine karşın yaşam kalitesi genel puanında öncesine göre artış olduğu gözlenmiştir.
Etik Beyan
In order to carry out the research, ethical approval was obtained from the Medical Research Ethics Committee of a university (date: 02.10.2019 Number:19-10T/61)
Kaynakça
- Altay, N., Törüner, E. T. & Sarı, Ç. (2017). The effect of drawing and writing techniques on the anxiety level of children undergoing cancer treatment. European Journal of Oncology Nursing, 28, 1-6. https://doi.org/10.1016/j.ejon.2017.02.007
- Al-Yateem, N. & Rossiter, R. C. (2017). Unstructured play for anxiety in pediatric inpatient care. J. Spec. Pediatr. Nurs., 22(1). https://doi.org/10.1111/jspn.12166
- Angström-Brännström, C., Norberg, A., Strandberg, G., Söderberg, A. & Dahlqvist, V. (2010). Parents’ experiences of what comforts them when their child is suffering from cancer. Journal of Pediatric Oncology Nursing, 27(5), 266-275. https://doi.org/10.1177/1043454210364
- Aslan, H. (2018). The effect of the experience of playing games with toys composed of materials for invasive attempt on invasive attempt-induced pain among children with cancer. (Doctoral thesis). https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=V3TP7rMDTvNIfb46zC-MGw&no=SpdlxrnijMG01H00qu4_9w
- Association of Pediatric Oncology Nurses. (2021). Pediatric hematology-oncology nursing. https://aphon.org/about-us/pediatric-hematology-oncology-nursing Accessed time: Jan, 2021.
- Bahrami, M. & Arbon, P. (2012). How do nurses assess quality of life of cancer patients in oncology wards and palliative settings? European Journal of Oncology Nursing, 16(3), 212-219. https://doi.org/10.1016/j.ejon.2011.05.003
- Baxter, A. L., Watcha, M. F., Baxter, W. V., Leong, T. & Wyatt, M. M. (2011). Development and validation of a pictorial nausea rating scale for children. Pediatrics, 127(6), 1542-1549. https://doi.org/10.1542/peds.2010-1410
- Caleffi, C. C. F., Rocha, P. K., Anders, J. C., Souza, A. I. J., Burciaga, V. B., Serapião, & L. Da S. (2016). Contribution of structured therapeutic play in a nursing care model for hospitalised children. Revista Gaucha de Enfermagem, 37(2), 1-8. https://doi.org/10.1590/1983-1447.2016.02.58131
- Campos, M. C., Rodrigues, K. C. S. & Pinto, M. C. M. (2010). Evaluation of the behavior of the preschool one just admitted in the unit of pediatrics and the use of the therapeutic toy. Einstein, 8(1), 10-17. https://doi.org/0.1590/S1679-45082010AO1462
- Chan, C. W., Lam, L. W., Li, C. K., Cheung. J. S., Cheng. K. K., Chik. K. W., … & Tnag, W. P.Y. (2015). Feasibility of psychoeducational interventions in managing chemotherapy- associated nausea and vomiting (CANV) in pediatric oncology patients. Eur J Oncol Nurs., 9(2),182-90. https://doi.org/10.1016/j.ejon.2014.09.002
- Chung, J. O. K., Li, W. H. C., Cheung, A.T., Ho, L. L. K., Xia, W., Chan, G. C. F. & Lopez, V. (2021). Relationships among resilience, depressive symptoms, self‐esteem, and quality of life in children with cancer. Psycho‐Oncology, 30(2), 194-201. https://doi.org/10.1002/pon.5548
