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Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye

Yıl 2025, Cilt: 8 Sayı: 1, 90 - 102, 20.06.2025

Yakup Kara , Meryem Kara , Saliha Dinç

https://doi.org/10.35206/jan.1591193

Öz

Hawthorn (Crataegus spp.) fruits are widely recognized for their biologically active components and high nutritional content. This study examined the total flavonoid content (TFC), the total phenolic content (TPC), the antioxidant activity, and the phenolic composition of hawthorn fruit obtained from Sivas markets in Türkiye. The TPC and TFC contents were determined to be 2.160 mg GAE/ g FW and 0.193 mg QE/ g FW, respectively. Antioxidant activity was assessed using FRAP and DPPH assays with values of 0.709±0.028 µmol TE/g FW and 3.563±0.039 mg/mL, respectively. According to findings of phenolic composition, p-OH benzoic acid and ellagic acid were found to be the most abundant phenolic components of hawthorn fruits. In particular, this study revealed the existence of significant phenolic compounds pinocembrin (0.176 µg/g FW) and chrysin (0.166 µg/g FW) in hawthorn fruits for the first time, developing the understanding of variation in phytochemical composition and antioxidant potential. The outcomes of this research will provide important information about the phenolic composition, antioxidant activity, and potential nutritional benefits of hawthorn fruits from this area.