- van Dijk, M., Koot, H. M., Saad, H. H. A., Tibboel, D. & Passchier, J. (2002). Observational visual analog scale in pediatric pain assessment: Useful tool or good riddance? The Clinical Journal of Pain, 18(5), 310-316. https://doi.org/0.1097/00002508-200209000-00006
- Frygner-Holm, S., Russ, S., Quitmann, J., Ring, L., Zyga, O., Hansson, M., … & Höglund, A. T. (2020). Pretend play as an intervention for children with cancer: A feasibility study. Journal of Pediatric Oncology Nursing, 37(1), 65-75. https://doi.org/10.1177/1043454219874695
- Gariepy, N. & Howe, N. (2003). The therapeutic power of play: Examining the play of young children with leukaemia. Child Care, Health, and Development, 29, 523-537. https://doi.org/10.1046/j.1365-2214.2003.00372.x
- Godino-Iáñez, M. J., Martos-Cabrera, M. B., Suleiman-Martos, N., Gómez-Urquiza, J. L., Vargas-Román, K., Membrive-Jiménez, M.J. & Albendín-García, L. (2020). Play therapy as an ıntervention in hospitalized children: A systematic review. Healthcare, 29, 8(3), 239. doi: 10.3390/healthcare803023. https://doi.org/10.3390/healthcare8030239
- Griffiths, M. (2005). Video games and health. Video gaming is safe for most players and can be useful in health care. BMJ, 331, 7509, 122-123. https://doi.org/10.1136/bmj.331.7509.122
- Kabak, V. Y., Yakut, Y., Çetin, M. & Düger, T. (2016). Reliability and validity of the Turkish version of the PedsQL 3.0 cancer module for 2-to 7-year-old and the PedsQL 4.0 generic core scales for 5-to 7-year-old: the Hacettepe University experience. Turkish Journal of Hematology, 33(3), 236. https://doi.org/10.4274/tjh.2015.0242
Karakaya, A. & Gözen, D. (2016). The effect of distraction on pain level felt by school-age children during venipuncture procedure--randomized controlled trial. Pain Manag Nurs., 17(1), 47–53. https://doi.org/10.1016/j.pmn.2015.08.005
- Klimek, L. & Bergmann, K. C., Biedermann, T., Bousquet, J., Hellings, P., Jung, K., ... & Pfaar, O. (2017). Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care. Allergo Journal International, 26(1), 16-24. https://doi.org/10.1007/s40629-016-0006-7
- Kurudirek, F. & Arıkan, D. (2020). Effects of therapeutic clowning on pain and anxiety during intrathecal chemotherapy in Turkey. Journal of Pediatric Nursing, 53, 6-13. https://doi.org/10.1016/j.pedn.2020.01.015
- Li, W. H., Chung, J. O., & Ho, E. K. (2011). The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer. Journal of Clinical Nursing, 20 (15-16), 2135- 2143. https://doi.org/10.1111/j.1365-2702.2011.03733.x
- Li, H. C., Williams, P. D., Lopez, V., Chung, J. O. & Chiu, S. Y. (2013). Relationships among therapy-related symptoms, depressive symptoms, and quality of life in Chinese children hospitalized with cancer: an exploratory study. Cancer Nurs., (5), 346-354. https://doi.org/10.1097/NCC.0b013e31824062ec
- Li, W. H. C., Chan, S. S. C., Wong, E. M. L., Kwok, M. C. & Lee, I. T. L. (2014). Effect of therapeutic play on pre- and post-operative anxiety and emotional responses in Hong Kong Chinese children: A randomised controlled trial. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 20, 7(7), 36–39. Accessed link: https://www.hkmj.org/system/files/hkm1406sp7p36.pdf , Accessed time: Jan, 2021.
- Li, W. H., Chung, J. O. K., Ho, K. Y. & Kwok, B. M. C. (2016). Play interventions to reduce anxiety and negative emotions in hospitalized children. BMC Pediatrics, 16(1), 1-9. https://doi.org/10.1186/s12887-016-0570-5
- Linder, L. A. & Hooke, M.C. (2019). Symptoms in children receiving treatment for cancer-part ii: pain, sadness, and symptom clusters. J Pediatr Oncol Nurs., 36(4), 262-279. https://doi.org/10.1177/1043454219849578
- Madden, J. R., Mowry, P., Gao, D., Cullen, P. M. & Foreman, N. K. (2010). Creative arts therapy improves quality of life for pediatric brain tumor patients receiving outpatient chemotherapy. Journal of Pediatric Oncology Nursing, 27, 133-145. https://doi.org/10.1177/1043454209355452
- Manav, G. & Ocakci, A. F. (2016). Play model for “evaluation of self-concept of children with cancer. Iranian Journal of Nursing snd Midwifery Research, 21(2), 124. https://doi.org/10.4103/1735-9066.178227
- McCulloch, R., Hemsley, J. & Kelly, P. (2014). Symptom management during chemotherapy. Paediatrics and Child Health, 24(4), 166-171. https://doi.org/10.1016/j.paed.2018.02.003
- Mohammadi, A., Mehraban, A. H., Damavandi, S. A., Zarei, M. A. & Haghani, H. (2021). The effect of play-based occupational therapy on symptoms and participation in daily life activities in children with cancer: A randomized controlled trial. British Journal of Occupational Therapy, 84(7). https://doi.org/10.1177/0308022620987125
- Newmani, A. R., Haglund, K. & Rodgers, C.C. (2019) Pediatric oncology nurses' perceptions of prognosis-related communication. Nurse Outlook, 67(1), 101-114. https://doi.org/10.1016/j.outlook.2018.11.001
- Ozcan, H. (2012) Investigation of the effect of art therapy study on the quality of life of children with cancer (Master thesis). https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=86XXXOd8YRS-rgHrNQwcgQ&no=DbqCrWT95wyxLNlLo2pQhw
- Paula, A., Artilheiro, S., De Amorim Almeida, F., Maria, J. & Chacon, F. (2011). Use of therapeutic play in preparing preschool children for outpatient chemotherapy. Acta Paul Enferm Hospital, 24(5), 611–616. Accessed link: http://www.scielo.br/pdf/ape/v24n5/en_03v24n5.pdf
- Rosenberg, A. R., Orellana, L., Ullrich, C., Kang, T., Geyer, J. R., Feudtner, C., .... Wolfe, J. (2016). Quality of life in children with advanced cancer: a report from the PediQUEST study. Journal of Pain and Symptom Management, 52(2), 243-253. https://doi.org/10.1016/j.jpainsymman.2016.04.002
- Silva, S. G. T., Santos, M. A., Floriano, C. M. F., Damião, E. B. C., Campos, F. V. & Rossato, L. M. (2017). Influence of therapeutic play on the anxiety of hospitalized school-age children: Clinical trial. Rev Bras Enferm., 70(6), 1244-1249. https://doi.org/10.1590/0034-7167-2016-0353
- Sitaresmi, M. N., Mostert, S., Purwanto, I., Gundy, C. M., Sutaryo, & Veerman, A. J. (2009). Chemotherapy-related side effects in childhood acute lymphoblastic leukemia in Indonesia: parental perceptions. Journal of Pediatric Oncology Nursing, 26(4), 198-207. https://doi.org/10.1177/1043454209340315
- Stenmarker, E., Mellgren, K., Matus, M., Hakansson, A. S. & Stenmarker, M. (2018). Health-related quality of life, culture and communication: a comparative study in children with cancer in Argentina and Sweden. Journal of Patient-Reported Outcomes, 2(1), 1-12. https://doi.org/10.1186/s41687-018-0075-0
- Tanir, M. K. & Kuguoglu, S., (2011). Turkish validity and reliability of a Pediatric Quality of Life cancer module for children aged 8-12 and parents. Asian Pacific Journal of Cancer Prevention, 12, 125-130
- Thrane, S. (2013). Effectiveness of integrative modalities for pain and anxiety in children and adolescents with cancer: a systematic review. Journal of Pediatric Oncology Nursing, 30(6), 320-332. https://doi.org/10.1177/1043454213511538
Varni, J. W. & Limbers, C. A. (2009). The pediatric quality of life inventory: measuring pediatric health-related quality of life from the perspective of children and their parents. Pediatric Clinics of North America, 56(4), 843-863. https://doi.org/10.1016/j.pcl.2009.05.016
- Yıldız, G. K. (2018). The effect of a tablet game and training book developed for children who receive chemotherapy on symptom management and quality of life. (Doctoral thesis). https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=kae6r1bAOG2H4BrZGqbfKQ&no=eNUowAChLRVosWkaLOq5vA
THE EFFECT OF THERAPEUTIC PLAY ON THE QUALITY OF LIFE AND SYMPTOM CONTROL OF CHILDREN WITH CANCER
Yıl 2025,
Cilt: 13 Sayı: 2, 294 - 312, 25.06.2025
Hatice Uzşen
,
Zümrüt Başbakkal
Öz
Study aimed to investigate effect of therapeutic play on quality of life and symptom control of children with cancer. Participants were 15 children, aged 6-12, who were diagnosed with cancer, and treated in oncology-hematology clinics. Data were collected from two university hospitals between 2019-2021. It was quasi-experimental clinical research with single-group pretest-posttest model. Pediatric Patient Information Form, PedsQL Cancer Module, and Visual Analog Scale for symptoms were used as data collection tools. Mean PedsQL Cancer Module total score of children was 57.97±14.83 before therapeutic play and 62.08±12.97 after therapeutic play. There was no statistical difference between time-dependent median PedsQL Cancer Module total scores of children (p>0.05). According to Visual Analog Scale for symptoms, there was statistically significant difference in all symptoms after therapeutic play intervention (p˂0.05). Study showed that therapeutic play affected symptom control of pediatric patients receiving long cancer treatment. No statistically significant difference was found between scores children obtained from PedsQL Cancer Module Child Report before, during, and after therapeutic play intervention. However, PedsQL Cancer Module Child Report total score increased.