Anahtar Kelimeler

Hawthorn Antioxidant activity Phenolic composition Sivas

Kaynakça

  • Ağlar, E., Sümbül, A., Karakaya, O. & Ozturk, B. (2020). Determination of the quality characteristics of naturally growing Hawthorn in Susehri. Acta Scientiarum Polonorum. Hortorum Cultus 19(1): 61-70.
  • Akbulut, H. F. (2024). Crataegus monogyna jacq. Ve crataegus laevigata (poir.) Dc. Kirmizi aliç türlerinin meyve, çekirdek, sap kisimlarinin fitokimyasal ve antioksidan özellikler açisindan değerlendirilmesi. Gıda 49(4): 669-681.
  • Ali, M., Muhammad, S., Shah, M. R., Khan, A., Rashid, U., Farooq, U., Ullah, F., Sadiq, A., Ayaz, M., Ali, M., Ahmad, M. & Latif, A. (2017). Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking. Front Pharmacol 8: 327.
  • Alirezalu, A., Ahmadi, N., Salehi, P., Sonboli, A., Alirezalu, K., Mousavi Khaneghah, A., Barba, F. J., Munekata, P. E. S. & Lorenzo, J. M. (2020). Physicochemical Characterization, Antioxidant Activity, and Phenolic Compounds of
  • Hawthorn (Crataegus spp.) Fruits Species for Potential Use in Food Applications. Foods 9(4): 436. Bengü, A. Ş., Ertem, H. İ. & Bayramoğlu Akkoyun, M. (2023). Determinatıon of Some Biochemical Values of Crataegus orientalis (Eastern Hawthorn) Fruit Obtaıned from Genc District of Bingol. Türk Tarım ve Doğa Bilimleri Dergisi 10(4): 977-983.
  • Ceylan, Ş., Yarar, R., Camadan, Y., Saral, Ö. & Özşen, Ö. (2019). Determination of Antioxidant and Antimicrobial Activities of Some Medicinal Plants Grown in Şırnak Region of Turkey. Erzincan University Journal of Science and Technology 12(2): 628-638.
  • Çınar, N., Bayır Yeğin, A., Ayas, F. & Uysal Bayer, F. (2020). Batı Akdeniz Bölgesi Crataegus spp. Taksonlarında Fenolik/ Flavonoit Madde Miktarları, Antioksidan ve Antimikrobiyal Aktivite Değerleri. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24(2): 464-473.
  • Dinç, S., Kara, M., Takma, Ç., Kara, Y. & Kolaylı, S. (2024). Strawberries from Konya in the Central Anatolia Region of Türkiye: Phenolic Profile, Antioxidant Potential and Mineral Composition. Applied Fruit Science 66(4): 1229-1240.
  • Elbatreek, M. H., Mahdi, I., Ouchari, W., Mahmoud, M. F. & Sobeh, M. (2023). Current advances on the therapeutic potential of pinocembrin: An updated review. Biomedicine & Pharmacotherapy 157: 114032.
  • González-Jiménez, F. E., Salazar-Montoya, J. A., Calva-Calva, G. & Ramos-Ramírez, E. G. (2018). Phytochemical Characterization, In Vitro Antioxidant Activity, and Quantitative Analysis by Micellar Electrokinetic Chromatography of Hawthorn (Crataegus pubescens) Fruit. Journal of Food Quality 2018(1): 2154893.
  • Katanić Stanković, J. S., Mićanović, N., Grozdanić, N., Kostić, A. Ž., Gašić, U., Stanojković, T. & Popović-Djordjević, J. B. (2022). Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. Horticulturae 8(11): 1053.
  • Kemal, M., Esertaş, Ü. Z. Ü., Kanbur, E. D., Kara, Y., Özçelik, A. E., Can, Z. & Kolaylı, S. (2023). Characterization of the black cumin (Nigella sativa L.) honey from Türkiye. Food Bioscience 53: 102760.
  • Li, H., Gao, L., Shao, H., Li, B., Zhang, C., Sheng, H. & Zhu, L. (2022). Elucidation of active ingredients and mechanism of action of hawthorn in the prevention and treatment of atherosclerosis. Journal of Food Biochemistry 46(12): e14457.
  • Manuja, R., Sachdeva, S., Jain, A. & Chaudhary, J. (2013).A Comprehensive Review on Biological Activities of P-Hydroxy Benzoic Acid and Its Derivatives.
  • Molyneux, P. (2004). THE USE OF THE STABLE FREE RADICAL DIPHENYLPICRYLHYDRAZYL (DPPH) FOR ESTIMATING ANTIOXIDANT ACTIVITY. Songklanakarin Journal of Science and Technology (SJST) 26: 211-219.
  • Mraihi, F., Hidalgo, M., de Pascual-Teresa, S., Trabelsi-Ayadi, M. & Chérif, J.-K. (2015). Wild grown red and yellow hawthorn fruits from Tunisia as source of antioxidants. Arabian Journal of Chemistry 8(4): 570-578.
  • Muradoğlu, F., Gürsoy, S. & Yıldız, K. (2019). Quantification Analysis of Biochemical and Phenolic Composition in
  • Hawthorn (Crataegus spp.) Fruits. Erwerbs-Obstbau 61(2): 189-194.
  • Natić, M., Pavlović, A., Bosco, F. L., Stanisavljević, N., Zagorac, D. D., Akšić, M. F. & Papetti, A. (2019). Nutraceutical properties and phytochemical characterization of wild Serbian fruits. European Food Research and Technology 245(2): 469-478.
  • Nazhand, A., Lucarini, M., Durazzo, A., Zaccardelli, M., Cristarella, S., Souto, S. B., Silva, A. M., Severino, P., Souto, E. B. & Santini, A. (2020). Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties. Forests 11(5): 564.
  • Oğuzhan Çalışkan, S. B., Derya Kılıç (2022).Hawthorn cultivation. In Minor Fruits, 1-32 (Ed M. P. Melekber Sülüşoğlu Durul). Ankara, Türkiye: Iksad Publication.
  • Ozderin, S. (2024). Chemical Properties, Antioxidant, and Antimicrobial Activities of Fruit extracts of Crataegus monogyna var. odemisii. BioResources 19(1): 1542-1557.
  • Özcan, M. M., Uslu, N. & Ahmed, I. A. M. (2023). Comparison of Physical and Bioactive Properties, Phenolic Compounds and Nutrients of Raw and Dehydrated Hawthorn (Crataegus spp.) Fruits. Erwerbs-Obstbau 65(4): 1119-1126.
  • Serteser, A., Kargioğlu, M., Gök, V., Bağci, Y., Ozcan, M. M. & Arslan, D. (2008). Determination of antioxidant effects of some plant species wild growing in Turkey. Int J Food Sci Nutr 59(7-8): 643-651.
  • Sharifi-Rad, J., Quispe, C., Castillo, C. M. S., Caroca, R., Lazo-Vélez, M. A., Antonyak, H., Polishchuk, A., Lysiuk, R., Oliinyk, P., De Masi, L., Bontempo, P., Martorell, M., Daştan, S. D., Rigano, D., Wink, M. & Cho, W. C. (2022). Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential. Oxid Med Cell Longev 2022: 3848084.
  • Song, J., He, Y., Luo, C., Feng, B., Ran, F., Xu, H., Ci, Z., Xu, R., Han, L. & Zhang, D. (2020). New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily. Pharmacological Research 161: 105109.
  • Sümbül, A., Yaman, M. & Topcu, Y. (2024). Effects of Different Treatments on Germination Capacity of Hawthorn (Crataegus spp.) Seeds. Erciyes Tarım ve Hayvan Bilimleri Dergisi 7(1): 1-7.
  • Tang, Z.-X., Zeng, Y.-K., Zhou, Y., Zang, S.-L., He, P.-G. & Fang, Y.-Z. (2006). Determination of Active Ingredients of Hawthorn by Capillary Electrophoresis with Electrochemical Detection. Chinese Journal of Chemistry 24(10): 1378-1383.
  • Turnalar Ülger, T., Oçkun, M. A., Guzelmeric, E., Sen, N. B., Sipahi, H., Özhan, Y., Kan, Y. & Yesilada, E. (2023). Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species. Molecules 28(18).
  • Yang, B. & Liu, P. (2012). Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. J Sci Food Agric 92(8): 1578-1590.
  • Zhang, Z., Chang, Q., Zhu, M., Huang, Y., Ho, W. K. & Chen, Z. (2001). Characterization of antioxidants present in hawthorn fruits. J Nutr Biochem 12(3): 144-152.