Etik Beyan
In order to carry out the research, ethical approval was obtained from the Medical Research Ethics Committee of a university (date: 02.10.2019 Number:19-10T/61)
Teşekkür
Thanks to children and parents.
Kaynakça
- Altay, N., Törüner, E. T. & Sarı, Ç. (2017). The effect of drawing and writing techniques on the anxiety level of children undergoing cancer treatment. European Journal of Oncology Nursing, 28, 1-6. https://doi.org/10.1016/j.ejon.2017.02.007
- Al-Yateem, N. & Rossiter, R. C. (2017). Unstructured play for anxiety in pediatric inpatient care. J. Spec. Pediatr. Nurs., 22(1). https://doi.org/10.1111/jspn.12166
- Angström-Brännström, C., Norberg, A., Strandberg, G., Söderberg, A. & Dahlqvist, V. (2010). Parents’ experiences of what comforts them when their child is suffering from cancer. Journal of Pediatric Oncology Nursing, 27(5), 266-275. https://doi.org/10.1177/1043454210364
- Aslan, H. (2018). The effect of the experience of playing games with toys composed of materials for invasive attempt on invasive attempt-induced pain among children with cancer. (Doctoral thesis). https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=V3TP7rMDTvNIfb46zC-MGw&no=SpdlxrnijMG01H00qu4_9w
- Association of Pediatric Oncology Nurses. (2021). Pediatric hematology-oncology nursing. https://aphon.org/about-us/pediatric-hematology-oncology-nursing Accessed time: Jan, 2021.
- Bahrami, M. & Arbon, P. (2012). How do nurses assess quality of life of cancer patients in oncology wards and palliative settings? European Journal of Oncology Nursing, 16(3), 212-219. https://doi.org/10.1016/j.ejon.2011.05.003
- Baxter, A. L., Watcha, M. F., Baxter, W. V., Leong, T. & Wyatt, M. M. (2011). Development and validation of a pictorial nausea rating scale for children. Pediatrics, 127(6), 1542-1549. https://doi.org/10.1542/peds.2010-1410
- Caleffi, C. C. F., Rocha, P. K., Anders, J. C., Souza, A. I. J., Burciaga, V. B., Serapião, & L. Da S. (2016). Contribution of structured therapeutic play in a nursing care model for hospitalised children. Revista Gaucha de Enfermagem, 37(2), 1-8. https://doi.org/10.1590/1983-1447.2016.02.58131
- Campos, M. C., Rodrigues, K. C. S. & Pinto, M. C. M. (2010). Evaluation of the behavior of the preschool one just admitted in the unit of pediatrics and the use of the therapeutic toy. Einstein, 8(1), 10-17. https://doi.org/0.1590/S1679-45082010AO1462
- Chan, C. W., Lam, L. W., Li, C. K., Cheung. J. S., Cheng. K. K., Chik. K. W., … & Tnag, W. P.Y. (2015). Feasibility of psychoeducational interventions in managing chemotherapy- associated nausea and vomiting (CANV) in pediatric oncology patients. Eur J Oncol Nurs., 9(2),182-90. https://doi.org/10.1016/j.ejon.2014.09.002
- Chung, J. O. K., Li, W. H. C., Cheung, A.T., Ho, L. L. K., Xia, W., Chan, G. C. F. & Lopez, V. (2021). Relationships among resilience, depressive symptoms, self‐esteem, and quality of life in children with cancer. Psycho‐Oncology, 30(2), 194-201. https://doi.org/10.1002/pon.5548
- van Dijk, M., Koot, H. M., Saad, H. H. A., Tibboel, D. & Passchier, J. (2002). Observational visual analog scale in pediatric pain assessment: Useful tool or good riddance? The Clinical Journal of Pain, 18(5), 310-316. https://doi.org/0.1097/00002508-200209000-00006
- Frygner-Holm, S., Russ, S., Quitmann, J., Ring, L., Zyga, O., Hansson, M., … & Höglund, A. T. (2020). Pretend play as an intervention for children with cancer: A feasibility study. Journal of Pediatric Oncology Nursing, 37(1), 65-75. https://doi.org/10.1177/1043454219874695
- Gariepy, N. & Howe, N. (2003). The therapeutic power of play: Examining the play of young children with leukaemia. Child Care, Health, and Development, 29, 523-537. https://doi.org/10.1046/j.1365-2214.2003.00372.x
- Godino-Iáñez, M. J., Martos-Cabrera, M. B., Suleiman-Martos, N., Gómez-Urquiza, J. L., Vargas-Román, K., Membrive-Jiménez, M.J. & Albendín-García, L. (2020). Play therapy as an ıntervention in hospitalized children: A systematic review. Healthcare, 29, 8(3), 239. doi: 10.3390/healthcare803023. https://doi.org/10.3390/healthcare8030239
- Griffiths, M. (2005). Video games and health. Video gaming is safe for most players and can be useful in health care. BMJ, 331, 7509, 122-123. https://doi.org/10.1136/bmj.331.7509.122
- Kabak, V. Y., Yakut, Y., Çetin, M. & Düger, T. (2016). Reliability and validity of the Turkish version of the PedsQL 3.0 cancer module for 2-to 7-year-old and the PedsQL 4.0 generic core scales for 5-to 7-year-old: the Hacettepe University experience. Turkish Journal of Hematology, 33(3), 236. https://doi.org/10.4274/tjh.2015.0242
Karakaya, A. & Gözen, D. (2016). The effect of distraction on pain level felt by school-age children during venipuncture procedure--randomized controlled trial. Pain Manag Nurs., 17(1), 47–53. https://doi.org/10.1016/j.pmn.2015.08.005
- Klimek, L. & Bergmann, K. C., Biedermann, T., Bousquet, J., Hellings, P., Jung, K., ... & Pfaar, O. (2017). Visual analogue scales (VAS): Measuring instruments for the documentation of symptoms and therapy monitoring in cases of allergic rhinitis in everyday health care. Allergo Journal International, 26(1), 16-24. https://doi.org/10.1007/s40629-016-0006-7
- Kurudirek, F. & Arıkan, D. (2020). Effects of therapeutic clowning on pain and anxiety during intrathecal chemotherapy in Turkey. Journal of Pediatric Nursing, 53, 6-13. https://doi.org/10.1016/j.pedn.2020.01.015
- Li, W. H., Chung, J. O., & Ho, E. K. (2011). The effectiveness of therapeutic play, using virtual reality computer games, in promoting the psychological well-being of children hospitalised with cancer. Journal of Clinical Nursing, 20 (15-16), 2135- 2143. https://doi.org/10.1111/j.1365-2702.2011.03733.x
- Li, H. C., Williams, P. D., Lopez, V., Chung, J. O. & Chiu, S. Y. (2013). Relationships among therapy-related symptoms, depressive symptoms, and quality of life in Chinese children hospitalized with cancer: an exploratory study. Cancer Nurs., (5), 346-354. https://doi.org/10.1097/NCC.0b013e31824062ec
- Li, W. H. C., Chan, S. S. C., Wong, E. M. L., Kwok, M. C. & Lee, I. T. L. (2014). Effect of therapeutic play on pre- and post-operative anxiety and emotional responses in Hong Kong Chinese children: A randomised controlled trial. Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 20, 7(7), 36–39. Accessed link: https://www.hkmj.org/system/files/hkm1406sp7p36.pdf , Accessed time: Jan, 2021.