SİVAS/ TÜRKİYE ALICININ FENOLİK PROFİLİ VE ANTİOKSİDAN POTANSİYELİ

Yıl 2025, Cilt: 8 Sayı: 1, 90 - 102, 20.06.2025

Yakup Kara , Meryem Kara , Saliha Dinç

https://doi.org/10.35206/jan.1591193

Öz

Alıç (Crataegus spp.) meyvesi, biyolojik olarak aktif bileşenleri ve yüksek besin içeriği ile geniş çapta tanınmaktadır. Bu çalışmada, Türkiye'nin Sivas pazarlarından temin edilen alıç meyvesinin toplam flavonoid içeriği (TFC), toplam fenolik içeriği (TPC), antioksidan aktivitesi ve fenolik bileşimini incelenmiştir. TPC ve TFC değerleri sırasıyla 2.160 mg GAE/g FW ve 0.193 mg QE/g FW olarak belirlenmiştir. Antioksidan aktivite, FRAP ve DPPH yöntemleri kullanılarak değerlendirilmiş olup sırasıyla 0.709±0.028 µmol TE/g FW ve 3.563±0.039 mg/mL olarak ölçülmüştür. Fenolik bileşim bulgularına göre, alıç meyvesinin en yüksek fenolik bileşenleri olarak p-OH benzoik asit ve ellajik asit tespit edilmiştir. Özellikle bu çalışma, alıç meyvesinde ilk kez önemli fenolik bileşikler olan pinosembrin (0.176 µg/g FW) ve kersin (0.166 µg/g FW) varlığını ortaya koyarak fitokimyasal bileşimdeki çeşitlilik ve antioksidan potansiyelin anlaşılmasını geliştirmiştir. Bu araştırmanın sonuçları, bölgedeki alıç meyvelerinin fenolik bileşimi, antioksidan aktivitesi ve potansiyel besin faydaları hakkında önemli bilgiler sağlayacaktır.