- Li, W. H., Chung, J. O. K., Ho, K. Y. & Kwok, B. M. C. (2016). Play interventions to reduce anxiety and negative emotions in hospitalized children. BMC Pediatrics, 16(1), 1-9. https://doi.org/10.1186/s12887-016-0570-5
- Linder, L. A. & Hooke, M.C. (2019). Symptoms in children receiving treatment for cancer-part ii: pain, sadness, and symptom clusters. J Pediatr Oncol Nurs., 36(4), 262-279. https://doi.org/10.1177/1043454219849578
- Madden, J. R., Mowry, P., Gao, D., Cullen, P. M. & Foreman, N. K. (2010). Creative arts therapy improves quality of life for pediatric brain tumor patients receiving outpatient chemotherapy. Journal of Pediatric Oncology Nursing, 27, 133-145. https://doi.org/10.1177/1043454209355452
- Manav, G. & Ocakci, A. F. (2016). Play model for “evaluation of self-concept of children with cancer. Iranian Journal of Nursing snd Midwifery Research, 21(2), 124. https://doi.org/10.4103/1735-9066.178227
- McCulloch, R., Hemsley, J. & Kelly, P. (2014). Symptom management during chemotherapy. Paediatrics and Child Health, 24(4), 166-171. https://doi.org/10.1016/j.paed.2018.02.003
- Mohammadi, A., Mehraban, A. H., Damavandi, S. A., Zarei, M. A. & Haghani, H. (2021). The effect of play-based occupational therapy on symptoms and participation in daily life activities in children with cancer: A randomized controlled trial. British Journal of Occupational Therapy, 84(7). https://doi.org/10.1177/0308022620987125
- Newmani, A. R., Haglund, K. & Rodgers, C.C. (2019) Pediatric oncology nurses' perceptions of prognosis-related communication. Nurse Outlook, 67(1), 101-114. https://doi.org/10.1016/j.outlook.2018.11.001
- Ozcan, H. (2012) Investigation of the effect of art therapy study on the quality of life of children with cancer (Master thesis). https://tez.yok.gov.tr/UlusalTezMerkezi/tezDetay.jsp?id=86XXXOd8YRS-rgHrNQwcgQ&no=DbqCrWT95wyxLNlLo2pQhw
- Paula, A., Artilheiro, S., De Amorim Almeida, F., Maria, J. & Chacon, F. (2011). Use of therapeutic play in preparing preschool children for outpatient chemotherapy. Acta Paul Enferm Hospital, 24(5), 611–616. Accessed link: http://www.scielo.br/pdf/ape/v24n5/en_03v24n5.pdf
- Rosenberg, A. R., Orellana, L., Ullrich, C., Kang, T., Geyer, J. R., Feudtner, C., .... Wolfe, J. (2016). Quality of life in children with advanced cancer: a report from the PediQUEST study. Journal of Pain and Symptom Management, 52(2), 243-253. https://doi.org/10.1016/j.jpainsymman.2016.04.002
- Silva, S. G. T., Santos, M. A., Floriano, C. M. F., Damião, E. B. C., Campos, F. V. & Rossato, L. M. (2017). Influence of therapeutic play on the anxiety of hospitalized school-age children: Clinical trial. Rev Bras Enferm., 70(6), 1244-1249. https://doi.org/10.1590/0034-7167-2016-0353
- Sitaresmi, M. N., Mostert, S., Purwanto, I., Gundy, C. M., Sutaryo, & Veerman, A. J. (2009). Chemotherapy-related side effects in childhood acute lymphoblastic leukemia in Indonesia: parental perceptions. Journal of Pediatric Oncology Nursing, 26(4), 198-207. https://doi.org/10.1177/1043454209340315
- Stenmarker, E., Mellgren, K., Matus, M., Hakansson, A. S. & Stenmarker, M. (2018). Health-related quality of life, culture and communication: a comparative study in children with cancer in Argentina and Sweden. Journal of Patient-Reported Outcomes, 2(1), 1-12. https://doi.org/10.1186/s41687-018-0075-0
- Tanir, M. K. & Kuguoglu, S., (2011). Turkish validity and reliability of a Pediatric Quality of Life cancer module for children aged 8-12 and parents. Asian Pacific Journal of Cancer Prevention, 12, 125-130
- Thrane, S. (2013). Effectiveness of integrative modalities for pain and anxiety in children and adolescents with cancer: a systematic review. Journal of Pediatric Oncology Nursing, 30(6), 320-332. https://doi.org/10.1177/1043454213511538
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