Anahtar Kelimeler

Alıç Antioksidan aktivite Fenolik bileşimi Sivas

Kaynakça

  • Ağlar, E., Sümbül, A., Karakaya, O. & Ozturk, B. (2020). Determination of the quality characteristics of naturally growing Hawthorn in Susehri. Acta Scientiarum Polonorum. Hortorum Cultus 19(1): 61-70.
  • Akbulut, H. F. (2024). Crataegus monogyna jacq. Ve crataegus laevigata (poir.) Dc. Kirmizi aliç türlerinin meyve, çekirdek, sap kisimlarinin fitokimyasal ve antioksidan özellikler açisindan değerlendirilmesi. Gıda 49(4): 669-681.
  • Ali, M., Muhammad, S., Shah, M. R., Khan, A., Rashid, U., Farooq, U., Ullah, F., Sadiq, A., Ayaz, M., Ali, M., Ahmad, M. & Latif, A. (2017). Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking. Front Pharmacol 8: 327.
  • Alirezalu, A., Ahmadi, N., Salehi, P., Sonboli, A., Alirezalu, K., Mousavi Khaneghah, A., Barba, F. J., Munekata, P. E. S. & Lorenzo, J. M. (2020). Physicochemical Characterization, Antioxidant Activity, and Phenolic Compounds of
  • Hawthorn (Crataegus spp.) Fruits Species for Potential Use in Food Applications. Foods 9(4): 436. Bengü, A. Ş., Ertem, H. İ. & Bayramoğlu Akkoyun, M. (2023). Determinatıon of Some Biochemical Values of Crataegus orientalis (Eastern Hawthorn) Fruit Obtaıned from Genc District of Bingol. Türk Tarım ve Doğa Bilimleri Dergisi 10(4): 977-983.
  • Ceylan, Ş., Yarar, R., Camadan, Y., Saral, Ö. & Özşen, Ö. (2019). Determination of Antioxidant and Antimicrobial Activities of Some Medicinal Plants Grown in Şırnak Region of Turkey. Erzincan University Journal of Science and Technology 12(2): 628-638.
  • Çınar, N., Bayır Yeğin, A., Ayas, F. & Uysal Bayer, F. (2020). Batı Akdeniz Bölgesi Crataegus spp. Taksonlarında Fenolik/ Flavonoit Madde Miktarları, Antioksidan ve Antimikrobiyal Aktivite Değerleri. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 24(2): 464-473.
  • Dinç, S., Kara, M., Takma, Ç., Kara, Y. & Kolaylı, S. (2024). Strawberries from Konya in the Central Anatolia Region of Türkiye: Phenolic Profile, Antioxidant Potential and Mineral Composition. Applied Fruit Science 66(4): 1229-1240.
  • Elbatreek, M. H., Mahdi, I., Ouchari, W., Mahmoud, M. F. & Sobeh, M. (2023). Current advances on the therapeutic potential of pinocembrin: An updated review. Biomedicine & Pharmacotherapy 157: 114032.
  • González-Jiménez, F. E., Salazar-Montoya, J. A., Calva-Calva, G. & Ramos-Ramírez, E. G. (2018). Phytochemical Characterization, In Vitro Antioxidant Activity, and Quantitative Analysis by Micellar Electrokinetic Chromatography of Hawthorn (Crataegus pubescens) Fruit. Journal of Food Quality 2018(1): 2154893.
  • Katanić Stanković, J. S., Mićanović, N., Grozdanić, N., Kostić, A. Ž., Gašić, U., Stanojković, T. & Popović-Djordjević, J. B. (2022). Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia. Horticulturae 8(11): 1053.
  • Kemal, M., Esertaş, Ü. Z. Ü., Kanbur, E. D., Kara, Y., Özçelik, A. E., Can, Z. & Kolaylı, S. (2023). Characterization of the black cumin (Nigella sativa L.) honey from Türkiye. Food Bioscience 53: 102760.
  • Li, H., Gao, L., Shao, H., Li, B., Zhang, C., Sheng, H. & Zhu, L. (2022). Elucidation of active ingredients and mechanism of action of hawthorn in the prevention and treatment of atherosclerosis. Journal of Food Biochemistry 46(12): e14457.
  • Manuja, R., Sachdeva, S., Jain, A. & Chaudhary, J. (2013).A Comprehensive Review on Biological Activities of P-Hydroxy Benzoic Acid and Its Derivatives.
  • Molyneux, P. (2004). THE USE OF THE STABLE FREE RADICAL DIPHENYLPICRYLHYDRAZYL (DPPH) FOR ESTIMATING ANTIOXIDANT ACTIVITY. Songklanakarin Journal of Science and Technology (SJST) 26: 211-219.
  • Mraihi, F., Hidalgo, M., de Pascual-Teresa, S., Trabelsi-Ayadi, M. & Chérif, J.-K. (2015). Wild grown red and yellow hawthorn fruits from Tunisia as source of antioxidants. Arabian Journal of Chemistry 8(4): 570-578.
  • Muradoğlu, F., Gürsoy, S. & Yıldız, K. (2019). Quantification Analysis of Biochemical and Phenolic Composition in
  • Hawthorn (Crataegus spp.) Fruits. Erwerbs-Obstbau 61(2): 189-194.
  • Natić, M., Pavlović, A., Bosco, F. L., Stanisavljević, N., Zagorac, D. D., Akšić, M. F. & Papetti, A. (2019). Nutraceutical properties and phytochemical characterization of wild Serbian fruits. European Food Research and Technology 245(2): 469-478.
  • Nazhand, A., Lucarini, M., Durazzo, A., Zaccardelli, M., Cristarella, S., Souto, S. B., Silva, A. M., Severino, P., Souto, E. B. & Santini, A. (2020). Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties. Forests 11(5): 564.
  • Oğuzhan Çalışkan, S. B., Derya Kılıç (2022).Hawthorn cultivation. In Minor Fruits, 1-32 (Ed M. P. Melekber Sülüşoğlu Durul). Ankara, Türkiye: Iksad Publication.
  • Ozderin, S. (2024). Chemical Properties, Antioxidant, and Antimicrobial Activities of Fruit extracts of Crataegus monogyna var. odemisii. BioResources 19(1): 1542-1557.
  • Özcan, M. M., Uslu, N. & Ahmed, I. A. M. (2023). Comparison of Physical and Bioactive Properties, Phenolic Compounds and Nutrients of Raw and Dehydrated Hawthorn (Crataegus spp.) Fruits. Erwerbs-Obstbau 65(4): 1119-1126.
  • Serteser, A., Kargioğlu, M., Gök, V., Bağci, Y., Ozcan, M. M. & Arslan, D. (2008). Determination of antioxidant effects of some plant species wild growing in Turkey. Int J Food Sci Nutr 59(7-8): 643-651.
  • Sharifi-Rad, J., Quispe, C., Castillo, C. M. S., Caroca, R., Lazo-Vélez, M. A., Antonyak, H., Polishchuk, A., Lysiuk, R., Oliinyk, P., De Masi, L., Bontempo, P., Martorell, M., Daştan, S. D., Rigano, D., Wink, M. & Cho, W. C. (2022). Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential. Oxid Med Cell Longev 2022: 3848084.
  • Song, J., He, Y., Luo, C., Feng, B., Ran, F., Xu, H., Ci, Z., Xu, R., Han, L. & Zhang, D. (2020). New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily. Pharmacological Research 161: 105109.
  • Sümbül, A., Yaman, M. & Topcu, Y. (2024). Effects of Different Treatments on Germination Capacity of Hawthorn (Crataegus spp.) Seeds. Erciyes Tarım ve Hayvan Bilimleri Dergisi 7(1): 1-7.
  • Tang, Z.-X., Zeng, Y.-K., Zhou, Y., Zang, S.-L., He, P.-G. & Fang, Y.-Z. (2006). Determination of Active Ingredients of Hawthorn by Capillary Electrophoresis with Electrochemical Detection. Chinese Journal of Chemistry 24(10): 1378-1383.
  • Turnalar Ülger, T., Oçkun, M. A., Guzelmeric, E., Sen, N. B., Sipahi, H., Özhan, Y., Kan, Y. & Yesilada, E. (2023). Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species. Molecules 28(18).
  • Yang, B. & Liu, P. (2012). Composition and health effects of phenolic compounds in hawthorn (Crataegus spp.) of different origins. J Sci Food Agric 92(8): 1578-1590.
  • Zhang, Z., Chang, Q., Zhu, M., Huang, Y., Ho, W. K. & Chen, Z. (2001). Characterization of antioxidants present in hawthorn fruits. J Nutr Biochem 12(3): 144-152.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Mühendisliği
Bölüm Araştırma Makaleleri
Yazarlar

Yakup Kara 0000-0003-3121-5023

Meryem Kara 0000-0003-0893-867X

Saliha Dinç 0000-0003-2485-8434

Yayımlanma Tarihi 20 Haziran 2025
Gönderilme Tarihi 25 Kasım 2024
Kabul Tarihi 11 Mayıs 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 8 Sayı: 1

Kaynak Göster

APA Kara, Y., Kara, M., & Dinç, S. (2025). Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye. Journal of Apitherapy and Nature, 8(1), 90-102. https://doi.org/10.35206/jan.1591193
AMA Kara Y, Kara M, Dinç S. Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye. J.Apit.Nat. Haziran 2025;8(1):90-102. doi:10.35206/jan.1591193
Chicago Kara, Yakup, Meryem Kara, ve Saliha Dinç. “Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye”. Journal of Apitherapy and Nature 8, sy. 1 (Haziran 2025): 90-102. https://doi.org/10.35206/jan.1591193.
EndNote Kara Y, Kara M, Dinç S (01 Haziran 2025) Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye. Journal of Apitherapy and Nature 8 1 90–102.
IEEE Y. Kara, M. Kara, ve S. Dinç, “Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye”, J.Apit.Nat., c. 8, sy. 1, ss. 90–102, 2025, doi: 10.35206/jan.1591193.
ISNAD Kara, Yakup vd. “Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye”. Journal of Apitherapy and Nature 8/1 (Haziran 2025), 90-102. https://doi.org/10.35206/jan.1591193.
JAMA Kara Y, Kara M, Dinç S. Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye. J.Apit.Nat. 2025;8:90–102.
MLA Kara, Yakup vd. “Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye”. Journal of Apitherapy and Nature, c. 8, sy. 1, 2025, ss. 90-102, doi:10.35206/jan.1591193.
Vancouver Kara Y, Kara M, Dinç S. Phenolic Profile and Antioxidant Potential of Hawthorn From The Sivas Region of Türkiye. J.Apit.Nat. 2025;8(1):90-102.
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  • 23484   ASOS Index